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Chandersekar L.,Jagdishprasad Jhabarmal Tibrewala University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

Acne vulgaris is one of the most common skin diseases, which is observed in about 90% of young adults sometime or the other in their life. The present review article describes the pathophysiology and topical therapy for acne. The pathophysiological factors that cause the development of acne are [1)Abnormal keratinization and desquamation of pilosebaceous follicular epithelium [comedogenesis), [2) Increased sebum production, [3) Follicular proliferation of Propionibacterium acnes and [4) Inflammation. No topical therapies influence the production of sebum .Topical tretinoin [all-trans-retinoic acid) slows the desquamation process, thereby reducing the number of microcomedones & comedones. Adapalene- a naphthoic acid derivative a far more stable molecule than tretnoin offers comparable efficacy and also less irritating. Salicylic acid is effective against comedones and inflammatory lesions in acne vulgaris .Topical isotretinoin is effective against both non-inflammatory and inflammatory lesions. Benzoyl peroxide[BP) for topical therapy is an oxidizing agent that is bactericidal for P.acnes. Azelaic acid is effective against mild to moderate inflammatory and non-inflammatory acne. Topical antibiotics like erythromycin, clindamycin and metronidazole also cause a decrease in the production of chemotactic factors by P.acnes, reducing the tendency towards inflammation. Use of intralesional corticosteroids is popular in severe nodular or systic forms of acne. Other modes of treatments also discussed.

Chauhan H.N.,K K Shah Jarodwala Maninagar Science College | Vyas N.N.,P.A. College | Doshi A.V.,Jagdishprasad Jhabarmal Tibrewala University
Molecular Crystals and Liquid Crystals | Year: 2013

A novel homologous series entitled α-4-[4′-n-Alkoxy benzoyloxy] benzoyl β-4″-chloro phenyl ethylenes consists of 12 homologues. The pentyl to tetradecyl homologues are enatiotropically nematogenic and all of the other homologues (methyl to butyl and hexadecyl) are nonmesogenic. The textures of the nematogenic mesophase are threaded or Schlieren in nature. The transition temperatures were determined by an optical polarizing microscope with a heating stage. The phase diagram of the novel series shows a normal behavior with negligible abnormality in trend of the nematic-isotropic transition curve and exhibits an odd-even effect as expected. The nematic thermal stability is 149.4°C on average. The series is nematogenic without any smectogenic character. The mesogenic properties of the novel series are compared with known series that are structurally similar. © 2013 Copyright Taylor and Francis Group, LLC.

Chauhan H.N.,Shri University | Chauhan H.N.,K K Shah Jarodwala Maninagar Science College | Doshi A.V.,Jagdishprasad Jhabarmal Tibrewala University
Der Pharma Chemica | Year: 2012

Titled homologous series consists of eleven homologues. Methyl to n-butyl and hexadecyl derivatives are nonliquid crystal while rest of the homologes Viz. n-pentyl to n-tetradecyl derivatives are only enantiotropic nematogenic without exhibition of any smectic character. Odd even effect is observed in nematic-isotropic transition curve. A phase diagram shows that Solid-isotropic or nematic transition curve follows. zigzag path of rising and falling. Nematic-isotropic transition curve behaves in normal manner. Analytical data support the structures of molecules. Texture of nematic mesophase is schlierens or threaded type. Transition and melting temperatures of homologues are determined from hot stage polarising microscope. Liquid Crystal (LC) properties of the series are compared with other structurally similar homologous series. Series is entirly nematogenic with relatively high melting type.

Chandersekar L.,Jagdishprasad Jhabarmal Tibrewala University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

The skin is the interface between man and his environment. It is involved in water regulation, protection against micro-organisms, thermoregulation, excretion, vitamin D synthesis, and the reception of various stimuli. Wrinkles are a major topic in dermocosmetics as it is fundamental to understand modifications associated with cutaneous damage. Aging is a multistep, multifaceted, time-dependent phenomenon characterized by the decreased ability of a system to respond to exogenous and endogenous stress from either physical, chemical or biologic agents. It is only in the last 30 years researchers have become aware of the distinction between intrinsic , chronologic aging and extrinsic aging due to habitual sun exposure. In Skin, the principle extrinsic factor is ultraviolet light(UV) which is responsible for the constellation of changes termed photoaging. This review provides an overview on mechanisms of skin aging.

Das B.,Jagdishprasad Jhabarmal Tibrewala University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Objective: The objective of this research was to develop and validate a simple, sensitive and specific Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) quantification of Gabapentin in human plasma. The analytical method consists of liquid-liquid extraction of plasma sample followed by the determination of Gabapentin by a LC-MS/MS. Method: The analyte was separated on a Zorbax Eclipse XDB -C18 (150 x 4.6 mm, 5 μ) column with an isocratic mobile phase of Methanol: Water (50: 50 v/v, pH of 3.0) at a flow rate of 0.8 mL/min. Protonated ions formed by a turbo ionspray in a positive mode was used to detect analyte and internal standard (IS). The MS/MS detection was made by monitoring the fragmentation of m/z 172.20→154.20 for Gabapentin and m/z 176.40→158.10 for internal standard on a mass spectrometer. Results: The method was validated over the concentration range of 51.356 ng/mL to 8217.008 ng/mL for Gabapentin in human plasma with correlation coefficient greater than 0.98. Conclusion: The developed method was successfully applied for analyzing Gabapentin in plasma samples for a bioequivalence study with healthy volunteers.

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