Jagdishprasad Jhabarmal Tibrewala University

jjtu.ac.in
Jhunjhunun, India
SEARCH FILTERS
Time filter
Source Type

Kulkarni C.,Jagdishprasad Jhabarmal Tibrewala University
2016 International Conference on Information Technology, InCITe 2016 - The Next Generation IT Summit on the Theme - Internet of Things: Connect your Worlds | Year: 2016

Reusing of code has been a very common practice in software development. This practice has been implemented to reduce programming time and efforts greatly. This copying and pasting behavior of programmers leads to cloning of codes and therefore has a very serious impact on the maintenance of the software systems. Many clone detection tool has been proposed to find out the copied code. However, refactoring of code is still a challenging part as most of the ongoing tools depend on detection of clone rather than the ability to make decision on refactorability. These tools do not guarantee whether such codes can be safely refactored or not. Our aim mainly lies on detecting the possibility of refactoring a code. To find out whether the code clone can be securely refactored or not, three methods are applied: Nesting Structure Mapping, Statement Mapping and Precondition Examination. In order to refactor the code, we apply some techniques like Pull-Up Method and Push-Down Method. In our approach, we have tried to find the refactorable code using the methods and also refactored the code so as to remove the problem of code cloning. © 2016 IEEE.


Chauhan H.N.,K K Shah Jarodwala Maninagar Science College | Vyas N.N.,P.A. College | Doshi A.V.,Jagdishprasad Jhabarmal Tibrewala University
Molecular Crystals and Liquid Crystals | Year: 2013

A novel homologous series entitled α-4-[4′-n-Alkoxy benzoyloxy] benzoyl β-4″-chloro phenyl ethylenes consists of 12 homologues. The pentyl to tetradecyl homologues are enatiotropically nematogenic and all of the other homologues (methyl to butyl and hexadecyl) are nonmesogenic. The textures of the nematogenic mesophase are threaded or Schlieren in nature. The transition temperatures were determined by an optical polarizing microscope with a heating stage. The phase diagram of the novel series shows a normal behavior with negligible abnormality in trend of the nematic-isotropic transition curve and exhibits an odd-even effect as expected. The nematic thermal stability is 149.4°C on average. The series is nematogenic without any smectogenic character. The mesogenic properties of the novel series are compared with known series that are structurally similar. © 2013 Copyright Taylor and Francis Group, LLC.


Chauhan H.N.,Shri University | Chauhan H.N.,K K Shah Jarodwala Maninagar Science College | Doshi A.V.,Jagdishprasad Jhabarmal Tibrewala University
Der Pharma Chemica | Year: 2012

Titled homologous series consists of eleven homologues. Methyl to n-butyl and hexadecyl derivatives are nonliquid crystal while rest of the homologes Viz. n-pentyl to n-tetradecyl derivatives are only enantiotropic nematogenic without exhibition of any smectic character. Odd even effect is observed in nematic-isotropic transition curve. A phase diagram shows that Solid-isotropic or nematic transition curve follows. zigzag path of rising and falling. Nematic-isotropic transition curve behaves in normal manner. Analytical data support the structures of molecules. Texture of nematic mesophase is schlierens or threaded type. Transition and melting temperatures of homologues are determined from hot stage polarising microscope. Liquid Crystal (LC) properties of the series are compared with other structurally similar homologous series. Series is entirly nematogenic with relatively high melting type.


Sahu P.K.,Jiwaji University | Sahu P.K.,Jagdishprasad Jhabarmal Tibrewala University | Gupta S.K.,Jiwaji University | Thavaselvam D.,Canadian Department of National Defence | And 2 more authors.
European Journal of Medicinal Chemistry | Year: 2012

A novel, one-pot, simple, efficient procedure for 4H-pyrimido[2,1-b] benzothiazole (4a-h), pyrazole (6a-d) and benzylidene (7a-d) derivatives of curcumin under solvent and solvent free conditions in microwave with good yield is have been synthesized. The synthesized compounds were evaluated for their antibacterial activity against gram-positive and gram-negative bacteria viz. Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi, Escherichia coli, Bacillus cereus and Providencia rettgeri and antifungal activity against fungi viz Aspergillus niger, Aspergillus fumigates, Aspergillus flavus. Detailed mechanistic study shows reaction proceeds through Knoevenagel type intermediate 3a which has been suggested as key intermediate for reaction (Fig. 3). © 2012 Elsevier Masson SAS. All rights reserved.


Sahu P.K.,Jiwaji University | Sahu P.K.,Jagdishprasad Jhabarmal Tibrewala University | Gupta S.K.,Jiwaji University | Agarwal D.D.,Jiwaji University | Agarwal D.D.,Jagdishprasad Jhabarmal Tibrewala University
Industrial and Engineering Chemistry Research | Year: 2014

A convenient and rapid method is described for the synthesis of nitrogen heterocyclic derivatives by one-pot three-component reaction of substituted aromatic aldehydes, dicarbonyl- and 2-aminobenzothiazole/3-amino-1,2,4-triazole/ urea/thiourea using commercially available chitosan in 2% acetic acid in aqueous media at 60-65 C. Chitosan was used as an efficient biodegradable and reusable green catalyst for this multicomponent reaction. The chitosan catalyst can be reused 10 times in fresh reaction. Catalytic activity has been sustained in the first five runs but slightly decreased in subsequent cycles. © 2014 American Chemical Society.


Sahu P.K.,Jiwaji University | Sahu P.K.,Jagdishprasad Jhabarmal Tibrewala University | Agarwal D.D.,Jiwaji University | Agarwal D.D.,Jagdishprasad Jhabarmal Tibrewala University
RSC Advances | Year: 2013

A kaolin catalyzed solvent-free synthesis for new heterocyclic compounds is described. A series of heterocyclic compounds can be readily obtained using the three-component reaction of diketones, aldehydes and 2-amino benzothiazole, urea or thiourea. The mechanism of the three component kaolin catalyzed Biginelli (using urea and thiourea) and Biginelli like (using 2-amino benzothiazole) reaction has been investigated. This is the first time that we have isolated and characterized the key intermediates using 1H NMR, 13C NMR and ESI-mass spectral characterization. Imine 3 and Knoevenagel type intermediate 4 were strongly suggested as key intermediates by mechanistic study. The reaction is simple, clean and good yield is obtained within minutes. © 2013 The Royal Society of Chemistry.


Chauhan H.N.,Jagdishprasad Jhabarmal Tibrewala University | Chauhan H.N.,Gujarat University | Doshi A.V.,Jagdishprasad Jhabarmal Tibrewala University
Molecular Crystals and Liquid Crystals | Year: 2012

Eleven members of a novel homologous series of α-3-[-4′-n- alkoxy cinnamoyloxy] phenyl β-4″-methoxy benzoyl ethylenes were synthesized. The methyloxy, ethyloxy, butyloxy, and hexadecyloxy homologues are nonmesomorphic, while all the other homologues are mesomorphic. The mesomorphic homologues are enantiotropically smectogenic in combination with nematogenic character, except for the propyloxy homologue, which shows only nematogenic character. A phase diagram of the series shows the expected mesomorphic behavior. Transition temperatures of this series are observed through an optical polarizing microscope equipped with a heating stage. An odd-even effect is observed for nematic-isotropic transition curve. Analytical data supports the structures of the molecules. Mesomorphic temperature range varies from 23°C to 51°C. Liquid crystal properties of this series are compared with a structurally similar homologous series. The smectic and nematic thermal stability of the series are 138.8°C and 165.7°C, respectively. The nematic phase shows a threaded or schlieren texture, and the smectic phase is a smectic A phase. Copyright © Taylor & Francis Group, LLC.


Chandersekar L.,Jagdishprasad Jhabarmal Tibrewala University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

Acne vulgaris is one of the most common skin diseases, which is observed in about 90% of young adults sometime or the other in their life. The present review article describes the pathophysiology and topical therapy for acne. The pathophysiological factors that cause the development of acne are [1)Abnormal keratinization and desquamation of pilosebaceous follicular epithelium [comedogenesis), [2) Increased sebum production, [3) Follicular proliferation of Propionibacterium acnes and [4) Inflammation. No topical therapies influence the production of sebum .Topical tretinoin [all-trans-retinoic acid) slows the desquamation process, thereby reducing the number of microcomedones & comedones. Adapalene- a naphthoic acid derivative a far more stable molecule than tretnoin offers comparable efficacy and also less irritating. Salicylic acid is effective against comedones and inflammatory lesions in acne vulgaris .Topical isotretinoin is effective against both non-inflammatory and inflammatory lesions. Benzoyl peroxide[BP) for topical therapy is an oxidizing agent that is bactericidal for P.acnes. Azelaic acid is effective against mild to moderate inflammatory and non-inflammatory acne. Topical antibiotics like erythromycin, clindamycin and metronidazole also cause a decrease in the production of chemotactic factors by P.acnes, reducing the tendency towards inflammation. Use of intralesional corticosteroids is popular in severe nodular or systic forms of acne. Other modes of treatments also discussed.


Das G.K.,Jagdishprasad Jhabarmal Tibrewala University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Objective: The objective of this research was to develop and validate a simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantification of Topiramate in human plasma. Method: The analytical method consists of solid phase extraction of plasma sample followed by the determination of Topiramate by a LC-MS/MS. The analyte was separated on Advance Hypurity C18 (50 x 4.6 mm, 5μ) column with an isocratic mobile phase of Acetonitrile and 2mM ammonium acetate buffer in the volume ratio of 80:20 v/v at a flow rate of 0.8 mL/min. Results: Protonated ions formed by a turbo ion spray in a negative mode were used to detect analyte and internal standard (IS). The MS/MS detection was made by monitoring the fragmentation of m/z 338.00→77.50 for Topiramate and m/z 350.40→90.10 for internal standard on a mass spectrometer. The method was validated over the concentration range of 20.721 ng/mL to 605.656 ng/mL for Topiramate in human plasma with correlation coefficient greater than 0.99. Conclusion: The developed method was successfully applied for analyzing Topiramate in plasma samples for a bioequivalence study with healthy volunteers.


Das B.,Jagdishprasad Jhabarmal Tibrewala University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Objective: The objective of this research was to develop and validate a simple, sensitive and specific Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) quantification of Gabapentin in human plasma. The analytical method consists of liquid-liquid extraction of plasma sample followed by the determination of Gabapentin by a LC-MS/MS. Method: The analyte was separated on a Zorbax Eclipse XDB -C18 (150 x 4.6 mm, 5 μ) column with an isocratic mobile phase of Methanol: Water (50: 50 v/v, pH of 3.0) at a flow rate of 0.8 mL/min. Protonated ions formed by a turbo ionspray in a positive mode was used to detect analyte and internal standard (IS). The MS/MS detection was made by monitoring the fragmentation of m/z 172.20→154.20 for Gabapentin and m/z 176.40→158.10 for internal standard on a mass spectrometer. Results: The method was validated over the concentration range of 51.356 ng/mL to 8217.008 ng/mL for Gabapentin in human plasma with correlation coefficient greater than 0.98. Conclusion: The developed method was successfully applied for analyzing Gabapentin in plasma samples for a bioequivalence study with healthy volunteers.

Loading Jagdishprasad Jhabarmal Tibrewala University collaborators
Loading Jagdishprasad Jhabarmal Tibrewala University collaborators