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Dhaka, Bangladesh

Jagannath University is a Government-Financed Public University in Sadarghat, Dhaka the capital of Bangladesh. Jagannath University is in the southern part of Dhaka city near the river Buriganga. Wikipedia.

Alam M.S.,Jagannath University | Nam Y.-J.,Dongguk University | Lee D.-U.,Dongguk University
European Journal of Medicinal Chemistry | Year: 2013

In the present study, a series of (Z)-2,3-diphenylacrylonitrile analogs were synthesized and then evaluated in terms of their cytotoxic activities against four human cancer cell lines, e.g. lung cancer (A549), ovarian cancer (SK-OV-3), skin cancer (SK-MEL-2), and colon cancer (HCT15), as well as anti-microbial activities against three microbes, e.g. Staphylococcus aureus, Salmonella typhi, and Aspergillus niger. The title compounds were synthesized by Knoevenagel condensation reaction of benzyl cyanide or p-nitrobenzyl cyanide with substituted benzaldehydes in good yields. Most of the compounds exhibited significant suppressive activities against the growth of all cancer cell lines. Compound 3c was most active in inhibiting the growth of A549, SK-OV-3, SK-MEL-2, and HCT15 cells lines with IC50 values of 0.57, 0.14, 0.65, and 0.34 mg/mL, respectively, followed by compounds 3f, 3i, and 3h. Compound 3c exhibited 2.4 times greater cytotoxic activity against HCT15 cells, whereas it showed similar potency against SK-OV-3 cells to that of the standard anti-cancer agent doxorubicin. Structure-activity relationship study revealed that electron-donating groups at the para-position of phenyl ring B were more favorable for improved cytotoxic activity, whereas the presence of electron-withdrawing groups was unfavorable compare to unsubstituted acrylonitrile. An optimal electron density on phenyl ring A of (Z)-2,3-diphenylacrylonitrile analogs was crucial for their cytotoxic activities against human cancer cell lines used in the present study. Qualitative structure-cytotoxic activity relationships were studied using physicochemical parameters; a good correlation between calculated polar surface area (PSA), a lipophobic parameter, and cytotoxic activity was found. Moreover, all compounds showed significant anti-bacterial activities against S. typhi, whereas compound 3k showed potent inhibition against both S. aureus and S. typhi bacterial strains. © 2013 Elsevier Masson SAS. All rights reserved. Source

Rahman A.K.M.L.,Kyushu University | Rahman A.K.M.L.,Jagannath University | Kumashiro M.,Kyushu University | Ishihara T.,Kyushu University
Catalysis Communications | Year: 2011

The direct synthesis of formic acid by partial oxidation of methane was studied using hydrogen peroxide (H2O2) as oxidant with keeping reaction temperature of 373 K and a pressure of 2.6 MPa. High yield (13.0%) and selectivity (66.8%) of formic acid (HCOOH) an important oxygenated compound in chemical industry were achieved using protonated pentasil-type zeolite (H-ZSM-5) as a solid acid catalyst. Tryphenylphosphene(Ph3P) was used as a promoter in reaction system. A fairly large amount of CO 2 was also observed as deep oxidation product. © 2011 Elsevier B.V. Source

Singh J.,Jagannath University | Kumar D.,Jagannath Gupta Institute of Engineering and Technology | Kumar S.,National Institute of Technology Jamshedpur
Ain Shams Engineering Journal | Year: 2013

In this paper, a user friendly algorithm based on new homotopy perturbation transform method (HPTM) is proposed to solve nonlinear fractional Fornberg-Whitham equation in wave breaking. The new homotopy perturbation transform method is combined form of Laplace transform, homotopy perturbation method and He's polynomials. The nonlinear terms can be easily handled by the use of He's polynomials. The numerical solutions obtained by the proposed method indicate that the approach is easy to implement and computationally very attractive. © 2012 Ain Shams University. Production and hosting by Elsevier B.V. All rights reserved. Source

Alam M.S.,Jagannath University | Choi J.-H.,Dongguk University | Lee D.-U.,Dongguk University
Bioorganic and Medicinal Chemistry | Year: 2012

4-Aminoantipyrine (4-amino-1,5-dimethyl-2-phenylpyrazole-3-one) and its analogues have been found to be compounds of interest for their anti-inflammatory, analgesic, antiviral, antipyretic, antirheumatic and antimicrobial activities. In the present study, Schiff base analogues of 4-aminoantipyrine were synthesized by the condensation reaction with substituted benzaldehydes and then evaluated for their antioxidant and anti-inflammatory activities. From among the synthesized compounds (3a-m, 4 and 5), 3k and 3f exhibited the highest antioxidant activity followed by 3g, 3l, 3c, 3i, 5, 3m and 3h. The IC 50 values for compounds 3k and 3f were found to be 0.44 and 0.93 μM, respectively, comparable to that of ascorbic acid (IC 50 0.41 μM), a standard antioxidant agent. From the comparisons between the hydroxylated and methoxylated compounds, the rank order of antioxidant activity for the products resulting from benzylidene phenyl ring substitution was 2,4,6-OH > 3,4-OH > 3-OMe-4-OH > 3,5-OMe-4-OH > 2,4-OH > 3-Me-4-OMe > 3,4-OMe > 4-OMe > 4-OH. The structure-activity relationship study revealed that the position and nature of the substituted group on the benzylidene phenyl ring of the Schiff base analogues of 4-aminoantipyrine play an important role in their antioxidant activity. The anti-inflammatory activity of 3f, which also exhibited excellent antioxidant activity, was evaluated in terms of its inhibition of NO production, an inflammatory modulator, in LPS pretreated RAW 264.7 cells using the Griess method. We also examined whether or not this compound had effect on iNOS and COX-2 mRNA expression in RAW 264.7 cells. It was observed that compound 3f significantly reduced NO production and inhibited LPS-stimulated iNOS and COX-2 mRNA levels in a dose-dependent manner. Overall, 3f showed promising antioxidant and anti-inflammatory activities and may be used as the lead compound in a future study. © 2012 Elsevier Ltd. All rights reserved. Source

Rahman M.M.,Konkuk University | Li X.-B.,Konkuk University | Kim J.,Konkuk University | Lim B.O.,Konkuk University | And 3 more authors.
Sensors and Actuators, B: Chemical | Year: 2014

A simple and cheap cholesterol biosensor was designed by immobilizing cholesterol oxidase (ChOx) and horseradish peroxidase (HRP) onto a poly(thionine)-modified glassy carbon electrode (GCE/PTH). Being mediated by hydroquinone (HQ), the immobilized HRP exhibited excellent electrocatalytic activity in reducing H2O2, which was produced from cholesterol by the enzymatic reaction of ChOx. The linear detection range for cholesterol was 25-125 μM, with a detection limit (S/N = 3) and a sensitivity of 6.3 μM and 0.18 μA/cm2/μM, respectively, under optimal conditions. The highly reproducible and sensitive GCE/PTH/ChOx/HRP sensor exhibited an interference-free signal for cholesterol detection with excellent recoveries for real sample analysis. © 2014 Elsevier B.V. Source

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