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Seogwipo Si, South Korea

Nho Y.-C.,Korea Atomic Energy Research Institute | Park J.-S.,Korea Atomic Energy Research Institute | Shin J.-W.,Korea Atomic Energy Research Institute | Lim Y.-M.,Korea Atomic Energy Research Institute | And 5 more authors.
Journal of the Korean Physical Society | Year: 2015

A buccal delivery system provides a much milder environment for drug delivery compared to an oral delivery which presents a hostile environment for drugs, especially proteins and polypeptides, owing to acid hydrolysis. Local delivery in an oral cavity has particular applications in the treatment of toothaches, periodontal disease, and bacterial infections. Poly(acrylic acid) (PAA)-based hydrogels prepared using a chemical initiator have been attempted for a mucoadhesive system owing to their flexibility and excellent bioadhesion. In this experiment, PAA and polyethylene glycol (PEG) were selected to prepare using a radiation process a bioadhesive hydrogel for adhesion to mucosal surfaces. PAA and PEG were dissolved in purified water to prepare a homogeneous PAA/PEG solution, and the solution was then irradiated using an electron beam at dose up to 70 kGy to make the hydrogels. Their physical properties, such as gel percent, swelling percent, and adhesive strength to mucosal surfaces, were investigated. In this experiment, various amounts of PEG were incorporated into the PAA to enhance the mucoadhesive property of the hydrogels. The effect of the molecular weight of PEG on the mucoadhesion was also examined. © 2015, The Korean Physical Society.


Jeong J.-O.,Korea Atomic Energy Research Institute | Jeong S.I.,Korea Atomic Energy Research Institute | Shin Y.M.,Korea Atomic Energy Research Institute | Park J.-S.,Korea Atomic Energy Research Institute | And 5 more authors.
Polymer (Korea) | Year: 2015

Polycaprolactone (PCL) and biphasic calcium phosphate (BCP) have been considered as useful materials for orthopedic devices and osseous implants because of their biocompatibility and bone-forming activity. However, PCL-based scaffolds have hydrophobic surfaces reducing initial cell adhesion or proliferation. To overcome the limitation, we fabricated surface-modified PCL/BCP nanofibers using gamma-irradiation for bone tissue engineering. PCL/BCP nanofibers were prepared by electrospinning and then we supplemented hydrophilicity by introducing acrylic acid (AAc) through gamma-irradiation. We confirmed the surface of nanofibers by SEM, and then the initial viability of MG63 was significantly increased on the AAc grafted nanofibers, and alkaline phosphatase activity(1.239±0.226 nmole/ug/min) improved on the modified nanofibers than that on the non-modified nanofibers(0.590±0.286 nmole/ug/min). Therefore, AAc-grafted nanofibers may be a good tool for bone tissue engineering applications. © 2015 The Polymer Society of Korea. All rights reserved.


Jeong S.I.,Korea Atomic Energy Research Institute | Jeong J.-O.,Korea Atomic Energy Research Institute | Choi J.-B.,Korea Atomic Energy Research Institute | Shin Y.M.,Korea Atomic Energy Research Institute | And 6 more authors.
Tissue Engineering and Regenerative Medicine | Year: 2014

Bacterial cellulose(BC) scaffolds are generated from gel by gluconacetobacter hansenii TL-2C. BC has good properties such as high-burst pressure and the ultrafine highly nanofibrous structure of mimic natural extra celluar matrix(ECM) for tissue engineering. In this study, 2-aminoethyl methacrylate(AEMA) was grafted onto BC surface using gamma-irradiation and then heparin immobilized it using EDC/NHS reaction. The surface morphology of scaffolds were confirmed BC membranes by SEM for heparin and AEMA grafted it, so that it was not changed surface morphology. The result of TBO, fluorescamine staining, ATR-FTIR confirmed that heparin and AEMA immobilized it. Also result of in vitro test, heparin immobilized AEMA-BC proliferation of hMSC to higher than unmodified BC by CCK-8 and ALP activity then heparin immobilized AEMA-BC cumulative of BMP-2 was confirmed decrease by release test. Therefore, heparin and AEMA grafted BC scaffolds have been possible to tissue scaffold in bone tissue engineering. © 2014 The Korean Tissue Engineering and Regenerative Medicine Society and Springer Science+Business Media Dordrecht.

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