Jacksonville Beach, FL, United States
Jacksonville Beach, FL, United States

Jacksonville University is a private university in Jacksonville, Florida, United States. The school was founded in 1934 as a two-year college and was known as Jacksonville Junior College until 1958, when it shifted its focus to four-year university degrees and adopted its present name. It is a member of the Independent Colleges and Universities of Florida and is accredited by the Southern Association of Colleges and Schools and the Association to Advance Collegiate Schools of Business . Its sports teams are known as the Jacksonville Dolphins. Wikipedia.


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Bates E.R.,University of Michigan | Lau W.C.,University of Michigan | Angiolillo D.J.,Jacksonville University
Journal of the American College of Cardiology | Year: 2011

Multidrug therapy increases the risk for drugdrug interactions. Clopidogrel, a prodrug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y 12 adenosine diphosphate (ADP) receptor, decreasing platelet activation and aggregation processes. Atorvastatin, omeprazole, and several other drugs have been shown in pharmacodynamic studies to competitively inhibit CYP activation of clopidogrel, reducing clopidogrel responsiveness. Conversely, other agents increase clopidogrel responsiveness by inducing CYP activity. The clinical implications of these pharmacodynamic interactions have raised concern because many of these drugs are coadministered to patients with coronary artery disease. There are multiple challenges in proving that a pharmacodynamic drugdrug interaction is clinically significant. To date, there is no consistent evidence that clopidogreldrug interactions impact adverse cardiovascular events. Statins and proton pump inhibitors have been shown to decrease adverse clinical event rates and should not be withheld from patients with appropriate indications for therapy because of concern about potential clopidogreldrug interactions. Clinicians concerned about clopidogreldrug interactions have the option of prescribing either an alternative platelet P2Y12 receptor inhibitor without known drug interactions, or statin and gastro-protective agents that do not interfere with clopidogrel metabolism. © 2011 American College of Cardiology Foundation.


Sharma R.,Jacksonville University | Hudak M.L.,Jacksonville University
Clinics in Perinatology | Year: 2013

Necrotizing enterocolitis (NEC) primarily affects premature infants. It is less common in term and late preterm infants. The age of onset is inversely related to the postmenstrual age at birth. In term infants, NEC is commonly associated with congenital heart diseases. NEC has also been associated with other anomalies. More than 85% of all NEC cases occur in very low birth weight infants or in very premature infants. Despite incremental advances in our understanding of the clinical presentation and pathophysiology of NEC, universal prevention of this disease continues to elude us even in the twenty-first century. © 2013 Elsevier Inc.


Kaunitz A.M.,Jacksonville University | Manson J.E.,Jacksonville University
Obstetrics and Gynecology | Year: 2015

Most menopausal women experience vasomotor symptoms with bothersome symptoms often lasting longer than one decade. Hormone therapy (HT) represents the most effective treatment for these symptoms with oral and transdermal estrogen formulations having comparable efficacy. Findings from the Women's Health Initiative and other recent randomized clinical trials have helped to clarify the benefits and risks of combination estrogen-progestin and estrogenalone therapy. Absolute risks observed with HT tended to be small, especially in younger women. Neither regimen increased all-cause mortality rates. Given the lower rates of adverse events on HT among women close to menopause onset and at lower baseline risk of cardiovascular disease, risk stratification and personalized risk assessment appear to represent a sound strategy for optimizing the benefit-risk profile and safety of HT. Systemic HT should not be arbitrarily stopped at age 65 years; instead treatment duration should be individualized based on patients' risk profiles and personal preferences. Genitourinary syndrome of menopause represents a common condition that adversely affects the quality of life of many menopausal women. Without treatment, symptoms worsen over time. Low-dose vaginal estrogen represents highly effective treatment for this condition. Because custom-compounded hormones have not been tested for efficacy or safety, U.S. Food and Drug Administration (FDA)-approved HT is preferred. A low-dose formulation of paroxetine mesylate currently represents the only nonhormonal medication FDA-approved to treat vasomotor symptoms. Gynecologists and other clinicians who remain abreast of data addressing the benefit-risk profile of hormonal and nonhormonal treatments can help menopausal women make sound choices regarding management of menopausal symptoms. © 2015 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.


Laparoscopic pancreaticoduodenectomy is a technically demanding procedure. In this video, we demonstrate the technical aspects of performing the procedure. In a 50-year-old male with ascending cholangitis, endoscopic retrograde cholangiopancreatography was unsuccessful, and percutaneous transhepatic cholangiography was carried out for biliary decompression. Endoscopic ultrasound plus fine-needle aspiration showed pancreatic head adenocarcinoma. The procedure was carried out using five trocars, and extensive lymphadenectomy was undertaken. The uncinate process was skeletonized off the superior mesenteric artery. The right lateral aspect of the superior mesenteric vein-portal vein confluence was involved with the cancer. The laparoscopic linear stapler was used to transect part of the vein en bloc with the specimen. All margins were negative and all the anastomoses were done using laparoscopic intracorporeal suturing. Operative time was 8 h 20 min, and hospital stay was 5 days. Final pathology was T3 N1 (one lymph node out of 40 was positive). Conclusion Laparoscopic pancreaticoduodenectomy can be performed safely in selected cases of pancreatic head cancer with vascular involvement. Skilled laparoscopic skills are necessary to execute such procedures safely. © 2014 Society of Surgical Oncology.


Ackerman M.B.,Jacksonville University
Orthodontics : the art and practice of dentofacial enhancement | Year: 2011

Removable retainer wear is most related to patient comfort and acceptance. Patient compliance is essential for retention and maintenance of the orthodontic treatment results. Even though patients are educated about the need for prolonged retention after active treatment and asked to sign informed consent regarding the risk of noncompliance (relapse) prior to treatment, most orthodontists would estimate that at least half of their teenage patients do not comply at optimal levels. The aim of the present study was to quantify teenage patient compliance with removable maxillary retention and compare actual usage vs prescribed usage between subjects who knew they were being monitored via an implanted microsensor in the retainer and those subjects who were unaware of any monitoring. The final sample consisted of 9 subjects in the test group (5 males and 4 females) and 10 subjects in the control group (4 males and 6 females). The evidence suggests that individuals who were made aware of the orthodontist's ability to monitor compliance wore the device for a significantly larger number of hours per day than those who were unaware of this fact. Patients reporting full usage of the retainer wore the appliance a mean of 4.3 hours more per day than those reporting less than full usage, holding all other variables constant. Patients who misrepresented their retainer use (reported full usage but wore the device less than 19 hours per day) wore the appliance a mean 12.4 hours less than the more honest patients who participated in the study.


Our knowledge of the mechanisms of platelet-mediated thrombosis has increased dramatically over the last 40 years. This increased understanding has identified treatment strategies for acute coronary syndromes (ACS) by targeting key mediators of platelet activation and aggregation processes. Aspirin (acetylsalicylic acid) monotherapy improves patient outcomes by irreversibly inhibiting the cyclooxygenase (COX)-1 enzyme in the arachidonic acid pathway. The later-developed thienopyridines, prodrugs that irreversibly inhibit the P2Y12 receptor, and therefore adenosine diphosphate (ADP) binding, further enhance platelet inhibition and patient outcomes. The thienopyridine clopidogrel has been the standard of care, but it is limited by variable response and treatment failure. A more potent thienopyridine, prasugrel, requires fewer hepatic metabolic steps for activation, and elicits significantly improved outcomes for patients with ACS. The increased potency of prasugrel is associated with an increase in Thrombolysis in Myocardial Infarction (TIMI)-defined major bleeding compared with clopidogrel. Ticagrelor represents a new chemical class of agents called the cyclopentyltriazolopyrimidines. It interacts reversibly with the platelet P2Y12 receptor, and does not require metabolic bioactivation for activity. Data show a significant improvement in ischaemic outcomes, including mortality, for ticagrelor compared with clopidogrel, without an increase in overall major bleeding, although non-coronary artery bypass graft bleeding is increased. Glycoprotein IIbIIIa targeted agents (abciximab, tirofiban and eptifibatide) are also used in ACS patients undergoing percutaneous coronary interventions. These inhibitors utilize a different mechanism of action by preventing fibrinogen-mediated platelet aggregation. Other therapeutic strategies for platelet inhibition are being evaluated, including the investigative protease-activated receptor (PAR)-1 and thromboxane A2 antagonists. This review highlights the mechanisms of action of these agents, and the continuing evolution of ACS therapy. Adis © 2012 Springer International Publishing AG. All rights reserved.


Capodanno D.,Jacksonville University | Angiolillo D.J.,Jacksonville University
Journal of the American College of Cardiology | Year: 2010

Antithrombotic therapy represents the mainstay of treatment for prevention of recurrent ischemic events in patients with atherothrombotic disease processes. Although the benefits of antithrombotic pharmacotherapy in the elderly are well established, the elderly are generally more vulnerable to the adverse effects of antithrombotic drugs. Such higher vulnerability may be related to distinct pharmacokinetic and pharmacodynamic responses in the late age of life, during which drugdrug interactions due to polypharmacy further enhance the risk of adverse effects associated with the use of antithrombotic agents. Given that the prevalence of atherothrombotic disease, as well as diseases with thromboembolic potential, increases exponentially with age and that the elderly population is in continuous growth, understanding strategies of antithrombotic management in these patients is of key importance. The present paper provides an overview of the current available evidence on the use of antithrombotic therapy in elderly patients with the primary focus on treatment of coronary artery disease. © 2010 American College of Cardiology Foundation Published by Elsevier Inc.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: S-STEM:SCHLR SCI TECH ENG&MATH | Award Amount: 625.67K | Year: 2014

The Mathematics, Engineering, and Physics (MEP) Scholars program at Jacksonville University is contributing well-prepared individuals to the science, technology, engineering, and mathematics (STEM) workforce by providing an educational experience that emphasizes student discovery. This program is designed to increase enrollment of students, including those from underrepresented groups, and improve retention of scholars through graduation or transfer to an affiliated institution in engineering-related disciplines. The project can serve as a model for similar institutions, particularly those that utilize a 3 + 2 program with affiliated universities for students to earn an engineering degree.

The project is recruiting annual cohorts of students based on academic ability and financial need and supporting them by the development of a Residential Learning Community (RLC), faculty mentors, tutoring, peer study groups, college survival skills training, and career development. The program is collecting information on how an RLC works as well as how the systemic implementation of the numerous support structures impacts the retention and graduation of STEM majors. Women and underrepresented minorities are being targeted in recruitment and retained via the social and academic support structures of an RLC. The program is being assessed based on enrollment, mid-term and final grades, attendance at extracurricular functions, career plans, resiliency, engagement of faculty and students, learning motivation, and learning strategies. Outcomes and knowledge gained are being broadly disseminated.

The participation by scholars in project-based courses, mathematical modeling contests, and enrollment in paired courses enables them to discover the connections between physics and mathematics. The scholars are being encouraged to participate in an annual mathematical modeling competition, undergraduate research, and internships with local government and industry partners. Support structures are scheduled within the targeted majors to deliver maximum impact to each student and to equip each student to succeed. Mentoring provides feedback and guidance and grounds students in their chosen disciplines. Undergraduate research, internships, and career development solidifies their learning and prepares them professionally. To ensure best practices in STEM teaching, a Learning Community (LC) is being created for the MEP faculty and tutors. Faculty and tutors are participating in workshops and regular meetings to discuss best practices in STEM education, teaching strategies, and the progress of the program.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: ANTARCTIC ORGANISMS & ECOSYST | Award Amount: 57.95K | Year: 2015

There are a number of areas of Antarctic research by scientists from the United States where rebreather technology (which unlike normal SCUBA diving releases few if any air bubbles) would be valuable tools. These include but are not limited to behavioral studies (because noise from bubbles released by standard SCUBA alters the behavior of many marine organisms), studies of communities on the underside of sea ice (because the bubbles disrupt the communities while or before they are sampled), and studies of highly stratified lake communities (because the bubbles cause mixing and because lighter line could be used to tether a diver to the surface which would probably also cause less water column disruption). The latter scientific advantage of less mixing in highly stratified (not naturally mixed) lakes is also a significant environmental advantage of rebreathers. However, for safety reasons, no US science projects will be approved for the use of rebreathers until they are tested by the US Antarctic Program (USAP). This award provides funds for the USAP Scientific Diving Officer to conduct such tests in conjunction with other diving professionals experienced in polar diving in general and specifically with rebreather technology in non-polar environments.

A team of six scientific diving professionals will evaluate seven or more commercial rebreather models that are being most commonly used in non-polar scientific diving. This will be done through holes drilled or melted in sea ice at McMurdo Station, Antarctica. A limited number of test dives of the best performing models will subsequently be made in stratified lakes in the McMurdo Dry Valleys.


The significance and importance of this project resides in the diversification and broadening of the STEM talent pipeline in cybersecurity in predominantly undergraduate and liberal arts schools (small institutions). This is achieved by the creation of a curriculum that accommodates students of different levels of computer literacy, that focuses on experiential learning, and that utilizes institutional collaboration via cloud computing. This project will mitigate the challenges small institutions currently face in the cybersecurity area, for example, a tight computer science curriculum and the inability to support the expensive infrastructure required for cybersecurity education. Integrated into this project is research as to whether using this new curriculum and the related online projects, students will attain the same, or an increase, level of cybersecurity learning.

This project will address the above challenges by creating a range of cybersecurity learning opportunities that emphasize hands-on and realistic experimentation for students in small institutions. First, this project will attract a diverse population of students by introducing cybersecurity topics through multiple paths of study and engagement. Students will be introduced to cybersecurity concepts through manageable, stand alone course modules and laboratory exercises. Interested students can study further by taking two cybersecurity focused courses and cybersecurity capstone projects created by this project. Using all these materials students can create a cybersecurity concentration. Second, the project will use the Global Environment for Network Innovation (GENI) infrastructure in the development of empirical labs and the capstone project assignments. GENI offers an affordable cloud solution to small institutions that lack the infrastructure to support sophisticated computer labs. The learning impact of the new curriculum will be evaluated by quantitative competency assessments that are administered yearly. Student cybersecurity persistence will be assessed by a longitudinal study of the number of cybersecurity courses taken during a students course of study. Qualitative assessment of the curriculum will take the form of student interviews and focus groups to gauge attitude towards course modules, perception of learning gains and comfort level with the pedagogies employed. In addition to the collaboration of three college level institutions, this project will leverage relationships with local community colleges to further develop a cybersecurity workforce. This partnership provides a diverse set of students that will support the evidence-based evaluation of student cybersecurity learning via this approach.

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