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Wiacek M.,Jedrzej Sniadecki Academy of Physical Education and Sport
Current Women's Health Reviews

Background: A consensus among women is that the menopause is imminently associated with a reduction in the level of physical fitness, which is associated with an increase in body-weight and emotional disturbances. Such an understanding of the menopausal transition is strengthened by plethora of scientific reports on the biology of the menopause. However, there is a dearth of data on a means of modulation, other than pharmaceutical, of these detrimental phenomena. Discussion: The majority of scientific reports indicates that menopause and/or ageing is associated with an increase in Body Mass Index (BMI), Waist Circumference (WC), Total Cholesterol (TC), Tri-glyceride (TG), High-Density Cholesterol (HDL-C), Low-Density Cholesterol (LDL-C), Luteinizing hormone (LH), and Follicle Stimulation hormone (FSH) levels. Additionally, recent reports indicated that menopausal transition is also associated with changes in blood pressure (BP), serum uric acid levels (SUA), and serum creatinine (SCR). It has been shown that during the menopause, an interplay of these homeostasis regulating parameters adversely influences health-related quality of life (HQoL). Currently, physical exercises are considered as an alternative to pharmaceutical means of positive modulation of age-dependent physiological changes. Summary: Through a combination of the results of scientific reports on an influence of physical exercises on the set of physiological parameters, I have established that physical exercises, encompassing endurance, aerobic, and strength exercises, may be used as a happy medium for preserving a high level of HQoL in ageing and menopausal women. However, I postulate that physical exercises applied in this regard should not be focused on an increase in a fitness level, expressed as an increase in a maximal oxygen capacity, but instead on a abate of the total body fat. © 2013 Bentham Science Publishers. Source

Wiacek M.,Jedrzej Sniadecki Academy of Physical Education and Sport | Zubrzycki I.Z.,Jedrzej Sniadecki Academy of Physical Education and Sport | Bojke O.,Jedrzej Sniadecki Academy of Physical Education and Sport | Kim H.-J.,Hanyang University

Objective The purpose of this cross-sectional study was to assess the association of the menopausal transition with changes in vitamins. Methods The study group comprised women aged 17-85 years from the Third National Health and Nutrition Examination Survey (NHANES), which was conducted between 1988 and 1994, and from the NHANES surveys conducted between 1999 and 2006. Menopausal status was defined using the time since the last period, < 2, 2-12, and > 12 months, for the pre-, peri-, and postmenopause, respectively. The data-cleaning technique employing serum follicle stimulating hormone activity resulted in pre-, peri- and postmenopausal samples encompassing the following age brackets: 17-50, 42-51, and 46-85 years. Statistical inferences were analyzed using non-parametric techniques. Results Significant increases in vitamin A and vitamin E concentrations across all phases of the menopausal transition were observed. There was a gradual decrease in the vitamin C concentration across all stages of the menopause but a fairly stable concentration of vitamin B12. There was a statistically significant increase in vitamin D between the pre- and postmenopause. Body mass index correlated negatively with serum vitamin concentration in the pre- and postmenopause. Conclusions Vitamin A should be supplemented in postmenopausal women to decrease the risk of bone fracture. The daily diet should be supplemented with vitamin B12, to avoid possible neurological symptoms due to vitamin B12 deficiency, and with vitamin D to decrease the risk of developing secondary hyperparathyroidism. Due to an adverse influence on serum vitamin concentration, body mass index should be monitored in pre- and postmenopausal women. © 2013 International Menopause Society. Source

Wiacek M.,Hanyang University | Wiacek M.,Jedrzej Sniadecki Academy of Physical Education and Sport | Uddin N.,Hanyang University | Kim H.-J.,Hanyang University | Zubrzycki I.Z.,Hanyang University
Protein and Peptide Letters

Copepods are the most abundant multicellular animal group and are often most important component of zooplankton and indicators of local and global climate change. Among this broad group of animals, Calanus sinicus holds an important role in the ecosystems of The East China Sea, The Korea Strait, and The East Sea. By comparing the response of their proteomes to ecologically viable environment changes, this study tried to identify molecular responses accountable for compensation of a change in metabolic rates. Using two-dimensional gel electrophoresis and mass spectrometry on C. sinicus sampled at its native environment, 45 distinct proteins were identified that changed abundance as a function of environment changes i.e., temperature elevation and/or oxygen decrease, and 14 that are only present in proteome adapted to higher temperature/lower oxygen. Although the study failed to find heat shock proteins, the abundance of disulfide-isomerase A3 precursor was higher in species thriving at higher temperatures/lower oxygen. The abundance of proteins responsible for redox homeostasis, DNA maintenance, and chromatin rearrangement was also higher at elevated temperature. Also, the molecular machinery responsible for xenobiotic metabolism is mobilized at higher temperatures/ lower oxygen levels. These data indicate fine adjustment of molecular apparatus in response to changes in living environment. © 2013 Bentham Science Publishers. Source

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