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Konishi Y.,Oklahoma Medical Research Foundation | Enomoto M.,Hist Science Laboratory Co. | Hayashi Y.,Central Institute for Experimental Animals
Journal of Toxicologic Pathology | Year: 2011

The Japanese Society of Toxicologic Pathology (JSTP) has a differing conceptual framework from the Japanese Society of Pathology (JSP) and Japanese Society of Toxicology (JST) and was founded in 1985 by the leadership of late Dr. Yasukazu Nishiyama with the cooperation of several founding members and the support of JSP. The aim of the JSTP is to improve the human and animal health using an interdisciplinary scientific approach based on pathology and toxicology. In its development as a professional society, the JSTP has established society rules and activities. The JSTP has grown in terms of membership and financial aspects and is now recognized not only domestically but also internationally as a well-organized scientific society. To maintain the high professional standard and visibility of JSTP, we here provide the historical background of the society as a basis for current members to contribute to the continued improvement of our scientific organization. © 2011 The Japanese Society of Toxicologic Pathology.

Kawaguchi K.,Calpis Co. | Nakamura T.,Calpis Co. | Kamiie J.,Azabu University | Takahashi T.,Hist Science Laboratory Co. | Yamamoto N.,Calpis Co.
Bioscience, Biotechnology and Biochemistry | Year: 2012

The antihypertensive peptides, Val-Pro-Pro and Ile- Pro-Pro, were successfully detected in the aorta of spontaneously hypertensive rats after orally administering these peptides by a guanidine-thiocyanate treatment to prevent proteolysis. Cy3-labeled versions of both peptides were localized in the endothelial cells of arterial vessels in the rats. The accumulation of both peptides in the endothelial cells suggested in vivo inhibitory activity of the angiotensin I-converting enzyme.

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