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Roissy-en-Brie, France

Warlin D.,Public and Government Affairs
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology | Year: 2013

Superparamagnetic iron oxide (SPIO) nanoparticles are a relatively large class of contrast agents for magnetic resonance imaging. According to their biodistribution, distinct classes of SPIO nanoparticles have been investigated for clinical applications either as macrophage imaging agents or blood pool agents. Contrast agents which are pharmaceutics followed the same development rules as therapeutic drugs. Several drawbacks such as clinical development difficulties, organization of market access and imaging technological developments have limited the widespread use of these products. SPIO nanoparticles that are composed of thousands iron atoms providing large T2* effects are particularly suitable for theranostic. Stem cell migration and immune cell trafficking, as well as targeted SPIO nanoparticles for molecular imaging studies are mainly at the stage of proof of concept. A major economic challenge in the development of molecular imaging associated with a therapeutic treatment/procedure is to define innovative business models compatible with the needs of all players taking into account that theranostic solutions are promising to optimize resource allocation and ensure that expensive treatments are prescribed to responding patients. © 2013 Wiley Periodicals, Inc.

"ExxonMobil is hurling ethics accusations against a team of Columbia University journalists whose reporting helped stoke calls for probes into whether the company deliberately misled the public about climate change. The oil giant went on the offensive in a Nov. 20 letter, a copy of which was obtained by POLITICO. It comes as investigations by the Columbia journalists in the Los Angeles Times and a separate report by the nonprofit website InsideClimate News continue to stoke Democratic calls for a federal probe into whether the company concealed its internal understanding of the global warming threat posed by burning fossil fuels. Exxon, which through its foundation gave more than $200,000 to the university last year, addressed the letter to Columbia President Lee Bollinger and sent a copy to university trustees. In the letter, Exxon Vice President for Public and Government Affairs Kenneth Cohen accuses a Columbia journalism professor and her team of potentially violating the university's policy on research misconduct by downplaying or ignoring information provided by the company. Cohen asks Bollinger for an opportunity to discuss "the possible remedies available to us" and seems to suggest the episode may damage Exxon's relationship with the university in the future." "Why Are So Many Americans Skeptical About Climate Change? a Study Offers a Surprising Answer." (Washington Post) "Exxon Sowed Doubt About Climate Science for Decades by Stressing Uncertainty" (InsideClimate News) "Exxon Made Deep Cuts in Climate Research Budget in the 1980s" (InsideClimate News) "Funding From Exxon or Koch Brothers Gave Deniers a Megaphone in Climate Change Debate" (TakePart) "Exxon Mobil Investigated for Possible Climate Change Lies by New York Attorney General" (New York Times)

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