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Namdaroglu S.,Izmir Bozyaka Education and Research Hospital | Tekgunduz E.,Ankara Oncology Research Hospital | Altuntas F.,Ankara Oncology Research Hospital
Hematology Reports | Year: 2016

Essential thrombocythemia (ET) is a Philadelphia chromosome (Ph)-negative myeloproliferative neoplasm. It is characterized by thrombocytosis and megakaryocytic hyperplasia of the bone marrow with JAK2V617F mutation. Iron-refractory iron deficiency anemia (IRIDA) is an autosomal recessive disorder, which is mainly characterized by iron deficiency anemia not responding to oral iron intake, but partially responding to parenteral iron therapy. Recently, it has been shown that IRIDA has stemmed from mutations in the gene TMPRSS6, which encodes a transmembrane serine protease (matriptase- 2) expressed by the liver. Renal cell carcinoma (RCC) accounts for 2-3% of all cancers. As the most common solid lesion in the kidneys, it represents approximately 90% of all renal malignancies. Approximately 30% of patients with symptomatic RCCs seem to display paraneoplastic syndromes. The symptom that may result from erythrocytosis is the most wellknown paraneoplastic hematological event. Here, we report a patient who presents with coexistence of RCC and thrombocytosis, which hasn’t been caused by hormonal factors that are produced in tumor cells. This patient has been therefore diagnosed with ET. The patient who was expected to display RCC with polycythemia, conversely present with IRIDA. © S. Namdaroğlu et al. 2016.

Uyar I.,Ege Maternity and Gynecology Training and Research Hospital | Gulhan I.,Izmir Bozyaka Education and Research Hospital | Sipahi M.,Ege Maternity and Gynecology Training and Research Hospital | Hanhan H.M.,Ege Maternity and Gynecology Training and Research Hospital | Ozeren M.,Ege Maternity and Gynecology Training and Research Hospital
Fertility and Sterility | Year: 2011

Objective: To present a case of unicornuate uterus with ipsilateral ectopic ovary and renal agenesis. Design: Case report. Setting: Research hospital. Patient(s): A 26-year-old woman with a 5-year history of primary infertility was admitted to our clinic. A unicornuate uterus without contralateral horn, with ipsilateral ectopic ovary and renal agenesis, was diagnosed. Intervention(s): Diagnostic laparoscopy, ovarian stimulation. Main Outcome Measure(s): During laparoscopy, a unicornuate uterus without a contralateral horn, together with ectopic ovary, was observed. Result(s): We visualized the right ectopic ovary on ultrasound after ovarian stimulation. Conclusion(s): We present a rare clinical entity that exhibits a unicornuate uterus without a contralateral horn, with ipsilateral right ectopic ovary and renal agenesis together. We conclude that ovarian stimulation is a useful approach in the diagnosis of ectopic ovaries. Copyright © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.

Yalbuzdag S.A.,Izmir Bozyaka Education and Research Hospital | Sarifakioglu B.,Namik Kemal University | Afsar S.I.,Baskent University | Celik C.,Sevket Yilmaz Education and Research Hospital | And 4 more authors.
Journal of Stroke and Cerebrovascular Diseases | Year: 2015

Background In recent years, vitamin D deficiency has been suggested as a risk factor for ischemic stroke and stroke severity in both animal models and clinical studies. In this retrospective study, we investigated the relationship between 25-hydroxyvitamin D [25(OH)D] levels and functional outcomes in stroke patients during neurological rehabilitation program. We also investigated whether there is an association between 25(OH)D levels and cognitive impairment. Methods The study included the medical records of 120 stroke patients who participated in a neurological rehabilitation program. The motor and cognitive components of the Functional Independence Measurements of all patients at admission and discharge were recorded. The Functional Ambulatory Scale was used to assess motor functional status, and the Turkish-validated version of the minimental state examination test was used to assess cognitive status. Results A significant correlation was found between 25(OH)D level and cognitive impairment among patients who had ischemic strokes. High levels of 25(OH)D were associated with greater functional gain during the rehabilitation program in both ischemic stroke patients and hemorrhagic stroke patients. Conclusions High 25(OH)D levels might be associated with greater functional improvement and with less cognitive impairment in stroke patients. © 2015 by National Stroke Association.

Kose S.,Izmir Tepecik Education and Research Hospital | Tatar B.,Izmir Tepecik Education and Research Hospital | Atalay S.,Izmir Tepecik Education and Research Hospital | Erden M.,Izmir Tepecik Education and Research Hospital | Tatar E.,Izmir Bozyaka Education and Research Hospital
Renal Failure | Year: 2013

Background: Incidence of allergic reactions is increased in hemodialysis (HD) patients. However, the prevalence of latex allergy is not exactly known in HD patients. The aim of this present study is to determine the prevalence of latex allergy in HD patients. Methods: A total of 205 adult HD patients were included in the study. Questionnaires were completed during patient interviews, and their consents were provided. Latex prick test and latex specific IgE test (HY-TEC, K82) were performed. Mean age of the patients was 52 ± 14 (25-79) years, and 61% was male. Mean dialysis duration was 38 months, and 21% of them were diabetics. Only five patients had allergic complaints in their histories, and none of them had severe anaphylaxis history. Latex prick test was positive in two patients. Latex specific IgE test was positive in five patients. Overall latex sensitivity was defined as 3.4%. Conclusion: No increased prevalence in latex allergy was determined in HD patients. Latex allergy incidence may be increased in atopic HD patients. Therefore, the use of latex products should be avoided as much as possible especially in atopic HD patients. © 2013 Informa Healthcare USA, Inc.

Objective: It is now important to distinguish between adenocarcinoma and squamous cell carcinoma of the lung because of target-specific treatments. Our study aimed to study the efficiency of Thyroid Transcription Factor-1 (TTF-1), cytokeratin 5/6 (CK5/6) and p63 in distinguishing between adenocarcinoma and squamous cell carcinoma and to study the contribution of these markers to the diagnosis in non-small cell lung cancer. Material and Method: Immunohistochemically, TTF-1, CK 5/6 and p63 were used in 72 cases of squamous cell carcinoma, 19 cases of adenocarcinoma, and 29 cases of non-small cell lung cancer whose final diagnosis was decided with the subsequent resection material. The specificity, sensitivity, and positive and negative predictive value were calculated for each marker. Results: TTF-1 positivity was seen in none of the 72 squamous cell carcinomas but in all of 19 adenocarcinoma cases. CK5/6 negativity was seen in all cases of adenocarcinoma and in two cases of squamous cell carcinoma. p63 was positive in all squamous cell carcinomas and in 4 adenocarcinomas. Cytokeratin 5/6, p63 positivity and TTF-1 negativity were observed in 17 non-small cell lung cancers whose final diagnosis was squamous cell carcinoma. None of the 12 non-small cell lung cancers whose final diagnosis was adenocarcinoma exhibited positive staining for CK5/6. However, p63 staining was not seen in the biopsy but was focal in the surgical specimen in one case. All the 12 non-small cell lung cancers whose certain diagnosis was adenocarcinoma were positive for TTF-1. TTF-1, CK 5/6 and p63 seem to be useful for differentiating adenocarcinoma from squamous cell carcinoma with 100% specificity, 100% sensitivity and 100% specificity, 97% sensitivity and 87% specificity, and 100% sensitivity, respectively. Conclusion: We concluded that TTF-1 is a reliable marker for sub typing lung cancer. Different staining patterns can be seen with CK5/6 and p63; however, if they are used together with TTF-1 and interpreted correctly, they can be of help for the final diagnosis even in cases in which the morphology is unclear. © 2015, Federation of Turkish Pathology Societies. All Rights Reserved.

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