Izhevsk State Medical Academy

Izhevsk, Russia
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Malinin O.V.,Izhevsk State Medical Academy | Platonov A.E.,Central Research Institute of Epidemiology
Infectious Diseases | Year: 2017

Background: Intravenous ribavirin has been reported to be an effective treatment for haemorrhagic fever with renal syndrome (HFRS) caused by Hantaan virus in Asia. However, its therapeutic benefits for HFRS caused by Puumala virus (PUUV) in Europe are still unknown. Methods: A randomized, open-label study of efficacy and safety of intravenous ribavirin in the treatment of HFRS was conducted in the European part of Russia. Seventy-three patients with suspected HFRS within 4 d of the onset of the disease were randomized to receive either intravenous ribavirin (33 mg/kg, followed by 16 mg/kg given every 6 h for 4 d and by 8 mg/kg given every 8 h for 3 d) plus standard therapy (n = 37) or standard therapy alone (n = 36). The primary outcome was the average change from baseline in viral load over time estimated as area under the viral load curve minus baseline (AUCMB). Fifty-five patients with HFRS confirmed by nested reverse transcriptase – polymerase chain reaction (PCR) assay were included in the assessment of the efficacy. All patients entered into the clinical trial were included in the assessment of the safety. Results: PUUV was detected in all cases of confirmed HFRS. Viral load kinetics were similar in both treatment groups. Significantly more patients receiving ribavirin than standard therapy experienced low haemoglobin level (95% vs 36%), hyperbilirubinemia (81% vs 3%), sinus bradycardia (43% vs 14%), and rash (19% vs 0%). Conclusions: Results of the study showed insufficient efficacy and safety of intravenous ribavirin in the treatment of HFRS caused by PUUV. © 2017 Society for Scandinavian Journal of Infectious Diseases

Vakhrushev Ya.M.,Izhevsk State Medical Academy | Lukashevich A.P.,Izhevsk State Medical Academy
Terapevticheskii Arkhiv | Year: 2017

Aim. To perform a comprehensive study of intestinal digestion, absorption, and microbiocenosis in various stages of cholelithiasis (CL). Subjects and methods. A total of 76 patients with of CL, including 44 patients with its Stage I and 32 patients with Stage II, were examined. Mono-, di-and polysaccharide load tests and a scatological study were performed to evaluate the processes of digestion and absorption in the intestine. The hydrogen breath test using lactulose was carried out to study small intestinal bacterial overgrowth (SIBO). The state of colon microbiocenosis was determined by plating feces onto various selective nutrient media. Results. All digestive process stages in the small intestine were noted to be impaired in CL. In Stage I CL, cavitary digestion was mainly impaired; in Stage II, all digestive and absorptive processes were abnormal. Scatological examination in patients with Stage I CL revealed steatorrhea in 79.5%, creatorrhea in 75%, and amylorrhea in 36.4%. In Stage II CL, digestive and absorptive disorders progressed. SIBO was detected in 68.5% whereas in 70% of cases, it was located in the distal small intestine in the presence of insufficiency of the ileocecal sphincter apparatus. A regularity was found between the severity of SIBO and impaired small intestinal cavitary digestion. SIBO was more common in the pre-gallstone stage of CL than in its gallstone stage. Dysbiosis of the colon was detected in 100% of the examined patients with CL; moreover, as the latter progressed, dysbiosis worsened. Conclusion. There is new information about impaired intestinal digestion and microbiocenosis in patients with CL.

Urakova M.A.,Izhevsk State Medical Academy | Bryndina I.G.,Izhevsk State Medical Academy
Neuroscience and Behavioral Physiology | Year: 2016

We report here our studies of the surfactant system and the water balance of the lungs after intracerebral hemorrhage in conditions of bilateral capsaicin blockade of the vagus nerve. The fractional composition of alveolar phospholipids was studied by thin layer chromatography; the surface activity of surfactants was studied using a modified Wilhelm method; measures of pulmonary water balance were calculated using dry and wet lung weights. Intracerebral hemorrhage was accompanied by degradation of surface-active properties, a decrease in the total phospholipid content of surfactant, changes in their fractional composition, and hyperhydration of the lungs. When the neuropeptide depot in capsaicin-sensitive afferents of the vagus nerves was depleted, changes in the surface activity of the lungs became more marked and the total phospholipid content of surfactant and measures of pulmonary water balance normalized. These results show that capsaicin-sensitive afferents of the vagus nerve play an important role in impaired surfactant functions and pulmonary water balance after intracerebral hemorrhage. © 2016, Springer Science+Business Media New York.

Iryanov Y.M.,Russian Ilizarov Scientifi nter for Restorative Traumatology and Orthopaedics | Kiryanov N.A.,Izhevsk State Medical Academy
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk | Year: 2015

Background: Non-drug correction of reparative bone tissue regeneration in different pathological states - one of the most actual problems of modern medicine. Objective: Our aim was to conduct morphological analysis of the influence of electromagnetic radiation of ultra-high frequency and low intensity on reparative osteogenesis and angiogenesis in fracture treatment under transosseous osteosynthesis. Methods: A controlled nonrandomized study was carried out. In the experiment conducted on rats we modeled tibial fracture with reposition and fixation of the bone fragments both in control and experimental groups. In the animals of the experimental group the fracture zone was exposed to low intensity electromagnetic radiation of ultra-high frequency. Exposure simulation was performed in the control group. The operated bones were examined using radiography, light and electronic microscopy, X-ray electronic probe microanalysis. Results: It has been established that electromagnetic radiation of ultra-high frequency sessions in fracture treatment stimulate secretory activity and degranulation of mast cells, produce microcirculatory bed vascular permeability increase, endotheliocyte migration phenotype expression, provide endovascular endothelial outgrowth formation, activate reparative osteogenesis and angiogenesis while fracture reparation becomes the one of the primary type. The full periosteal, intermediary and intraosteal bone union was defined in 28 days. Conclusion: Among the therapeutic benefits of electromagnetic radiation of ultra-high frequency in fracture treatment we can detect mast cell secretory activity stimulation and endovascular angiogenesis activation.

The review of the existing evidence on the problem of excessive mortality in Russia has demonstrated that the country is at the initial stage of the irreversible depopulation process. The current healthcare situation, in regard to cardiovascular disease (CVD), does not provide much hope for the effectiveness of existing measures for fatal CVD prevention. It is clear that a large-scale focussed analysis of the clinical and organisational limitations of the existing prevention systems is urgently needed. This discussion should be started in the nearest future.

Dimov A.S.,Izhevsk State Medical Academy
Cardiovascular Therapy and Prevention (Russian Federation) | Year: 2015

Prevention of the diseases, particularly cardial pathology, has its very significant controversies. The idea of the risk factors did not give the expected results. Causality of the majority of diseases is still unknown or not fully understood. This leads to inability of predicting. The article provides the reader with theoretical and practical experience evaluation of the XX century upon the problem of causality (etiology) of diseases. The original definition of causality is expressed and vindicated as its applied significance.

Zajnaeva T.P.,Izhevsk State Medical Academy | Yegorkina S.B.,Izhevsk State Medical Academy
Human Ecology | Year: 2016

The impact of the isolated low-frequency rotating electric field (the REF) and the one combined with animal immobilisation on the "mother-placenta-fetus" system in rats with various prognostic stress resistance was studied. The research showed that on the 10th experiment day stress hormone content in the blood plasma increased in experimental rats compared to the control group; the increase degree was dependant on individual species stress-resistance. Thus, on isolated action of technogeneous rotating electric field the level of 11-oxocorticosteroids increased by 7,8 % (p > 0,05) in "active" female rats and by 71,7 %in "passive" ones. In conditions of action of combined rotating electric field with immobilization of experimental animals the level of corticosteroids increased by 63,8 % (p < 0,05) in stress-resistant rats and by 35,4 % (p < 0,05) in stress-non-resistant rats. The results of the pathomorphological study of the afterbirth and fetuses from the experimental female rats indicated that the REF leads to the structural plasenta changes, hemodynamical disturbances and are accompanied by the late fetus growth and high embrional mortality rate. The most marked functional and structural changes in the afterbirth were seen under the REF combined with animal immobilisation. © 2016, Springer New York LLC. All rights reserved.

Gaisin I.R.,Izhevsk State Medical Academy
Terapevticheskii Arkhiv | Year: 2012

Aim. To investigate cardiorenal correlations in pregnant patients with arterial hypertension. Material and methods. Risk factors (RF), initial stages, progression, andfinal stage of both cardiovascular disease (CVD) and chronic kidney disease (CKD) were analysed in a cohort of 159pregnant women with hypertensive disorders versus a cohort of 32 healthy pregnant controls. Cardiorenal continuum factors were investigated in patients with different ways of gestational hypertension (HT) diagnosis: 13 with isolated clinic HT (ICHT), 11 - isolated ambulatory HT (IAHT), and 18 - HT found by all three blood pressure (BP) measurement modalities (clinic, ambulatory, and home BP).Results. A novel cardiorenal continuum exists in pregnant women with HT where chronic IIT (essential HT) on the one hand and pre-eclampsia on the other hand may lead through the common RF and initial stages (subclinical organ damage) to the stage ofprogression (CVD, CKD) and to the final stage (cardiovascular events and renal failure). The number of RF, signs of subclinical organ damage, and total cardiovascular risk progressively increase from the condition of being normotensive on clinic, home, and 24-hour definitions to the condition of being found hypertensive by one, two and all three BP measurement methods, forming the continuum "healthypregnant women - ICHT- IAHT-gestational HT" in which each item is almost the same as the ones next to it hut the last is veiy different from the first. Conclusion. Assessment of the cardiorenal state in all pregnant women allows to compose the cline "healthy pregnants - gestational HT- stage I essential HT- stage II essential HT-pre-eclampsia - essential HT with superimposed pre-eclampsia" with growing risk of CVD and CKD and a potential danger of cardiovascular events (complications) and chronic renal failure.

Urakov A.L.,Izhevsk State Medical Academy
IOP Conference Series: Materials Science and Engineering | Year: 2016

The paper states that assigning certain physical and chemical characteristics to pills and medical drugs solutions can substitute for the development of new drugs (which is essentially equivalent to the creation of new medicines). It is established that the purposeful change of physical and chemical characteristics of the standard («old») materials (in other words, the known substances) is fundamental for the production of solid and liquid medicines, which allows us to get «new» structures and materials. The paper shows that assigning new physical and chemical properties to «old» materials and their further usage for the production of tablets and solutions from the «old» and well-known medicines can turn even very «old» medicine into very «novel» (moreover, even very fashionable) one with unprecedented (fantastic) pharmacological activity and new mechanisms of action. © Published under licence by IOP Publishing Ltd.

Urakov A.,Izhevsk State Medical Academy | Urakova N.,Izhevsk State Medical Academy
Journal of Physics: Conference Series | Year: 2015

In the laboratory studied the dynamics of rheology of water solutions with plasma- inflammatory and antiseptic funds when mixing them with blood, plasma and pus under the influence of the following physical and chemical factors of local interaction: gravity, specific gravity, temperature, relative viscosity, internal pressure, sparkling water, total concentration of the ingredients, surface activity, volume of acid and osmotic activity of medicines. Found that the rheology of biological liquids improve hyperthermic, highly alkaline and highly carbonated solution medicines. For the dilution of pus, dense festering mass of sulfur plugs and tear stones invited to apply heated to +39 - +42°C with aqueous solution of 0.5 - 3% hydrogen peroxide and 0.5 - 10% sodium bicarbonate saturated with carbon dioxide to excess pressure 0.2 ATM. © Published under licence by IOP Publishing Ltd.

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