izarov Russian Research Center For Restorative Traumatology And Orthopaedics

Kurgan, Russia

izarov Russian Research Center For Restorative Traumatology And Orthopaedics

Kurgan, Russia

Time filter

Source Type

Stupina T.A.,izarov Russian Research Center For Restorative Traumatology And Orthopaedics | Stepanov M.A.,izarov Russian Research Center For Restorative Traumatology And Orthopaedics | Teplen'kii M.P.,izarov Russian Research Center For Restorative Traumatology And Orthopaedics
Bulletin of Experimental Biology and Medicine | Year: 2015

The role of subchondral bone in the restoration of the articular cartilage was determined in experiments on mongrel dogs subjected to gonarthrosis modeling followed by subchondral zone tunneling and introduction of bone marrow suspension into the canal. Light microscopy, computer histomorphometry, and electron probe microanalysis showed that stimulation of functional activity of chondrocytes was achieved via correction of homeostasis of the cartilage and subchondral bone and improvement of tissue trophic. Restoration of the microarchitecture of the subchondral bone and improving its vascularization after tunneling with the introduction of bone marrow suspension into the drill holes enhances chondrocyte metabolism and recovers their functionality. © 2015 Springer Science+Business Media New York


Stogov M.V.,izarov Russian Research Center For Restorative Traumatology And Orthopaedics | Tushina N.V.,izarov Russian Research Center For Restorative Traumatology And Orthopaedics | Emanov A.A.,izarov Russian Research Center For Restorative Traumatology And Orthopaedics
Bulletin of Experimental Biology and Medicine | Year: 2015

Concentrations of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2), stem cell factor (SCF), vascular endothelial growth factor (VEGF), and transforming growth factor β1 (TGF-β1) were measured in the blood serum of dogs subjected to experimental lengthening of shin bones. In animals subjected to shin bone lengthening at a rate of 1 mm/day in 4 steps, the concentrations of SCF and TGF-β1 significantly increased in the middle of distraction and IGF-1 concentration increased by the end of distraction. In animals subjected to lengthening at a rate of 1.5 mm/day in 6 steps, the levels of IGF-1 and TGF-β1 significantly increased in the middle of distraction and the concentration of IGF-2 at the end of distraction. In animals subjected to lengthening at a rate of 3 mm/day in 120 steps, the concentrations of IGF-1 and TGF-β1 significantly decreased in the middle of distraction and concentrations of IGF-1, VEGF, and TGF-β1 increased by the end of distraction. © 2015, Springer Science+Business Media New York.


PubMed | izarov Russian Research Center For Restorative Traumatology And Orthopaedics
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2015

Concentrations of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2), stem cell factor (SCF), vascular endothelial growth factor (VEGF), and transforming growth factor 1 (TGF-1) were measured in the blood serum of dogs subjected to experimental lengthening of shin bones. In animals subjected to shin bone lengthening at a rate of 1 mm/day in 4 steps, the concentrations of SCF and TGF-1 significantly increased in the middle of distraction and IGF-1 concentration increased by the end of distraction. In animals subjected to lengthening at a rate of 1.5 mm/day in 6 steps, the levels of IGF-1 and TGF-1 significantly increased in the middle of distraction and the concentration of IGF-2 at the end of distraction. In animals subjected to lengthening at a rate of 3 mm/day in 120 steps, the concentrations of IGF-1 and TGF-1 significantly decreased in the middle of distraction and concentrations of IGF-1, VEGF, and TGF-1 increased by the end of distraction.


PubMed | izarov Russian Research Center For Restorative Traumatology And Orthopaedics
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2015

The role of subchondral bone in the restoration of the articular cartilage was determined in experiments on mongrel dogs subjected to gonarthrosis modeling followed by subchondral zone tunneling and introduction of bone marrow suspension into the canal. Light microscopy, computer histomorphometry, and electron probe microanalysis showed that stimulation of functional activity of chondrocytes was achieved via correction of homeostasis of the cartilage and subchondral bone and improvement of tissue trophic. Restoration of the microarchitecture of the subchondral bone and improving its vascularization after tunneling with the introduction of bone marrow suspension into the drill holes enhances chondrocyte metabolism and recovers their functionality.

Loading izarov Russian Research Center For Restorative Traumatology And Orthopaedics collaborators
Loading izarov Russian Research Center For Restorative Traumatology And Orthopaedics collaborators