Iwakura Hospital

Iwakura, Japan

Iwakura Hospital

Iwakura, Japan
SEARCH FILTERS
Time filter
Source Type

Oya S.,Iwakura Hospital | Yamada K.,Seijoh University
Rigakuryoho Kagaku | Year: 2015

[Purpose] To examine the relationships between air temperature change and physical activity amounts and activities of daily living of home-dwelling stroke patients. [Subjects] The subjects were home-dwelling stroke patients: 6 with certified support needs, the Support group; and 8 with certified care needs, the Care group. [Methods] Air temperature data was collected for 1 year, and the months in which it was below 17˚C were called the Cold period, and those in which was ≥17˚C were called the Warm period. Physical activity was measured with a pedometer, and ADL assessments were made using the functional independence measure (FIM). [Results] A tendency to take fewer steps in the Cold period, which was not reversed in the following Warm period, was noted in the Support group. Over the year, there was no change in the number of steps taken by the Care group, and neither group showed a change in FIM score. [Conclusion] There is a possibility that physical activity amounts in the Cold period will decline, with the attendant prospective risk that ADL will also decline. © 2015 Society of Physical Therapy Science (Rigaku Ryoho Kagakugakkai). All rights reserved.


Nakatochi M.,Nagoya University | Ichihara S.,Jichi Medical University | Yamamoto K.,Kurume University | Naruse K.,Aichi Gakuin University | And 4 more authors.
Clinical Epigenetics | Year: 2017

Background: Development of cardiovascular disease (CVD), including coronary artery disease, arrhythmia, and ischemic stroke, depends on environmental and genetic factors. To investigate the epigenetic basis of myocardial infarction (MI), we performed an epigenome-wide association study for this condition in elderly Japanese subjects. A total of 192 case subjects with MI and 192 control subjects were recruited from hospital attendees and the general population, respectively. Genome-wide DNA methylation (DNAm) profiles for DNA isolated from whole blood were obtained by analysis with an Infinium HumanMethylation450 BeadChip. The relation of DNAm sites found to be significantly associated with MI to nearby single nucleotide polymorphisms (SNPs) previously shown to be associated with CVD was assessed in the control group. Findings: Three DNAm sites (cg06642177, cg07786668, cg17218495) showed genome-wide significant associations with MI (p = 4.33 × 10−8, 3.96 × 10−10, and 3.77 × 10−8, respectively). Two of these sites (cg07786668, cg17218495) still showed such associations after adjustment for classical risk factors of MI (p = 1.04 × 10−7 and 6.60 × 10−8, respectively). The DNAm sites cg07786668 and cg17218495 are located in ZFHX3 (zinc finger homeobox 3) and SMARCA4 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4) genes, respectively. SNPs in ZFHX3 or SMARCA4 that were previously found to be associated with CVD were not significantly associated with these DNAm sites in our control subjects. Conclusions: We identified two DNAm sites—cg07786668 in ZFHX3 and cg17218495 in SMARCA4— that are independently and significantly associated with MI. Our results suggest that the development of MI might be influenced by changes in DNAm at these sites via a pathway that differs from that affected by CVD-associated SNPs in these genes. The Kita-Nagoya Genomic Epidemiology (KING) study, which was the source of control samples in the present study, was registered in ClinicalTrials.gov (NCT00262691) on 6 December 2005. © 2017, The Author(s).


Choi H.,Iwakura Hospital | Yamashita T.,Kyoto Prefectural University of Medicine | Wada Y.,Kyoto Prefectural University of Medicine | Kohigashi M.,Red Cross | And 7 more authors.
Journal of Affective Disorders | Year: 2013

Objective To investigate the course and influencing factors of postpartum depression in women during the child rearing period. Methods Data were collected during 0-year-old baby check-ups and a follow-up investigation. 262 participants were included in the analysis. Both surveys employed the Zung Self-Rating Depression Scale (ZSDS). The first also comprised the State Trait Anxiety Inventory, Parental Bonding Instrument (PBI), and Borderline Scale Index, enabling sub-division of participating subjects into healthy/pathological groups. ZSDS group and survey scores were compared using the t-test. Results The average ages of the children and the ZSDS scores in both surveys were 7.0±3.2 and 21.8±2.4 months, 40.6±7.9 and 40.1±8.7, respectively, with no significant differences among depression scores. When subjects were divided according to individual scale scores, and survey scores compared, depression significantly improved in the high trait/state anxiety group, high PBI maternal care score group, nonborderline personality (BP) trait group, and breast feeding group, whereas depression was significantly exacerbated in the low PBI maternal care score group. Discussion Postpartum depression characterized by strong anxiety and a depressive state in mothers with favorable psychological backgrounds showed gradual improvement. We noted an exacerbation of depression during the separation period in mothers who had received poor maternal care. We assume that the feeling of abandonment induced by individuation of their children is a major factor. Limitations There is concern that some depressive women may have dropped out due to a performance bias. Conclusions Sharing our findings about exacerbation/improvement of depression among medical staff may be beneficial for postpartum mothers. © 2013 Elsevier B.V.


Tominaga T.,Health Management Doctors Office Mental Health | Tominaga T.,Kyoto Prefectural University of Medicine | Choi H.,Iwakura Hospital | Nagoshi Y.,Red Cross | And 2 more authors.
Neuropsychiatric Disease and Treatment | Year: 2014

Purpose: A multidimensional intervention integrating alexithymia, negative affect, and type of coping strategy is needed for the effective treatment of somatoform disorder; however, few studies have applied this approach to the three different dimensions of alexithymia in patients with somatoform disorder. The purpose of this study was to determine the relationship between type of coping strategy and three different dimensions of alexithymia expressed in patients. Patients and methods: A total of 196 patients with somatoform disorder completed the 20-item Toronto Alexithymia Scale, the Zung Self-Rating Depression Scale, the Spielberger State-Trait Anxiety Inventory, the Somatosensory Amplification Scale, and the Lazarus Stress Coping Inventory. The relationships between alexithymia (Toronto Alexithymia Scale - 20 score and subscales), demographic variables, and psychological inventory scores were analyzed using Pearson's correlation coefficients and stepwise multiple regression analysis. Results: The mean Toronto Alexithymia Scale - 20 total score (56.1±10.57) was positively correlated with the number of physical symptoms as well as with psychopathology scores (Self-Rating Depression Scale, State-Trait Anxiety Inventory trait, state, and Somatosensory Amplification Scale), but negatively correlated with planful problem solving, confrontive coping, seeking social support, and positive reappraisal coping scores. With respect to coping strategy, multiple regression analyses revealed that "difficulty in identifying feelings" was positively associated with an escape-avoidance strategy, "difficulty in describing feelings" was negatively associated with a seeking social support strategy, and "externally oriented thinking" was negatively associated with a confrontive coping strategy. Conclusion: Alexithymia was strongly associated with the number of somatic symptoms and negative affect. Patients with high "difficulty in describing feelings" tend to rely less on seeking social support, and patients with high "externally oriented thinking" tend to rely less on confrontive coping strategies. The coping skills intervention implemented should differ across individuals and should be based on the alexithymia dimension of each patient. © 2014 Tominaga et al.


Nakatochi M.,Nagoya University | Ichihara S.,Mie University | Yamamoto K.,Kurume University | Ohnaka K.,Kyushu University | And 8 more authors.
Diabetologia | Year: 2015

Aims/hypothesis: To investigate epigenetic regulation of the plasma concentration of resistin, we performed an epigenome-wide association study for this variable and DNA methylation (DNAm) in an elderly Japanese cohort and then assessed the relation of single nucleotide polymorphisms (SNPs) associated with the plasma resistin concentration to DNAm level at identified sites. Methods: The association of plasma resistin level with DNAm status was examined in 191 nondiabetic elderly men with the Illumina Infinium HumanMethylation450 BeadChip array. The association between DNAm status at specific sites in the flanking region of the resistin gene (RETN) and RETN mRNA abundance was then evaluated with a public data set for 1202 monocyte samples from a multi-ethnic cohort. Finally, the association of DNAm status and SNPs in the promoter region of RETN was assessed in two cohorts comprising a total of 478 Japanese individuals. Results: DNAm status at cg02346997 located in the RETN promoter region showed a negative genome-wide significant association with the plasma resistin level (p = 6.02 × 10−10). Four DNAm sites in the RETN promoter region including cg02346997 (p = 4.23 × 10−70) showed a negative genome-wide significant association with RETN mRNA abundance in monocytes. Furthermore, the number of minor alleles of the RETN promoter SNPs rs34861192 and rs3219175 was negatively associated with DNAm level at cg02346997 (p = 4.43 × 10−17). Conclusions/interpretation: Our results suggest that RETN promoter SNPs might influence the circulating resistin level through an effect on DNAm at cg02346997 and on RETN mRNA abundance in monocytes. © 2015, Springer-Verlag Berlin Heidelberg.


PubMed | Iwakura Hospital, Aichi Gakuin University, Kyushu University, Tokai Gakuin University and 4 more.
Type: Journal Article | Journal: Diabetologia | Year: 2015

To investigate epigenetic regulation of the plasma concentration of resistin, we performed an epigenome-wide association study for this variable and DNA methylation (DNAm) in an elderly Japanese cohort and then assessed the relation of single nucleotide polymorphisms (SNPs) associated with the plasma resistin concentration to DNAm level at identified sites.The association of plasma resistin level with DNAm status was examined in 191 nondiabetic elderly men with the Illumina Infinium HumanMethylation450 BeadChip array. The association between DNAm status at specific sites in the flanking region of the resistin gene (RETN) and RETN mRNA abundance was then evaluated with a public data set for 1202 monocyte samples from a multi-ethnic cohort. Finally, the association of DNAm status and SNPs in the promoter region of RETN was assessed in two cohorts comprising a total of 478 Japanese individuals.DNAm status at cg02346997 located in the RETN promoter region showed a negative genome-wide significant association with the plasma resistin level (p = 6.02 10(-10)). Four DNAm sites in the RETN promoter region including cg02346997 (p = 4.23 10(-70)) showed a negative genome-wide significant association with RETN mRNA abundance in monocytes. Furthermore, the number of minor alleles of the RETN promoter SNPs rs34861192 and rs3219175 was negatively associated with DNAm level at cg02346997 (p = 4.43 10(-17)).Our results suggest that RETN promoter SNPs might influence the circulating resistin level through an effect on DNAm at cg02346997 and on RETN mRNA abundance in monocytes.


Takeda A.,Chubu University | Takeda A.,Nagoya Institute of Technology | Takata K.,Toyota National College of Technology | Nagao H.,Iwakura Hospital | And 2 more authors.
IEEJ Transactions on Fundamentals and Materials | Year: 2012

We previously measured for healthy subjects and patients who require hemodialysis the complex relative permittivity (ε r′- jε r″) of whole blood, and found that ε r′-axis intercept ε rt′ of straight line approximation to the Cole-Cole plots at frequencies from 200 MHz to 1 GHz is significantly different with a level of less than 1 % among its averaged values for healthy subjects and patients before and after dialysis, though any correlations between ε rt′ and blood urea nitrogen (BUN) and creatinine being used as main indices for hemodialysis evaluation have not so far been clarified. In this study, to make correlation analyses between the intercept ε rt′ and blood biochemical components for nine patients before and after hemodialysis, we measured six kinds of their blood components including BUN and creatinine, and calculated their Pearson product-moment correlation coefficients for ε rt′ along with significant probability P based on a t-test. It should be noted that P is a reference probability to determine whether or not a null hypothesis can be rejected, and that the P value of 0.05 is commonly used as a significance level for statistical test. As a result, we found that a strong correlation with P < 0.05 is observed between ε rt′ and albumin, while there are not always significant correlations with P > 0.05 between ε rt′ and other blood components including BUN and creatinine. Although albumin is not used as an index for hemodialysis efficiency, it can reflect water amount in blood vessels and liver operation. This finding implies that ε rt′ could be used as an index for evaluating blood viscosity and liver function. © 2012 The Institute of Electrical Engineers of Japan.


Takeda A.,Chubu University | Takeda A.,Nagoya Institute of Technology | Takata K.,Toyota National College of Technology | Nagao H.,Iwakura Hospital | And 2 more authors.
IEEJ Transactions on Fundamentals and Materials | Year: 2014

For reducing the hemodialysis time of kidney disease patients, we are attempting to monitor hemodialysis quality in a real time based on dielectric constants of blood. Using a network analyzer with an open-ended coaxial-type dielectric probe, we measured complex relative permittivities ranging from 200 MHz to 6 GHz for blood of eighteen kidney disease patients before and after hemodialysis, and then derived from them admittance consisting of conductance G [S/m] and susceptance B [S/m] in order to make statistical correlation analyses between the G-B plots and blood biochemical components. As a result, we found that significant correlations are observed between the parameters of the linear approximations to the G-B plots at frequencies from 4 GHz to 6 GHz and blood urea nitrogen or creatinine before and after the hemodialysis. This finding suggests a possibility of real-time monitoring of the hemodialysis quality. © 2014 The Institute of Electrical Engineers of Japan.


Takeda A.,Chubu University | Takeda A.,Nagoya Institute of Technology | Takata K.,Toyota National College of Technology | Nagao H.,Iwakura Hospital | And 2 more authors.
IEEJ Transactions on Electronics, Information and Systems | Year: 2013

For evaluating the quality of hemodialysis from the limited volume of human blood using a commercially available open-ended coaxial probe, we previously measured for 10 normal healthy subjects and 9 patients who require hemodialysis the dielectric properties of 2.5 ml whole blood with a temperature of 25 degrees centigrade in a syringe with a diameter of 20 mm and a depth of 8 mm. In this study, we measured the complex relative permittivity of water and human blood when changing temperature from 25 to 37 degrees centigrade in order to examine the correlation between them, and calculated their Pearson product-moment correlation coefficients for ε r' and ε r'' along with significant probability P based on a t-test. It should be noted that P is a reference probability to determine whether or not a null hypothesis can be rejected, and that the P value of 0.05 is commonly used as a significance level for a statistical test. As a result, it was found for the complex relative permittivity of water that there is approximately good agreement between the measured results and calculated ones from the Kaatze formula expressed as a function of temperature, and that strong correlations with P < 0.05 are also confirmed between the complex relative permittivity and temperature. For the human blood, on the other hand, we found that a strong correlation with P < 0.05 is observed between ε r'' and temperature, while there is not always significant correlation with P > 0.05 between ε r' and temperature. © 2013 The Institute of Electrical Engineers of Japan.


Takeda A.,Chubu University | Takeda A.,Nagoya Institute of Technology | Takata K.,Toyota National College of Technology | Nagao H.,Iwakura Hospital | And 2 more authors.
IEEJ Transactions on Electronics, Information and Systems | Year: 2011

Before evaluating the quality of hemodialysis from the limited volume of human blood using a commercially available open-ended coaxial probe, we previously measured the complex relative permittivity of pure water from 200 MHz to 6 GHz with respect to its measured liquid volume, and revealed that 1.9 ml water in a beaker with a diameter of 24 mm and a depth of 2 mm gives a variation within ±0.5 % for the real part and ±7 % for the imaginary part. Based on the above finding, we measured the dielectric properties of 2.5 ml whole blood at 25°C for 10 normal healthy subjects and 9 hemodialysis patients. The measured results on healthy subjects show good agreement with the data reported by Gabriel for human blood at 37°C, while they provide different dispersion characteristics of straight lines for their Cole-Cole plots. The measured results on the patients give further different dispersion characteristics in comparison with the healthy subjects. In order to investigate the above differences statistically, the student t-test was conducted to reveal that permittivity at infinite frequency for the Cole-Cole plots is significantly different with a level of 1 % among its averaged values for normal healthy subjects and patients before dialysis. © 2011 The Institute of Electrical Engineers of Japan.

Loading Iwakura Hospital collaborators
Loading Iwakura Hospital collaborators