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Iwaki, Japan

Iwaki Meisei University is a Private university, located in the city of Iwaki, Fukushima, Japan. Wikipedia.

Cholesterol is one of the major constituents of mammalian cell membranes. It plays an indispensable role in regulating the structure and function of cell membranes and affects the pathology of various diseases. In recent decades much attention has been paid to the existence of membrane microdomains, generally termed lipid “rafts”, and cholesterol, along with sphingolipids, is thought to play a critical role in raft structural organization and function. Cholesterolbinding probes are likely to provide useful tools for analyzing the distribution and dynamics of membrane cholesterol, as a structural element of raft microdomains, and elsewhere within the cell. Among the probes, non-toxic derivatives of perfringolysin O, a cholesterol-binding cytolysin, bind cholesterol in a concentrationdependent fashion with a strict threshold. They selectively recognize cholesterol in cholesterol-enriched membranes, and have been used in many studies to detect microdomains in plasma and intracellular membranes. Anti-cholesterol antibodies that recognize cholesterol in domain structures have been developed in recent years. In this chapter, we describe the characteristics of these cholesterolbinding proteins and their applications to studies on membrane cholesterol localization. © Springer Science+Business Media B.V. 2010. Source

Eguchi M.,Kitasato University | Kikuchi Y.,Kitasato University | Kikuchi Y.,Iwaki Meisei University
Journal of Infectious Diseases

Background. Most antigens from intracellular bacteria or vaccines induce both humoral and cell-mediated immune responses, but interactions between these responses are not fully understood. This study aims to resolve how specific antibodies participate in the activation of specific T cells in protecting hosts against Salmonella enterica serotype Typhimurium (S, typhimurium) infection. Methods. Mice were administered anti-Salmonella immunoglobulin G (IgG) 1 day before Salmonella infection, and survival rate was observed. For in vitro assay, Salmonella bacteria were treated with anti- Salmonella IgG or control IgG before infection of the RAW264.7 or HEp2 cells. After infection, cell-associated bacteria number, induction of apoptosis, and production of nitric oxide were examined. In addition, antigen presentation assays using Salmonella-primed T cells were performed. Results. Treatment of S. typhimurium with anti- Salmonella IgG enhanced the macrophages' uptake of bacteria and induced high-frequency apoptotic cell death. In vitro antigen presentation assay revealed that the extracellular vesicles isolated from apoptotic cells caused by infection with anti- Salmonella IgG-treated S. typhimurium facilitated the responses of Salmonella-specific T cells. Conclusion. Our findings suggest that humoral immunity cooperates with cell-mediated immunity upon induction of apoptosis in host cells to establish protective immunity against Salmonella infection, even if it does not directly eliminate intracellular microorganisms. © 2010 by the Infectious Diseases Society of America. All rights reserved. Source

Akasaka R.,Kyushu Sangyo University | Tanaka K.,Nihon University | Higashi Y.,Iwaki Meisei University
International Journal of Refrigeration

The vapor-liquid coexistence curves near the critical point of the binary mixture of 2,3,3,3-tetrafluoropropene (R-1234yf) + difluoromethane (R-32) were measured by means of the visual observation of meniscus disappearance. Eleven, eighteen, and eleven saturated densities were obtained for mixtures with 50.00 mass%, 80.01 mass%, and 90.00 mass% of R-1234yf, respectively. The critical temperatures, critical densities, and critical molar volumes of the mixtures were determined from the meniscus disappearing level and the intensity of the critical opalescence. The critical pressures of the mixtures were also determined from the analysis of pρTx measurements. The composition dependence of the critical parameters was formulated with simple correlations. © 2013 Elsevier Ltd and IIR. All rights reserved. Source

Fukunaga M.,Nihon University | Shimizu N.,Iwaki Meisei University
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

A high-speed algorithm for computing fractional differentiations and fractional integrations in fractional differential equations is proposed. In this algorithm, the stored data are not the function to be differentiated or integrated but the weighted integrals of the function. The intervals of integration for the memory can be increased without loss of accuracy as the computing time-step n increases. The computing cost varies as n log n, as opposed to n2 of standard algorithms. © 2013 The Author(s) Published by the Royal Society. All rights reserved. Source

Takahashi M.,Training Institute for Correctional Personnel | Mori T.,Iwaki Meisei University | Kroner D.G.,Southern Illinois University Carbondale
Law and Human Behavior

The main purpose of the current research is to examine the applicability of the Youth Level of Service/Case Management Inventory (YLS/CMI) in a Japanese juvenile offender population. Three hundred eighty-nine youths who were released from the five Juvenile Classification Homes were followed for approximately one and half years. Results show that the YLS/CMI total score significantly predict recidivism. Survival time analysis demonstrates that the YLS/CMI total score also significantly predicted faster time to recidivism. The overall findings support adequate predictive validity of the YLS/CMI total score, but subscales lacked content representativeness and predictive validity in this sample. Canadian and Japanese cultural differences in criminal history and substance abuse are contributors to the lack of content representativeness. © 2013 American Psychological Association. Source

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