Iwaki Meisei University

Iwaki, Japan

Iwaki Meisei University is a Private university, located in the city of Iwaki, Fukushima, Japan. Wikipedia.

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Higashi Y.,Iwaki Meisei University
Refrigeration Science and Technology | Year: 2015

Measurements of PρTx properties, saturated densities and critical parameters for low GWP refrigerant mixtures of 50.00 mass% R1234yf (2, 3, 3, 3-tetrafluoroprop-1-ene; CF3CF=CH2) + 50.00 mass% R1234ze(E) (trans-1, 3, 3, 3-tetrafluoroprop-1-ene; CF3CH=CHF) system were measured with two types of isochoric methods. As for PρTx properties, 5 isochores were obtained in the range of temperatures from 310 K to 430 K, of pressures from 837 kPa to 6774 kPa, and of densities from 100 kg·m-3 to 900 kg·m-3. As for the saturated densities, 9 saturated vapor densities and 6 saturated liquid densities were measured for temperatures from 354.622 K to 374.280 K and for densities between 219 kg·m-3 and 870 kg·m-3. On the basis of the present data, the critical temperature Tc = 374.28 K, critical density ρc = 480 kg·m-3, and critical pressure Pc = 3524 kPa for 50% R 1234yf + 50% R 1234ze(E) mixture were determined by the direct observation of meniscus disappearance.

Sato A.,Iwaki Meisei University | Ebina K.,Iwaki Meisei University
European Journal of Pharmacology | Year: 2013

Platelet-activating factor (PAF) is a potent lipid mediator that is implicated in numerous inflammatory diseases. Under inflammatory conditions, PAF is biosynthesized through the remodelling pathway and elicits many inflammatory responses through binding to its specific PAF receptor. Endogenous bioactive endothelins (ETs: ET-1, -2, and -3) are also considered potent inflammatory mediators that play a critical role in many inflammatory diseases. In this perspective, we provide a brief overview of possible common mechanisms in ETs and PAF receptor function for inflammatory responses. Accumulating evidence strongly suggests that ET-3, but not ET-1 and ET-2, can attenuate PAF-induced inflammation through direct binding of the Tyr-Lys-Asp (YKD) region in the peptide to PAF and its metabolite/precursor lyso-PAF, followed by inhibition of binding between PAF and its receptor. Additionally, YKD sequence-containing peptides may be useful as a novel type of anti-inflammatory drugs targeting this mechanism. These findings should lead to new treatment strategies for numerous inflammatory diseases by targeting the common mechanism in ET and PAF receptor function. © 2013 Elsevier B.V. All rights reserved.

Kawaguchi K.,Iwaki Meisei University | Matsumoto T.,Iwaki Meisei University | Kumazawa Y.,Iwaki Meisei University | Kumazawa Y.,Vino Science Japan Inc.
Current Topics in Medicinal Chemistry | Year: 2011

Oxidative stress and inflammatory responses sustained for a long period of time cause many diseases. A proinflammatory cytokine, tumor necrosis factor α (TNF-α), plays a pivotal role in the pathogenesis of chronic and autoimmune diseases. The present review, supplemented by hitherto unpublished data of the authors and their coworkers, shows that the intake of polyphenols contained in natural sources, such as hydroxytyrosol, tyrosol, oleuropein (olives), naringin and hesperidin (Citrus fruits), resveratrol, procyanidins or oligomeric procyanidin (grapes or grape seed extracts), (-)-epigallocatechin gallate (green tea) and quercetin (grapes, green tea) etc., are able to modulate chronic inflammatory diseases, such as type 2 diabetes, rheumatoid arthritis, inflammatory bowel disease, and affect the formation and interaction of advanced glycation end products with their respective receptors. Furthermore, potent activities of fermented grape marc, prepared as a fine lyophilized powder from fresh skin and seeds of a Japanese grape strain (Koshu) and then fermented with Lactobacillus plantarum, are described. Finally, the bioavailability of representative polyphenols will be discussed. © 2011 Bentham Science Publishers Ltd.

Sato A.,Iwaki Meisei University | Ebina K.,Iwaki Meisei University
Inflammation Research | Year: 2013

Objective: The aim of this study was to clarify a role of endothelins (ETs: ET-1, -2, and -3) and their receptors (ETA, ETB1, and ETB2) in inflammatory responses. Methods: Male Wistar rats (180-220 g) were used. The effects of ETs in the absence or presence of the ETA antagonist BQ-123/the selective ETB2 antagonist BQ-788, and the effect of the selective ETB1 agonist IRL-1620 and the nonselective ETB agonist BQ-3020, on rat hind paw oedema induced by several proinflammatory substances were examined. The involvement of nitric oxide (NO) in the effects of ETs on the paw oedema was investigated using the NO synthase inhibitor NG-nitro-l-arginine methyl ester (L-NAME). Results: ET-3, which acts mainly on ETB, at low concentrations specifically inhibited platelet-activating factor (PAF)-induced paw oedema, whereas neither ET-1 nor ET-2, both of which act on ETA and ETB, showed inhibitory activity. The inhibition by ET-1 and ET-3 (each 0.5 pmol/paw) in the presence of BQ-123 (66.4 ± 6.7 % and 65.4 ± 22.6 %, respectively), was comparable to that by ET-3 (0.5 pmol/paw) alone (65.4 ± 10.9 %), whereas neither ET-1 nor ET-3 in the presence of BQ-788 showed inhibitory activity. BQ-3020 (0.5 pmol/paw) inhibited the oedema by 50.9 ± 6.0 %, whereas IRL-1620 showed almost no activity. Additionally, L-NAME markedly attenuated the inhibitory effects of ET-3 on PAF-induced paw oedema. These results indicate that ETB2 may mediate NO production and attenuation of PAF-induced inflammatory responses. Moreover, ET-3 (0.5 pmol/paw) inhibited the oedema induced by ET-1 at higher dose and zymosan by 76.6 ± 11.0 and 85.4 ± 13.6 %, respectively, indicating that ET-3 at lower concentrations inhibits the paw oedema induced by various inflammatory substances. Conclusions: ET-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and NO production. © 2013 Springer Basel.

Takahashi M.,Training Institute for Correctional Personnel | Mori T.,Iwaki Meisei University | Kroner D.G.,Southern Illinois University Carbondale
Law and Human Behavior | Year: 2013

The main purpose of the current research is to examine the applicability of the Youth Level of Service/Case Management Inventory (YLS/CMI) in a Japanese juvenile offender population. Three hundred eighty-nine youths who were released from the five Juvenile Classification Homes were followed for approximately one and half years. Results show that the YLS/CMI total score significantly predict recidivism. Survival time analysis demonstrates that the YLS/CMI total score also significantly predicted faster time to recidivism. The overall findings support adequate predictive validity of the YLS/CMI total score, but subscales lacked content representativeness and predictive validity in this sample. Canadian and Japanese cultural differences in criminal history and substance abuse are contributors to the lack of content representativeness. © 2013 American Psychological Association.

Akasaka R.,Kyushu Sangyo University | Tanaka K.,Nihon University | Higashi Y.,Iwaki Meisei University
International Journal of Refrigeration | Year: 2013

The vapor-liquid coexistence curves near the critical point of the binary mixture of 2,3,3,3-tetrafluoropropene (R-1234yf) + difluoromethane (R-32) were measured by means of the visual observation of meniscus disappearance. Eleven, eighteen, and eleven saturated densities were obtained for mixtures with 50.00 mass%, 80.01 mass%, and 90.00 mass% of R-1234yf, respectively. The critical temperatures, critical densities, and critical molar volumes of the mixtures were determined from the meniscus disappearing level and the intensity of the critical opalescence. The critical pressures of the mixtures were also determined from the analysis of pρTx measurements. The composition dependence of the critical parameters was formulated with simple correlations. © 2013 Elsevier Ltd and IIR. All rights reserved.

Fukunaga M.,Nihon University | Shimizu N.,Iwaki Meisei University
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences | Year: 2013

A high-speed algorithm for computing fractional differentiations and fractional integrations in fractional differential equations is proposed. In this algorithm, the stored data are not the function to be differentiated or integrated but the weighted integrals of the function. The intervals of integration for the memory can be increased without loss of accuracy as the computing time-step n increases. The computing cost varies as n log n, as opposed to n2 of standard algorithms. © 2013 The Author(s) Published by the Royal Society. All rights reserved.

Ohno-Iwashita Y.,Iwaki Meisei University
Sub-Cellular Biochemistry | Year: 2010

Cholesterol is one of the major constituents of mammalian cell membranes. It plays an indispensable role in regulating the structure and function of cell membranes and affects the pathology of various diseases. In recent decades much attention has been paid to the existence of membrane microdomains, generally termed lipid “rafts”, and cholesterol, along with sphingolipids, is thought to play a critical role in raft structural organization and function. Cholesterolbinding probes are likely to provide useful tools for analyzing the distribution and dynamics of membrane cholesterol, as a structural element of raft microdomains, and elsewhere within the cell. Among the probes, non-toxic derivatives of perfringolysin O, a cholesterol-binding cytolysin, bind cholesterol in a concentrationdependent fashion with a strict threshold. They selectively recognize cholesterol in cholesterol-enriched membranes, and have been used in many studies to detect microdomains in plasma and intracellular membranes. Anti-cholesterol antibodies that recognize cholesterol in domain structures have been developed in recent years. In this chapter, we describe the characteristics of these cholesterolbinding proteins and their applications to studies on membrane cholesterol localization. © Springer Science+Business Media B.V. 2010.

Akasaka R.,Kyushu Lutheran College | Tanaka K.,Iwaki Meisei University | Higashi Y.,Iwaki Meisei University
International Journal of Refrigeration | Year: 2010

This paper presents a timely and reliable equation of state for 2,3,3,3-tetrafluoropropene (HFO-1234yf) whose thermodynamic property information is strongly desired. The Patel-Teja (PT) equation of state and the extended corresponding state (ECS) model have been individually applied to property modeling for this new refrigerant. Comparisons of predicted values with the equation/model were made with the most recent experimental data. Both the PT equation of state and the ECS model can represent the vapor pressures with an accuracy of 0.2%. However, the ECS model is much better than the PT equation of state in the predictions for the liquid density and isobaric heat capacity. The uncertainties of calculated values with the ECS model are 0.5% in liquid density and 2.5% in isobaric heat capacity. The use of the ECS model is recommended for a detailed assessment of HFO-1234yf. Thermodynamic property tables and diagrams generated using the ECS model are provided. © 2009 Elsevier Ltd and IIR.

Tanaka K.,Iwaki Meisei University | Higashi Y.,Iwaki Meisei University
International Journal of Refrigeration | Year: 2010

Measurements of the thermodynamic properties of HFO-1234yf were conducted. The critical temperature TC, critical density ρC, and critical pressure PC, were measured by the visual observation of the meniscus disappearance, and were determined to be 367.85 ± 0.01 K, 478 ± 3 kg/m3, and 3382 ± 3 kPa, respectively. Vapor pressures were measured by a batch-type calorimeter with a metal-bellows in the temperature range from 310 K to 360 K and correlated by the Wagner-type equation. Surface tensions were measured by the differential capillary-rise method in the temperature range from 273 K to 340 K and correlated by the van der-Waals type equation. The acentric factor was determined to be 0.280 with the vapor pressure correlation. Based on the critical parameters and acentric factor, saturated vapor and liquid densities were estimated by the Peng-Robinson equation and the Hankinson-Thomson equation, respectively. The heat of vaporization was also calculated from the Clausius-Clapeyron equation. © 2009 Elsevier Ltd and IIR.

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