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Okumura A.,Juntendo University | Yamamoto T.,Tokyo Womens Medical University | Shimojima K.,Tokyo Womens Medical University | Honda Y.,Iwaki Kyoritsu General Hospital | And 3 more authors.
Epilepsia | Year: 2011

There are only two reports on epileptic patients associated with microduplication of 2q. We found a de novo duplication of chromosome 2q24.2q24.3 in another infant with neonatal epilepsy. The patient had refractory focal seizures since the third day of life. Her seizures were refractory against phenobarbital and levetiracetam, but were controlled by valproate. Array comparative genomic hybridization revealed a 5.3-Mb duplication of 2q24.2q24.3, where at least 22 genes including a cluster of voltage-gated sodium channel genes (SCN1A, SCN2A, SCN3A, SCN7A, and SCN9A) and one noncoding RNA are located. © 2011 International League Against Epilepsy. Source


Asano S.,Iwaki Kyoritsu General Hospital
Journal of clinical and experimental hematopathology : JCEH | Year: 2012

In this review, representative types of granulomatous lymphadenitis (GLA) are described. GLA can be classified as noninfectious GLA and infectious GLA. Noninfectious GLA includes sarcoidosis and sarcoid-like reaction. The cause of sarcoidosis remains unknown, but it has good prognosis. Sarcoid-like reaction, which is considered to be a biological defense mechanism, is observed in regional lymph nodes with many underlying diseases. Infectious GLA can be classified as suppurative lymphadenitis (LA) and nonsuppurative LA. Suppurative LA generally shows follicular hyperplasia and sinus histiocytosis in the early phase. In tularemia and cat scratch disease, monocytoid B lymphocytes (MBLs) with T cells and macrophages contribute to the formation of granuloma. However, none of the epithelioid cell granulomas of Yersinia LA contains MBLs like in cat scratch disease. In addition, almost all have a central abscess in granulomas induced by Gram-negative bacteria. In terms of the lymph nodes, tularemia and cat scratch disease are apt to affect the axillary and cervical regions while Yersinia LA affects the mesenteric lymph node. Nonsuppurative LA includes tuberculosis and BCG-histiocytosis. These are induced by delayed allergic reaction of M. tuberculosis. Tuberculosis LA mainly appears in the cervical lymph node. Organisms are histologically detected by Ziehl-Neelsen staining in the necrotic area. Toxoplasmosis is also a nonsuppurative protozoan infection (Toxoplasma gondii). In toxoplasma LA, MBLs can also be seen, but round and organized, well-formed granulomas are not found in this disease. Furthermore, necrosis is not induced and there are no accompanying neutrophils, eosinophils and fibrosis. GLA described above is associated with characteristic histological findings. An accurate pathological diagnosis using the above findings can lead to precise treatment. Source


Sano H.,Tohoku University | Mineta M.,Iwaki Kyoritsu General Hospital | Kita A.,Red Cross | Itoi E.,Tohoku University
Journal of Orthopaedic Science | Year: 2010

Background. Surgical treatment of massive rotator cuff tears is challenging for shoulder surgeons. The purpose of this study was to investigate both clinical outcomes and cuff integrity after tendon patch grafting using the long head of the biceps (LHB) tendon for irreparable massive rotator cuff tears. Methods. A short deltoid splitting approach was used to expose the torn cuff tendon stump. After tenodesis of the LHB tendon, its intraarticular portion was resected. If the size of the harvested tendon was smaller than that of the cuff defect, it was split into two layers. Then, the LHB tendon was sutured to the remnant cuff tendons and fi xed to the footprint using the transosseous suture technique. A total of 14 patients (12 men, 2 women; average age 64 years) underwent this procedure. The average postoperative follow-up period was 28 months (range 12-51 months). Active elevation angle of the shoulder as well as the Japanese Orthopaedic Association (JOA) score were assessed before surgery and at the time of follow-up. Postoperative cuff integrity was assessed using T2-weighted magnetic resonance imaging (MRI). Results. All cuff defects were successfully closed with this technique. Average active elevation angle improved from 69° to 149°. Total JOA score also improved from 54.7 points to 83.1 points. Thirteen shoulders showed no re-tearing on T2-weighted MRI; a minor discontinuity of the repaired cuff tendon was observed in the other shoulder. Conclusions. The LHB tendon is available in case tenodesis or tenotomy is needed. The resected tendon may be used as a graft for rotator cuff repair without any additional skin incision, which could reduce both the surgical invasion and the risk of infection. The LHB tendon patch grafting may be one of the useful options for surgical treatment of irreparable massive rotator cuff tears. © The Japanese Orthopaedic Assocation. Source


Ikemoto K.,Iwaki Kyoritsu General Hospital
African Journal of Psychiatry (South Africa) | Year: 2015

Brain bank is an indispensable research resource for pathophysiological studies of mental illnesses. In Japan, a national law for autopsy and dead body storage (1949) has been applied to manage brain bank, though this law is said to need some amendment for research use of human brain materials. In history of Japanese psychiatry, problems of Utsunomiya Hospital, which continued from 1960's and manifested in 1987, caused serious incredulity on psychiatric research and psychiatric medicine. There has been tremendous illegality including autopsy performed by "no" autopsy-qualified individuals such as nurses in Utsunomiya Hospital. In 1987, the Law of Mental Health was amended in Japan in order to protect patients' human right. Recently, following the Great East Japan Earthquake and nuclear disaster in 2011, Fukushima Psychiatric Brain bank, established in 1997, continued its activity in spite of lacking an autopsy-qualified researcher among them. This illegality has been concealed for approximately 2 years. Some problems of human right which have been infringed by brain researchers of psychiatric brain bank and of post-mortem brain studies of psychiatric illnesses in Japan are described. © 2015 Ikemoto K. Source


Ikemoto K.,Iwaki Kyoritsu General Hospital
African Journal of Psychiatry (South Africa) | Year: 2015

Brain bank is an indispensable research resource for pathophysiological studies of mental illnesses. In Japan, a national law for autopsy and dead body storage has been applied to manage brain bank, though this law is said to need some amendment for research use of human brain materials. In history of Japanese psychiatry, problems of Utsunomiya Hospital, manifested in 1987, caused serious loss of credit on psychiatric research and psychiatric medicine. It was reported that autopsy had been done by no autopsy-qualified individuals for example nurses in Utsunomiya Hospital. Recently, following the Great East Japan Earthquake and nuclear disaster, Fukushima Psychiatric Brain bank, established in 1997, has continued its activity in spite of lacking an autopsy-qualified researcher among them. This illegality has been concealed for approximately 2 years. Some problems which have disturbed development of psychiatric brain bank and post-mortem brain studies of psychiatric illnesses in Japan were discussed. © 2015 Ikemoto K. Source

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