Okhowat J.,Ivf Centers Prof Zech Bregenz In Bregenz |
Murtinger M.,Ivf Centers Prof Zech Bregenz In Bregenz |
Schuff M.,Ivf Centers Prof Zech Bregenz In Bregenz |
Wogatzky J.,Ivf Centers Prof Zech Bregenz In Bregenz |
And 5 more authors.
Alternative Therapies in Health and Medicine | Year: 2015
Context • Massage therapy is increasingly used to relieve physical and mental discomfort and is suggested as a safe therapeutic modality, without any significant risks or any known side effects. Although a multitude of complementary therapies, such as acupuncture, are applied in reproductive medicine, no information is available with regard to the application of massage as an adjuvant therapy in assisted- reproduction techniques (ARTs). Objectives • This study was intended to assess the effectiveness of a deep relaxation (andullation) therapy based on oscillating vibrations when used prior to embryo transfer (ET) in in vitro fertilization (IVF) cryo-cycles. Design • The research team designed a retrospective, observational study. Participants willing to undergo the massage treatment were allocated to the intervention (andullation) group. Setting • The study was performed at the IVF Centers Prof. Zech-Bregenz in Bregenz, Austria. Participants • A total of 267 IVF patients, with a mean age of 36.3 y, participated in this single-center study. Intervention • All patients receiving a transfer of vitrified and warmed blastocysts between January and December 2012 were included in the evaluation. Prior to ET, the andullation group received a standardized program of therapy—a 30-min, deep relaxation massage on an oscillating (vibrating) device, whereas the control group did not. Outcome Measures • To determine efficacy, the primary outcomes that the study measured were (1) pregnancy rates (PRs), by testing urine and obtaining a positive β-human chorionic gonadotropin (β-hCG); and (2) ongoing, pregnancies (oPR), by observation of fetal heartbeat and birth rates (BR) as well as miscarriage rates. The patients’ medical histories and types of infertility as well as the quality of the embryo transfers (ETs) were evaluated. Results • In patients using the massage therapy prior to ET, significantly higher PRs, oPRs, and BRs were observed compared with the control group—PR: 58.9% vs 41.7%, P <.05; oPR: 53.6% vs 33.2%, P <.01; and BR: 32.0% vs 20.3%, P <.05. No differences were detected among groups for patients’ ages, hormonal substitution protocols, endometrium structures and buildups, quality of transferred embryos, or quality of transfers. No adverse effects were noted in the massage group. Conclusions • The research team’s results suggested that andullation therapy prior to blastocyst transfer in a cryo- cycle improves embryo implantation, most likely due to a reduction in stress (ie, a relaxation effect on patients), a reduction in uterine contractions, and, probably, an enhancement of the blood flow in the abdominal region. These findings provide support for use of andullation as a complementary therapy for ART. © 2015 InnoVision Communications. All rights reserved.
Neyer A.,Ivf Centers Prof Zechbregenz |
Zintz M.,Ivf Centers Prof Zechbregenz |
Stecher A.,Ivf Centers Prof Zechbregenz |
Bach M.,Ivf Centers Prof Zechbregenz |
And 4 more authors.
Journal of Assisted Reproduction and Genetics | Year: 2015
Purpose: Various time-lapse studies have postulated embryo selection criteria based on early morphokinetic markers. However, late paternal effects are mostly not visible before embryonic genome activation. The primary objective of this retrospective study was to investigate whether those early morphokinetic algorithms investigated by time-lapse imaging are reliable enough to allow for the accurate selection of those embryos that develop into blastocysts, while of course taking into account the correlation with the type of injected spermatozoa. Methods: During a period of 18 months, a total of 461 MII oocytes from 43 couples with severe male factor infertility and previous “external” IVF failures after cleavage-stage embryo transfer (ET) were fertilized by intracytoplasmic morphologically selected sperm injection (IMSI). Thereof, 373 embryos were monitored in a time-lapse incubator until ET on day 5. Blastocyst outcome in combination with three previously postulated MKc (cc2: t3–t2, 5–12 h; t3, 35–40 h; t5, 48–56 h) and the morphology of the selected sperm were analyzed. Results: A significant increase in the rate of blastocysts (54.0 vs. 36.3 %; P < 0.01) and top blastocysts (25.3 vs. 10.8 %; P < 0.001) was observed in the group of those meeting all three morphokinetic criteria (MKc3). However, MKc3 were only met in 23.3 % of all embryos. Moreover, TBR was influenced by the type of injected spermatozoa. In both groups, TBR decreased dramatically (MKc3, 35.0 vs. 17.0 %; MKc < 3, 14.2 vs. 8.4 %) when class II/III sperm instead of class I were injected. Conclusion: Early morphokinetic parameters might give some predictive information but fail to serve as a feasible selective tool for the prediction of blastocyst development given the influence of the type of spermatozoa injected. © 2015, Springer Science+Business Media New York.