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Voronova M.I.,RAS Institute of Chemistry | Zakharov A.G.,RAS Institute of Chemistry | Kuznetsov O.Y.,Ivanovo State Medical Academy | Surov O.V.,RAS Institute of Chemistry
Materials Letters | Year: 2012

The properties of two cellulose samples obtained by separation from water dispersion of whiskers by the two different methods, namely freeze-drying and water evaporation, have been investigated. The way cellulose is separated has been shown to have an effect on the properties of the material produced. © 2011 Elsevier B.V. All rights reserved. Source

Mironov A.A.,Istituto di Oncologia Molecolare di Fondazione Italiana per la Ricerca sul Cancro | Sesorova I.V.,Ivanovo State Medical Academy | Beznoussenko G.V.,Istituto di Oncologia Molecolare di Fondazione Italiana per la Ricerca sul Cancro
Histochemistry and Cell Biology | Year: 2013

The transport of proteins and lipids is one of the main cellular functions. The vesicular model, compartment (or cisterna) maturation model, and the diffusion model compete with each other for the right to be the paradigm within the field of the intra-Golgi transport. These models have significant difficulties explaining the existing experimental data. Recently, we proposed the kiss-and-run (KAR) model of intra-Golgi transport (Mironov and Beznoussenko in Int J Mol Sci 13(6):6800-6819, 2012), which can be symmetric, when fusion and fission occur in the same location, and asymmetric, when fusion and fission take place at different sites. Here, we compare the ability of main models of the intra-Golgi transport to explain the existing results examining the evidence in favor and against each model. We propose that the KAR model has the highest potential for the explanation of the majority of experimental observations existing within the field of intracellular transport. © 2013 Springer-Verlag Berlin Heidelberg. Source

Vaiman M.,Tel Aviv University | Nagibin A.,Ivanovo State Medical Academy | Olevson J.,Tel Aviv University
Surgery Today | Year: 2010

Purpose: To compare the rates of postsurgical complications following a primary and completed thyroidectomy for multinodular goiter (MNG). Methods: A total of 7123 cases of thyroidectomy in two hospitals from 1990 to 2007 (n = 3834 [53.83%] total [TT], n = 2238 [31.42%] subtotal [ST], and n = 1051 [14.75%] hemithyroidectomy [HT]) were studied for complications. The follow-up checked for injury of the laryngeal nerves, hypoparathyroidism, pathology recurrence, and appearance of neoplasm. Results: Postoperative mean follow-up: 7 years 9 months Primary operation: permanent recurrent laryngeal nerve (RLN) injury was observed in 1.4% in the TT group, 1.2% in the ST, and 0.9% in the HT group (P > 0.1 vs ST and TT). Permanent hypocalcaemia: 3.5% in TT group, 2.5% in the ST, in 1.4% in the HT. Eight hundred and seventy-seven patients suffered recurrence of MNG (n = 482 after ST, n = 395 after HT). Five hundred and sixty-four recurrent cases required a completion thyroidectomy. Reoperations: Permanent RLN injury was observed in 3% in the post-ST group and 2.5% in the post-HT group. Permanent hypocalcemia: 5.9% in the post-ST group and 4% in the post-HT group. Conclusion: There is no significant difference in complications between a primary TT and ST. The rates of complications after a completed thyroidectomy are significantly higher in comparison with the primary operations. High rates of reoperation in cases of recurrent pathology and incidental carcinoma were reported. © 2010 Springer. Source

Myasoedova E.,Rochester College | Myasoedova E.,Ivanovo State Medical Academy | Matteson E.L.,Mayo Medical School | Talley N.J.,University of Newcastle | Crowson C.S.,Mayo Medical School
Journal of Rheumatology | Year: 2012

Objective. To assess the incidence and mortality impact of upper and lower gastrointestinal (GI) events in rheumatoid arthritis (RA) compared to non-RA subjects. Methods. We identified incident upper and lower GI events and estimated their incidence rates using person-year methods in a population-based incident RA cohort of residents of Olmsted County, Minnesota, USA (1987 American College of Rheumatology criteria first fulfilled between January 1, 1980, and January 1, 2008) and non-RA subjects from the same population. Results. The study included 813 patients with RA and 813 non-RA subjects (mean followup 10.3 and 10.8 yrs, respectively); 68% women; mean age 55.9 yrs in both cohorts. The rate of upper GI events/100 person-years was 2.9 in RA versus 1.7 in the non-RA cohort (rate ratio 1.7, 95% CI 1.4, 2.2); for lower GI events, the rates were 2.1 in RA versus 1.4 in the non-RA cohort (rate ratio 1.5, 95% CI 1.1, 1.9). The incidence of upper GI bleed, perforation, ulcer, obstruction, and any upper GI event in RA declined over calendar time; the incidence of lower GI events remained unchanged. Exposure to glucocorticoids, prior upper GI disease, abdominal surgery, and smoking were associated with lower GI events in RA. Both upper and lower GI events were associated with increased mortality risk in RA. Conclusion. There is increased risk of serious upper and lower GI events in RA compared to non-RA subjects, and increased GI-related mortality in RA. Prominent declines in incidence of upper, but not lower GI events in RA highlight the need for studies investigating lower GI disease in patients with RA. The Journal of Rheumatology Copyright © 2012. All rights reserved. Source

Meshkova E.M.,Ivanovo State Medical Academy | Tomilova I.K.,Ivanovo State Medical Academy
Neurochemical Journal | Year: 2015

We present a review of the experimental and clinical data on the functioning of monoaminergic systems in the fetal and newborn brain under normal conditions and in antenatal hypoxia. The neurotrophic, morphogenetic, and adaptive roles of biogenic amines in the central nervous system during ontogenesis are discussed. Changes in the synthesis, release, reception, and degradation of neurotransmitters that occur during oxygen deficiency and cause an imbalance in excitation and inhibition in the brain are summarized. We analyzed the possible impacts of emerging impairments on the formation and development of neurological and somatic pathologies. © 2015, Pleiades Publishing, Ltd. Source

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