Ivanovo State Medical Academy

Ivanovo, Russia

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Ivanova Y.B.,Russian Academy of Sciences | Parfenov A.S.,Ivanovo State Medical Academy | Mamardashvili N.Z.,Russian Academy of Sciences
Russian Journal of Physical Chemistry A | Year: 2017

The kinetics of complex formation between zinc and 5,10,15,20-tetraphenylporphyrin and 5,10,15,20-tetra(4-hydroxyphenyl)porphyrin in acetonitrile is studied in the temperature range from 298 to 318 K. The fluorescent properties of these compounds are examined, the emission in the red region of the spectrum is measured, and the fluorescence quantum yields are determined. It is found that although the electronic absorption spectra of the studied compounds are almost identical, hydroxyl substituents are observed to have a considerable effect on the chelating ability of ligands. The rate constant of the formation of ZnT(4-OH-Ph)P is thus approximately three times higher than that of ZnTPhP, with the energy consumption being lower (about 20 kJ mol–1). The calculated fluorescence quantum yields of H2TPhP, H2T(4-OH-Ph) P, ZnTPhP, and ZnT(4-OH-Ph)P in acetonitrile are half those in toluene, while the ratio between the quantum yields of ligands and their metal complexes is a constant equal to approximately 3 and does not depend on which solvent is used. © 2017, Pleiades Publishing, Ltd.

PubMed | Moscow Institute of Physics and Technology, Saint Petersburg State University, All Russian Research Institute of Physiology and Ivanovo State Medical Academy
Type: Journal Article | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2017

Investigation of the neuroprotective properties of lithium ascorbate on the stress models in vivo and in vitro.Neurocytological and behavioral studies on nerve cell culture and animal stress models.Significant neuroprotective effect of lithium ascorbate in neuronal cultures exposed to glutamate toxicity and adaptogenic effect of this drug in stress model in rats were shown.The results suggest lithium ascorbate has a high neuroprotective potential in stress models in vivo and in vitro.

Myasoedova E.,Mayo Medical School | Myasoedova E.,Ivanovo State Medical Academy | Crowson C.S.,Mayo Medical School | Nicola P.J.,University of Lisbon | And 5 more authors.
Journal of Rheumatology | Year: 2011

Objective. To examine the influence of rheumatoid arthritis (RA) characteristics and antirheumatic medications on the risk of heart failure (HF) in patients with RA. Methods. A population-based incidence cohort of RA patients aged ≥ 18 years (1987 American College of Rheumatology criteria first met between January 1, 1980, and January 1, 2008) with no history of HF was followed until onset of HF (defined by Framingham criteria), death, or January 1, 2008. We collected data on RA characteristics, antirheumatic medications, and cardiovascular (CV) risk factors. Cox models adjusting for age, sex, and calendar year were used to analyze the data. Results. The study included 795 RA patients [mean age 55.3 yrs, 69% women, 66% rheumatoid factor (RF)-positive]. During the mean followup of 9.7 years, 92 patients developed HF. The risk of HF was associated with RF positivity (HR 1.6, 95% CI 1.0, 2.5), erythrocyte sedimentation rate (ESR) at RA incidence (HR 1.6, 95% CI 1.2, 2.0), repeatedly high ESR (HR 2.1, 95% CI 1.2, 3.5), severe extra - articular manifestations (HR 3.1, 95% CI 1.9, 5.1), and corticosteroid use (HR 2.0, 95% CI 1.3, 3.2), adjusting for CV risk factors and coronary heart disease (CHD). Methotrexate users were half as likely to have HF as nonusers (HR 0.5, 95% CI 0.3, 0.9). Conclusion. Several RA characteristics and the use of corticosteroids were associated with HF, with adjustment for CV risk factors and CHD. Methotrexate use appeared to be protective against HF. These findings suggest an independent effect of RA on HF that may be further modified by antirheumatic treatment. The Journal of Rheumatology Copyright © 2011. All rights reserved.

Mironov A.A.,Instituto Of Oncologia Molecolare Of Fondazione Italiana Per La Ricerca Sul Cancro | Sesorova I.V.,Ivanovo State Medical Academy | Beznoussenko G.V.,Instituto Of Oncologia Molecolare Of Fondazione Italiana Per La Ricerca Sul Cancro
Histochemistry and Cell Biology | Year: 2013

The transport of proteins and lipids is one of the main cellular functions. The vesicular model, compartment (or cisterna) maturation model, and the diffusion model compete with each other for the right to be the paradigm within the field of the intra-Golgi transport. These models have significant difficulties explaining the existing experimental data. Recently, we proposed the kiss-and-run (KAR) model of intra-Golgi transport (Mironov and Beznoussenko in Int J Mol Sci 13(6):6800-6819, 2012), which can be symmetric, when fusion and fission occur in the same location, and asymmetric, when fusion and fission take place at different sites. Here, we compare the ability of main models of the intra-Golgi transport to explain the existing results examining the evidence in favor and against each model. We propose that the KAR model has the highest potential for the explanation of the majority of experimental observations existing within the field of intracellular transport. © 2013 Springer-Verlag Berlin Heidelberg.

Voronova M.I.,RAS Institute of Chemistry | Zakharov A.G.,RAS Institute of Chemistry | Kuznetsov O.Y.,Ivanovo State Medical Academy | Surov O.V.,RAS Institute of Chemistry
Materials Letters | Year: 2012

The properties of two cellulose samples obtained by separation from water dispersion of whiskers by the two different methods, namely freeze-drying and water evaporation, have been investigated. The way cellulose is separated has been shown to have an effect on the properties of the material produced. © 2011 Elsevier B.V. All rights reserved.

Vaiman M.,Tel Aviv University | Nagibin A.,Ivanovo State Medical Academy | Olevson J.,Tel Aviv University
Surgery Today | Year: 2010

Purpose: To compare the rates of postsurgical complications following a primary and completed thyroidectomy for multinodular goiter (MNG). Methods: A total of 7123 cases of thyroidectomy in two hospitals from 1990 to 2007 (n = 3834 [53.83%] total [TT], n = 2238 [31.42%] subtotal [ST], and n = 1051 [14.75%] hemithyroidectomy [HT]) were studied for complications. The follow-up checked for injury of the laryngeal nerves, hypoparathyroidism, pathology recurrence, and appearance of neoplasm. Results: Postoperative mean follow-up: 7 years 9 months Primary operation: permanent recurrent laryngeal nerve (RLN) injury was observed in 1.4% in the TT group, 1.2% in the ST, and 0.9% in the HT group (P > 0.1 vs ST and TT). Permanent hypocalcaemia: 3.5% in TT group, 2.5% in the ST, in 1.4% in the HT. Eight hundred and seventy-seven patients suffered recurrence of MNG (n = 482 after ST, n = 395 after HT). Five hundred and sixty-four recurrent cases required a completion thyroidectomy. Reoperations: Permanent RLN injury was observed in 3% in the post-ST group and 2.5% in the post-HT group. Permanent hypocalcemia: 5.9% in the post-ST group and 4% in the post-HT group. Conclusion: There is no significant difference in complications between a primary TT and ST. The rates of complications after a completed thyroidectomy are significantly higher in comparison with the primary operations. High rates of reoperation in cases of recurrent pathology and incidental carcinoma were reported. © 2010 Springer.

Myasoedova E.,Rochester College | Myasoedova E.,Ivanovo State Medical Academy | Matteson E.L.,Mayo Medical School | Talley N.J.,University of Newcastle | Crowson C.S.,Mayo Medical School
Journal of Rheumatology | Year: 2012

Objective. To assess the incidence and mortality impact of upper and lower gastrointestinal (GI) events in rheumatoid arthritis (RA) compared to non-RA subjects. Methods. We identified incident upper and lower GI events and estimated their incidence rates using person-year methods in a population-based incident RA cohort of residents of Olmsted County, Minnesota, USA (1987 American College of Rheumatology criteria first fulfilled between January 1, 1980, and January 1, 2008) and non-RA subjects from the same population. Results. The study included 813 patients with RA and 813 non-RA subjects (mean followup 10.3 and 10.8 yrs, respectively); 68% women; mean age 55.9 yrs in both cohorts. The rate of upper GI events/100 person-years was 2.9 in RA versus 1.7 in the non-RA cohort (rate ratio 1.7, 95% CI 1.4, 2.2); for lower GI events, the rates were 2.1 in RA versus 1.4 in the non-RA cohort (rate ratio 1.5, 95% CI 1.1, 1.9). The incidence of upper GI bleed, perforation, ulcer, obstruction, and any upper GI event in RA declined over calendar time; the incidence of lower GI events remained unchanged. Exposure to glucocorticoids, prior upper GI disease, abdominal surgery, and smoking were associated with lower GI events in RA. Both upper and lower GI events were associated with increased mortality risk in RA. Conclusion. There is increased risk of serious upper and lower GI events in RA compared to non-RA subjects, and increased GI-related mortality in RA. Prominent declines in incidence of upper, but not lower GI events in RA highlight the need for studies investigating lower GI disease in patients with RA. The Journal of Rheumatology Copyright © 2012. All rights reserved.

Meshkova E.M.,Ivanovo State Medical Academy | Tomilova I.K.,Ivanovo State Medical Academy
Neurochemical Journal | Year: 2015

We present a review of the experimental and clinical data on the functioning of monoaminergic systems in the fetal and newborn brain under normal conditions and in antenatal hypoxia. The neurotrophic, morphogenetic, and adaptive roles of biogenic amines in the central nervous system during ontogenesis are discussed. Changes in the synthesis, release, reception, and degradation of neurotransmitters that occur during oxygen deficiency and cause an imbalance in excitation and inhibition in the brain are summarized. We analyzed the possible impacts of emerging impairments on the formation and development of neurological and somatic pathologies. © 2015, Pleiades Publishing, Ltd.

Gromova O.A.,Ivanovo State Medical Academy | Torshin I.Y.,Ivanovo State Medical Academy | Gogoleva I.V.,Ivanovo State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

Cerebrolysin is the drug which contains peptides derived from the brain of a pig. It is used in neurological practice for recovery of stroke patients and treatment of dementia. Despite the evidence-basis and some experimental studies, the distinct mechanisms of pharmacological action of this drug remain unclear for most neurologists. In this paper, we present results of a molecular-biological analysis of peptide content of cerebrolysin. We have demonstrated the presence of active peptide fragments of nerve growth factor, enkephalins, orexin, halanin. The results of current clinical and experimental studies of cerebrolysin have been compared. The activity of above-mentioned neuropeptides explain experimental and clinical details of all known effects (neurotrophic, neuroprotective and immunomodulating) of cerebrolysin in ischemic and neurodegenerative CNS injuries. The analysis allowed to make conclusions about mechanisms of cerebrolysin action that were important for increasing the efficacy of this drug in clinical practice.

PubMed | Moscow Institute of Physics and Technology and Ivanovo State Medical Academy
Type: Journal Article | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2017

A complex study of pharmacological properties of magnesium pyroglutamate using the modern methods of chemoinformatics and bioinformatics.Pharmacological properties of magnesium pyroglutamate were studied using chemoinformatic and bioinformatic analyses.Neurotropic effects of magnesium pyroglutamate are due to an influence on the synthesis of neuropeptides containing pyroglutamate (orexin, thyroliberin, neurotensin etc) and due to the similarity between pyroglutamate-anion with some neuroactive components (L-theanine, 2-pirrolydinone, piracetam).The results of the study suggest neuroprotective, sedative and antidepressive properties of magnesium pyroglutamate which are realized by pyroglutamate-anion in the synergism with magnesium cation.

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