Ivanovo State Medical Academy

Ivanovo, Russia
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Ivanova Y.B.,Russian Academy of Sciences | Parfenov A.S.,Ivanovo State Medical Academy | Mamardashvili N.Z.,Russian Academy of Sciences
Russian Journal of Physical Chemistry A | Year: 2017

The kinetics of complex formation between zinc and 5,10,15,20-tetraphenylporphyrin and 5,10,15,20-tetra(4-hydroxyphenyl)porphyrin in acetonitrile is studied in the temperature range from 298 to 318 K. The fluorescent properties of these compounds are examined, the emission in the red region of the spectrum is measured, and the fluorescence quantum yields are determined. It is found that although the electronic absorption spectra of the studied compounds are almost identical, hydroxyl substituents are observed to have a considerable effect on the chelating ability of ligands. The rate constant of the formation of ZnT(4-OH-Ph)P is thus approximately three times higher than that of ZnTPhP, with the energy consumption being lower (about 20 kJ mol–1). The calculated fluorescence quantum yields of H2TPhP, H2T(4-OH-Ph) P, ZnTPhP, and ZnT(4-OH-Ph)P in acetonitrile are half those in toluene, while the ratio between the quantum yields of ligands and their metal complexes is a constant equal to approximately 3 and does not depend on which solvent is used. © 2017, Pleiades Publishing, Ltd.

Volkova T.G.,Ivanovo State University | Talanova I.O.,Ivanovo State Medical Academy
Zhidkie Kristally i Ikh Prakticheskoe Ispol'zovanie | Year: 2016

Possibility of intermolecular hydrogen bonds formation in associates of pentyl ester of p-(N-α-Dglucopyranoside) aminobenzoic acid was studied. In order to reveal the features of hydrogen bond system in Hcomplexes being studied the comparative analysis of experimental and theoretical IR spectra of dimer molecules was carried out. The assessment of interaction energy between two molecules and its decomposition by Morokum's method was also given. It was found that the predominant contributions in the interaction energy were electrostatic and exchange repulsion terms. According to the obtained data, the cyclic form of glucose residue leads to low probability of associate formation.

Akaizin E.S.,Ivanovo State Medical Academy | Akaizina A.E.,Ivanovo State Medical Academy
Klinichescheskaya Laboratornaya Diagnostika | Year: 2017

The volatile fatty acids are metabolites of bacteria reflecting condition and disbiotic alterations of microflora of gastrointestinal tract. The study was carried out to determine qualitatively volatile fatty acids in saliva of children with dysfunction of biliary tract and healthy ones. The indices of volatile fatty acids were analyzed in 46 children aged 7-17 years and with dysfunction of biliary tract. The comparison group included 34 healthy children aged from 7 to 17 years. The gas-liquid chromatography was applied to qualitatively detect acetic, butyric, isovaleric acids (volatilefatty acids). The automated gas Chromatograph "Crystal deluxe 4000" with capillary column "HP-FFAP" and flame ionizing detector was used. The study established decreasing of anaerobic index, increasing of acetic, propionic acids and sum of volatile fatty acids in saliva of children of main group as opposed to children of comparison group. The possible role of bacterial metabolites and bacteria in pathogenesis of dysfunction of biliary tract in children. The description is made of one of possible mechanisms of increasing of volatile fatty acids in saliva under dysfunction of biliary tract. The integral indices of volatile fatty acids of saliva are the new additional criteria for diagnostic of dysfunction of biliary tract in children.

Torshin I.Yu.,Moscow Institute of Physics and Technology | Gromova O.A.,Ivanovo State Medical Academy | Semenov V.A.,Kemerovo State Medical Academy | Grishina T.R.,Ivanovo State Medical Academy
Nevrologiya, Neiropsikhiatriya, Psikhosomatika | Year: 2016

The paper presents a systematic analysis of experimental and clinical studies of etifoxine. The anxiolytic effect of etifoxine is due, firstly, to the modulation of GABA receptor activity and, secondly, to that of metabolism of neurosteroids that are themselves characterized by anxiolytic and neuroprotective properties. The results of clinical trials of etifoxine are also analyzed. In addition to its anxiolytic effect that partially persists even after treatment discontinuation, etifoxine is ascertained to be characterized by analgesic, neurotrophic and neuroprotective properties.

Gromova O.A.,Ivanovo State Medical Academy | Torshin I.Yu.,Moscow Institute of Physics and Technology | Fedotova L.E.,Ivanovo State Medical Academy | Gromov A.N.,Russian Academy of Sciences
Nevrologiya, Neiropsikhiatriya, Psikhosomatika | Year: 2016

Ethylmethylhydroxypyridine succinate (EMHPS) is used in the therapy of ischemic stroke. A more complete understanding of the conditions that can affect the clinical efficacy of EMHPS needs the most complete information about its molecular mechanisms of action. Objective: to comparatively analyze the properties of EMHPS using the newest area of postgenomic pharmacology - chemoreactome simulation. Succinic acid and citicoline were used as the molecules of comparison (control molecules). Material and methods: Chemoreactome analysis was employed to assess the biological activity of a test molecule (simulation of the affinity profile of the examined molecular structure for various proteome proteins). A new mathematical method based on the combinatorial theory of solvability was devised for chemoinformational analysis. Results and discussion: Chemoreactome simulation has shown that EMHPS may be an agonist of acetylcholine and GABA receptors, as well as that of cannabinoid receptor type 2. The anti-inflammatory effect of an EMHPS molecule may be due to the inhibition of synthesis of proinflammatory prostaglandins. Its higher safety (a weaker effect on serotonin and opioid receptors and lower interaction with Erg channels and the enzymes monoamine oxidase and cytochrome CYP1A1) distinguish EMHPS from the molecules of comparison (citicolne and succinic acid). The predicted properties of the molecule of EMHPS make a substantial contribution to its neuroprotective effect. Conclusion. The results of chemoreactome analysis could reveal not only quite unexpected mechanisms of action of EMHPS, but also its mechanisms of synergic action with pyridoxine and magnesium. Owing to a combination of EMHPS with pyridoxine and magnesium, there is an increase in the antioxidant, anticonvulsant, stress- and neuroprotective, nootropic, and anxiolytic effects of EMHPS via activation of pyridoxinedependent and magnesium-dependent proteins. The combination of EMHPS with pyridoxine and magnesium also contributes to the potentiation of hemodynamic, antiplatelet, antiaggregant, and anticoagulant actions, activates homocysteine neutralization and anti-inflammatory protection, and decreases the risk of proarrhythmic effects.

Myasoedova E.,Mayo Medical School | Myasoedova E.,Ivanovo State Medical Academy | Crowson C.S.,Mayo Medical School | Nicola P.J.,University of Lisbon | And 5 more authors.
Journal of Rheumatology | Year: 2011

Objective. To examine the influence of rheumatoid arthritis (RA) characteristics and antirheumatic medications on the risk of heart failure (HF) in patients with RA. Methods. A population-based incidence cohort of RA patients aged ≥ 18 years (1987 American College of Rheumatology criteria first met between January 1, 1980, and January 1, 2008) with no history of HF was followed until onset of HF (defined by Framingham criteria), death, or January 1, 2008. We collected data on RA characteristics, antirheumatic medications, and cardiovascular (CV) risk factors. Cox models adjusting for age, sex, and calendar year were used to analyze the data. Results. The study included 795 RA patients [mean age 55.3 yrs, 69% women, 66% rheumatoid factor (RF)-positive]. During the mean followup of 9.7 years, 92 patients developed HF. The risk of HF was associated with RF positivity (HR 1.6, 95% CI 1.0, 2.5), erythrocyte sedimentation rate (ESR) at RA incidence (HR 1.6, 95% CI 1.2, 2.0), repeatedly high ESR (HR 2.1, 95% CI 1.2, 3.5), severe extra - articular manifestations (HR 3.1, 95% CI 1.9, 5.1), and corticosteroid use (HR 2.0, 95% CI 1.3, 3.2), adjusting for CV risk factors and coronary heart disease (CHD). Methotrexate users were half as likely to have HF as nonusers (HR 0.5, 95% CI 0.3, 0.9). Conclusion. Several RA characteristics and the use of corticosteroids were associated with HF, with adjustment for CV risk factors and CHD. Methotrexate use appeared to be protective against HF. These findings suggest an independent effect of RA on HF that may be further modified by antirheumatic treatment. The Journal of Rheumatology Copyright © 2011. All rights reserved.

Mironov A.A.,Instituto Of Oncologia Molecolare Of Fondazione Italiana Per La Ricerca Sul Cancro | Sesorova I.V.,Ivanovo State Medical Academy | Beznoussenko G.V.,Instituto Of Oncologia Molecolare Of Fondazione Italiana Per La Ricerca Sul Cancro
Histochemistry and Cell Biology | Year: 2013

The transport of proteins and lipids is one of the main cellular functions. The vesicular model, compartment (or cisterna) maturation model, and the diffusion model compete with each other for the right to be the paradigm within the field of the intra-Golgi transport. These models have significant difficulties explaining the existing experimental data. Recently, we proposed the kiss-and-run (KAR) model of intra-Golgi transport (Mironov and Beznoussenko in Int J Mol Sci 13(6):6800-6819, 2012), which can be symmetric, when fusion and fission occur in the same location, and asymmetric, when fusion and fission take place at different sites. Here, we compare the ability of main models of the intra-Golgi transport to explain the existing results examining the evidence in favor and against each model. We propose that the KAR model has the highest potential for the explanation of the majority of experimental observations existing within the field of intracellular transport. © 2013 Springer-Verlag Berlin Heidelberg.

Voronova M.I.,RAS Institute of Chemistry | Zakharov A.G.,RAS Institute of Chemistry | Kuznetsov O.Y.,Ivanovo State Medical Academy | Surov O.V.,RAS Institute of Chemistry
Materials Letters | Year: 2012

The properties of two cellulose samples obtained by separation from water dispersion of whiskers by the two different methods, namely freeze-drying and water evaporation, have been investigated. The way cellulose is separated has been shown to have an effect on the properties of the material produced. © 2011 Elsevier B.V. All rights reserved.

Vaiman M.,Tel Aviv University | Nagibin A.,Ivanovo State Medical Academy | Olevson J.,Tel Aviv University
Surgery Today | Year: 2010

Purpose: To compare the rates of postsurgical complications following a primary and completed thyroidectomy for multinodular goiter (MNG). Methods: A total of 7123 cases of thyroidectomy in two hospitals from 1990 to 2007 (n = 3834 [53.83%] total [TT], n = 2238 [31.42%] subtotal [ST], and n = 1051 [14.75%] hemithyroidectomy [HT]) were studied for complications. The follow-up checked for injury of the laryngeal nerves, hypoparathyroidism, pathology recurrence, and appearance of neoplasm. Results: Postoperative mean follow-up: 7 years 9 months Primary operation: permanent recurrent laryngeal nerve (RLN) injury was observed in 1.4% in the TT group, 1.2% in the ST, and 0.9% in the HT group (P > 0.1 vs ST and TT). Permanent hypocalcaemia: 3.5% in TT group, 2.5% in the ST, in 1.4% in the HT. Eight hundred and seventy-seven patients suffered recurrence of MNG (n = 482 after ST, n = 395 after HT). Five hundred and sixty-four recurrent cases required a completion thyroidectomy. Reoperations: Permanent RLN injury was observed in 3% in the post-ST group and 2.5% in the post-HT group. Permanent hypocalcemia: 5.9% in the post-ST group and 4% in the post-HT group. Conclusion: There is no significant difference in complications between a primary TT and ST. The rates of complications after a completed thyroidectomy are significantly higher in comparison with the primary operations. High rates of reoperation in cases of recurrent pathology and incidental carcinoma were reported. © 2010 Springer.

Myasoedova E.,Rochester College | Myasoedova E.,Ivanovo State Medical Academy | Matteson E.L.,Mayo Medical School | Talley N.J.,University of Newcastle | Crowson C.S.,Mayo Medical School
Journal of Rheumatology | Year: 2012

Objective. To assess the incidence and mortality impact of upper and lower gastrointestinal (GI) events in rheumatoid arthritis (RA) compared to non-RA subjects. Methods. We identified incident upper and lower GI events and estimated their incidence rates using person-year methods in a population-based incident RA cohort of residents of Olmsted County, Minnesota, USA (1987 American College of Rheumatology criteria first fulfilled between January 1, 1980, and January 1, 2008) and non-RA subjects from the same population. Results. The study included 813 patients with RA and 813 non-RA subjects (mean followup 10.3 and 10.8 yrs, respectively); 68% women; mean age 55.9 yrs in both cohorts. The rate of upper GI events/100 person-years was 2.9 in RA versus 1.7 in the non-RA cohort (rate ratio 1.7, 95% CI 1.4, 2.2); for lower GI events, the rates were 2.1 in RA versus 1.4 in the non-RA cohort (rate ratio 1.5, 95% CI 1.1, 1.9). The incidence of upper GI bleed, perforation, ulcer, obstruction, and any upper GI event in RA declined over calendar time; the incidence of lower GI events remained unchanged. Exposure to glucocorticoids, prior upper GI disease, abdominal surgery, and smoking were associated with lower GI events in RA. Both upper and lower GI events were associated with increased mortality risk in RA. Conclusion. There is increased risk of serious upper and lower GI events in RA compared to non-RA subjects, and increased GI-related mortality in RA. Prominent declines in incidence of upper, but not lower GI events in RA highlight the need for studies investigating lower GI disease in patients with RA. The Journal of Rheumatology Copyright © 2012. All rights reserved.

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