Its Paramedical College Pharmacy

Ghāziābād, India

Its Paramedical College Pharmacy

Ghāziābād, India

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Kumar S.S.,ITS Paramedical College Pharmacy | Kumar Y.,ITS Paramedical College Pharmacy | Khan M.S.Y.,Jamia Hamdard University | De Clercq E.,Rega Institute for Medical Research
Natural Product Research | Year: 2011

The steroids 3,6,17-trihydroxy-stigmasta-4,7,24(28)-triene (A) and 14,15,18,20-diepoxyturbinarin (B) were isolated from the cyclohexane extract of brown alga, Turbinaria conoides (J. Agardh) Kutzing, and have been reported for their antimicrobial activity by us. In this study, the isolated compounds were evaluated for comprehensive antihistaminic, antiviral and cytotoxicity screening. The antihistaminic study was performed using invitro standard animal models. Evaluation of the potency (EC50), affinity (pA2) and the maximal response (Emax) of the histamine alone and in the presence of the compounds were determined. Antiviral activity and cytotoxicity were performed in Crandell-Rees feline kidney (CRFK) cells by a colorimetric formazan-based MTS assay. No significant antiviral activity or cytotoxicity were observed for the compounds in the CRFK cells. Compound A inhibited the histamine-induced concentration at 20 μg mL -1(p <0.05). The most significant inhibition (97%) was observed for compound B (p <0.01) at the same concentration, which was comparable to that of the positive control chlorpheniramine maleate (10 μg mL -1). This potentiality suggests that 14,15,18,20-diepoxyturbinarin (B) can be developed as a new lead antihistaminic agent. © 2011 Taylor &Francis.


Jawla S.,Its Paramedical College Pharmacy | Kumar Y.,Its Paramedical College Pharmacy | Khan M.S.Y.,Jamia Hamdard University
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: Bougainvillea spectabilis (B. spectabilis) is one of the main constituent of various herbal formulations available for diabetes. The aim of present study was to screen hypoglycemic potential of B. spectabilis stem bark extracts in albno rats (Wistar strain). Methods: The EtOH extracts (100, 250 and 500 mg/kg/day) of the B. spectabilis were administered to both normal and alloxan induced diabetic rats at defined time intervals. Blood glucose levels were measured at 0, 0.5, 1, 2, 4, 6 h, and on 0, 1, 3, 5, 7th day after oral administration of extracts. Of the doses test, highest anti-hyperglycemic effect was observed by the extract of stem bark at 250 mg/kg after a week treatment. Results: B. spectabilis stem bark extract exhibited significant hypoglycemic activity at different doses and intervals. Stem bark extract was found to be 22.2% more potent than standard oral hypoglycemic drug, glibenclamide 0.2 mg/kg. Conclusion: Treatment of alloxan induced diabetic rats up to a week with stem bark extract reversed the permanent hyperglycemia. Hence, B. spectabilis stem bark alcoholic extract exhibited potent hypoglycemic activity. © 2012 Asian Pacific Tropical Biomedical Magazine.


Jawla S.,Its Paramedical College Pharmacy | Kumar Y.,Its Paramedical College Pharmacy | Khan M.S.Y.,Jamia Hamdard University
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: To screen the antimicrobial and antihyperglycemic activities of Musa paradisiaca (M. paradisiaca) flowers. Methods: The EtOH and EtOH: water (1:1) extracts of M. paradisiaca flowers were screened for antibacterial and antifungal activity against standard strains of Bacillus subtilis (B. subtilis), Bacillus cereus (B. cereus), Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumoniae), Proteus mirabilis (P. mirabilis), Pseudomonas aeruginosa (P. aeruginosa), Streptococcus pneumoniae (S. pneumoniae), Staphylococcus aureus (S. aureus), Salmonella typhimurium (S. typhimurium) and Candida albicans (C. albicans), Cryptococcus albidus (C. albidus) against amikacin and clotrimazole respectively. Both the extracts were also administered to normal and alloxan induced diabetic rats. The blood glucose levels were measured daily after oral administration of extracts at doses of 100, 250 and 500 mg/(kg.d). Result: The EtOH and EtOH: water (1:1) extracts exhibited antimicrobial activity with minimum inhibitory concentrations ranging from 5.62-25.81 and 7.60-31.50 μg/mL respectively. Both the extracts reversed the permanent hyperglycemia within a week in alloxan induced diabetic rats. The EtOH extract (250 mg/kg) was found to be 7.69% more potent hypoglycemic effect than standard oral hypoglycemic drug, glibenclamide 0.2 mg/kg b.w., respectively. Conclusion: The alcoholic extracts of M. paradisiaca flowers showed potent antihyperglycemic and moderate antimicrobial activities. © 2012 Asian Pacific Tropical Biomedical Magazine.


Gaur P.K.,Its Paramedical College Pharmacy | Mishra S.,Jamia Hamdard University | Bajpai M.,Its Paramedical College Pharmacy | Mishra A.,Its Paramedical College Pharmacy
BioMed Research International | Year: 2014

Solid lipid nanoparticle is an efficient lipid based drug delivery system which can enhance the bioavailability of poorly water soluble drugs. Efavirenz is a highly lipophilic drug from nonnucleoside inhibitor category for treatment of HIV. Present work illustrates development of an SLN formulation for Efavirenz with increased bioavailability. At first, suitable lipid component and surfactant were chosen. SLNs were prepared and analyzed for physical parameters, stability, and pharmacokinetic profile. Efavirenz loaded SLNs were formulated using Glyceryl monostearate as main lipid and Tween 80 as surfactant. ESLN-3 has shown mean particle size of 124.5 ± 3.2 nm with a PDI value of 0.234, negative zeta potential, and 86% drug entrapment. In vitro drug release study has shown 60.6-98.22% drug release in 24 h by various SLN formulations. Optimized SLNs have shown good stability at 40°C ± 2°C and 75 ± 5 % relative humidity (RH) for 180 days. ESLN-3 exhibited 5.32-fold increase in peak plasma concentration (C max ) and 10.98-fold increase in AUC in comparison to Efavirenz suspension (ES). © 2014 Praveen Kumar Gaur et al.


Kumar S.S.,Its Paramedical College Pharmacy | Kumar Y.,Its Paramedical College Pharmacy | Khan M.S.Y.,Jamia Hamdard University | Gupta V.,Its Paramedical College Pharmacy
Natural Product Research | Year: 2010

Two new steroids 3,6,17-trihydroxy-stigmasta-4,7,24(28)-triene (1) and 14,15,18,20-diepoxyturbinarin (3), together with a known compound, fucosterol (2), were isolated from the cyclohexane extract of Turbinaria conoides. The structures were elucidated on the basis of spectroscopic evidence. The isolated compounds were screened against a panel of microorganisms. Minimum inhibitory concentrations (MICs) were determined by the standard broth dilution method. Compounds 1-3 exhibited moderate antibacterial activity against the tested bacteria and inhibited the fungal growth with MIC values ranging from 2 to 16 g mL-1. Compound 3 was found to be most potent against Aspergillus niger, with an MIC value of 2.0 g mL-1. The isolation of antifungal compounds from T. conoides is reported for the first time. These results suggested that 14,15,18,20-diepoxyturbinarin (3) could be developed as a new lead antifungal agent. © 2010 Taylor & Francis.


Madan S.,Central Indian Pharmacopoeial Laboratory | Ahmad S.,Jamia Hamdard University | Singh G.N.,Central Indian Pharmacopoeial Laboratory | Kohli K.,Jamia Hamdard University | And 3 more authors.
Indian Journal of Natural Products and Resources | Year: 2010

The Sweet Herb of Paraguay, Stevia rebaudiana (Bert.) Bertoni is fast becoming a major source of high potency sweetener which produces sweet taste but has no calorific value. Many research activities on its chemical and biological properties have been done in recent past. Several countries including India have started its commercial cultivation. The published literature on this crop is quite scattered. Therefore an effort to compile the literature and review the current status of research and development including cultivation practices has been done in this paper.


PubMed | Its Paramedical College Pharmacy and Jamia Hamdard University
Type: | Journal: BioMed research international | Year: 2014

Solid lipid nanoparticle is an efficient lipid based drug delivery system which can enhance the bioavailability of poorly water soluble drugs. Efavirenz is a highly lipophilic drug from nonnucleoside inhibitor category for treatment of HIV. Present work illustrates development of an SLN formulation for Efavirenz with increased bioavailability. At first, suitable lipid component and surfactant were chosen. SLNs were prepared and analyzed for physical parameters, stability, and pharmacokinetic profile. Efavirenz loaded SLNs were formulated using Glyceryl monostearate as main lipid and Tween 80 as surfactant. ESLN-3 has shown mean particle size of 124.5 3.2 nm with a PDI value of 0.234, negative zeta potential, and 86% drug entrapment. In vitro drug release study has shown 60.6-98.22% drug release in 24 h by various SLN formulations. Optimized SLNs have shown good stability at 40C 2C and 75 5% relative humidity (RH) for 180 days. ESLN-3 exhibited 5.32-fold increase in peak plasma concentration (C max) and 10.98-fold increase in AUC in comparison to Efavirenz suspension (ES).


Chauhan D.,Sunder Deep Pharmacy College | Siddqui A.A.,Hamdard University | Kataria R.,ITS Paramedical College Pharmacy
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

A new series of 1-(6-amino-1,3-benzothiazol-2-yl)-3-(substitutedphenyl)-1H-pyrazole-4-carbaldehyde, 5a-g, were synthesized. All the newly synthesized compounds were screened for their in vitro antibacterial activity, against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa and for antifungal activity against Aspergillus niger and Candida albicans. Compounds 5b, 5f, 5d, 5a showed excellent in vitro antibacterial activity and antifungal activity than the standard drugs. All the compounds were characterized by IR, 1HNMR, LCMS mass and C, H, N analyses.


Sadish Kumar S.,Its Paramedical College Pharmacy | Jayendra,Its Paramedical College Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2012

The steroids of the brown alga Turbinaria conoides were recognized as having mild-to-moderate cytotoxicity in HeLa cell, as it is being investigated towards determination of toxicity with various drugs. The cytotoxicity in HeLa cells was expressed in terms of 50% cytotoxic concentration (CC50). These oxygenated steroids exhibited cytotoxicity against HeLa cells with CC50 values ranging from 60.9 μg/mL to >100 μg/mL. To analyse for their cytotoxicity, Quantitative structure activity relationship (QSAR) study was performed. It was done by multiple regression analysis with simulated annealing method of partial least square (PLS) model. A PLS model (r2 = 0.90, q2 = 0.80, pred_r2 = 0.96) was used as a base of consensus prediction of cytotoxicity. QSAR studies indicated the carbon atom (T_C_O_4: 12%) and any atom (T_2_2_7: 15%) away from the oxygen and double bond respectively, atomic valence connectivity indexorder 0 (chiV0: 50%) and distance between most hydrophobic and hydrophilic point on the VanderWaals surface (XAMostHydrophobicHydrophilic distance: 20%) correlating well with mild cytotoxicity while the partial charges of the molecules (dipole moment: 25%) contributing moderate cytotoxicity. The 3D QSAR model further described that less bulkier substituent is required at steric site S_2441. Thus it can be concluded from the present study that cytotoxicity can be achieved by modifying the aromatic ring and preferring less bulky group to reduce steric hindrance.


Jawla S.,Its Paramedical College Pharmacy | Kumar Y.,Its Paramedical College Pharmacy | Khan M.S.Y.,Hamdard University
Tropical Journal of Pharmaceutical Research | Year: 2013

Purpose: To isolate and identify the constituents of Bougainvillea spectabilis Willd (Nyctaginaceae) stem bark. Methods: The methanol extract of Bougainvillea spectabilis stem bark powder was suspended in water and extracted with dichloromethane (CH2Cl2), ethyl acetate (EtOAc), and butanol (BuOH) successively. The ethyl acetate fraction was loaded in a column packed with silica gel and eluted with a gradient of chloroform (CHCl3): methanol (MeOH), and water yielded five fractions (A - E). Chemical constituents were isolated by repeated column chromatography of these fractions. Results: Column chromatography of fractions B and C afforded four compounds identified as pinitol, β- sitosterol, quercetin and quercetin-3-O-α-L-rhamnopyranoside. For the first time, pinitol, β-sitosterol, quercetin and quercetin-3-O-α-L-rhamnopyranoside were isolated from the stem bark of B. spectabilis Willd. Conclusion: An antidiabetic principle, pinitol, was successfully isolated from the stem bark of B. spectabilis Willd. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.

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