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Ghāziābād, India

Yasir M.,Uttarakhand Technical University | Yasir M.,ITS Pharmacy College | Sara U.V.S.,Raj Kumar Goel Institute of Technology
Research Journal of Pharmacy and Technology

The aim of the present work was to develop and validate a sensitive, simple, accurate, precise and cost effective UV spectrophotometric method for the analysis of antipsychotic drug i.e haloperidol in prepared pharmaceutical formulations of solid lipid nanoparticles. The different analytical performance parameters such as linearity, range, precision, accuracy, limit of detection (LOD) and limit of quantification (LOQ) were determined according to International Conference on Harmonization (ICH) Q2 (R1) guidelines. The study was performed in phosphate buffer of pH 7.4. The peak (λmax) of haloperidol appeared at a wavelength of 247.5 nm in Phosphate buffer (pH 7.4). Beer- Lambert’s law was obeyed in the concentration range of 2–20 μg/ml with correlation coefficient (R2) 0.9994. The results of the study demonstrated that the developed procedure is accurate, precise and reproducible (relative standard deviation 2%), while being simple, cheap and less time consuming. The results of stability study indicate that the drug was stable in selected medium after storage up to 48 h and was not affected by light and dark cycles. Therefore, this method can be suitably applied for the estimation of haloperidol in prepared solid lipid nanoparticles. © RJPT All right reserved. Source

Mishra S.,Jamia Hamdard University | Aeri V.,Jamia Hamdard University | Gaur P.K.,ITS Pharmacy College | Jachak S.M.,National Institute of Pharmaceutical Education and Research
BioMed Research International

Boerhavia diffusa (BD) is a plant of rasayana category as per ayurvedic claims. It is reported to possess antiaging, disease prevention, and life strengthening activities which hold enormous influence in disease burden and affordability/availability of healthcare in the world. Objective. This paper has been compiled to comment on the studies reported for BD to highlight its chemical and therapeutic potential along with its ethnopharmacological considerations. Methods. In the present paper, a detailed account of chemical constituents and pharmacological activities has been presented. All the findings were correlated with modern pharmacological activities to appraise the value of BD. Results. Chemical analysis of BD gives a wide variety of chemical constituents, namely, rotenoids, flavonoids, xanthones, purine nucleoside, lignans, and steroids. Various ethnopharmacological reports emphasize its role in disorders of reproductive system, gastrointestinal system, respiratory system, urinary system, hepatic system/jaundice, cardiovascular system, and cancer. Conclusions. The studies on the therapeutic activities of BD range from studies on crude extracts to isolated compounds; however some of the studies require sophistication and validated results. BD is a plant of enormous importance in the purview of its chemical and therapeutic properties. © 2014 Shikha Mishra et al. Source

Sharma R.,ITS Pharmacy College | Yasir M.,ITS Pharmacy College | Asif M.,ITS Pharmacy College
Journal of Applied Pharmaceutical Science

The main objective of this study was to prepare and evaluate PSA-PEG nanoparticles containing paclitaxel as a model drug by nanoprecipitation method. The influence of different experimental parameters on the particles size, entrapment efficiency, percent drug released etc was evaluated. SEM indicated that nanoparticles have discrete spherical structure without aggregation. The average particle size was found to be 123 -405 nm. The particle size of nanoparticles increases gradually with PSA-PEG polymer concentration. The drug content of nanoparticles also increases with increasing polymer concentration up to particular value. The in-vitro drug release behavior from all drug loaded batches was found to be zero order and provided sustained release over a period of 24 hours. Nanoparticles were stored at different temperatures and humidity as per ICH guidelines to check the stability. Source

Nagar P.,ITS Pharmacy College | Singh K.,ITS Pharmacy College | Chauhan I.,ITS Pharmacy College | Verma M.,ITS Pharmacy College | And 4 more authors.
Journal of Applied Pharmaceutical Science

Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. Formulation of a convenient dosage form for oral administration, by considering swallowing difficulty especially in case of geriatric and pediatric patient leads to poor patient compliance. To troubleshoot such problems a new dosage form known as orally disintegrating tablet (ODT), has been developed which rapidly disintegrate & dissolve in saliva and then easily swallowed without need of water which is a major benefit over conventional dosage form. In addition, patients suffering from dysphasia, motion sickness, repeated emesis and mental disorders prefer such preparation because they cannot swallow large quantity of water. Further, drugs exhibiting satisfactory absorption from the oral mucosa or intended for immediate pharmacological action can be advantageously formulated in such type of dosage form. The popularity and usefulness of the formulation resulted in development of several ODT technologies for preparation. The current article is focused on ideal characteristics, advantages and disadvantages, formulation aspects, formulation technologies, evaluation of products and future potential. Various marketed preparations along with numerous scientific advancements made so far in this avenue have also been discussed. Source

Khan A.,ITS Pharmacy College | Yasir M.,ITS Pharmacy College | Asif M.,ITS Pharmacy College | Chauhan I.,ITS Pharmacy College | And 4 more authors.
Journal of Applied Pharmaceutical Science

The goal of delivery system is to get optimal therapeutic management. But, it still remains a challenge in the field of pharmaceuticals for delivery of ionic species and some non ionic. Several transdermal approaches have been used and recently there has been a great attention in using iontophoretic technique for the transdermal drug delivery of medications, both ionic and non ionic. This technique of facilitated movement of ions across a membrane under the influence of an externally applied electric potential difference is one of the most promising physical skin penetrations enhancing method. The payback of using iontophoretic technique includes improved systemic bioavailability ensuing from bypassing the first metabolism. Variables due to oral administration, such as pH, the presence of food or enzymes and transit times can all be eliminated. This article is an overview of the history of iontophoresis, mechanism, principles and factors influencing iontophoresis and its application for various dermatological conditions. Source

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