Its Paramedical College Pharmacy

Ghāziābād, India

Its Paramedical College Pharmacy

Ghāziābād, India
SEARCH FILTERS
Time filter
Source Type

Jain E.,Ram Eesh Institute of Vocational and Technical Education | Kumar Y.,ITS Paramedical College Pharmacy | Stables J.,U.S. National Institutes of Health | Sinha R.,Ram Eesh Institute of Vocational and Technical Education
Medicinal Chemistry | Year: 2010

A series of novel (±) 3-menthone semicarbazides (1-7) and thiosemicarbazides (8-14) were synthesized using an appropriate synthetic route and characterized by thin layer chromatography and spectral analysis. The anticonvulsant activity of synthesized compounds was established after intraperitoneal administration in three seizure models in mice which include maximal electroshock seizure (MES), subcutaneous pentylene tetrazole (scPTZ) induced seizure and minimal neurotoxicity test. Seven compounds exhibited protection in both models and N1 - (4-fluorophenyl) - N4- (menth-3-one) semicarbazide (4) emerged as the most active compound with MES ED50 of 44.15mg/kg and scPTZ ED50 of 38.68mg/kg at 0.25h duration. These compounds were found to elevate γ-amino butyric acid (GABA) levels in the midbrain region, thus indicating that (±) 3-menthone semicarbazides could be considered as a lead molecule in designing of a potent anticonvulsant drug. © 2010 Bentham Science Publishers Ltd.


Jain J.,RamEesh Institute of Vocational and Technical Education | Kumar Y.,ITS Paramedical College Pharmacy | Sinha R.,RamEesh Institute of Vocational and Technical Education | Kumar R.,RamEesh Institute of Vocational and Technical Education | Stables J.,U.S. National Institutes of Health
Medicinal Chemistry | Year: 2011

A series of ten compounds (Compounds J1-J10) of (±) 3-menthone aryl acid hydrazone was synthesized and characterized by thin layer chromatography and spectral analysis. Synthesized compounds were evaluated for anticonvulsant activity after intraperitoneal (i.p) administration to mice by maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure method and minimal clonic seizure test. Minimal motor impairment was also determined for these compounds. Results obtained showed that four compounds out of ten afforded significant protection in the minimal clonic seizure screen at 6 Hz. Compound J6, 4-Chloro-N-(2-isopropyl-5- methylcyclohexylidene) benzohydrazide was found to be the most active compound with MES ED50 of 16.1 mg/kg and protective index (pI) of greater than 20, indicating that (±) 3-menthone aryl acid hydrazone possesses better and safer anticonvulsant properties than other reported menthone derivatives viz. menthone Schiff bases, menthone semicarbazides and thiosemicarbazides. © 2011 Bentham Science Publishers Ltd.


Jawla S.,Its Paramedical College Pharmacy | Kumar Y.,Its Paramedical College Pharmacy | Khan M.S.Y.,Jamia Hamdard University
Latin American Journal of Pharmacy | Year: 2013

Bougainvillea spectabilis is used in various herbal formulations for treatment of diabetes. The present study aimed on isolation of phytoconstituents and antihyperglycemic screening of B. spectabilis root bark extracts. The EtOH extract of B. spectabilis root bark fractionated and upon repeated column chromatography of fractions on silica gel (CHCl3: MeOH), Sephadex LH-20 (CHCl3: MeOH) and ODS column (MeOH: H2O) afforded four compounds: pinitol, β-sitosterol, quercetin and quercetin-3-O-rutinoside. The EtOH extract was administered to both normal and alloxan induced diabetic albino (Wistar) rats. The blood glucose levels were measured at 0, 0.5, 1, 2, 4, and 6 h, and on 0, 1, 3, 5, and 7th day after oral administration of extract at doses of 100, 300, and 500 mg/kg/day. The EtOH extract (500 mg/kg) found to be 18.8% more potent than standard oral hypoglycemic drug, glibenclamide 0.2 mg/kg b.w. after a week. Pinitol, β-sitosterol, quercetin and quercetin-3-O-rutinoside have been isolated for the first time from B. spectabilis root bark.


Jawla S.,Its Paramedical College Pharmacy | Kumar Y.,Its Paramedical College Pharmacy | Khan M.S.Y.,Jamia Hamdard University
Pharmacologyonline | Year: 2011

Background and the purpose of study: Bougainvillea -spectabilis is a part of various herbal formulations for the treatment of diabetes. The present study was aimed to study the hypoglycemic activity of Bougainvillea spectabilis root bark extract in vivo in albno Wistar rats. Methods: Bougainvillea spectabilis root bark extracted with ethanol and administered to both normal and alloxan induced diabetic rats. The blood glucose levels were measured at 0-6 hours, and on 0- 7 days after oral administration of EtOH extract at doses of 50, 100 and 200 mg/kg/day. Results: Bougainvillea spectabilis root bark exhibited significant hypoglycemic activity at different doses and intervals. Highest hypoglycemic activity was observed with root bark extract at 100 mg/kg/day after 7 days. It was found to be 12.5% more potent than standard oral hypoglycemic drug, glibenclamide 0.2 mg/kg. Major conclusion: Permanent hyperglycemia in alloxan induced diabetic rats was reversed when treated up to a week with EtOH extract of B. spectabilis root bark. This study provides first scientific evidence that the EtOH extract of root bark of Bougainvillea spectabilis have anti-diabetic efficacy.


Jawla S.,Its Paramedical College Pharmacy | Kumar Y.,Its Paramedical College Pharmacy | Khan M.S.Y.,Jamia Hamdard University
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: Bougainvillea spectabilis (B. spectabilis) is one of the main constituent of various herbal formulations available for diabetes. The aim of present study was to screen hypoglycemic potential of B. spectabilis stem bark extracts in albno rats (Wistar strain). Methods: The EtOH extracts (100, 250 and 500 mg/kg/day) of the B. spectabilis were administered to both normal and alloxan induced diabetic rats at defined time intervals. Blood glucose levels were measured at 0, 0.5, 1, 2, 4, 6 h, and on 0, 1, 3, 5, 7th day after oral administration of extracts. Of the doses test, highest anti-hyperglycemic effect was observed by the extract of stem bark at 250 mg/kg after a week treatment. Results: B. spectabilis stem bark extract exhibited significant hypoglycemic activity at different doses and intervals. Stem bark extract was found to be 22.2% more potent than standard oral hypoglycemic drug, glibenclamide 0.2 mg/kg. Conclusion: Treatment of alloxan induced diabetic rats up to a week with stem bark extract reversed the permanent hyperglycemia. Hence, B. spectabilis stem bark alcoholic extract exhibited potent hypoglycemic activity. © 2012 Asian Pacific Tropical Biomedical Magazine.


Jawla S.,Its Paramedical College Pharmacy | Kumar Y.,Its Paramedical College Pharmacy | Khan M.S.Y.,Jamia Hamdard University
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: To screen the antimicrobial and antihyperglycemic activities of Musa paradisiaca (M. paradisiaca) flowers. Methods: The EtOH and EtOH: water (1:1) extracts of M. paradisiaca flowers were screened for antibacterial and antifungal activity against standard strains of Bacillus subtilis (B. subtilis), Bacillus cereus (B. cereus), Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumoniae), Proteus mirabilis (P. mirabilis), Pseudomonas aeruginosa (P. aeruginosa), Streptococcus pneumoniae (S. pneumoniae), Staphylococcus aureus (S. aureus), Salmonella typhimurium (S. typhimurium) and Candida albicans (C. albicans), Cryptococcus albidus (C. albidus) against amikacin and clotrimazole respectively. Both the extracts were also administered to normal and alloxan induced diabetic rats. The blood glucose levels were measured daily after oral administration of extracts at doses of 100, 250 and 500 mg/(kg.d). Result: The EtOH and EtOH: water (1:1) extracts exhibited antimicrobial activity with minimum inhibitory concentrations ranging from 5.62-25.81 and 7.60-31.50 μg/mL respectively. Both the extracts reversed the permanent hyperglycemia within a week in alloxan induced diabetic rats. The EtOH extract (250 mg/kg) was found to be 7.69% more potent hypoglycemic effect than standard oral hypoglycemic drug, glibenclamide 0.2 mg/kg b.w., respectively. Conclusion: The alcoholic extracts of M. paradisiaca flowers showed potent antihyperglycemic and moderate antimicrobial activities. © 2012 Asian Pacific Tropical Biomedical Magazine.


Gaur P.K.,Its Paramedical College Pharmacy | Mishra S.,Jamia Hamdard University | Bajpai M.,Its Paramedical College Pharmacy | Mishra A.,Its Paramedical College Pharmacy
BioMed Research International | Year: 2014

Solid lipid nanoparticle is an efficient lipid based drug delivery system which can enhance the bioavailability of poorly water soluble drugs. Efavirenz is a highly lipophilic drug from nonnucleoside inhibitor category for treatment of HIV. Present work illustrates development of an SLN formulation for Efavirenz with increased bioavailability. At first, suitable lipid component and surfactant were chosen. SLNs were prepared and analyzed for physical parameters, stability, and pharmacokinetic profile. Efavirenz loaded SLNs were formulated using Glyceryl monostearate as main lipid and Tween 80 as surfactant. ESLN-3 has shown mean particle size of 124.5 ± 3.2 nm with a PDI value of 0.234, negative zeta potential, and 86% drug entrapment. In vitro drug release study has shown 60.6-98.22% drug release in 24 h by various SLN formulations. Optimized SLNs have shown good stability at 40°C ± 2°C and 75 ± 5 % relative humidity (RH) for 180 days. ESLN-3 exhibited 5.32-fold increase in peak plasma concentration (C max ) and 10.98-fold increase in AUC in comparison to Efavirenz suspension (ES). © 2014 Praveen Kumar Gaur et al.


Madan S.,Central Indian Pharmacopoeial Laboratory | Ahmad S.,Jamia Hamdard University | Singh G.N.,Central Indian Pharmacopoeial Laboratory | Kohli K.,Jamia Hamdard University | And 3 more authors.
Indian Journal of Natural Products and Resources | Year: 2010

The Sweet Herb of Paraguay, Stevia rebaudiana (Bert.) Bertoni is fast becoming a major source of high potency sweetener which produces sweet taste but has no calorific value. Many research activities on its chemical and biological properties have been done in recent past. Several countries including India have started its commercial cultivation. The published literature on this crop is quite scattered. Therefore an effort to compile the literature and review the current status of research and development including cultivation practices has been done in this paper.


Sadish Kumar S.,Its Paramedical College Pharmacy | Jayendra,Its Paramedical College Pharmacy
International Journal of Pharma and Bio Sciences | Year: 2012

The steroids of the brown alga Turbinaria conoides were recognized as having mild-to-moderate cytotoxicity in HeLa cell, as it is being investigated towards determination of toxicity with various drugs. The cytotoxicity in HeLa cells was expressed in terms of 50% cytotoxic concentration (CC50). These oxygenated steroids exhibited cytotoxicity against HeLa cells with CC50 values ranging from 60.9 μg/mL to >100 μg/mL. To analyse for their cytotoxicity, Quantitative structure activity relationship (QSAR) study was performed. It was done by multiple regression analysis with simulated annealing method of partial least square (PLS) model. A PLS model (r2 = 0.90, q2 = 0.80, pred_r2 = 0.96) was used as a base of consensus prediction of cytotoxicity. QSAR studies indicated the carbon atom (T_C_O_4: 12%) and any atom (T_2_2_7: 15%) away from the oxygen and double bond respectively, atomic valence connectivity indexorder 0 (chiV0: 50%) and distance between most hydrophobic and hydrophilic point on the VanderWaals surface (XAMostHydrophobicHydrophilic distance: 20%) correlating well with mild cytotoxicity while the partial charges of the molecules (dipole moment: 25%) contributing moderate cytotoxicity. The 3D QSAR model further described that less bulkier substituent is required at steric site S_2441. Thus it can be concluded from the present study that cytotoxicity can be achieved by modifying the aromatic ring and preferring less bulky group to reduce steric hindrance.


Jawla S.,Its Paramedical College Pharmacy | Kumar Y.,Its Paramedical College Pharmacy | Khan M.S.Y.,Hamdard University
Tropical Journal of Pharmaceutical Research | Year: 2013

Purpose: To isolate and identify the constituents of Bougainvillea spectabilis Willd (Nyctaginaceae) stem bark. Methods: The methanol extract of Bougainvillea spectabilis stem bark powder was suspended in water and extracted with dichloromethane (CH2Cl2), ethyl acetate (EtOAc), and butanol (BuOH) successively. The ethyl acetate fraction was loaded in a column packed with silica gel and eluted with a gradient of chloroform (CHCl3): methanol (MeOH), and water yielded five fractions (A - E). Chemical constituents were isolated by repeated column chromatography of these fractions. Results: Column chromatography of fractions B and C afforded four compounds identified as pinitol, β- sitosterol, quercetin and quercetin-3-O-α-L-rhamnopyranoside. For the first time, pinitol, β-sitosterol, quercetin and quercetin-3-O-α-L-rhamnopyranoside were isolated from the stem bark of B. spectabilis Willd. Conclusion: An antidiabetic principle, pinitol, was successfully isolated from the stem bark of B. spectabilis Willd. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.

Loading Its Paramedical College Pharmacy collaborators
Loading Its Paramedical College Pharmacy collaborators