Monte Porzio Catone, Italy
Monte Porzio Catone, Italy

Time filter

Source Type

Mrema E.J.,University of Milan | Mrema E.J.,Muhimbili University of Health and Allied Sciences | Rubino F.M.,University of Milan | Mandic-Rajcevic S.,University of Milan | And 6 more authors.
Human and Experimental Toxicology | Year: 2013

Despite extensive use of organochlorinated pesticides (OCPs) such as dichlorodiphenyltrichloroethane (DDT) in Italy in the 1940s to 1970s, especially for public health control ofmalariamosquitoes, information on their exposure levels among the general population is limited. TheseOCPs can be a source of health risk to human. A total of 137 blood sampleswere collected fromresidents of the general population of three Italian towns,Novafeltria, Pavia and Milan, to determine the levels of eightOCPs in blood serum. The concentrations of beta-hexachlorocyclohexane, hexachlorobenzene (HCB), 1,1-dichloro-2-(o- chlorophenyl)-2-(p-chlorophenyl)ethylene, 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE), 1,1-dichloro-2-(o-chlorophenyl)-2-(p- chlorophenyl)ethane, 1,1-dichloro- 2,2-bis (4-chlorophenyl)ethane, 1,1,1-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-ethane and 1,1,1-trichloro- 2,2-bis(p-chlorophenyl) ethane were measured by gas chromatography-mass spectrometry. Variations in serum concentrations of OCPs with respect to place of residence, gender, age and body mass index (BMI) were evaluated by non-parametric tests. p,p'-DDE and HCB were the most abundant and major contributors of total OCP concentration. Their levels differed significantly between the three towns with a trend Milan > Novafeltria > Pavia ( p < 0.0001). Females had significantly higher concentrations of HCB and p,p'-DDE than males in the overall population sample.HCB concentrations were significantly higher in females than in males ofMilan (p=0.029).We observed positive correlations of p,p'-DDE and HCB with age in Novafeltria subjects (r = 0.468, p = 0.004). Total OCP concentrations differed significantly across BMI categories (p = 0.018) in overall population. We have demonstrated a clear pattern of themainOCPs in a fairly large population. Generally, our study provides information on OCPs exposure among the Italian general population and provides indications for further investigations. © The Author(s) 2013.


de Boer E.,University of Groningen | Romkema S.,University of Groningen | Cutti A.G.,Italian Workers' Compensation Authority | Brouwers M.A.,De Hoogstraat Rehabilitation | And 2 more authors.
Archives of Physical Medicine and Rehabilitation | Year: 2016

Objectives To determine intermanual transfer effects in patients with a below-elbow amputation using a myoelectric prosthesis and to establish whether laterality affects these effects. Design Case-control. Setting A standardized setting in a rehabilitation clinic. Participants A convenience sample (N=44) of experienced myoelectric prosthesis users (n=22) and matched controls (n=22). Controls were matched on sex, age (±5y), and hand dominance. Interventions Both the experienced group and the control group performed several tasks using a prosthesis simulator attached to their nonaffected arm. Main Outcome Measures Movement time, force control, Box and Block test (BBT) scores, and duration of hand opening. Results Movement times of myoelectric prosthesis users were shorter, and these users had significantly higher BBT scores and shorter hand opening durations than those of controls. No intermanual transfer effects on force control and no laterality effects were found. Conclusions Intermanual transfer effects were present in experienced myoelectric prosthesis users with a below-elbow amputation, independent of laterality. These findings support the clinical relevance of intermanual transfer training, which may facilitate persons with an upper limb amputation to start training directly after the amputation. © 2016 American Congress of Rehabilitation Medicine


PubMed | University of Groningen, Italian Workers Compensation Authority and De Hoogstraat Rehabilitation
Type: Journal Article | Journal: Archives of physical medicine and rehabilitation | Year: 2016

To determine intermanual transfer effects in patients with a below-elbow amputation using a myoelectric prosthesis and to establish whether laterality affects these effects.Case-control.A standardized setting in a rehabilitation clinic.A convenience sample (N=44) of experienced myoelectric prosthesis users (n=22) and matched controls (n=22). Controls were matched on sex, age (5y), and hand dominance.Both the experienced group and the control group performed several tasks using a prosthesis simulator attached to their nonaffected arm.Movement time, force control, Box and Block test (BBT) scores, and duration of hand opening.Movement times of myoelectric prosthesis users were shorter, and these users had significantly higher BBT scores and shorter hand opening durations than those of controls. No intermanual transfer effects on force control and no laterality effects were found.Intermanual transfer effects were present in experienced myoelectric prosthesis users with a below-elbow amputation, independent of laterality. These findings support the clinical relevance of intermanual transfer training, which may facilitate persons with an upper limb amputation to start training directly after the amputation.


Barone A.,Freelance | Piccioni R.,Italian Workers Compensation Authority
Proceedings of Forum Acusticum | Year: 2014

The school gymnasium are often characterized by an unfavourable acoustic climate. The effectiveness of speech communication is deeply restricted because of the very poor intelligibility rating; moreover this acoustic climate produces a remarkable stress level, particularly to the teachers, that spend the most part of their working time in these environments. The cause of this situation consists of several factors, that have been carefully analysed: The raised level of background noise, due to the sound pollution coming from outside, that is mainly originated by road traffic. The room sizes, that are lower than the ones prescribed by the law. Physical activities take place in environments originally designed for different purposes, because of the few resources available for the educational sector. The raised noise levels due to overcrowding. For the above mentioned reasons very often the gyms give hospitality to the pupils of other close schools at the same time. The poor acoustic absorption, as evidenced by the high reverberation times data. The surfaces of the environments are very reflective, because of the lacking in interventions for improving the acoustic quality. The noise levels at which teachers and students are exposed to, are lower compared with the limits ratified by the law; nevertheless they determine a very high psychological disease; moreover the teachers show problems with their vocal cords, because of the vocal effort they perform to make their voice more intelligible; this effort has no significant effect on the speech communication. In this paper we present the results of acoustic quality assessment, performed in a school gym in Rome, and a proposal to improve the acoustic comfort that can be carried out quickly and a relatively low cost.


Martino G.,University of Rome Tor Vergata | Martino G.,Instituto Of Ricovero E Cura A Carattere Scientifico Santa Lucia Foundation | Ivanenko Y.P.,Instituto Of Ricovero E Cura A Carattere Scientifico Santa Lucia Foundation | Serrao M.,Rehabilitation Center Policlinico Italia | And 8 more authors.
Journal of Neurophysiology | Year: 2014

Several studies have demonstrated how cerebellar ataxia (CA) affects gait, resulting in deficits in multijoint coordination and stability. Nevertheless, how lesions of cerebellum influence the locomotor muscle pattern generation is still unclear. To better understand the effects of CA on locomotor output, here we investigated the idiosyncratic features of the spatiotemporal structure of leg muscle activity and impairments in the biomechanics of CA gait. To this end, we recorded the electromyographic (EMG) activity of 12 unilateral lower limb muscles and analyzed kinematic and kinetic parameters of 19 ataxic patients and 20 age-matched healthy subjects during overground walking. Neuromuscular control of gait in CA was characterized by a considerable widening of EMG bursts and significant temporal shifts in the center of activity due to overall enhanced muscle activation between late swing and mid-stance. Patients also demonstrated significant changes in the intersegmental coordination, an abnormal transient in the vertical ground reaction force and instability of limb loading at heel strike. The observed abnormalities in EMG patterns and foot loading correlated with the severity of pathology [International Cooperative Ataxia Rating Scale (ICARS), a clinical ataxia scale] and the changes in the biomechanical output. The findings provide new insights into the physiological role of cerebellum in optimizing the duration of muscle activity bursts and the control of appropriate foot loading during locomotion. © 2014 the American Physiological Society.


Iavicoli S.,Italian Workers Compensation Authority | Leka S.,University of Nottingham | Jain A.,University of Nottingham | Persechino B.,Italian Workers Compensation Authority | And 3 more authors.
Journal of Risk Research | Year: 2014

Psychosocial risks in the workplace have been identified as some of the most significant emerging risks, particularly since issues such as work-related stress, which is closely linked to psychosocial risks, are widely recognised as major challenges in modern occupational safety and health. This paper presents the policy framework and key initiatives that have been implemented for the management of psychosocial risks in the workplace in Europe. It discusses several approaches and initiatives, both from a hard and soft law perspective, that have been implemented at European Union and national level. Within this context, it discusses the key issues that pertain to the development of national approaches, focussing as an example on the Management Standards for work-related stress developed in the UK and their recent adaptation in Italy. The Italian approach is discussed in detail as an example that may highlight key process elements in the development of psychosocial risk management policies, and promote good practice in this area through lessons learned. It is concluded that it is more pressing now than ever for a critical evaluation of efforts employed so far to address psychosocial risks to be conducted, and an approach at European level to be developed that will allow both flexibility and a certain level of benchmarking across members states. Such an approach can be supported by European bodies, responsible for surveillance and promotion of good practice, working in collaboration with similar national bodies. © 2013 Taylor and Francis.


Tinelli E.,University of Rome La Sapienza | Francia A.,University of Rome La Sapienza | Quartuccio E.M.,University of Rome La Sapienza | Morreale M.,University of Rome La Sapienza | And 5 more authors.
American Journal of Neuroradiology | Year: 2013

BACKGROUND AND PURPOSE: Psychiatric symptoms occur in approximately 30% of patients with MS. Such symptoms include OCD, which may interfere heavily with the patient's daily life. We hypothesized that the widespread involvement of both GM and WM, which characterizes MS, may be responsible for the occurrence of OCD when specific brain structures are affected. The aim of this study was to evaluate the relationship between GM and WM tissue damage and OCD in patients with MS. MATERIALS AND METHODS: We evaluated 16 patients with relapsing-remitting MS who had been diagnosed with OCD on the basis of the Diagnostic and Statistical Manual of Mental Disorders (4th edition) and 15 age- and sex-matched patients with relapsing-remitting MS with no psychiatric disorders as a CG. The MR study (1.5T) included 3D T1-weighted fast-field echo sequences, DTI (32 directions), and conventional MRI. Images were processed using SPM5, FSL, and Jim 5.0 software to evaluate VBM, TBSS, and global and regional LV, respectively. RESULTS: The VBM analysis revealed a set of clusters of reduced GM volume in the OCD group, compared with the CG, located in the right inferior and middle temporal gyri and in the inferior frontal gyrus. TBSS did not detect any differences in the FA values between the 2 groups; global and regional LV values also did not differ significantly between the 2 groups. CONCLUSIONS: Our study suggests that OCD in MS may be caused by damage in the right frontotemporal cortex.


Barone A.,Independent Professional | Piccioni R.,Italian Workers Compensation Authority
22nd International Congress on Sound and Vibration, ICSV 2015 | Year: 2015

This study is about the acoustic improvement of a call center made up of six open-space areas. This kind of environment must have all the necessary requirements for a place dedicated to continuous telephone contact with users. Adequate soundproofing of different workstations must be provided, to ensure good sound quality through the headphones and avoid an unfavourable acoustic environment where operators have to make excessive vocal effort. Aim of the project is to examine and evaluate acoustic comfort parameters, mainly background noise and reverberation time. As regards the first parameter, measurement results have been compared with reference "curves" defining acoustic suitability of different types of environment, related to their characteristics and uses. Moreover, reverberation time values have been compared with reference optimal threshold values for these environments. Based on our measurements, environments were characterized by considerable background noise, impulsive tones and high reverberation times. Therefore, an improvement plan was proposed based on the application of sound absorbing panels. The improvement plan was gradually optimized by applying panels on increasingly large surfaces while monitoring results until achieving the best possible performance. To this purpose, prediction models were used which were tested based on actual in situ reverberation times, during the different panel application steps. Noise measurements performed after the improvement were good and confirmed the effectiveness of the plan.


Mrema E.J.,University of Milan | Mrema E.J.,Muhimbili University of Health and Allied Sciences | Rubino F.M.,University of Milan | Mandic-Rajcevic S.,University of Milan | And 6 more authors.
Human and Experimental Toxicology | Year: 2014

Concentrations of 36 polychlorinated biphenyl (PCB) congeners were measured in serum of 372 Italian residents of general population living in Novafeltria, Pavia, and Milan. Total PCB level differed significantly between these sites (p < 0.0001) with median concentrations of 836.50, 1354.57, and 2062.08 pmol/g lipid, respectively. However, there is no evidence for the difference in distribution of total PCB levels by genders. Total dioxin-like PCBs differed significantly (p < 0.0001) between the sites (median 109.78, 50.88, and 166.99 pmol/g lipid, respectively) and genders of Novafeltria and Pavia (p = 0.011 and 0.009, respectively). PCB 138, 153, 170, and 180 differed significantly between the places of residence (p < 0.0001) with higher values in Milan population. In the overall population, total PCB and PCB 138, 153, 156, 170, and 180 correlated positively with age (correlations range between 0.320 and 0.569, p < 0.0001). In Novafeltria, the correlations ranged between 0.545 and 0.670, and in Pavia, the correlations ranged between 0.516 and 0.666. In Milan, correlations with age range between 0.327 and 0.417 for total PCB and congeners 138, 153, and 180. With an exception of PCB 170, there was no evidence of significant difference in the distribution of most abundant PCB congeners and total PCB across the body mass index categories. © The Author(s) 2013.


PubMed | University of Rome La Sapienza, University of Rome Tor Vergata, Rehabilitation Center Policlinico Italia, Italian Workers Compensation Authority and Instituto Of Ricovero E Cura A Carattere Scientifico Santa Lucia Foundation
Type: Journal Article | Journal: Journal of neurophysiology | Year: 2014

Several studies have demonstrated how cerebellar ataxia (CA) affects gait, resulting in deficits in multijoint coordination and stability. Nevertheless, how lesions of cerebellum influence the locomotor muscle pattern generation is still unclear. To better understand the effects of CA on locomotor output, here we investigated the idiosyncratic features of the spatiotemporal structure of leg muscle activity and impairments in the biomechanics of CA gait. To this end, we recorded the electromyographic (EMG) activity of 12 unilateral lower limb muscles and analyzed kinematic and kinetic parameters of 19 ataxic patients and 20 age-matched healthy subjects during overground walking. Neuromuscular control of gait in CA was characterized by a considerable widening of EMG bursts and significant temporal shifts in the center of activity due to overall enhanced muscle activation between late swing and mid-stance. Patients also demonstrated significant changes in the intersegmental coordination, an abnormal transient in the vertical ground reaction force and instability of limb loading at heel strike. The observed abnormalities in EMG patterns and foot loading correlated with the severity of pathology [International Cooperative Ataxia Rating Scale (ICARS), a clinical ataxia scale] and the changes in the biomechanical output. The findings provide new insights into the physiological role of cerebellum in optimizing the duration of muscle activity bursts and the control of appropriate foot loading during locomotion.

Loading Italian Workers' Compensation Authority collaborators
Loading Italian Workers' Compensation Authority collaborators