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San Fedele Superiore, Italy

D'Alessandro A.,University of Tuscia | D'Alessandro A.,Italian National Blood Center | Liumbruno G.,Italian National Blood Center | Liumbruno G.,Immunohematology and Transfusion Medicine Unit | And 4 more authors.
Journal of Proteomics | Year: 2010

The first umbilical cord blood (UCB) transplant to a sibling with Fanconi's anaemia in 1988 represented a breakthrough in the field of transplantation. Thereon, several transplants have been performed with UCB-derived hematopoietic stem cells (HSCs) and a plethora of studies have investigated the plasticity of UCB-derived stem and progenitor cells. However, these studies have not been hitherto translated into clinical trials and, although UCB is routinely used as an alternative source of HSCs, no substantial advances have been made in the field of clinical regenerative medicine. The real deal is the lack of knowledge about the molecular processes governing the events of differentiation which transform immature UCB stem cells into terminally-committed hematopoietic, muscle, bone and nervous cells. In order to fill this void, several studies have been recently focused on the identification of the peculiar proteomic profile of UCB-derived stem cells. Hereby, we concisely review recent proteomic surveys addressing UCB-derived stem and progenitor cells. Notably, comparative studies detected a wider spectrum of proteins in immature cells rather than in more differentiated populations, as if maturation events could represent a bottleneck to protein expression. Future research projects should try to shed light on these processes and their completion could pave the way for unprecedented treatments. © 2009 Elsevier B.V. All rights reserved.

Cillo U.,University of Padua | Burra P.,University of Padua | Mazzaferro V.,Italian National Cancer Institute | Belli L.,Niguarda Hospital | And 4 more authors.
American Journal of Transplantation | Year: 2015

Since Italian liver allocation policy was last revised (in 2012), relevant critical issues and conceptual advances have emerged, calling for significant improvements. We report the results of a national consensus conference process, promoted by the Italian College of Liver Transplant Surgeons (for the Italian Society for Organ Transplantation) and the Italian Association for the Study of the Liver, to review the best indicators for orienting organ allocation policies based on principles of urgency, utility, and transplant benefit in the light of current scientific evidence. MELD exceptions and hepatocellular carcinoma were analyzed to construct a transplantation priority algorithm, given the inequity of a purely MELD-based system for governing organ allocation. Working groups of transplant surgeons and hepatologists prepared a list of statements for each topic, scoring their quality of evidence and strength of recommendation using the Centers for Disease Control grading system. A jury of Italian transplant surgeons, hepatologists, intensivists, infectious disease specialists, epidemiologists, representatives of patients' associations and organ-sharing organizations, transplant coordinators, and ethicists voted on and validated the proposed statements. After carefully reviewing the statements, a critical proposal for revising Italy's current liver allocation policy was prepared jointly by transplant surgeons and hepatologists. © Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.

Kaye S.,Ocular Tissue Advisory Group Audit Subgroup | Baddon A.,St Pauls Eye Hospital | Jones M.,Ocular Tissue Advisory Group Audit Subgroup | Armitage W.J.,Ocular Tissue Advisory Group Audit Subgroup | And 2 more authors.
Cell and Tissue Banking | Year: 2010

Reporting and investigation of serious adverse events and reactions associated with tissue and cell transplantation is a fundamental aspect of ensuring adequate levels of safety and quality and is a requirement of the European Union Directives on tissues and cells. In the UK, a system for the reporting and analysis of events and reactions associated with ocular tissue transplantation is well established. It is operated by a network of individuals and organisations, each with clearly defined roles and responsibilities, following written procedures for reporting and investigation. Analysis of reports indicates that the most important adverse reactions associated with this type of tissue transplantation are endophthalmitis (0.58%) and primary graft failure (0.3%). This system allows the analysis of all types of events and reactions by the professionals involved so that trends can be identified and services improved. Tools to evaluate the severity and imputability of individual events or reactions, such as those developed by the EUSTITE project, can be utilised to facilitate the selection of those cases meeting the criteria for reporting to the Competent Authority. This vigilance model has been shown to be effective and could be applied in other fields of tissue or cell transplantation. © 2009 Springer Science+Business Media B.V.

Lombardini L.,Italian National Transplant Center | Bosi A.,University of Florence | Grosz S.,FH Campus Wien, University of Applied Sciences | Pamphilon D.,Jacie Executive Committee | And 6 more authors.
Vox Sanguinis | Year: 2013

There have been great advances over the last decades in haematopoietic stem cell (HSC) transplantation, using either bone marrow, peripheral blood or cord blood-derived stem cells. The coming into force of the European legislation on tissues and cells and the consequent transposition of Directives into national laws have required the health authorities in the Member States (MS) and the scientific societies to review the transplantation activities to ensure the circulation of safe HSC products. Here, the regulatory inspection process performed by the Competent Authorities and the professional voluntary accreditation process of the Transplant Programmes active in Italy is compared. © 2013 International Society of Blood Transfusion.

Mazzoni D.,University of Bologna | Cicognani E.,University of Bologna | Mosconi G.,Nephrology and Dialysis Unit | Totti V.,Nonprofit Foundation for the Advancement of Organ and Tissue Transplantation | And 3 more authors.
Transplantation Proceedings | Year: 2014

Objective Considering the importance of sport activity for enhancing quality of life, the aim of this study was to investigate the effects of regular sport activity on quality of life of kidney transplant recipients.Methods Health-related quality of life (HRQoL) was assessed with the use of the SF-36 questionnaire on a group of 118 active kidney transplant patients (AKTPs) practicing different sports at low to moderate intensity (5 ± 4 h/wk). Scores were compared with those of 79 sedentary kidney transplant patients (SKTPs) and with 120 active healthy control subjects (AHCs).Results AKTPs reported higher scores than SKTPs in the SF-36 scales of Physical Functioning (P <.05), Role Limitations due to Physical Problems (P <.05), General Health (P <.01), Vitality (P <.05), Social Functioning (P <.05), Role Limitations due to Emotional Problems (P <.05), and Mental Health (P <.01). AKTPs obtained higher scores than AHCs on the Mental Health (P <.01) and Social Functioning scales (P <.01) and similar scores (P >.05) on all the other scales. The effect of quantity of sport activity was significant on the General Health (P <.01; η2 = 0.05), and Role Physical scales (P =.04; η2 = 0.03), with higher sport activity associated with higher HRQoL. The effect of sex was significant for Bodily Pain (P =.05; η2 = 0.02), Vitality (P =.08; η2 = 0.06), Social Functioning (P =.08; η2 = 0.05), and Mental Health (P =.05; η2 = 0.02), with male participants scoring higher than female participants.Conclusions This study indicates that regular sport activity significantly improves different dimensions of HRQoL among kidney transplant recipients. The benefits of sport activity go beyond its impact on physical health to involve psychologic and social components of quality of life. Spontaneous and low to moderate sport activity may play an important role after kidney transplantation that has been largely underestimated in the literature. © 2014 Elsevier Inc. All rights reserved.

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