Italian Institute of Technology

www.iit.it
Genoa, Italy

The Istituto Italiano di Tecnologia is a foundation established jointly by the "Ministero dell'Istruzione, dell'Università e della Ricerca" and the "Ministero dell'Economia e delle Finanze" to promote excellence in basic and applied research and to contribute to the economic development of Italy. Primary goals of the IIT are the creation and dissemination of scientific knowledge as well as strengthening Italy's technological competitiveness. To achieve these two goals, the IIT will cooperate with both academic institutions and private organizations, fostering through these partnerships scientific development, technological advances and training in high technology.The Scientific Plan 2009-2011 aims at developing the results of the start-up and sets a general framework which combines the integration and the reinforcement of the departments, the national network and the research platforms.The Scientific Plan 2009-2011 is the evolution of the 2005-2008 plan, which was dealing with a large scale program on Humanoid Robotics. According to the 2005-2008 strategic plan, the Humanoid Robotics program had a strong interdisciplinary character, merging human and humanoid technologies through the development of 3 technology platforms: Robotics, Neuroscience and Drug Discovery and Development , supported by a few facilities for nano-biotechnologies . Each platform was meant to develop specific topicsinorganic systems, textilefluorescent nanoprobes, nanocarrier for in vivo drug delivery, nanospectroscopies will be developed. Integrated Multiscale Computational Technology: developing advanced modeling of complex systems of interest to the above platforms.The implementation of the scientific program outlined so far will require the following actions: Empowerment of the shared laboratories, consolidating the interdisciplinary facilities in the following structures: Creation of eight IIT centers established nationwide: Launch of exploratory research programs in collaboration with other research Institutions.Details on the scientific activity to be performed within each platform are given in the following Scientific PlanRecently a ninth centre was created, The Brain Center for Motor and Social Cognition: SMC@UniPr – Parma, Università di Parma Wikipedia.

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Patent
Italian Institute of Technology | Date: 2017-04-12

A haptic interface system comprising: a shell (2) which is moved on a reference surface (Sref) by a user; an actuator (4) mechanically coupled to the shell (2), which provides a haptic stimulus on a fingertip of the user; and a motor assembly (10, 12, 14, 20), which moves the actuator (4) with three degrees of freedom. The haptic interface system also includes: a localization system (80, 82, 102, 104), which determines the position and orientation of the shell (2) with respect to the reference surface (Sref); and a control stage (70, 104), which controls the motor assembly (10, 12, 14, 20) so as to move the actuator (4) as a function of the position of the shell (2), in an invariant manner with respect to the orientation of the shell (2).


A device for harvesting energy from a fluidic flow, including a flexible structure (4, 6, 8, 10, 12, 66, 70) formed by: a base layer (12); a conductive layer (8), made of a conductive material and laid on the base layer (12); and a piezoelectric layer (6), made of a piezoelectric material and laid on the conductive layer (8). The base layer (12), the conductive layer (8), and the piezoelectric layer (6) form a crystalline structure (50) including a plurality of pseudomorphic portions (52).


Patent
Italian Institute of Technology | Date: 2017-04-05

A read circuit for an electrical signal produced by a POSFET device is disclosed which comprises a transconductance amplifier (4) connected at its inverting input to the output of the POSFET device (1), at least one neuron (8a, 8b) connected to the output of said transconductance amplifier, said amplifier being adapted to receive a signal from the POSFET device representative of a force or pressure exerted on it and to produce at its output at least one current signal (I0-, I0+) representative of such force or pressure, the at least one neuron being adapted to receive said current signal and to produce an output signal (12a, 12b) being a pulse train with frequency proportional to said current signal.


The device (10) comprises: a support structure (12); an optical element (14) having an optically useful surface, which is designed to interact with an incident light beam, in particular with a laser beam; and a mechanism (16), which is mounted on said support structure (12) and is able to cause said optical element (14) to rotate in the space around a first and a second fixed rotation axes (X, Y), which are perpendicular to one another. The mechanism (16) comprises a first rotary assembly (18), which is articulated, relative to the optical element (14), around a first mobile support axis (A), which is rotary and perpendicular relative to the first rotation axis (X), the first rotary assembly (18) being also coupled, in a rotary manner, to the support structure (12) so as to rotate around the first rotation axis (X), in order to cause the optical element (14) to rotate around the first rotation axis (X), and allowing the optical element (14) to rotate around the first mobile support axis (A). The mechanism (16) comprises, furthermore, a second rotary assembly (20), which is articulated, relative to the optical element (14), around a second mobile support axis (B), which is rotary relative to the second rotation axis (Y) and perpendicular to the first mobile support axis (A), the second rotary assembly (20) being also coupled, in a rotary manner, to the support structure (12) so as to rotate around the second rotation axis (Y), in order to cause the optical element (14) to rotate around the second rotation axis (Y), and allowing the optical element (14) to rotate around the second support axis (B). The first rotary assembly (18) has a through cavity (18a) defined around the first rotation axis (X), which is designed to be passed through by the beam of light (L) and faces the optical element (14). The device (10) comprises, furthermore, a first linear actuator (22), which is designed to cause the first rotary assembly (18) to rotate, thus exerting upon the latter a stress in a first actuating direction (Z1) that is transversely spaced apart relative to the first rotation axis (X) and to said through cavity (18a). The device (10) comprises, furthermore, a second linear actuator (24), which is designed to cause the second rotary assembly (20) to rotate, thus exerting upon the latter a stress in a second actuating direction (Z2) that is spaced apart relative to the second rotation axis (Y) and to the through cavity (18a).


The present invention relates to Compounds of Formula (I) and pharmaceutical compositions containing the same. It further relates to their use in the prevention or treatment of central nervous system diseases or disorders, in particular, cognitive, neurodegenerative or neuronal diseases or disorders.


Patent
Italian Institute of Technology | Date: 2017-03-08

The present invention relates to a method for producing a totally endogenous bioengineered tissue including a first layer of connective tissue and a second layer of epithelial tissue, to a tissue equivalent obtained thereby and to a method for determining the effect of a chemical substance or an agent on skin employing the tissue equivalent.


Patent
Italian Institute of Technology | Date: 2017-04-12

Laser device characterized in that it comprises, as gain medium, a film of colloidal nanocrystals of semiconductor material, wherein said nanocrystals are two-dimensional nanocrystals suitable for forming quantum wells for confinement of the charge carriers in the nanocrystals and having a biexciton gain mechanism.


Patent
Italian Institute of Technology | Date: 2017-01-25

Composite material comprising a matrix (10) of elastic and electrically insulating material, and a filler (20) of electrically conducting material embedded within the matrix (10). The filler forms a conductive path (21) defining an active electrode adapted to be associated with a reference electrode (40) for forming an electrical signal output. A deformable gap (30) is formed between an outer surface of the conductive path (21) and an inner surface of the matrix (10), in such a way that the application of a mechanical load to the composite material causes the surface of the conductive path (21) and the surface of the matrix (10) to be brought closer together, and the removal of the mechanical load causes the surface of the conductive path (21) and the surface of the matrix (10) to be moved away from one another as a result of the elastic force of the material of the matrix (10). At the electrical signal output, the composite material produces a signal depending on a triboelectric charge accumulated by the conductive path (21), in response to external stresses.


Patent
Italian Institute of Technology | Date: 2017-06-21

A method is disclosed for enhancing the simulation of the interaction between at least a first and a second molecular system, the interaction resulting from actual attraction and repulsion forces between the at least a first and a second molecular system. The method comprises applying an additional virtual electrostatic force between the at least a first and a second molecular system, which force has a functional form of the type of a modulated electrostatic interaction.


Patent
Italian Institute of Technology and The Regents Of The University Of California | Date: 2017-03-22

The present invention relates to substituted benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides substituted benzoxazolone derivatives for use in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.

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