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Barone A.,University of Genoa | Marconcini S.,University of Genoa | Giacomelli L.,Istituto Stomatologico Tirreno | Rispoli L.,University of Rome La Sapienza | And 2 more authors.
Journal of Oral and Maxillofacial Surgery | Year: 2010

Purpose: The purpose of this study was to investigate and compare, in a randomized and controlled clinical trial, the use of ultrasound bone surgery devices and the use of rotary instruments in lower third molar extractions. Materials and Methods: We selected 26 patients (12 women and 14 men) for this study; the mean age was 31.2 years (range, 24-45 years). A randomized clinical trial was planned. Patients in the control group received treatment with the conventional rotary instruments; patients in the test group received treatment with the ultrasound bone surgery tools. Twenty-six third molars were allocated to the test and control groups according to a computer-generated randomization list. All the surgical procedures were performed by the same surgeon. Pain, trismus, cheek swelling, and number of analgesics taken were evaluated at baseline (before surgery) and at the first-, third-, fifth-, and seventh-day visits. Results: Pain levels (evaluated on a visual analog scale) were higher in the control group when compared with the ultrasonic group; however, no statistically significant differences were found. On the contrary, the number of analgesics taken in the test group was significantly lower when compared with the control group. The occurrence of trismus was significantly higher in the control group when compared with the test group. The clinical values of cheek swelling were higher in the rotary group when compared with the ultrasound group at the fifth-day visit. Conclusion: This study showed that the use of ultrasound bone surgery for third molar extraction significantly reduced the occurrence of postsurgical trismus, the occurrence of swelling, and the number of analgesics taken after surgery. © 2010 American Association of Oral and Maxillofacial Surgeons. Source


Orlando B.,University of Genoa | Orlando B.,University of Pisa | Giacomelli L.,Istituto Stomatologico Tirreno | Ricci M.,University of Genoa | And 2 more authors.
Archives of Oral Biology | Year: 2013

Little is still known about the molecular mechanisms involved in the process of osteogenesis. In this paper, the leader genes approach, a new bioinformatics method which has already been experimentally validated, is adopted in order to identify the genes involved in human osteogenesis. Interactions among genes are then calculated and genes are ranked according to their relative importance in this process. In total, 167 genes were identified as being involved in osteogenesis. Genes were divided into 4 groups, according to their main function in the osteogenic processes: skeletal development; cell adhesion and proliferation; ossification; and calcium ion binding. Seven genes were consistently identified as leader genes (i.e. the genes with the greatest importance in osteogenesis), while 14 were found to have slightly less importance (class B genes). It was interesting to notice that the larger part of leader and class B genes belonged to the cell adhesion and proliferation or to the ossification sub-groups. This finding suggested that these two particular sub-processes could play a more important role in osteogenesis. Moreover, among the 7 leader genes, it is interesting to notice that RUNX2, BMP2, SPARC, PTH play a direct role in bone formation, while the 3 other leader genes (VEGF, IL6, FGF2) seem to be more connected with an angiogenetic process. Twenty-nine genes have no known interactions (orphan genes). From these results, it may be possible to plan an ad hoc experimentation, for instance by microarray analyses, focused on leader, class B and orphan genes, with the aim to shed new light on the molecular mechanisms underlying osteogenesis. © 2012 Elsevier Ltd. Source


Ricci M.,Istituto Stomatologico Tirreno | Ricci M.,Nanoworld Institute | Garoia F.,University of Ferrara | Tabarroni C.,University of Ferrara | And 7 more authors.
Archives of Oral Biology | Year: 2011

Aim: Recent research has focused attention on the single nucleotide polymorphisms (SNPs) involved in the host response in periodontitis. However, so as to combine the relatively small effects of individual genes the use of multi locus genetic risk (GRS) has been proposed. This study aims to evaluate whether the genetic risk score may predict periodontitis onset and progression. Materials and methods: Fifty patients were divided into various groups according to periodontal status. Total DNA was isolated from epithelial oral cells by a masked operator and the selected SNPs were analysed. A GRS was calculated using an additive model. Results: We found a strong association only between TNF rs1800629 and diffused forms of periodontitis. Data show that GRS is able to discriminate diffused forms of periodontitis from localized ones. Finally, a progressive increase of the GRS is evident in advanced periodontitis in comparison with early forms. Discussion: In recent years, research on genetic polymorphism has had limited success in predicting the susceptibility to periodontal disease. However, our results indicate that the use of the genetic risk score could be promising. Further studies are necessary to include data from multiple genes so as to confirm our result. © 2011 Elsevier Ltd. All rights reserved. Source


Ricci M.,Nanoworld Institute | Mangano F.,Private Practice | Tercio T.,Nanoworld Institute | Tonelli P.,University of Florence | And 3 more authors.
Surface and Interface Analysis | Year: 2012

The present study was designed to evaluate the characteristics and the topography of a new implant surface. Titanium discs were manufactured using master alloy powder (Ti-6Al-4V) with a particle size of 25-45 μm as the basic material (Leader Implants, Milan, Italy). We acquired images in three different dimensional ranges of decreasing dimensions: 30 (dimensional class A), 10 (dimensional class B), and 5 μm2 (dimensional class C). For each dimensional range, we collected five (dimensional classes A and B) to ten (dimensional classes C) different images, belonging both to the center and to the edge of the slide Results In dimensional class A, implant surface showed an average roughness value (Ra) of 0.6 μm, whereas the root mean square roughness (Rrms) value was 0.78 μm. In the dimensional class B, value of Ra was 133.4 μm and value of Rrms was 161.7 μm. Finally, at a smaller level as in dimensional class C, value of Ra was 68.5 μm and Rrms was 81.05 μm. Moreover, the peak to peak value was 369.5 μm and the average height value was 187.3 μm Discussion The surface which results from direct laser fabrication process has an ideal nano-roughness to enhance protein adsorption and to facilitate precursor osteoblast adhesion. In conclusion, direct laser forming surface seems to be a promising technique for forming dental implants from titanium alloys. Copyright © 2012 John Wiley & Sons, Ltd. Source


Ricci M.,Istituto Stomatologico Tirreno | Marchisio O.,Istituto Stomatologico Tirreno | Genovesi A.M.,Istituto Stomatologico Tirreno | Gelpi F.,Istituto Stomatologico Tirreno | And 10 more authors.
Minerva Stomatologica | Year: 2013

Background: The aim of present study was to clinically assess and compare a sonic toothbrush versus a rotating oscillating power toothbrush on plaque removal and gingival health in reducing plaque and bleeding on probing. Methods: Patients were selected according to specific inclusion and exclusion criteria and they were enrolled in test group or control group using Random Allocation Software. Visual score plaque index (PI) was recorded by the same blind operator using a plaque revelator and bleeding on probing (BoP) index was recorded using a periodontal probe at baseline, 15th day and 30th day. Results: The group of patients who used sonic toothbrush showed a greater reduction of PI and BoP comparing with patients who used rotating-oscillating power toothbrush. Conclusions: Although this pilot study has several limitations, it seems to indicate that sonic toothbrushes are capable of removing plaque and reducing bleeding on probing better than electric toothbrushes. Source

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