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Rome, Italy

Liu Y.-S.,Changchun University | Gadau M.,Hong Kong Baptist University | Zhang G.-X.,Changchun University | Liu H.,Changchun University | And 9 more authors.
Evidence-based Complementary and Alternative Medicine | Year: 2016

In planning for a large-scale multicenter trial to evaluate the effect of acupuncture for the treatment of lateral elbow pain, a pilot study was conducted. This was a prospective, investigator- and patient-blinded, nonrandomized, placebo controlled trial. Subjects were evaluated at baseline, before fourth, seventh, and ninth treatment, and at a two-week posttreatment follow-up. The treatment group received unilateral acupuncture at LI 10 and LI 11 at the affected side with manual needle manipulation; the control group received sham-laser acupuncture at the same acupoints. Measures included (i) disabilities of the arm, shoulder, and hand (DASH) questionnaire, (ii) pain-free grip strength (PFGS), and (iii) a visual analogue scale (VAS) for pain. Significant differences in DASH score, PFGS, and VAS between treatment and control group were found at the ninth treatment (n = 20 for each group, P < 0.05). Only DASH showed significant differences compared to the control for all the measurement time points after treatment commenced and appears to be a sensitive and appropriate primary outcome measure for the future multisite trial. Results from this pilot study provided relevant information about treatment efficacy, credibility of control treatment, and sensitivity of different outcome measures for the planning of the future trial. © 2016 Yan-Song Liu et al. Source

Juel J.,University of Aalborg | Liguori S.,Istituto Paracelso | Liguori A.,Istituto Paracelso | Liguori A.,University of Rome La Sapienza | And 5 more authors.
Pain Practice | Year: 2016

Objective: Acupuncture is increasingly used as an alternative to medical therapy for various pain conditions. To study the effect of acupuncture in experimental and clinical studies, a control condition with sham acupuncture is needed. However, as such models have not been established in assessment of acupunctures effect against visceral pain, this study aimed to validate a new method for blinded sham acupuncture in experimental rectal pain. Methods: Fifteen subjects underwent a sequence of either sham or real acupuncture in randomized order. In the sham arm, a hollow inner tube with a sharp tip was fitted into an outer tube and subjects were blinded to the stimulations. Before and after the intervention, pain was induced by rectal stimulation with an inflatable balloon distended until the subjects' pain threshold was reached. The resting electroencephalogram (EEG) was quantified by spectral power analysis to explore the central nervous system effects objectively. Additionally, after the second study day, the subject was asked to indicate the sequence of interventions. Results: A significant increase in rectal balloon volume was observed after sham 12 ± 21 mL (P = 0.049) and acupuncture 17 ± 30 mL (P = 0.046). However, the change in volume was not different between groups (P = 0.6). No differences in EEG spectral power distributions between sham and acupuncture were seen (all P > 0.6). The correct sequence of sham and acupuncture was indicated by 36% of the subjects (P = 0.4). Conclusions: The presented sham procedure provides a valid method for blinding of “sham acupuncture” and may be used in future blinded controlled trials of acupuncture for visceral pain. © 2015 World Institute of Pain Source

Di Vico A.,Istituto Paracelso | Liguori S.,Istituto Paracelso | Silli L.,Istituto Paracelso | Rughini S.,Istituto Paracelso | Liguori A.,Istituto Paracelso
Progress in Nutrition | Year: 2014

Following a long debate, during last 20 years, regarding the genetics field of human common traits, we can underline the presence of a wide expression of gene variability, adding a large environment influence, we'll keep the concept that genes will hold our species traits unaltered during the millennia. Although, obesity is the result of an interaction between genetic factors and individual environment. The genetic contribution to interindividual variation in common obesity has been estimated at 40-70%. Yet despite a relatively high heritability, the search for obesity susceptibility genes has been an arduous task. The goal of this review is to check the published works on this matter (genetics and epigenetics influence on gene expression) and underline that according to the recent evident bases the genes associated with risk of obesity are susceptible to epigenetic mutations; the epigenetic markers influence the expression of genes associated with obesity. © Mattioli 1885 Source

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