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Perotti M.,University of Milan Bicocca | Caumo A.,Vita-Salute San Raffaele University | Brunani A.,Istituto Auxologico Italiano Piancavallo | Cambiaghi N.,Laboratory of Chemical and Clinical Analyses | And 8 more authors.
Clinical Endocrinology | Year: 2012

Objective Adult growth hormone deficiency (GHD) has detrimental effects on metabolic profile, leading to an increased cardiovascular mortality and morbidity. Above all, disturbance in postprandial triglyceride metabolism is of major concern because of the crucial role of triglyceride-rich lipoproteins in atherogenesis. The majority of previous studies on GH replacement have shown favourable changes in the fasting lipid profile. Aim of this study is to investigate whether this beneficial effect is exerted also on postprandial triglyceride (TG) metabolism. Patients and methods We challenged nine GHD patients with a standardized fat loading meal at baseline and after 6 months of GH replacement therapy. Nine healthy control subjects were similarly tested under baseline conditions. Blood samples were obtained before and up to 8 h after fat loading for serum lipid analysis. Results We found that GHD patients with fasting TG level in the normal range (1·29 ± 0·31 mm) had a delayed postprandial TG clearance compared to healthy controls (triglyceride level at 8 h, 3·82 ± 0·83 vs 1 ± 0·06 mm P < 0·01), and the postprandial hypertriglyceridaemia was not corrected by 6 months of GH therapy. Conclusions This study has shown for the first time that GHD adult patients have a higher postprandial triglyceridaemia compared to healthy controls when challenged by a standardized fat load and that this atherogenic feature is not normalized by short-term GH treatment despite a decrease in visceral fat mass described during the replacement therapy. © 2012 Blackwell Publishing Ltd. Source


Parisi F.,CNIT | Ferrari G.,CNIT | Cimolin V.,Polytechnic of Milan | Giuberti M.,Xsens Technologies | And 5 more authors.
2015 IEEE 12th International Conference on Wearable and Implantable Body Sensor Networks, BSN 2015 | Year: 2015

Recently, we have proposed a unified approach, based on the use of a Body Sensor Network (BSN) formed by a few body-worn wireless inertial nodes, for automatic assignment of Unified Parkinsons Disease Rating Scale (UPDRS) scores in the following tasks: Leg Agility (LA), Sit-to-Stand (S2S), and Gait (G). Unlike our previous works and the majority of the works appeared in the literature, where UPDRS tasks are investigated singularly, in the current paper we carry out a comparative investigation of the LA, S2S, and G tasks. In particular, we focus on the correlation between UPDRS values assigned to the three tasks by both an expert neurologist and our automatic system. We also consider an aggregate UPDRS score in order to highlight the relevance of each task in the assessment of the gravity of the Parkinson;s Disease (PD). © 2015 IEEE. Source


Parisi F.,University of Parma | Ferrari G.,University of Parma | Giuberti M.,Xsens Technologies | Contin L.,Telecom Italia | And 5 more authors.
BODYNETS 2014 - 9th International Conference on Body Area Networks | Year: 2014

In this paper, we focus on the Gait Analysis (GA) for patients affected by Parkinson's Disease (PD) using a wireless Body Sensor Network (BSN) equipped with Inertial Measurement Units (IMUs). We estimate spatio-temporal parameters and other kinematic variables to characterize the gait, in both Parkinsonians and healthy people. Gait features are compared with scores assigned by neurologists within the Unified Parkinson's Disease Rating Scale (UPDRS), with the ultimate goal of automatically determining the UPDRS score of the Gait Task (GT) carried out by Parkinsonians. Preliminary results show a high correlation between a few gait parameters (such as double support, stride length, and thigh range of rotation) and UPDRS scores. Copyright © 2014 ICST. Source


Valerio G.,Parthenope University of Naples | Manco M.,Area di Ricerca per le Malattie Multifattonah | Ambruzzi A.M.,Ospedale Pediatrico Bambino Gesu IRCCS | Bacchini D.,The Second University of Naples | And 20 more authors.
Minerva Pediatrica | Year: 2014

Obesity in childhood is associated with the presence of complications that can undermine health immediately or in the long term. Several conditions, such as pulmonary or orthopedic complications are strictly associated with the severity of overweight, since they are directly associated to the mechanic stress of fat tissue on the airways or on the bones. Other conditions, such as metabolic or liver complications, although increasing with the extent of overweight, are associated with insulin resistance, which can be modulated by different other factors (ethnicity, genetics, fat distribution) and can occur in overweight children as 'well. No less important are psychological correlates, such as depression and stigma, which can seriously affect the health related quality of life. Pediatric services for the care of childhood obesity need to be able to screen overweight and obese children for the presence of physical and psychological complications, which can be still reversed by weight loss. This article provides pediatricians a comprehensive update on the main complications in obese children and adolescents and their treatment. © 1996-2014. Source

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