Istech, Inc.

YORK, PA, United States

Istech, Inc.

YORK, PA, United States

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Ana G.,Institute for Cryogenic and Isotopic Technologies | Sofilca N.,Institute for Cryogenic and Isotopic Technologies | Niculescu A.,Institute for Cryogenic and Isotopic Technologies | Draghia M.,Istech, Inc.
Fusion Engineering and Design | Year: 2017

During normal operation of a CANDU reactor, large amounts of tritiated heavy water are being produced as result of neutron absorption by the heavy water used as moderator and cooling agent. Tritium in the heavy water brings a significant contribution to the personal doses and also represents an environmental hazard if water spills occur.The technology employed in the Pilot Plant for T2 and D2 separation from Rm. Valcea (Romania) is based on Liquid Phase Catalytic Exchange and Cryogenic Distillation (CD) processes and the whole system is in preoperational stage. The CD system consists of a cascade of four columns placed inside a vacuum insulated cold box and a refrigeration unit providing the cooling capacity for the columns condensers.This paper analyzes some critical scenarios due to single failure mode or a combination of failures such as loss of cooling capacity, loss of cooling agent into the columns, and loss of electric power, cases seen as conservative for the system in order to investigate the behavior during abnormal operation or accident.The study presented in the paper is concerning the CD system from Rm. Valcea but gives information and some references for the methodology that can be implemented for ITER Isotope Separation Systems. © 2017 Elsevier B.V.

Donover P.S.,Genomics Usa, Inc. | Yohn M.,Istech, Inc. | Sim M.,Istech, Inc. | Wright A.,Istech, Inc. | And 4 more authors.
Combinatorial Chemistry and High Throughput Screening | Year: 2013

The Lankenau Institute for Medical Research Chemical Genomics Center, Inc. has developed a new (patents issued and pending) Nanotube Automated Repository System (NARS) for dynamic storage of millions of 'single-shot' samples stored in a new monolithic microtiter-storage tube plate of our own design we call 'nanotubes.' We have integrated the NARS with customized software to efficiently access up to 10,000,000 samples stored continuously frozen (-20°C) in a dehumidified enclosure and sealed in a new microtiter NARS plate that is SBS compliant. Additional software was developed to analyze HTS data from orthogonally pooled compound libraries. Following 'de-convolution' of pooled HTS data, the software designates confirmatory retest samples to be 'cherry-picked' using the NARS. The application of a new, fully-integrated infrastructure for new leads discovery is described in detail. Other applications for our technologies and new infrastructure are discussed. © 2013 Bentham Science Publishers.

Ana G.,Institute for Cryogenic and Isotopic Technologies | Cristescu I.,Karlsruhe Institute of Technology | Draghia M.,Istech, Inc. | Bucur C.,Institute for Cryogenic and Isotopic Technologies | And 14 more authors.
Fusion Engineering and Design | Year: 2016

Cryogenic distillation (CD) of hydrogen in combination with Liquid Phase Catalytic Exchange (LPCE) or Combined Electrolytic Catalytic Exchange (CECE) process is used for tritium removal/recovery from tritiated water. Tritiated water is being obtained after long time operation of CANDU reactors, or in case of ITER mainly by the Detritiation System (DS). The cryogenic distillation system (CDS) used to remove/recover tritium from a hydrogen stream consists of a cascade of cryogenic distillation columns and a refrigeration unit which provides the cooling capacity for the condensers of CD columns. The columns, together with the condensers and the process heat-exchangers are accommodated in a vacuumed cold box. In the particularly case of the ICIT Plant, the cryogenic distillation cascade consists of four columns with diameters between 100-7 mm and it has been designed to process up to 10 mc/h of tritiated deuterium. This paper will present the steps undertaken for construction and commissioning of a pilot plant for tritium removal/recovery by cryogenic distillation of hydrogen. The paper will show besides preliminary data obtained during commissioning, also general characteristics of the plant and its equipments. © 2016 Elsevier B.V. All rights reserved.

Baek D.-Y.,Kyung Hee University | Yoo J.-H.,Istech, Inc. | Lee Y.,Istech, Inc. | Jo Y.,Kyung Hee University | And 4 more authors.
Biochip Journal | Year: 2012

We have developed microarray analysis pipeline software for covering the entire process of transcriptome data analysis. This software, part of the Korea Toxicogenomics Integrated System (KOTIS), is freely distributed to users who upload their microarray data to the KOTIS database, which is operated under the server system of the National Institute of Toxicological Research (NITR). The uploaded microarray data can be downloaded by users through a web search interface within KOTIS and are used as input data of the analysis software. The software, which consists of four major analysis modules and one meta-analysis module, is connected to a gene-related annotation database through the web. Major analysis modules consist of (1) data import and preprocessing, (2) differentially expressed gene finding, (3) clustering analysis, and (4) classification analysis. A gene-related annotation database provides the biological meanings of the analysis results. A highly standardized analysis flow, from data import to differentially expressed gene finding, can be easily implemented using the interface series of a run wizard. The KOTIS system and analysis software are accessible at © 2012 The Korean BioChip Society and Springer-Verlag Berlin Heidelberg.

Yoo J.-H.,Istech, Inc. | Ha I.-C.,Istech, Inc. | Jo Y.,Kyung Hee University | Jeong H.-S.,South Korea National institute of Food and Drug Safety Evaluation | And 2 more authors.
Biochip Journal | Year: 2012

KOTIS (Korea Toxicogenomics Integrated System) is the data warehouse for toxicogenomics research. It contains over 1,700 microarray experiments involved in 40 research projects. The main characteristic of KOTIS is that it has quality inspection modules for evaluating the quality of each microarray data. Furthermore, KOTIS automatically selects significant genes from the given experimental sets and provides well-annotated information with users. These powerful functions are very useful because users can easily identify the quality and the characteristics of each experiment without further data analysis. KOTIS is available at http://kotis. nifds. go. kr/. © 2012 The Korean BioChip Society and Springer-Verlag Berlin Heidelberg.

Yoo J.,Istech, Inc. | Ha I.C.,Istech, Inc. | Chang G.T.,Kyung Hee University | Jung K.S.,KOR National Institution of Health | And 2 more authors.
Biochip Journal | Year: 2011

Recently, Copy Number Variation (CNV) has been recognized as one of the most important genomic alterations in the study of human variation, as it can be employed as a novel marker for human disease studies. Thus, many hardware technologies have been developed to detect copy number variations, including chip-based technologies. However, owing to its complexity, relatively few analysis tools are currently available for CNV, and most public tools have only limited functions and Graphic User Interfaces (GUI). CNVAS is a powerful software package for the analysis of CNV. Two different algorithms, Smith Waterman (SW) and Circular Binary Segmentation (CBS), are implemented for the detection of CNV regions. Furthermore, in order to evaluate the relationship between phenotype and CNV, CNVAS can perform the Chi-square test and Fisher's exact test. Result visualization is another strong merit of the CNVAS software. CNVAS can show the analysis results in the form of chromosome ideograms, and these can be exported in the form of an image file. Furthermore, CNVAS has a database system, which can manage the user's data from different sources and under different experimental conditions. CNVAS is a web-based program, and users can freely access the CNVAS by connecting to © 2011 The KORn BioChip Society and Springer-Verlag Berlin Heidelberg.

Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 190.28K | Year: 2010

DESCRIPTION (provided by applicant): Innovative products that reduce the costs and increase the quality and productivity of drug discovery research are more important than ever. We will rigorously validate prototypes of compound management products that will help overcome limitations in the field of research materials management. Our NanoTube Automated Retrieval System (NARS) is based on technologies that are significantly more cost effective and more flexible in meeting the needs of more scientists than other solutions and resolves a problem that persists in the field; namely, that manual processing of compound libraries for high throughput screening (HTS) leads to their deterioration. The RandD proposed under Phase I will validate innovative repository solutions in a working HTS laboratory. The Specific Aims are: 1. Validate the suitability of our NanoTube 'Single-Shot Storage' (NS) compound storage plates. The NS technology is the foundation of innovative NARS product lines we envision. 2. Demonstrate proof of concept for the reliability of NARS technologies and designs in a working HTS environment. The strengths of this proposal are: 1) The NARS can be much more flexibly configured than prevailing systems. 2) Rapidly emerging biorespository markets create new opportunity and need for our approach. 3) Cost of consumables is 5-fold less expensive than other approaches (See Attachment 1). 4) Cost of NARS system is 3-fold less than prevailing systems (See Attachment 1). 5) The RandD will be carried out in an active compound management and HTS laboratory guided by a strategic alliance of experts in both automation engineering and drug discovery. The solutions we develop from this research will lead to products that enhance the quality of data from drug discovery research and allow for more reliable identification of new drugs in accordance with the NIH mission of improving health. Important application in the field of forensics and genetic screening are envisioned, pending proof of concept from the proposed research. PUBLIC HEALTH RELEVANCE: The proposed studies will establish proof of concept for innovative Automated Repository Systems and technologies that support drug discovery research. This research will lead to products that increase the quality of data in drug discovery and serve other health-related research fields in accordance with the NIH mission of improving health.

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