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Donover P.S.,Genomics Usa, Inc. | Yohn M.,Istech, Inc. | Sim M.,Istech, Inc. | Wright A.,Istech, Inc. | And 4 more authors.
Combinatorial Chemistry and High Throughput Screening | Year: 2013

The Lankenau Institute for Medical Research Chemical Genomics Center, Inc. has developed a new (patents issued and pending) Nanotube Automated Repository System (NARS) for dynamic storage of millions of 'single-shot' samples stored in a new monolithic microtiter-storage tube plate of our own design we call 'nanotubes.' We have integrated the NARS with customized software to efficiently access up to 10,000,000 samples stored continuously frozen (-20°C) in a dehumidified enclosure and sealed in a new microtiter NARS plate that is SBS compliant. Additional software was developed to analyze HTS data from orthogonally pooled compound libraries. Following 'de-convolution' of pooled HTS data, the software designates confirmatory retest samples to be 'cherry-picked' using the NARS. The application of a new, fully-integrated infrastructure for new leads discovery is described in detail. Other applications for our technologies and new infrastructure are discussed. © 2013 Bentham Science Publishers. Source


Ana G.,Institute for Cryogenic and Isotopic Technologies | Cristescu I.,Karlsruhe Institute of Technology | Draghia M.,Istech, Inc. | Bucur C.,Institute for Cryogenic and Isotopic Technologies | And 14 more authors.
Fusion Engineering and Design | Year: 2016

Cryogenic distillation (CD) of hydrogen in combination with Liquid Phase Catalytic Exchange (LPCE) or Combined Electrolytic Catalytic Exchange (CECE) process is used for tritium removal/recovery from tritiated water. Tritiated water is being obtained after long time operation of CANDU reactors, or in case of ITER mainly by the Detritiation System (DS). The cryogenic distillation system (CDS) used to remove/recover tritium from a hydrogen stream consists of a cascade of cryogenic distillation columns and a refrigeration unit which provides the cooling capacity for the condensers of CD columns. The columns, together with the condensers and the process heat-exchangers are accommodated in a vacuumed cold box. In the particularly case of the ICIT Plant, the cryogenic distillation cascade consists of four columns with diameters between 100-7 mm and it has been designed to process up to 10 mc/h of tritiated deuterium. This paper will present the steps undertaken for construction and commissioning of a pilot plant for tritium removal/recovery by cryogenic distillation of hydrogen. The paper will show besides preliminary data obtained during commissioning, also general characteristics of the plant and its equipments. © 2016 Elsevier B.V. All rights reserved. Source


Yoo J.,Istech, Inc. | Ha I.C.,Istech, Inc. | Chang G.T.,Kyung Hee University | Jung K.S.,KOR National Institution of Health | And 2 more authors.
Biochip Journal | Year: 2011

Recently, Copy Number Variation (CNV) has been recognized as one of the most important genomic alterations in the study of human variation, as it can be employed as a novel marker for human disease studies. Thus, many hardware technologies have been developed to detect copy number variations, including chip-based technologies. However, owing to its complexity, relatively few analysis tools are currently available for CNV, and most public tools have only limited functions and Graphic User Interfaces (GUI). CNVAS is a powerful software package for the analysis of CNV. Two different algorithms, Smith Waterman (SW) and Circular Binary Segmentation (CBS), are implemented for the detection of CNV regions. Furthermore, in order to evaluate the relationship between phenotype and CNV, CNVAS can perform the Chi-square test and Fisher's exact test. Result visualization is another strong merit of the CNVAS software. CNVAS can show the analysis results in the form of chromosome ideograms, and these can be exported in the form of an image file. Furthermore, CNVAS has a database system, which can manage the user's data from different sources and under different experimental conditions. CNVAS is a web-based program, and users can freely access the CNVAS by connecting to http://biomi.cdc.go.kr/CNVAS/. © 2011 The KORn BioChip Society and Springer-Verlag Berlin Heidelberg. Source


Baek D.-Y.,Kyung Hee University | Yoo J.-H.,Istech, Inc. | Lee Y.,Istech, Inc. | Jo Y.,Kyung Hee University | And 4 more authors.
Biochip Journal | Year: 2012

We have developed microarray analysis pipeline software for covering the entire process of transcriptome data analysis. This software, part of the Korea Toxicogenomics Integrated System (KOTIS), is freely distributed to users who upload their microarray data to the KOTIS database, which is operated under the server system of the National Institute of Toxicological Research (NITR). The uploaded microarray data can be downloaded by users through a web search interface within KOTIS and are used as input data of the analysis software. The software, which consists of four major analysis modules and one meta-analysis module, is connected to a gene-related annotation database through the web. Major analysis modules consist of (1) data import and preprocessing, (2) differentially expressed gene finding, (3) clustering analysis, and (4) classification analysis. A gene-related annotation database provides the biological meanings of the analysis results. A highly standardized analysis flow, from data import to differentially expressed gene finding, can be easily implemented using the interface series of a run wizard. The KOTIS system and analysis software are accessible at http://kotis.nitr.go.kr. © 2012 The Korean BioChip Society and Springer-Verlag Berlin Heidelberg. Source


Yoo J.-H.,Istech, Inc. | Ha I.-C.,Istech, Inc. | Jo Y.,Kyung Hee University | Jeong H.-S.,South Korea National institute of Food and Drug Safety Evaluation | And 2 more authors.
Biochip Journal | Year: 2012

KOTIS (Korea Toxicogenomics Integrated System) is the data warehouse for toxicogenomics research. It contains over 1,700 microarray experiments involved in 40 research projects. The main characteristic of KOTIS is that it has quality inspection modules for evaluating the quality of each microarray data. Furthermore, KOTIS automatically selects significant genes from the given experimental sets and provides well-annotated information with users. These powerful functions are very useful because users can easily identify the quality and the characteristics of each experiment without further data analysis. KOTIS is available at http://kotis. nifds. go. kr/. © 2012 The Korean BioChip Society and Springer-Verlag Berlin Heidelberg. Source

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