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Istanbul, Turkey

Diz-Kucukkaya R.,Istanbul Science University
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program | Year: 2013

Inherited platelet disorders (IPDs) are a heterogeneous group of diseases affecting platelet production, morphology, and function. The degree of thrombocytopenia and functional abnormality of platelets determines the clinical manifestations. Although severe deficiencies may cause excessive bleeding beginning in early childhood, most of IPDs have mild bleeding tendencies and therefore are not always easy to distinguish from acquired platelet disorders. The diagnosis of IPD may require extensive laboratory investigation, because current routine laboratory tests are not satisfactory for differential diagnosis in some cases, and most of the specific tests are not readily available in many countries. This review summarizes the classification and clinical and molecular characteristics of known IPDs, including Bernard-Soulier syndrome and Glanzmann thrombasthenia, with a focus on current challenges in the laboratory diagnosis and management of bleeding in these patients. Source


Sezer D.,Istanbul Science University
Physical Chemistry Chemical Physics | Year: 2014

The recently introduced methodology (Sezer, Phys. Chem. Chem. Phys., 2013, 15, 526) for calculating dynamic nuclear polarization (DNP) coupling factors through synergistic use of molecular dynamics (MD) simulations and the analytical model of diffusing hard spheres with spins at their centers (HSCS) is applied to several nitroxides in water. Computations with one TEMPONE and one TEMPOL in water agree with experiments at 0.35 T and 3.4 T, respectively. At 9.2 T the predicted coupling factors are larger by about 50% than the experimental numbers obtained with 1 M TEMPOL solution. MD simulations at this elevated concentration reveal nanoscopic TEMPOL clusters and qualitatively explain the lower experimental values. Comparing the dynamics from the MD simulations with those of the HSCS model, the assumption of centered spins is shown to be too limiting even for small molecules like TEMPOL and water. Using the available extension of the HSCS model to off-centered spins, the current procedure for analyzing hydration water dynamics from Overhauser DNP measurements on spin-labeled proteins is revisited. © 2014 the Owner Societies. Source


Kibaroglu A.,Istanbul Science University
Water International | Year: 2015

This article analyzes Turkey’s transboundary water policy by examining its institutional framework and basic principles. It explores the reasons why Turkey voted against the UN Watercourses Convention. Turkey’s harmonization with the water law of the European Union is also scrutinized with an aim to assess its implications for transboundary water policy making. Turkish water diplomacy faces new challenges, such as the devastating impacts of prolonged droughts as well as ongoing instability and conflicts in Syria and Iraq. Hence, it is imperative for Turkey to systematically reconcile its water policy objectives in accordance with the global norms that are adopted in this field. © 2014, © 2014 International Water Resources Association. Source


Ozturk A.,Abant Izzet Baysal University | Ucsular F.D.,Istanbul Science University
Clinical Rehabilitation | Year: 2011

Objective: To test the hypothesis that, in comparison with those in a control group, community-dwelling wheelchair users in Turkey who have completed the Wheelchair Skills Training Program have better total percentage performance and safety scores on the Wheelchair Skills Test. Design: Randomized controlled trial. Subjects: The study group comprised individuals (n = 24) who have to use a wheelchair for mobility in daily life. The subjects were randomly allocated to training (n = 14) and control groups (n = 10). Interventions: The training group attended a skill training session three times a week for four weeks. The control group did not participate in the training. Main outcome measures: At the beginning of the study, subjects underwent a Wheelchair Skills Test (version 4.1), which evaluated their performance and safety for a range of skills. The test was repeated at the end of the study. Results: The mean ± SD total percentage Wheelchair Skills Test performance scores increased significantly in both the training group (P = 0.002) and control group (P = 0.01), although the training group increased to a greater extent (P = 0.034). The training group's mean ± SD total percentage Wheelchair Skills Test safety scores increased significantly (P = 0.001), but there was no significant change in the control group. A statistically significant improvement was found between the total percentage Wheelchair Skills Test safety scores in the training group compared with the control group (P = 0.001). Conclusion: Community-living wheelchair users who received wheelchair skills training increased their total performance and safety scores to a greater extent than a control group. © The Author(s) 2010. Source


Balci C.,Istanbul Science University
Diagnostic and Interventional Radiology | Year: 2011

Magnetic resonance imaging (MRI) plays an important role in the assessment of chronic pancreatitis. By standard MRI techniques, decreased parenchymal signal on T1-weighted fat-suppressed images and delayed gradual enhancement on serial contrast enhanced images represent fibrotic changes caused by chronic inflammation. Magnetic resonance cholangiopancreaticography (MRCP) can reveal ductal changes, including side branch ectasias, that are related to tissue fibrosis and destruction. The exocrine function of the gland and an increased number of side branch ectasias can be evaluated with secretin-stimulated MRCP. Diffusion weighted imaging is an emerging technology that can complement standard MRI to assess the parenchymal changes associated with chronic pancreatitis. The same technique can also quantify the parenchymal response to secretin stimulation. This article reviews standard imaging techniques and new advancements in MRI technology as they relate to the assessment of chronic pancreatitis. © Turkish Society of Radiology 2011. Source

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