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Erkanli K.,Istanbul Mehmet Akif Ersoy Cardiovascular Surgery Education and Research Hospital | Onan B.,Istanbul Mehmet Akif Ersoy Cardiovascular Surgery Education and Research Hospital | Akturk I.F.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital | Bakir I.,Istanbul Mehmet Akif Ersoy Cardiovascular Surgery Education and Research Hospital
Heart Surgery Forum | Year: 2012

Interrupted aortic arch (IAA), a rare congenital malformation of the aortic arch, is defined as a loss of luminal continuity between the ascending and descending portions of the aorta. It is rarely diagnosed as an isolated anomaly in adulthood. Surgical repair is feasible through a sternotomy or thoracotomy incision. In this report, we describe the surgical repair of an isolated IAA in a 29-year-old patient by performing an ascending-to-descending aortic bypass via a sternotomy with cardiopulmonary bypass. © 2012 Forum Multimedia Publishing, LLC.


Onan B.,Nightingale | Onan B.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital | Onan I.S.,Nightingale | Kilickan L.,Nightingale | Sanisoglu I.,Nightingale
Journal of Cardiac Surgery | Year: 2013

Objective: To evaluate the effects of thoracic epidural anesthesia (TEA) as an adjunct to general anesthesia (GA) on postoperative pain after coronary artery bypass grafting (CABG). Methods: Between April 2009 and March 2010, 40 patients with ischemic heart disease scheduled for elective CABG were prospectively randomized to receive either GA (n = 20) or GA + TEA (n = 20). Through epidural catheters, patients received an infusion of (10-20 mg/h) 0.25%-bupivacaine intraoperatively and during the first 24 hours after surgery. Study endpoints included assessment of postoperative pain at rest and with coughing, rescue analgesic need, and postoperative course. Results: The differences in pain scores were decreased at rest during 6 (0.1 ± 0.3 vs. 2.4 ± 1.8; p < 0.05) and 12 hours (0.1 ± 0.3 vs. 3.9 ± 2.3; p < 0.05) and with coughing at 6 (0.1 ± 0.3 vs. 5.6 ± 2.2; p < 0.05), 12 (0.1 ± 0.3 vs. 5.9 ± 2.3; p < 0.05), and 24 hours (0.05 ± 0.2 vs. 4.6 ± 2.9; p < 0.05) in the GA + TEA group. At one-month follow-up, pain scores were decreased in GA + TEA group (0.3 ± 0.7 vs. 1.6 ± 1.3; p = 003). There was no significant difference at three and six months. Mechanical ventilation time (4.7 ± 1.2 vs. 2.9 ± 1.1 hours; p < 0.05), intensive care unit stay (28.4 ± 9.0 vs. 22.4 ± 3.4 hours; p < 0.05), and hospital stay (7.2 ± 1.1 vs. 6.1 ± 0.3 days; p = 0.001) were reduced in the GA + TEA group. Conclusions: TEA significantly reduced the intensity of postoperative pain and analgesic consumption in the early postoperative period following CABG. The delivery of effective analgesia along with conventional medications may prevent chronic pain after surgery. © 2013 Wiley Periodicals, Inc.


Onan I.S.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital | Haydin S.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital | Yeniterzi M.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital
Cardiology in the Young | Year: 2015

Inverted left atrial appendage is an unusual complication associated with congenital cardiac surgery. Inversion of the left atrial appendage may occur during the surgical procedure or afterwards. The left atrial appendage may invert iatrogenically or as a result of the negative pressure during placement or removal of the left atrial vent or during deairing manoeuvres. This event can be life-threatening because of the mass effect of the atrial appendage within the left atrial cavity. © Cambridge University Press 2014.


Erkanli Senturk G.,Acibadem University | Erkanli K.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital | Aydin U.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital | Yucel D.,Acibadem University | And 3 more authors.
Peptides | Year: 2013

Oxytocin (OXY), a well-known nonapeptide, plays a crucial role in reproduction, and has effects on modulating the immune and inflammatory processes in living organisms as well. Recently it is also known as an antioxidant in several organs. The present study aims to demonstrate the protective effect of OXY against ischemia/reperfusion (I/R) injury in urinary bladder tissue. Abdominal aorta of rats, were clamped to perform urinary bladder ischemia. OXY (0.5 μg/kg) was injected intraperitoneally before ischemia in I/R + OXY group, whereas the vehicle solution was injected to I/R group. At the end of reperfusion, tissue samples from urinary bladder were processed for histochemical, ultrastructural and biochemical analysis. Tissue sections were stained by toluidine blue for mast cell counting and hematoxylin-eosin for histopathology. In addition, malondialdehyde (MDA) and glutathione (GSH) levels were determined biochemically. The results demonstrated that there was an extreme damage at urothelium, dilatation of intercellular junctions, inflammatory cell infiltration in I/R group. I/R + OXY group demonstrated a reduction in the severity of urinary bladder damage. According to mast cell counting results, both granulated and degranulated mast cells were decreased in I/R + OXY group compared to I/R group. The mean MDA level was higher in I/R group compared to control and lower in I/R + OXY group compared to I/R group. GSH level reduced in I/R group compared to the control and increased in I/R + OXY group compared to I/R group. In conclusion, oxytocin, as confirmed by histological evaluation and biochemical assays has a potential protective effect in the urinary bladder tissue against ischemia/reperfusion injury. © 2013 Elsevier Inc. All rights reserved.


Haydin S.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital | Ozturk E.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital | Ergul Y.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital | Tuzcu V.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital
Journal of Cardiac Surgery | Year: 2013

Congenital complete atrioventricular block can be concomitant with congenital heart diseases or maternal connective tissue disorders like systemic lupus erythematosus and Sjögren's syndrome. Such patients may require implantation of a permanent pacemaker due to ventricular dysfunction. While many methods of pacemaker implantation have been tested, one that is optimal for low birth weight infants remains to be determined. We present a preterm infant with maternal Sjögren's syndrome with congenital heart block and describe the technique for implantation of an intrathoracic dual-chamber pacemaker. © 2013 Wiley Periodicals, Inc.

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