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Odemis E.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center and Research Hospital
Diagnostic and Interventional Radiology | Year: 2012

We present the case of a five-year-old boy with a caroticoazygous fistula, which is an extremely rare congenital vascular malformation. The patient also had patent ductus arteriosus, a common cause of continuous murmur. The murmur continued despite successful coil embolization of the ductus. Repeated catheter-angiography revealed a large caroticoazygous fistula. The fistula was successfully embolized using the Amplatzer® Vascular Plug 1. Transcatheter occlusion of caroticoazygous fistula was performed easily, safely, and efficiently with a vascular plug. © Turkish Society of Radiology 2012. Source


Akinci G.,Dr Behcet Uz Childrens Hospital | Topaloglu H.,Hacettepe University | Akinci B.,Dokuz Eylul University | Onay H.,Ege University | And 7 more authors.
European Journal of Medical Genetics | Year: 2016

Congenital generalized lipodystrophy type 4 is an extremely rare autosomal recessive disorder. We report our clinical experience on two unrelated Turkish patients with congenital generalized lipodystrophy type 4. A 13-year-old girl (patient-1) presented with generalized lipodystrophy and myopathy. Further tests revealed ventricular and supraventricular arrhythmias, gastrointestinal dysmotility, atlantoaxial instability, lumbosacral scoliosis, and metabolic abnormalities associated with insulin resistance. A 16-year-old girl (patient-2) with congenital generalized lipodystrophy type 4 was previously reported. Here, we report on her long term clinical follow-up. She received several course of anti-arrhythmic treatments for catecholaminergic polymorphic ventricular tachycardia and rapid atrial fibrillation. An implantable cardioverter defibrillator was also placed. A homozygous PTRF mutation, c.259C > T (p.Gln87*), was identified in patient-1. Congenital generalized lipodystrophy type 4 was caused by homozygous PTRF c.481-482insGTGA (p.Lys161Serfs*41) mutation in patient-2. Our data indicate that patients with congenital generalized lipodystrophy type 4 should be meticulously evaluated for cardiac, neuromuscular, gastrointestinal and skeletal diseases, as well as metabolic abnormalities associated with insulin resistance. © 2016 Elsevier Masson SAS. Source


Tanidir C.,Bakirkoy State and Research Hospital for Mental Health and Neurological Disorders | Tanidir I.C.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center and Research Hospital | Bahali K.,Bakirkoy State and Research Hospital for Mental Health and Neurological Disorders | Gunes H.,Bakirkoy State and Research Hospital for Mental Health and Neurological Disorders | And 3 more authors.
Klinik Psikofarmakoloji Bulteni | Year: 2016

Objective: In this study, we aimed to explore the effects of atomoxetine on thyroid functions in children and adolescents with attention deficit hyperactivity disorder. Methods: A retrospective chart review was done to evaluate the thyroid function tests of patients diagnosed with attention deficit hyperactivity disorder and treated with only atomoxetine. The thyroid function tests of 38 subjects, from both before atomoxetine was started and during an effective dose of atomoxetine treatment, were found from the patient charts and compared statistically. Results: There were no statistically significant differences between the baselines levels of thyroidstimulating hormone (TSH), free T4, and free T3 values and those during an effective dose of atomoxetine treatment. In one subject, four weeks after atomoxetine was started and titrated to the effective dose, an insignificant increase in TSH was observed, which decreased to the normal range after the discontinuation of the atomoxetine treatment. Conclusion: Therapeutic doses of atomoxetine do not seem to change thyroid functions in children and adolescents with attention deficit hyperactivity disorder. © 2016, Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali. All rights reserved. Source


Ergul Y.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center and Research Hospital | Tanidir I.C.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center and Research Hospital | Ozyilmaz I.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center and Research Hospital | Akdeniz C.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center and Research Hospital | Tuzcu V.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center and Research Hospital
Pediatrics International | Year: 2015

Background: Syncope is a frequent complaint in children and adolescents and may be a significant sign of serious pathology. Although patient history, family history, and physical examination are sufficient to reach a diagnosis in most cases of syncope, the cause of syncope still cannot be determined after initial investigation in one-third to half of all patients. The aim of this study was to evaluate the diagnostic yield of implantable loop recorder (ILR) in children with unexplained syncope. Methods: A retrospective review was carried out of clinical data, indications, findings, and a final management strategy in patients who underwent ILR implantation. Results: A total of 12 patients with a mean age of 9.4 ± 4.5 years underwent ILR (Reveal Plus; Medtronic) implantation. ILR implantation indication was syncope in all of the patients. Family history, routine cardiac assessment, including resting 12-lead electrocardiogram, transthoracic echocardiography, 24 h Holter recording, and event recorder findings, were normal with the exception of one patient with (previously corrected) tetralogy of Fallot. After an average of 20 months (range, 1-36 months), six patients developed symptoms. ILR memory showed torsades de pointes-ventricular fibrillation (n = 3), catecholaminergic polymorphic ventricular tachycardia (n = 1), asystole and ventricular tachycardia (n = 1), and normal sinus rhythm (n = 1). At the time of writing six patients were still in follow up with no symptoms after an average of 25.2 months. Conclusion: Implantable loop recorder plays an important role in the diagnosis of life-threatening arrhythmias in which syncope is otherwise unexplained. ILR implantation should be remembered in children whose symptoms are strongly correlated with rhythm disturbances. © 2014 Japan Pediatric Society. Source


Odemis E.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center and Research Hospital | Ozyilmaz I.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center and Research Hospital | Guzeltas A.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center and Research Hospital | Erek E.,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center and Research Hospital | And 2 more authors.
Artificial Organs | Year: 2013

Pulmonary atresia with intact ventricular septum (PAIVS) is characterized by a broad spectrum of heterogeneous morphologies. Perforation of the atretic valve, balloon dilatation, and stenting of the patent ductus arteriosus are the percutaneous techniques that are used with increasing frequency in our clinic as well. They have some advantages over surgery, including short hospital stay and short intensive care unit stay. The main goal of the primary interventional approach is to avoid surgery. However, a group of patients with PAIVS still need surgery due to poor right ventricular growth. Therefore, the final achievement of the initial percutaneous treatment strategies is still debatable. In this article, we present the early- and mid-term results of the percutaneous approach utilized at our clinic in order to investigate the final effects of interventional therapy according to initial morphology. Between May 2010 and May 2012, 15 neonates diagnosed with PAIVS underwent transcatheter intervention. Detailed echocardiographic examination focused on right ventricle size, and tricuspid valve morphology and coronary sinusoids were performed in all the patients before the intervention. Nine of the patients were boys and six were girls. The mean age was 11.40±12.87 days and mean weight was 3.34±0.46kg. Only one procedure-related mortality occurred. The mean follow-up period was 10.05±3.42 months (1-26 months). The mean duration of intensive care was 7.19±5.14 days. The mean follow-up time was 10.05±3.42 months. After this period, survival rate was 66% (10/15). Two of the patients achieved biventricular physiology after pulmonary valve perforation. Two patients still have univentricular physiology. Six patients have been followed as a one and half ventricle repair candidate. Five out of 15 patients had stent patency during 6 months of follow-up, while restenosis developed in one patient (1/5, 20%), who had undergone the Glenn operation at 5 months of age. Transcatheter management for PAIVS is a feasible, safe, and effective primary palliative treatment in newborns. Shunt surgery may be considered in cases where cyanosis occurs despite transcatheter intervention. Right ventricular size determines the type of intervention. The early outcomes can be comparable with surgical palliation. However, a group of PAIVS, particularly with severe right ventricular hypoplasia, needs surgery even after a successful primary percutaneous intervention. © 2013, The Authors. Artificial Organs © 2013, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc. Source

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