Istanbul Kemerburgaz University
Bagclar, Turkey
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Kaya N.,Istanbul Kemerburgaz University
Journal of Pediatric Hematology/Oncology | Year: 2017

The aim of this study was to determine usefulness of measurements of maximal systolic velocity of the hepatic artery with Doppler ultrasonography in the diagnosis of venoocclusive disease (VOD) after hematopoietic stem cell transplantation. We prospectively obtained 5 sonograms per patient: pretransplantation, day +1, +7, +14, and +28 on 36 nonconsecutive children who underwent hematopoietic stem cell transplantation. We examined the hepatic artery, the portal, hepatic and splenic veins, the thickness of the gallbladder wall, the presence of ascites, and the liver and spleen size. The diagnosis of VOD was based on clinical and laboratory data. Patients were divided into 2 groups: those with VOD (n=18) and those without VOD (n=18). The variance of 2 groups was analyzed. Vmax of the hepatic artery had a strong correlation with clinical VOD diagnosis (P<0.001). There was no statistically significant difference in the other Doppler parameters. The results of our study showed that the measurement of Vmax of the hepatic artery can provide important support in the diagnosis of VOD and can be useful in the follow-up of treatment response. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: REV-INEQUAL-08-2016 | Award Amount: 4.99M | Year: 2016

Since 2008 fiscal leaks have become an immediate policy challenge for EU governments, partly as a result of tax abuse. The COFFERS project unfolds as EU tax authorities transition to a new era in tackling tax abuse based upon policy innovation at the OECD, EU and national levels. COFFERS recognizes this creates a state of flux where much tax authority expertise regarding past regulations, systems and practices is now irrelevant and understanding has, instead, to focus upon the on-going change process. Deploying principles of evolutionary political economy COFFERS both studies and is an integral part of this change process. COFFERS recognizes that identifying and tackling the tax gap to relieve inequality is the ultimate aim. Noting the tax gap exists both domestically and internationally and ranges from criminal money laundering to sophisticated tax avoidance, COFFERS benchmarks current understanding of these issues, undertakes comparative analysis of approaches taken to tackle them across EU Member States, and assesses resources being allocated to the task of closing the tax gap. In parallel expert networks in business, the tax profession, secrecy jurisdictions and the criminal economy that develop the mechanisms undermining the expected effectiveness of tax systems will be appraised, especially with regard to responses to regulatory changes taking place. This results in COFFERS outputs that transmit analysis, risk assessment and policy advice. Deliverables of use to EU tax authorities include new tax gap analyses by state, tax risk maps identifying risk by jurisdiction, a new anatomy of money laundering risk, and tools to help tax authorities understand the risks that they face domestically and internationally. COFFERS delivers value for money in enhancing tax yield, effectiveness in creating the tools to achieve that goal, and behavioural change in taxpayers and their advisers as a result of recommendations made, all with the aim of reducing inequality.

Amasya G.,Ankara University | Badilli U.,Ankara University | Aksu B.,Istanbul Kemerburgaz University | Tarimci N.,Ankara University
European Journal of Pharmaceutical Sciences | Year: 2016

With Quality by Design (QbD), a systematic approach involving design and development of all production processes to achieve the final product with a predetermined quality, you work within a design space that determines the critical formulation and process parameters. Verification of the quality of the final product is no longer necessary. In the current study, the QbD approach was used in the preparation of lipid nanoparticle formulations to improve skin penetration of 5-Fluorouracil, a widely-used compound for treating non-melanoma skin cancer. 5-Fluorouracil-loaded lipid nanoparticles were prepared by the W/O/W double emulsion - solvent evaporation method. Artificial neural network software was used to evaluate the data obtained from the lipid nanoparticle formulations, to establish the design space, and to optimize the formulations. Two different artificial neural network models were developed. The limit values of the design space of the inputs and outputs obtained by both models were found to be within the knowledge space. The optimal formulations recommended by the models were prepared and the critical quality attributes belonging to those formulations were assigned. The experimental results remained within the design space limit values. Consequently, optimal formulations with the critical quality attributes determined to achieve the Quality Target Product Profile were successfully obtained within the design space by following the QbD steps. © 2016 Elsevier B.V. All rights reserved.

Metformin, first line medication in the treatment of type2 diabetes by millions of patients worldwide, causes gastrointestinal adverse effects (i.e. diarrhea) in approximately 30% of patients, frequently leading to discontinuation. Interestingly, metformin was reported to increase life span in a microscopic worm, Caenorhabditis elegans, by decreasing folate and methionine production of bacteria that this worm uses as a food source. Metformin can be expected to have a similar effect on some microorganisms of human gut microbiota. This can disturb the balance of gut microbiota and cause gastrointestinal adverse effects by altering folate production of some types of bacteria and suppress their growth. Metformin resistant probiotics can be discovered or generated by artificial evolution/selection, and used to prevent these adverse effects. These patients can also be managed with folate supplementation. © 2017 Elsevier Ltd

Gazi V.,Istanbul Kemerburgaz University
2012 IEEE Multi-Conference on Systems and Control, MSC 2012 | Year: 2012

In this article we analyze the stability of the particle dynamics in the Particle Swarm Optimization algorithm using tools from the nonlinear control systems literature including positive realness and stability of stochastic systems. © 2012 IEEE.

Gazi V.,Istanbul Kemerburgaz University
2014 European Control Conference, ECC 2014 | Year: 2014

In this article we consider the distributed output agreement problem in a class of heterogeneous multi-agent dynamic systems composed of single input single output linear systems with system uncertainties. Under very mild assumptions local adaptive internal model based controllers augmented with high gain observers are designed to achieve agreement of the agent outputs. The performance of the proposed controllers is verified for various neighborhood topologies using representative numerical simulations.

Cifter A.,Istanbul Kemerburgaz University
Electric Power Systems Research | Year: 2013

In this paper, electricity price behavior in the Nordic electric power market is forecasted with both the Markov-switching generalized autoregressive conditional heteroskedasticity (MS-GARCH) model and a set of different volatility models. The MS-GARCH model is estimated with two regimes, representing periods of low and high volatility. This study shows that electricity price volatility is not only highly volatile but also strongly regime-dependent. The empirical results show that the MS-GARCH model enables more accurate forecasting than the standard GARCH models, according to tail loss and reality check tests for one- and multi-step ahead forecasts. The results suggest that both the electricity generation companies and consumers of electricity could carry out better price forecasts by using the proposed MS-GARCH model. © 2013 Elsevier B.V. All rights reserved.

Adiguzel Y.,Istanbul Kemerburgaz University
Biophysical Reviews and Letters | Year: 2016

Biophysical economics is initiated with the long history of the relation of economics with ecological basis and biophysical perspectives of the physiocrats. It inherently has social, economic, biological, environmental, natural, physical, and scientific grounds. Biological entities in economy like the resources, consumers, populations, and parts of production systems, etc. could all be dealt by biophysical economics. Considering this wide scope, current work is a "biophysical economics at a glance" rather than a comprehensive review of the full range of topics that may just be adequately covered in a book-length work. However, the sense of its wide range of applications is aimed to be provided to the reader in this work. Here, modern approaches and biophysical growth theory are presented after the long history and an overview of the concepts in biophysical economics. Examples of the recent studies are provided at the end with discussions. This review is also related to the work by Cleveland, "Biophysical Economics: From Physiocracy to Ecological Economics and Industrial Ecology" [C. J. Cleveland, in Advances in Bioeconomics and Sustainability: Essay in Honor of Nicholas Gerogescu-Roegen, eds. J. Gowdy and K. Mayumi (Edward Elgar Publishing, Cheltenham, England, 1999), pp. 125-154.]. Relevant parts include critics and comments on the presented concepts in a parallelized fashion with the Cleveland's work. © 2016 World Scientific Publishing Company.

Gazi V.,Istanbul Kemerburgaz University
Physica D: Nonlinear Phenomena | Year: 2013

In this article a Lagrangian dynamics based approach for modeling swarm dynamics is presented. The approach is based on energy and is alternative to the commonly used Newtonian dynamics, which is based on forces. For that purpose first the concept of biological potential energy is introduced. Various components of the biological potential energy such as swarming potential energy, environmental potential energy, and predator potential energy are also introduced and example kernel functions discussed. Simple illustrative numerical simulations are also provided. © 2013 Elsevier B.V. All rights reserved.

Agency: European Commission | Branch: FP7 | Program: MC-CIG | Phase: FP7-PEOPLE-2013-CIG | Award Amount: 100.00K | Year: 2015

This study examines the cultural and political processes leading to the institution and resolution of the (unwritten) ban on the permanent theater, effective in Rome, from 154 BCE until the construction of Pompeys Theater-Portico Complex (61-55 BCE). Previously approached from the viewpoint provided through textual evidence, the crisis of the permanent theater has been interpreted as a power struggle between masses and the Roman elite. Building on my dissertation research, this work takes a new perspective. By situating the issue in an interdisciplinary Hellenistic context, my project presents the crisis of permanent theater as an inter-elite problem, a struggle between the Roman Senate and powerful political actors like Gnaeus Pompeius Magnus (the Great). To demonstrate this point, using historical and archaeological evidence, I analyze spatial development of Roman theater buildings in South Italy and Sicily parallel to the urban development in Rome in the period between the introduction of the Greek theater to Rome in 240 BCE and the construction of Pompeys Theater-Portico Complex. I focus on the monuments alongside the triumphal path leading to Pompeys monument. The exploration of theater and urban space is carried out together with narrative analysis of theatrical performances, processions and sacrifice, which occasionally take place in the context of a civic festival or triumphal celebration. An accompanying reconstruction of the theatrical events and triumphal procession in Rome concluding at Pompeys Theater-Portico complex illuminates how Roman theater building and urban space worked politically before and during the First Triumvirate. The three dimensional images produced by the research team illustrate theatrical moments increasing the popular appeal of published results. This study establishes cultural connections between the Hellenistic East and the Republican Rome contributing to European history and recent debates on globalization.

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