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Koras O.,Izmir Bozyaka Training and Research Hospital | Bozkurt I.H.,Izmir Bozyaka Training and Research Hospital | Yonguc T.,Izmir Bozyaka Training and Research Hospital | Degirmenci T.,Izmir Bozyaka Training and Research Hospital | And 4 more authors.
Urolithiasis | Year: 2014

The aim of the study was to assess the preoperative and intraoperative potential risk factors for infectious complications after percutaneous nephrolithotomy (PCNL). A total of 303 patients who underwent PCNL for renal stones were included in the recent study. A detailed history including past renal surgery, nephrostomy insertion and recurrent urinary infection were obtained from all patients. Preoperative urine culture, renal pelvic urine culture and stone culture were obtained from all patients. The intraoperative data were prospectively noted. All patients were followed up postoperatively for signs of systemic inflammatory response syndrome (SIRS) and sepsis. In 83 (27.4 %) of the patients, SIRS was observed and of these patients 23 (7.6 %) were diagnosed as sepsis. Escherichia coli was the most common organism detected in cultures, followed by Pseudomonasaeruginosa, Enterococcus and Klebsiella spp. in all patients. By multivariate logistic regression analysis, presence of infection stone, stone burden and recurrent urinary tract infection were associated with both SIRS and sepsis development. Presence of infection stone, stone burden ≥800 mm2 and recurrent urinary tract infection can be identified as independent predictors for the development of SIRS and sepsis. © 2014, Springer-Verlag Berlin Heidelberg. Source


Tutar O.,Istanbul University | Bas A.,Istanbul University | Gulsen G.,Istanbul Haseki Training and Research Hospital | Bayraktarov E.,Istanbul University
BMJ Case Reports | Year: 2012

Bifid mandibular condyle (BMC) is a rare asymptomatic morphological alteration with no predilection for age group or gender. Its morphology varies from a shallow groove to two condylar heads with separate necks, oriented mediolaterally or anteroposteriorly. This report describes an unusual case of bilateral mediolateral bifid condyle in a 24-year-old female patient with the main complaint of mouth-opening limitation. MRI and CT findings revealed bilateral bifid condyle. Copyright 2012 BMJ Publishing Group. All rights reserved. Source


Aktuglu M.B.,Istanbul Haseki Training and Research Hospital | Ayer M.,Istanbul Haseki Training and Research Hospital | Bireller E.S.,Istanbul University | Rencuzogullari C.,Istanbul University | And 8 more authors.
Medical Oncology | Year: 2014

The aim of this study was to assess the possible influence of genetic polymorphisms in hOGG1, XRCC1, XRCC3, XPD, XPG and APE1 on the observed DNA damage in a group of Turkish myelodysplastic syndrome (MDS) patients. A total of 39 patients with myelodysplastic syndrome and 78 age-matched healthy control subjects were included in our study. Polymerase chain reaction/restriction fragment length polymorphism analysis was performed for the detection of DNA repair gene variants. No significant differences in DNA repair enzymes APE1, XRCC1 and XPG were found between MDS patients and controls. On the other hand, XRCC3, XPD and hOGG1 were associated with an increased risk of MDS (p = 0.004, p = 0.000, p = 0.017, respectively). Specifically, Thr/Met genotype was more relevant in patients (p = 0.026) in XRCC3; in hOGG1, Cys+ genotype was found higher in patients (p = 0.017); and in XPD, Gln/Gln genotypes were found higher in the patient (p = 0.001). In conclusion, XRCC3, XPD and hOGG1 genotypes are associated with an increased MDS risk, suggesting their possible involvement in the pathogenesis and biology of this disease. © 2014 Springer Science+Business Media New York. Source


Aktuglu M.B.,Istanbul Haseki Training and Research Hospital | Ayer M.,Istanbul Haseki Training and Research Hospital | Bireller E.S.,Istanbul Haseki Training and Research Hospital | Rencuzogullari C.,Istanbul Haseki Training and Research Hospital | And 8 more authors.
Medical oncology (Northwood, London, England) | Year: 2014

The aim of this study was to assess the possible influence of genetic polymorphisms in hOGG1, XRCC1, XRCC3, XPD, XPG and APE1 on the observed DNA damage in a group of Turkish myelodysplastic syndrome (MDS) patients. A total of 39 patients with myelodysplastic syndrome and 78 age-matched healthy control subjects were included in our study. Polymerase chain reaction/restriction fragment length polymorphism analysis was performed for the detection of DNA repair gene variants. No significant differences in DNA repair enzymes APE1, XRCC1 and XPG were found between MDS patients and controls. On the other hand, XRCC3, XPD and hOGG1 were associated with an increased risk of MDS (p=0.004, p=0.000, p=0.017, respectively). Specifically, Thr/Met genotype was more relevant in patients (p=0.026) in XRCC3; in hOGG1, Cys+ genotype was found higher in patients (p=0.017); and in XPD, Gln/Gln genotypes were found higher in the patient (p=0.001). In conclusion, XRCC3, XPD and hOGG1 genotypes are associated with an increased MDS risk, suggesting their possible involvement in the pathogenesis and biology of this disease. Source

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