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Mexico City, Mexico

Aguilar-Ponce J.L.,Instituto Nacional Of Cancerologia | Granados-Garcia M.,Instituto Nacional Of Cancerologia | Cruz Lopez J.C.,ISSSTE | Maldonado-Magos F.,Instituto Nacional Of Cancerologia | And 8 more authors.
Oral Oncology | Year: 2013

Background: Many studies have shown gemcitabine and cisplatin are radiosensitizers. Concurrent chemoradiation seems to be an efficient approach for treatment of advanced head and neck cancer (HNC), but toxicity is significant. Objective: To evaluate safety and explore efficacy of alternating chemotherapy with gemcitabine and cisplatin concurrent with radiotherapy in patients with advanced non-metastatic HNC. Patients and Methods: Twenty-eight patients diagnosed with advanced Squamous Cell Carcinomas of the Head and Neck (SCCHN) in stages III (28%), IVa (36%), and IVb (36%) were treated with gemcitabine: 100 mg/m2 alternating with cisplatin: 50 mg/m 2 concurrent with radiotherapy at doses of 2 Gy/day until completing 70 Gy. While awaiting for concurrent treatment, eleven patients received induction chemotherapy with cisplatin: 100 mg/m2 and 5-FU: 1000 mg/m2. Toxicity, especially in relation to mucositis, xerostomy, dysphagia, leucopenia and radiodermitis was evaluated. Results: 5-year progression-free survival was 27.8 ± 17.2% (CI-95: 0-61.5) and overall survival was 55.9 ± 11% (CI: 34.4-77.5). Overall response rate was 93%; complete response was 64.3% and partial response was 28.6%. Extensive surgery for primary site was avoided in 19 patients (70.4%). Grade 3-4 adverse events were mucositis (46.4%), leucopenia (14.2%), dysphagia (25%), xerostomy (10.7%) and radiodermitis (3.6%). Response rates and toxicity were not significantly different among those patients with and without induction chemotherapy, but survival was higher in patients receiving induction. Conclusions: Gemcitabine alternating with cisplatin concurrent with radiotherapy is an active and safe treatment that deserves further study. © 2012 Elsevier Ltd. All rights reserved. Source


Garcia-Alcala H.,UPAEP University | Meaney-Mendiolea E.,ISSSTE | Vargas-Ayala G.,Nivel II del Sistema Nacional de Investigadores CONACyT | Vargas-Ayala G.,Colegio de Mexico | And 4 more authors.
Medicina Interna de Mexico | Year: 2011

Diabetes mellitus is a chronic disease characterized, among other cardiometabolic anomalies, by hyperglycemia and the development of micro and macrovascular outcomes in the long range. Treatment of Diabetes mellitus has to reduce fast and postprandial glycemia to near to normal values in order to diminish the frecuency and progression of micro and macrovascular complications. This paper reviews the mechanisms of carbohydrate intestinal absorption, and it is discussed the role of several hypoglucemic and antidiabetic drugs, mainly acarbose, an inhibitor of α-glucosidades, which has proved to reverse glucose intolerance and to delay the development of DM, reducing significatively both, fasting and postprandial glycemia, as well as improving insulin resistance, independently of age and gender. It is concluded that acarbose is among the first choice drugs used in the management of glucose intolerance and in the prevention of Diabetes mellitus, as well as one of the main drugs, used in monotherapy or in combination with other pharmacology agents, in the treatment of the established disease. Source


Roman-Guzman E.,ISSEMYM | Ruiz-Mercado H.,Hospital Regional Dr. Valentin Gomez Farias | Quero-Sandoval F.,ISSEMYM | Nolasco-De La Rosa A.L.,ISSEMYM | And 4 more authors.
Revista Mexicana de Angiologia | Year: 2014

Introduction. Deep vein thrombosis of the lower limbs, often coupled with anticoagulant management, surgery or interruption of the vena cava, to prevent associated complications such as; pulmonary embolism and post-thrombotic syndrome, should be taken into account possible vein anatomical variants of the lower limbs. Objective. The present study determinate that venous anatomical variant that exist in a group of patients. Material and methods. A retrospective cohort study (2011-2013) was conduced in 890 clinical and radiological records of venography to detect type of femoro-popliteal vein anatomical variants. The study only patients whith normal renal function and creatinine clearance. In all patients was used non ionic contrast (60-70 mL iopamidol 300 g/dL). Excluding patients with acute venous thrombosis and post-thrombotic syndrome. Results. Included 74 patients (84 cases) of 890 records reviewed with inclusion criteria. The common age was 47.1 years old ± 5 years, 55 women (74%), 19 male (26%). Anatomic variations: femoral unilateral in 54 patient (73%), femoral bilateral in 10 patient (13.5%), duplication of popliteal vein in 10 patient (13.5%), the most frequent duplication was the left femoral vein in 44 cases (52%). Conclusions. In the present study found 8.3% incidence, comparable only to the series of Francois (France) which was 12%. We believe that de problem exist and its detection is important to prevent complications from diagnosis and not undesirable treatment. Source


Garduno M.V.G.,National Autonomous University of Mexico | Mendoza P.D.,National Autonomous University of Mexico | Reyes A.M.,National Autonomous University of Mexico | Ramirez J.,ISSSTE | Gasga J.R.,National Autonomous University of Mexico
Acta Microscopica | Year: 2010

The mandibular necrosis seen in cancer pathologies following chemotherapy is a subject of interest to the whole biomedical community and specially dentists, who in the face of this problem don't find the solution in any routine treatment, since mandibular necrosis is initiated by any dental treatment and goes on until the entire mandible and occasionally the maxilla is damaged. In this work try to elucidate the process originating mandibular necrosis when patients treated with bisphosphonates after chemotherapy, undergo dental treatment. Therefore, healthy bone will also be studied in order to make a comparison. Necrosed and healthy bones were obtained by donation after medical biopsy. Bone was prepared for light microscopy, scanning electron microscopy (SEM) and X-ray energy dispersive spectrometry (EDS). The comparison of the necrosed and healthy bone indicated morphological and chemical differences. The electron microscopy and chemical analysis observations supported this. We can state that in necrosis vasculature collapses as indicated by other authors, but we suggest the circulatory lack alters severely the bone remodeling mainly in the alveoli, affecting the soft tissues feedback with bone and thus all of the tissue is lost. Source


Diaz-Olguin L.,ISSSTE | Coral-Vazquez R.M.,Institute Seguridad Y Servicios Sociales Of Los Trabajadores Del Estado | Canto-Cetina T.,National Polytechnic Institute of Mexico | Ramirez Regalado B.,ISSSTE | And 3 more authors.
Disease Markers | Year: 2011

Preeclampsia is a specific disease of pregnancy and believed to have a genetic component. The aim of this study was to investigate if three polymorphisms in eNOS or their haplotypes are associated with preeclampsia in Maya mestizo women. A case-control study was performed where 127 preeclamptic patients and 263 controls were included. Genotyped and haplotypes for the -768T→C, intron 4 variants, Glu298Asp of eNOS were determined by PCR and real-time PCR allelic discrimination. Logistic regression analysis with adjustment for age and body mass index (BMI) was used to test for associations between genotype and preeclampsia under recessive, codominant and dominant models. Pairwise linkage disequilibrium between single nucleotide polymorphisms was calculated by direct correlation r^{2}, and haplotype analysis was conducted. Women homozygous for the Asp298 allele showed an association of preeclampsia. In addition, analysis of the haplotype frequencies revealed that the -786C-4b-Asp298 haplotype was significantly more frequent in preeclamptic patients than in controls (0.143 vs. 0.041, respectively; OR =3.01; 95% CI = 1.74-5.23; P =2.9 × 10^{-4}). Despite the Asp298 genotype in a recessive model associated with the presence of preeclampsia in Maya mestizo women, we believe that in this population the -786C-4b-Asp298 haplotype is a better genetic marker. © 2011 - IOS Press and the authors. All rights reserved. Source

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