Israel Agricultural Research Organization

Beit Jann, Israel

Israel Agricultural Research Organization

Beit Jann, Israel
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Patent
Israel Agricultural Research Organization | Date: 2017-07-19

Isolated mogroside and mogrol biosynthetic pathway enzyme polypeptides useful in mogroside biosynthesis are provided. Mogroside biosynthetic pathway enzymes of the invention include squalene epoxidase (SE), expoxy hydratase (EH), cytochrome p450 (Cyp), cucurbitadienol synthase (CDS) and udp-glucosyl-transferase (UGT), Also provided are methods of producing a mogroside using the isolated mogroside and mogrol biosynthetic enzyme polypeptides, the methods comprising contacting a mogrol and/or a glycosylated mogrol (mogroside) with at least one UDP glucose glucosyl transferase (UGT) enzyme polypeptide of the invention catalyzing glucosylation of the mogrol and/or the glucosylated mogrol to produce a mogroside with an additional glucosyl moietie(s), thereby producing the mogroside. Alternatively or additionally provided is a method of synthesizing a mogrol, the method comprising contacting a mogrol precursor substrate with one or more mogrol biosynthetic pathway enzyme polypeptides as described herein catalyzing mogrol synthesis from the mogrol precursor substrate, thereby synthesizing the mogrol.


Patent
Israel Agricultural Research Organization | Date: 2017-01-18

A Cucumis melo plant or a part thereof, the plant bearing more than 12 fruit, the fruit being seedless. Methods of generating same and breeding same are also disclosed.


Patent
Simon Fraser University and Israel Agricultural Research Organization | Date: 2017-02-01

This disclosure describes compounds that affect the olfactory responses of the honey bee mite (Varroa destructor) and methods of use thereof. The compounds do not kill Varroa destructor, and are therefore unlikely to generate Varroa destructor resistance, compared to an acaricide. The compounds can work in conjunction with other mite control approaches, such as a bottom board excluder and sticky board control devices, and can enhance the performance of other forms of mite control while decreasing disadvantages associated therewith.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-03a-2014 | Award Amount: 6.92M | Year: 2015

This proposal SFS-03a-2014-aligned focuses to minimize the risk of introduction/impact of emerging pests threatening EU agriculture and forestry. The targets are: 1) Xylella fastidiosa and its vectors in olive, grapevine, citrus, stone fruit, ornamentals and landscape trees of high socio-economic importance; 2) Ca. Liberibacter solanacearum and its vectors affecting a number of strategic crops such as potato, tomato and carrot; and 3) Hymenoscyphus pseudoalbidus (anomorph. Chalara fraxinea) and Phytophtora spp. seriously affecting broadleaf and conifer species in forest ecosystems. Targeted pests, their vectors and the host response will be explored using innovative approaches (NGS, transcriptomic). Diseases surveillance and epidemiology given by current methods will integrate improved survey protocols and remote sensing. Innovative IPM will include studies of microbiome to develop sustainable solutions in line with the EU plant health legislation. New knowledge gained with POnTE will result in an outcome-based pest prevention and management work plan to: a) implement area-wide pest risk assessments; b) prevent the entry and develop surveillance and early detection tools (diagnostic kits, lab-on-chip, new biomarkers); c) mitigate the spread and reduce the socio-economic impact; d) IPM based on disease resistance, disease-free seeds, cultural practices and physical environmentally-friendly treatments; e) support knowledge-based decision-making policies at EU level. The proposal fosters and promotes a multi-actor approach and transnational research collaborations among 25 Partners at the forefront of research in plant protection, agro-engineering and economics. It involves key industries/SMEs that develop diagnostic kits and services, agrochemical and seed companies, stakeholder groups. End-users will participate in the development of the project and immediately implement the practical solutions derived from the outcomes to solve these serious emerging diseases.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.1.2-05 | Award Amount: 12.09M | Year: 2013

The objective of BIOCOMES is to develop 11 new biological control agents (BCAs) for key markets in European agriculture and forestry. BCAs were identified through market analysis by six manufactures of biological control products. BCAs will primarily be for use in open field crops of vegetables (3), of which 2 are also for use in protected crops, arable crops (3), fruit crops (3), and three different types of forests (2). Primary targeted pests are: gypsy moth (Lymantria dispar), pine weevil (Hylobius abietis), tomato pinworm (Tuta absoluta), white flies, aphids of fruit tree crops and Mamestra brassicae. Primary targeted pathogens are: damping-off diseases in forest nurseries, soilborne pathogens of oilseed rape and cereals, brown rot (Monilinia spp.) of stone fruit, and powdery mildew of cereals (Blumeria graminis). The economic sustainability during the entire development process will be assessed by the responsible industrial partners. The environmental sustainability will be quantified for each BCA by means of the Sustainable Process Index method. The entire developmental process for each of the 11 BCA products is guided by a consultancy partner specialized and leading in (bio) pesticide registration including risk assessments for European (bio) pesticide industries. In vitro production of entomopathogenic viruses as new innovative technique like will be developed aimed at a breakthrough in economic production. Downstream-technology and shelf life for entomopathogenic nematodes will be improved. BIOCOMES will communicate project results with all stakeholders with special attention to European IPM networks throughout the whole project duration. BIOCOMES combines the expertise of 10 industrial SME partners, 3 larger industrial partners and 14 research partners with 38% of the requested EU contribution supporting SMEs. All 11 BCA solutions will be novel IPM tools and new alternatives to replace major pesticide applications in European agriculture and forestry.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.71M | Year: 2015

In response to the increasing problem of water shortage, the reuse of treated urban wastewater is considered the most suitable and reliable alternative for sustainable water management and agricultural development. In spite of the benefits associated with this practice, major concerns currently exist, related to the adverse effects regarding chemical and biological contaminants of emerging concern such as antibiotics and mobile antibiotic resistance elements such as antibiotic resistant bacteria and resistance genes. These are now considered as a serious public health problem by various international organizations and the European Commission, because of their spread in the environment, the food chain, drinking water, etc. To tackle these problems, scientists with an interdisciplinary research/training background are urgently needed. This ETN will train a new generation of ESRs to address the risks associated with such contaminants and wastewater reuse. Innovative chemical, microbiological, toxicological and modelling tools, and novel process engineering will form the scientific and training core of their innovative research projects and training. The project will contribute to understanding the fate and transmission of antibiotics and resistance from wastewater to the environment and humans, through soil, ground/surface water and crops. Relevant ELVs will be determined, essential for the development and implementation of regulatory frameworks. This project directly tackles these aspects, by bringing together a multidisciplinary research team, with the private sector, and policy makers and through communication activities towards stakeholders and the wider public.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-03a-2014 | Award Amount: 7.00M | Year: 2015

Insects are the most diverse Class of life on earth, and different insects can be essential for, or highly damaging to, agriculture, horticulture and forestry. There is a pressing need, not just for new insecticides to combat resistance, but more specific, greener insecticides that target deleterious insects while sparing beneficial ones. This proposal aims to identify such insecticides by turning the insects own hormones against them, both by designing artificial neuropeptide mimetic analogs as candidate compounds, and by generating transgenic insects that carry deleterious neuropeptide payloads within them, that can propagate through a population and impact on survival at times of stress. We have assembled an international multi-actor consortium from EU member and associated member states, as well as a third country partner, with unparalleled experience in insect functional genomics, neuropeptide physiology, synthetic chemistry and synthetic biology, and in field-testing of candidates. Established links to agricultural, horticultural and forestry end-users, agencies/advisors and our SME partners ensure relevance to user need; and set out a pathway to exploitation and implementation of our results, for impact across three major economic sectors in the EU and globally. We will deliver novel, green neuropeptide-based insect pest biocontrol tools by: utilising beyond the State-of-the-Art technologies based on two approaches: rational design of neuropeptide hormone analogues; and development of genetically-encoded neuropeptides for translational insect synthetic biology in genetic pest management. bridging outstanding research and technology in neuroendocrinology and genetics to end user need, to ultimately produce neuropeptide hormone analogues and genetic pest management biocontrol tools. validating and demonstrating these novel insect biocontrol agents in laboratory, field and forest applications, based on user need and a market-driven approach.

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