Hajibeygi M.,Islamic Azad University at Varamin |
Shabanian M.,Islamic Azad University of Arak
Journal of Applied Polymer Science | Year: 2012
In this article, we have successfully synthesized a new dicarboxylic acid, from the two step reactions. At first 4,4'-bis(1,2-diphenoxyethane) dialdehyde was synthesized from 1,2-dibromoethane and 4-hydroxybenzaldehyde, then 4,4'-bis(1,2-diphenoxyethane) diacrylic acid was synthesized from 4,4'-bis(1,2-diphenoxyethane) dialdehyde and malonic acid in a solvent free reaction. Four new organosoluble and thermally stable polyamides (PAs) with good inherent viscosities containing photosensitive groups were synthesized from the direct polycondensation reaction of 4,4'-bis(1,2-diphenoxyethane) diacrylic acid with four various aromatic diamines containing photosensitive group, by two different methods such as direct polycondensation in a medium consisting of N-methyl-2-pyrrolidone (NMP)/triphenyl phosphite (TPP)/calcium chloride (CaCl 2)/pyridine (Py) and direct polycondensation in a tosyl chloride (TsCl)/pyridine (Py)/N,N-dimethylformamide (DMF) system. All of the above polymers were fully characterized by 1H-NMR, FTIR, gel permeation chromatography (GPC), elemental analysis, inherent viscosity, solubility tests, UV-vis spectroscopy, differential scanning calorimeter (DSC), thermogravimetric analysis (TGA). The resulted polyamides (PAs) have showed admirable good inherent viscosities, thermal stability and solubility. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 Copyright © 2012 Wiley Periodicals, Inc.
Seddigh S.,Islamic Azad University at Varamin
Computational Biology and Chemistry | Year: 2017
The P-type ATPases (P-ATPases) are present in all living cells where they mediate ion transport across membranes on the expense of ATP hydrolysis. Different ions which are transported by these pumps are protons like calcium, sodium, potassium, and heavy metals such as manganese, iron, copper, and zinc. Maintenance of the proper gradients for essential ions across cellular membranes makes P-ATPases crucial for cell survival. In this study, characterization of two families of P-ATPases including P-ATPase 13A1 and P-ATPase 13A3 protein was compared in two different insect species from different orders. According to the conserved motifs found with MEME, nine motifs were shared by insects of 13A1 family but eight in 13A3 family. Seven different insect species from 13A1 and five samples from 13A3 family were selected as the representative samples for functional and structural analyses. The structural and functional analyses were performed with ProtParam, SOPMA, SignalP 4.1, TMHMM 2.0, ProtScale and ProDom tools in the ExPASy database. The tertiary structure of Bombus terrestris as a sample of each family of insects were predicted by the Phyre2 and TM-score servers and their similarities were verified by SuperPose server. The tertiary structures were predicted via the “c3b9bA” model (PDB Accession Code: 3B9B) in P-ATPase 13A1 family and “c2zxeA” model (PDB Accession Code: 2ZXE) in P-ATPase 13A3 family. A phylogenetic tree was constructed with MEGA 6.06 software using the Neighbor-joining method. According to the results, there was a high identity of P-ATPase families so that they should be derived from a common ancestor however they belonged to separate groups. In protein–protein interaction analysis by STRING 10.0, six common enriched pathways of KEGG were identified in B. terrestris in both families. The obtained data provide a background for bioinformatic studies of the function and evolution of other insects and organisms. © 2017 Elsevier Ltd
Hosseinzadehdehkordi M.,Tarbiat Modares University |
Adelinik A.,Avicenna Research Institute |
Tashakor A.,Islamic Azad University at Varamin
European Journal of Pharmacology | Year: 2015
Exposure to arsenic is one of the major causes of lung cancer due to production of Reactive Oxygen Species (ROS). Herbal medicine is a new approach used for prevention or treatment of cancers. Among various herbal compounds, a lot of attention has been paid to curcumin, as antioxidant, anti-proliferative, anti-carcinogenic and anti-tumor and pro-apoptotic properties of curcumin have been well studied. In the present study, we investigated the effects of curcumin on lung cancer cell lines and arsenic-treated lung cancer cell lines, originated from different stages of lung cancer development. Here, we measured ROS generation and caspase 3/7 activity for both curcumin-treated cell lines and those co-treated with arsenic and curcumin. Then, we studied lipid peroxidation, intracellular ATP content, and cytochrome c release to further investigate how ROS generation and curcumin exert synergistic effects and direct cells toward apoptosis. According to our data, curcumin has a dual effect on ROS generation which is dependent on specific concentration as a threshold and seems to induce apoptosis by two different mechanisms. Moreover, for the first time we report that curcumin delays the drop in ATP levels in these cell lines and hence provides required energy for apoptosis process. Furthermore, western blot analysis reveals that release of cytochrome c is highest when ATP begins to drop in the presence of curcumin. To sum it up, it seems that curcumin is strong candidate for prevention or treatment of lung cancer, especially at stage 2. © 2015 Elsevier B.V. All rights reserved.
Davoodi H.,Shahid Beheshti University of Medical Sciences |
Esmaeili S.,Islamic Azad University at Varamin |
Mortazavian A.M.,Shahid Beheshti University of Medical Sciences
Comprehensive Reviews in Food Science and Food Safety | Year: 2013
Milk is considered to be the only foodstuff that contains approximately all different substances known to be essential for human nutrition. In terms of cancer risk, dairy foods have been reported as both protective and occasionally as harmful. The evidence that dairy foods can protect against cancer, or increase the risk of cancer is not conclusive. Overall, the proven health benefits of dairy foods greatly outweigh the unproven harm. Dairy foods should be encouraged as part of a varied and nutritious diet as they are essential to maintain good bone and dental health, to prevent osteoporosis, major cardiovascular disease risk factors, hypertension, type-2 diabetes, metabolic syndromes, as well as some cancers. The Cancer Council and USDA recommend 3 servings of milk and milk products daily. This article reviews the potential of milk and milk products (its indigenous or exogenous compounds) to inhibit different cancer risks. Also reviewed are the reports over the years that have suggested milk and the dairy industry as responsible agents for causing cancer. © 2013 Institute of Food Technologists®.
Farhadyar N.,Islamic Azad University at Varamin |
Sadjadi M.S.,Islamic Azad University at Tehran
Journal of Biomedical Nanotechnology | Year: 2011
In this work, we report enhancement of the stability and biocatalytic activities of the alkaline protease enzyme immobilized on a gold/TiO 2 core-shell nanowires. Gold/TiO 2 core-shell nanowires were firstly prepared by the sol-gel method using a mixture of aqueous solution of titanate and chloroauric acid (HAuCl 4) under ambient temperature and atmospheric condition and calcined then. As prepared nanowire was found to have a good surface biocompatibility for immobilization of the alkaline protease enzyme. The results obtained in this work showed that alkaline protease immobilized on gold-TiO 2 core shell is stable and bioactive at the alkaline pH and ambient temperature. The stability and the biocatalytic activity of the immobilized gold-TiO 2 core shell nano composites were monitored by UV-visible spectroscopy. Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and dispersive analysis of X-ray (EDAX) were used to characterize the size and morphology of the prepared materials. Copyright © 2011 American Scientific Publishers. All rights reserved.
Moghimi A.,Islamic Azad University at Varamin
E-Journal of Chemistry | Year: 2011
Modified nano polyacrylonitrile fiber (PANF) was prepared by adding acrylic fibers to methanolamine (MMA) with different concentration solutions. The stability of a chemically modified nano polyacrylonitrile fiber especially in concentrated hydrochloric acid which was then used as a recycling and pre-concentration reagent for further uses of modified nano polyacrylonitrile fiber. The application of this modified nano polyacrylonitrile fiber for sorption of a series of metal ions was performed by using different controlling factors such as the pH of metal ion solution and the equilibration shaking time by the static technique. Cr(III) was found to exhibit the highest affinity towards extraction by these modified nano polyacrylonitrile fiber phases. The pronounced selectivity was also confirmed from the determined distribution coefficient (Kd) of all the metal ions, showing the highest value reported for Cr(III) to occur by modified nano polyacrylonitrile fiber. The modified nano polyacrylonitrile fiber for selective extraction of Cr(III) were successfully accomplished in aqueous solution as well as preconcentration of low concentration of Cr(III) (60 pg mL-1) from natural tap water with a preconcentration factor of 100 for Cr(III) and then off-line Cr(III) in water samples were determined by flame atomic absorption.
Shahab Lavasani A.R.,Islamic Azad University at Varamin
Advances in Environmental Biology | Year: 2014
The aim of this research was to determine the survival of B.lactis and the effect of acidity development and salt concentration inLighvan cheese on the viability of B. lactis. This type of cheese is produced from ewe milk or the mix of ewe and goat. The effect of time on survival of B. lactis during the ripening of probiotic Lighvan cheese was significant (p<0.05). B. lactis cells survived in cheese samples at concentrations up to 6.84 log10 cfu/g for at least 60 days of storage time at 4 °C. High concentration of salt and acid production from fermentation decreased viability of B.lactis during ripening of Lighvan cheese. © 2014 AENSI Publisher All rights reserved.
Hajibeygi M.,Islamic Azad University at Varamin |
Shabanian M.,Islamic Azad University
Designed Monomers and Polymers | Year: 2013
A series new thermally stable and organosoluble polyamides (PAs) 5a-f and copolyamides 10a-f with good inherent viscosities were synthesized from the direct polycondensation reaction of 1,2-bis(4-carboxyphenoxy)ethane 3 with aromatic diamines 4a-f and from the diacid 3 as a first diacid monomer and 4,4′-bis(1,3-diphenoxypropane) diacrylic acid 9 as a second diacid monomer with aromatic diamines 4a-f, respectively. The dicarboxylic acid 9 was synthesized from the two step reactions. At first 4,4′-bis(1,3- diphenoxypropane) dialdehyde 8 was synthesized from 1,3-dibromopropane 6 and 4-hydroxybenzaldehyde 7, then 4,4′-bis(1,2-diphenoxyethane) diacrylic acid 9 was synthesized from dialdehyde 8 and malonic acid in a solvent free reaction. All of the above polymers were fully characterized by 1H NMR, Fourier transform infrared, elemental analysis, inherent viscosity, solubility tests, differential scanning calorimeter, thermogravimetric analysis, and derivative of thermogravimetric. The resulted PAs have shown admirable good inherent viscosities and thermal stability and solubility. Copyright © 2012 Taylor & Francis.
Farahmandjou M.,Islamic Azad University at Varamin
Acta Physica Polonica A | Year: 2013
In this study, Fe and Pt nanoparticles are first synthesized by decomposition of iron(II) chloride tetrahydrate and reduction of platinum(II) acetylacetonate. Then, FePt nanoparticles are similarly fabricated by adding Li- BEt3H to the phenyl ether solution in the presence of oleic acid, oleylamine surfactant at 100°C, followed by refiuxing at 255 °C. The samples were characterized by transmission electron microscopy and energy dispersive spectroscopy analyses after heat treatments. Transmission electron microscopy images show that self-assembled 8 nm Fe nanoparticles are formed as polygon shape, whereas Pt nanoparticles have broad size distribution. On the other hand, 4.5 nm FePt nanoparticles have standard division about 9%. The results of energy dispersive spectroscopy analysis reveal that the composition of Pt, Fe and FePt nanoparticles gives Fe56Pt44 stoichiometry.
Farahmandjou M.,Islamic Azad University at Varamin
Journal of Superconductivity and Novel Magnetism | Year: 2012
FePt magnetic nanoparticles have been synthesized by superhydride reduction of FeCl 2 and Pt(acac) 2 at high temperature. Adding superhydride (LiBEt3H) to the phenyl ether solution of FeCl 2 and Pt(acac) 2 in the presence of oleic acid, oleylamine, and 1,2-hexadecanediol at 190°C, followed by refluxing at 245°C, led to monodisperse 3.5 nm FePt nanoparticles. The effect of oleylamine and oleic acid surfactants on the nucleation and growth of FePt nanoparticles were studied. The size of Pt was controlled by oleylamine surfactant in nucleation stage. To prevent sintering of the FePt nanoparticles, oleic acid surfactant was used in growth stage. The energy dispersive spectroscopy results revealed that the particle composition was first Fe11Pt89 in nucleation stage and after adding superhydride the composition changed to Fe63Pt37 in growth stage. The structural and magnetic measurements indicated that the L10 structure of FePt nanoparticles is formed after annealing and the coercivity of superlattice FePt nanoparticles increases to 7.5 kOe after heat treatments. © Springer Science+Business Media, LLC 2012.