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Karami M.,Islamic Azad University at Falavarjan | Doudi M.,Islamic Azad University at Falavarjan | Setorki M.,Islamic Azad University at Izeh
Journal of Vector Borne Diseases | Year: 2013

Background & objectives: Leishmaniasis has an annual incidence of 0.5-1.5 million new cases and is endemic in 88 countries throughout the world. About 90% of cases of cutaneous leishmaniasis (CL) are reported from seven countries including Iran. Evidence suggests the increased annual incidence of this disease in Iran. Intracellular protozoan parasite, Leishmania, is an obligatory parasite. Sandflies transfer infectious forms of the parasite or its metacyclic promastigotes to its vertebrate hosts such as humans by biting. In order to review the epidemiology of CL in Isfahan, Iran, factors such as incidence, disease causes, geographic features, age, and sex distribution, nationality, and occupation of patients, and the clinical spectrum of disease were evaluated. Methods: During the study, 1315 patients with CL, who referred to the Dermatology and Leishmaniasis Research Center at Isfahan, were evaluated. Results: The highest prevalence of CL was observed in fall (54%) and in northern areas of Isfahan (60.9%). Although CL was prevalent in both men and women, it had higher incidence in men (61.8%). The majority of patients (31.2%) aged 21-30 yr old. Most lesions were nodule-shaped (36.5%) and in upper extremities (48.3%) particularly in men (32.4%). While 81.2% of the subjects were Iranian, others were Afghani or with other nationalities. Most patients had multiple lesions on their bodies and 141 individuals (10.7%) had a previous history of disease. Among all occupations, the highest prevalence of CL was detected in students (18.1%). The response to treatment with compounds of meglumine antimoniate (glucantime) was better than other treatments. Interpretation & conclusion: Unfortunately, the results showed that the prevalence of CL has been increasing annually in some provinces of Iran, especially in Isfahan Province. Nevertheless, further studies are required to determine the vectors, reservoirs, and species of disease and to design appropriate strategies to control the disease.


Doudi M.,Islamic Azad University at Falavarjan | Setorki M.,Islamic Azad University at Izeh | Narimani M.,Isfahan University of Medical Sciences
Medical Science Monitor | Year: 2012

Background: Zoonotic Cutaneous Leishmaniasis (ZCL) is a polymorphic disease. It is generally accepted that bacterial superinfection may play a role in the clinical appearance of the lesions and may delay or prevent the healing process. However, the pattern of bacterial pathogens involved has rarely been investigated. Material/Methods: The aim of this study was to identify the bacterial species contaminating the suspected ZCL and their susceptibility to commonly used antibiotics. Microscopic examination of stained smears and cultures were used to differentiate ZCL from non-ZCL lesions in a rural area north of Isfahan, Iran from July to December 2009. Bacteria were isolated from the lesions and identified and antibiotic susceptibility was determined by standard microbiological techniques. Results: The results show that 602 (68%) of 855 patients were positive for ZCL, of which 83.4% with volcano- shape, 8.8% psoriasiform, 6.6% popular form and 1.2% with other atypical forms of ZCL. The bacteria were isolated from 66.8% of ZCL (70% of volcano-shape, 60% of psoriasiform and 25% of popular form) and 64.7% of non-ZCL lesions. The most common species were Staphylococcus aureus (41.7%) and S. epidermidis (28%) followed by Bacillus sp. Streptococcus pyogenes, Escherichia coli, Klebsiella sp., Proteus sp., Enterobacter sp. and Pseudomonas aeroginosa. Ciprofloxacin, Erythromycin, Cefazolin and Clindamycin were the most effective antibiotics. Conclusions: Bacterial superinfection appears to be very common in ZCL, but its prevalence is not different from that of non-ZCL lesions and it has little effect on the clinical appearance of anthroponotic cutaneous Leishmaniasis (ACL). Local lesion care and management of bacterial superinfection must be considered in the treatment of ZCL.


Rafieian-Kopaei M.,Shahrekord University of Medical Sciences | Setorki M.,Islamic Azad University at Izeh | Doudi M.,Islamic Azad University at Falavarjan | Baradaran A.,Isfahan University of Medical Sciences | Nasri H.,Isfahan University of Medical Sciences
International Journal of Preventive Medicine | Year: 2014

Background: Atherosclerosis is the major cause of morbidities and mortalities worldwide. In this study we aimed to review the mechanism of atherosclerosis and its risk factors, focusing on new findings in atherosclerosis markers and its risk factors. Furthermore, the role of antioxidants and medicinal herbs in atherosclerosis and endothelial damage has been discussed and a list of important medicinal plants effective in the treatment and prevention of hyperlipidemia and atherosclerosis is presented. Methods: The recently published papers about atherosclerosis pathogenesis and herbal medicines effective in the treatment and prevention of hyperlipidemia and atherosclerosis were searched. Results: Inflammation has a crucial role in pathogenesis of atherosclerosis. The disease is accompanied by excessive fibrosis of the intima, fatty plaques formation, proliferation of smooth muscle cells, and migration of a group of cells such as monocytes, T cells, and platelets which are formed in response to inflammation. The oxidation of low density lipoprotein (LDL) to Ox-LDL indicates the first step of atherosclerosis in cardiovascular diseases. Malondialdehyde factor shows the level of lipoperoxidation and is a sign of increased oxidative pressure and cardiovascular diseases. In special pathological conditions such as severe hypercholesterolemia, peroxynitrite concentration increases and atherosclerosis and vascular damage are intensified. Medicinal plants have shown to be capable of interacting these or other pathogenesis factors to prevent atherosclerosis. Conclusions: The pathogenesis factors involved in atherosclerosis have recently been cleared and the discovery of these factors has brought about new hopes for better prevention and treatment of atherosclerosis.


Hosseinjani-Pirdehi H.,Guilan University | Rad-Moghadam K.,Guilan University | Youseftabar-Miri L.,Islamic Azad University at Izeh
Tetrahedron | Year: 2014

A domino reaction for the rapid and diverse synthesis of spiro[1H-pyrazolo[3,4-b]benzo[h]dihydroquinolin-4,3-indolin-2-ones] is reported. The synthesis represents a thermodynamically-favored four-component reaction between phenylhydrazine, isatins, naphthylamines, and 3-ketoesters giving the novel products in excellent yields under solvent-free conditions. Similar applications of anilines in place of naphthylamines have not led to formation of the expected 4-substituted pyrazolo[3,4-b]quinoline derivatives. The difference was ascribed to lower aromatic character of naphthylamines, with respect to anilines, which enables them to act easier as enamines in reaction with the postulated intermediates formed from condensation of isatins and the in situ generated pyrazolones. Surprisingly, 6-aminouracils in despite of their known enamine properties did not participate in reaction with isatins and pyrazolones, the merit of naphthylamines for this synthesis seems to be met by the favorable balance of their N- and C-nucleophilicity. © 2014 Elsevier Ltd. All rights reserved.


Sharifian I.,Islamic Azad University at Izeh
Comparative Clinical Pathology | Year: 2015

Lernaea cyprinacea and occurrence of Lernaeasis in farmed and wild warm water fishes is a major problem of aquaculture industry in Iran. The present study was conducted to compare the rate of L. cyprinacea infection between two separate populations of common carp, i.e., fish cultured in ponds and sampled from rice fields. To this end, fish sampling was done during 3 months in summer. After fish sampling, fish were transferred to lab for parasite study. Parasite incidence percent and density were calculated for two population carps. According to obtained results, the parasite incidence percent and density were significantly higher in fish samples taken from fish ponds than in those from rice fields (P < 0.05). In fact, fish from rice fields were more healthy compared to fish from monoculture ponds. In conclusion, our results show that the polyculture of carp with rice can control Lernaea infection. These results may be in relation to the controlling effects of used pesticides in particular diazinon in rice field on this parasite. © 2015, Springer-Verlag London.


Falehi A.D.,Islamic Azad University at Izeh
Journal of Electrical Engineering and Technology | Year: 2013

In this paper, a novel and robust Power System Stabilizer (PSS) is proposed as an effective approach to improve stability in electric power systems. The dynamic performance of proposed PSS has been thoroughly compared with Conventional PSS (CPSS). Both the Real Coded Genetic Algorithm (RCGA) and Particle Swarm Optimization (PSO) techniques are applied to optimum tune the parameter of both the proposed PSS and CPSS in order to damp-out power system oscillations. Due to the high sufficiency of both the RCGA and PSO techniques to solve the very non-linear objective, they have been employed for solution of the optimization problem. In order to verify the dynamic performance of these devices, different conditions of disturbance are taken into account in Single Machine Infinite Bus (SMIB) power system. Moreover, to ensure the robustness of proposed PSS in damping the power system multi-mode oscillations, a Multi Machine (MM) power system under various disturbances are considered as a test system. The results of nonlinear simulation strongly suggest that the proposed PSS significantly enhances the power system dynamic stability in both of the SMIB and MM power system as compared to CPSS.


Mansouri M.T.,Ahvaz Jundishapur University of Medical Sciences | Farbood Y.,Ahvaz Jundishapur University of Medical Sciences | Sameri M.J.,Ahvaz Jundishapur University of Medical Sciences | Sarkaki A.,Ahvaz Jundishapur University of Medical Sciences | And 2 more authors.
Food Chemistry | Year: 2013

Free radical-induced neural damage is implicated in neurodegenerative diseases and antioxidants have protective activity. In the present study, we examined the effect of gallic acid (GA; 50, 100 and 200 mg/kg, p.o. for 10 days) on memory deficit and cerebral oxidative stress induced by 6-hydroxydopamine (6-OHDA; 8 μg/2 μL) injected into the medial forebrain bundle (MFB, full nigral lesion) as an animal model of Parkinson's disease (PD). The results showed that 6-OHDA significantly reduced the passive avoidance memory performance, non-enzymatic (total thiol) and enzymatic [glutathione peroxidase (GPx)] antioxidant contents and increased the level of malondialdehyde (MDA) in the hippocampus and striatum of vehicle-treated group as compared to sham-operated rats. Furthermore, oral administration of GA significantly increased the passive avoidance memory, total thiol and GPx contents and also decreased MDA levels in the above tissues. The results suggest that GA has neuroprotective activity against 6-OHDA-induced oxidative stress via enhancement of cerebral antioxidant defence. © 2012 Elsevier Ltd. All rights reserved.


Molaei R.,Islamic Azad University at Izeh
Advances in Environmental Biology | Year: 2014

Background: Aim of this research was investigating influence of preschool on academic achievement and social adjustment on first grade elementary school students in Izeh. Statically sample included 3500 male and female students of first grade elementary in 140 elementary schools in Izeh. Random cluster sampling method selected in order to test Hypotheses. We used a questionnaire also validity, and reliability tested by Alpha cronbach (0.88). Results indicated that significant relationship exists between creativity between students who did not pass pre elementary school in comparison with students who passed pre elementary schools. Significant relationship exists between scores of female and male Significant relationship exists between academic achievement of male and female students who passed female and male students who passed pre-elementary schools. © 2014 AENSI Publisher All rights reserved.


Falehi A.D.,Islamic Azad University at Izeh
Research Journal of Applied Sciences, Engineering and Technology | Year: 2012

This study inspects the optimum location of STATCOM device in long transmission line to acquire the maximum power system transient stability improvement. STATCOM is a kind of prominent and effective shunt FACTS device which is used in power system to enhance the power system stability and to regulate the line voltage. When it has been placed at the center point of a transmission line, play a key role in controlling the reactive power flow and enhancing the power system transient stability. The active power losses caused by transmission line resistance alter the neutral position or optimum location of STATCOM in transmission line. RCGA optimization due to have high ability to solve non-linear objective function has been implanted to identify the optimum location of STATCOM. The results of non-linear simulation under severe disturbance approve that the optimum location of STATCOM in order to access the maximum power system transient stability by reducing the active power losses approaches to midpoint of transmission line. © Maxwell Scientific Organization, 2012.


Baeza-Carratala J.F.,University of Alicante | Sepehriannasab B.,Islamic Azad University at Izeh
Geobios | Year: 2014

Brachiopod fauna from central Iran, recorded in the upper part of the Shemshak Group and attributed to the upper Toarcian (Pseudoradiosa-Aalensis zones), are reported for the first time in Iran. The assemblage recognized includes six different taxa: Homoeorhynchia sepahanensis nov. sp., formally described in this paper, Globirhynchia subobsoleta, Pseudogibbirhynchia sp., Tetrarhynchiidae sp. indet., Monsardithyris? aff. haresfieldensis, and Zeilleria cf. leckenbyi. Analysis of faunal affinities with other paleobiogeographical regions shows a free connection of the central Iranian brachiopod fauna and wide areas of the northern shelf margin of the Tethys Ocean. This is due to an apparent disruption of bioprovinciality inferred for the late Toarcian-earliest Aalenian, congruent with a connection through the northern seaway across the peri-Laurasian epicontinental platforms. © 2014 Elsevier Masson SAS.

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