Islamic Azad University at Izeh
Khuzestan, Iran
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Setorki M.,Islamic Azad University at Izeh
Bangladesh Journal of Pharmacology | Year: 2016

The aim of this study was to observe the effect of Ziziphus spina-christi extract against anxiety related behavior induced by scopolamine. Rats were randomly divided into six groups, each group consists of eight rats. Vehicle group received distilled water, negative control received scopolamine (1 mg/ kg) and positive control received diazepam (1 mg/mL). Experimental groups received Z. spina-christi extract (50, 100 and 200 mg/kg IP) 30 min after scopolamine injection. Anxiety related behaviors were assessed using the elevated plus maze. The rotarod test was used to evaluate motor coordination. Administration of Z. spina-christi extract (200 mg/kg) significantly increased the time spent in the open arm of elevated plus maze. The extract also reduced the percentage of closed arms entries and time spent in the closed arms. Different concentration of Z. spina-christi extract didn’t affect motor coordination and balance. Hydro-alcoholic extract of Z. spina-christi significantly ameliorate scopolamine-induced anxiety. © 2016, Bangladesh Pharmacological Society. All rights reserved.

Kabiri N.,Shahrekord University of Medical Sciences | Setorki M.,Islamic Azad University at Izeh
Bangladesh Journal of Pharmacology | Year: 2016

The aim of study was to investigate the potential neuroprotective effects of Kombucha on cerebral damage induced by ischemia in rats (n=99). Cerebral infarct volume in the ischemic rats received Kombucha solution showed no significance alteration. However, the permeability of blood-brain barrier significantly decreased in both ischemic rats received 15 mg/kg Kombucha tea and Sham group. In addition, brain water content in the ischemic groups treated with Kombucha solution was significantly higher than the Sham group, although right hemispheres in all of the treated groups illustrated higher brain water content than the left ones. Brain anti-oxidant capacity elevated in the ischemic rats treated with Kombucha and in the Sham group. Brain and plasma malondialdehyde concentrations significantly decreased in both of the ischemic groups injected with Kombucha. The findings suggest that Kombucha tea could be useful for the prevention of cerebral damage. © 2016, Bangladesh Pharmacological Society. All rights reserved.

Shabani S.,Islamic Azad University at Izeh
UPB Scientific Bulletin, Series A: Applied Mathematics and Physics | Year: 2016

In this paper, we prove the strong convergence of the three-step iteration processes for some generalized nonexpansive multivalued mappings in the framework of CAT(1) spaces. The obtained results extend some recent known results. © 2016, Politechnica University of Bucharest. All rights reserved.

Setorki M.,Islamic Azad University at Izeh | Nazari B.,Isfahan University of Medical Sciences | Asgary S.,Isfahan University of Medical Sciences | Azadbakht L.,Isfahan University of Medical Sciences | Rafieian-Kopaei M.,Shahrekord University of Medical Sciences
African Journal of Pharmacy and Pharmacology | Year: 2011

The aim of the present study was to evaluate the effects of verjuice on atherosclerosis risk factors in rabbits fed a cholesterol-rich diet for how long. Two New Zealand rabbits were used for this study which lasted 8 weeks. The rabbits were divided to four groups and treated as follows normal diet, cholesterol-rich diet, cholesterol-rich diet supplemented with 5 ml verjuice and cholesterol-rich diet supplemented with 10 ml verjuice. The low density lipoprotein-cholesterol (LDL-C), malondialdehyde (MDA), oxidized LDL (ox-LDL), nitrite, nitrate; factor VII, fibrinogen and C-reactive protein (CRP) were measured before and after experimental feeding. In all groups, fatty streak formation in right and left coronary arteries were determined at the end of the study. Administration of low (5 ml) and high (10 ml) dose of verjuice significantly lowered the levels of fibrinogen (p<0.05) and atherosclerotic lesion in right and left coronary arteries (p<0.05). However, the serum level of nitrite and nitrate increased in both verjuice supplemented groups. Administration of 10 ml verjuice could significantly reduce the amount of MDA, ox-LDL, LDL-C (p<0.05). No significant effects were noted for CRP and factor VII after consumption of both doses of verjuice. We conclude that verjuice could reduce some atherosclerotic risk factors in long term treatment. © 2011 Academic Journals.

Karami M.,Islamic Azad University at Falavarjan | Doudi M.,Islamic Azad University at Falavarjan | Setorki M.,Islamic Azad University at Izeh
Journal of Vector Borne Diseases | Year: 2013

Background & objectives: Leishmaniasis has an annual incidence of 0.5-1.5 million new cases and is endemic in 88 countries throughout the world. About 90% of cases of cutaneous leishmaniasis (CL) are reported from seven countries including Iran. Evidence suggests the increased annual incidence of this disease in Iran. Intracellular protozoan parasite, Leishmania, is an obligatory parasite. Sandflies transfer infectious forms of the parasite or its metacyclic promastigotes to its vertebrate hosts such as humans by biting. In order to review the epidemiology of CL in Isfahan, Iran, factors such as incidence, disease causes, geographic features, age, and sex distribution, nationality, and occupation of patients, and the clinical spectrum of disease were evaluated. Methods: During the study, 1315 patients with CL, who referred to the Dermatology and Leishmaniasis Research Center at Isfahan, were evaluated. Results: The highest prevalence of CL was observed in fall (54%) and in northern areas of Isfahan (60.9%). Although CL was prevalent in both men and women, it had higher incidence in men (61.8%). The majority of patients (31.2%) aged 21-30 yr old. Most lesions were nodule-shaped (36.5%) and in upper extremities (48.3%) particularly in men (32.4%). While 81.2% of the subjects were Iranian, others were Afghani or with other nationalities. Most patients had multiple lesions on their bodies and 141 individuals (10.7%) had a previous history of disease. Among all occupations, the highest prevalence of CL was detected in students (18.1%). The response to treatment with compounds of meglumine antimoniate (glucantime) was better than other treatments. Interpretation & conclusion: Unfortunately, the results showed that the prevalence of CL has been increasing annually in some provinces of Iran, especially in Isfahan Province. Nevertheless, further studies are required to determine the vectors, reservoirs, and species of disease and to design appropriate strategies to control the disease.

Rafieian-Kopaei M.,Shahrekord University of Medical Sciences | Setorki M.,Islamic Azad University at Izeh | Doudi M.,Islamic Azad University at Falavarjan | Baradaran A.,Isfahan University of Medical Sciences | Nasri H.,Isfahan University of Medical Sciences
International Journal of Preventive Medicine | Year: 2014

Background: Atherosclerosis is the major cause of morbidities and mortalities worldwide. In this study we aimed to review the mechanism of atherosclerosis and its risk factors, focusing on new findings in atherosclerosis markers and its risk factors. Furthermore, the role of antioxidants and medicinal herbs in atherosclerosis and endothelial damage has been discussed and a list of important medicinal plants effective in the treatment and prevention of hyperlipidemia and atherosclerosis is presented. Methods: The recently published papers about atherosclerosis pathogenesis and herbal medicines effective in the treatment and prevention of hyperlipidemia and atherosclerosis were searched. Results: Inflammation has a crucial role in pathogenesis of atherosclerosis. The disease is accompanied by excessive fibrosis of the intima, fatty plaques formation, proliferation of smooth muscle cells, and migration of a group of cells such as monocytes, T cells, and platelets which are formed in response to inflammation. The oxidation of low density lipoprotein (LDL) to Ox-LDL indicates the first step of atherosclerosis in cardiovascular diseases. Malondialdehyde factor shows the level of lipoperoxidation and is a sign of increased oxidative pressure and cardiovascular diseases. In special pathological conditions such as severe hypercholesterolemia, peroxynitrite concentration increases and atherosclerosis and vascular damage are intensified. Medicinal plants have shown to be capable of interacting these or other pathogenesis factors to prevent atherosclerosis. Conclusions: The pathogenesis factors involved in atherosclerosis have recently been cleared and the discovery of these factors has brought about new hopes for better prevention and treatment of atherosclerosis.

Sharifian I.,Islamic Azad University at Izeh
Comparative Clinical Pathology | Year: 2015

Lernaea cyprinacea and occurrence of Lernaeasis in farmed and wild warm water fishes is a major problem of aquaculture industry in Iran. The present study was conducted to compare the rate of L. cyprinacea infection between two separate populations of common carp, i.e., fish cultured in ponds and sampled from rice fields. To this end, fish sampling was done during 3 months in summer. After fish sampling, fish were transferred to lab for parasite study. Parasite incidence percent and density were calculated for two population carps. According to obtained results, the parasite incidence percent and density were significantly higher in fish samples taken from fish ponds than in those from rice fields (P < 0.05). In fact, fish from rice fields were more healthy compared to fish from monoculture ponds. In conclusion, our results show that the polyculture of carp with rice can control Lernaea infection. These results may be in relation to the controlling effects of used pesticides in particular diazinon in rice field on this parasite. © 2015, Springer-Verlag London.

Mansouri M.T.,Ahvaz Jundishapur University of Medical Sciences | Farbood Y.,Ahvaz Jundishapur University of Medical Sciences | Sameri M.J.,Ahvaz Jundishapur University of Medical Sciences | Sarkaki A.,Ahvaz Jundishapur University of Medical Sciences | And 2 more authors.
Food Chemistry | Year: 2013

Free radical-induced neural damage is implicated in neurodegenerative diseases and antioxidants have protective activity. In the present study, we examined the effect of gallic acid (GA; 50, 100 and 200 mg/kg, p.o. for 10 days) on memory deficit and cerebral oxidative stress induced by 6-hydroxydopamine (6-OHDA; 8 μg/2 μL) injected into the medial forebrain bundle (MFB, full nigral lesion) as an animal model of Parkinson's disease (PD). The results showed that 6-OHDA significantly reduced the passive avoidance memory performance, non-enzymatic (total thiol) and enzymatic [glutathione peroxidase (GPx)] antioxidant contents and increased the level of malondialdehyde (MDA) in the hippocampus and striatum of vehicle-treated group as compared to sham-operated rats. Furthermore, oral administration of GA significantly increased the passive avoidance memory, total thiol and GPx contents and also decreased MDA levels in the above tissues. The results suggest that GA has neuroprotective activity against 6-OHDA-induced oxidative stress via enhancement of cerebral antioxidant defence. © 2012 Elsevier Ltd. All rights reserved.

Falehi A.D.,Islamic Azad University at Izeh
Research Journal of Applied Sciences, Engineering and Technology | Year: 2012

This study inspects the optimum location of STATCOM device in long transmission line to acquire the maximum power system transient stability improvement. STATCOM is a kind of prominent and effective shunt FACTS device which is used in power system to enhance the power system stability and to regulate the line voltage. When it has been placed at the center point of a transmission line, play a key role in controlling the reactive power flow and enhancing the power system transient stability. The active power losses caused by transmission line resistance alter the neutral position or optimum location of STATCOM in transmission line. RCGA optimization due to have high ability to solve non-linear objective function has been implanted to identify the optimum location of STATCOM. The results of non-linear simulation under severe disturbance approve that the optimum location of STATCOM in order to access the maximum power system transient stability by reducing the active power losses approaches to midpoint of transmission line. © Maxwell Scientific Organization, 2012.

Baeza-Carratala J.F.,University of Alicante | Sepehriannasab B.,Islamic Azad University at Izeh
Geobios | Year: 2014

Brachiopod fauna from central Iran, recorded in the upper part of the Shemshak Group and attributed to the upper Toarcian (Pseudoradiosa-Aalensis zones), are reported for the first time in Iran. The assemblage recognized includes six different taxa: Homoeorhynchia sepahanensis nov. sp., formally described in this paper, Globirhynchia subobsoleta, Pseudogibbirhynchia sp., Tetrarhynchiidae sp. indet., Monsardithyris? aff. haresfieldensis, and Zeilleria cf. leckenbyi. Analysis of faunal affinities with other paleobiogeographical regions shows a free connection of the central Iranian brachiopod fauna and wide areas of the northern shelf margin of the Tethys Ocean. This is due to an apparent disruption of bioprovinciality inferred for the late Toarcian-earliest Aalenian, congruent with a connection through the northern seaway across the peri-Laurasian epicontinental platforms. © 2014 Elsevier Masson SAS.

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