Islamiah College

Vaniyambadi, India

Islamiah College

Vaniyambadi, India
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Ogu G.I.,Novena University | Madar I.H.,Bharathidasan University | Madar I.H.,Islamiah College | Olueh A.A.,Novena University | Tayubi I.A.,KING.INFO
Annual Research and Review in Biology | Year: 2017

Aims: To investigate the susceptibility profile of bacterial isolates from hand dug wells and borehole waters within the Amai Kingdom, in Ukwuani Local Government Area of Delta State. Place and Duration of Study: Department of Microbiology, Novena University, between April 2016 and November 2016. Methodology: A total of 30 boreholes and 30 well water samples were randomly sourced using sterile tightly locked plastic containers and transported to the laboratory within 2 hours. The water samples were cultured using spread plate method and the pure bacterial isolates tested for susceptibility to some commercial antibiotic discs using the Kirby-Bauer method. Results: Bacteria were isolated respectively from 50% and 100% of the borehole and well water samples collected. A total of 45 bacterial isolates, distributed among the genera Staphylococcus (6.7%), Bacillus (10.0%), Escherichia (16.7%), Pseudomonas (11.7%) Enterobacter (8.3%), Proteus (10.0%), and Klebsiella (11.7%), was encountered. Majority of the isolates were sensitive to Amoxicillin-clavulanic acid, Ciprofloxacin, Ceftriaxone, Gentamicin, Ofloxacin, and resistant to Ampicillin, Cotrimoxazole and Tetracycline. Bacillus sp (56%) was more resistant (p=.05) than S. aureus (33%), while the most resistant Gram-negative bacteria was Pseudomonas sp. (54%), followed by both E. coli (44%) and Klebsiella sp (44%), and both Proteus sp., (33%) and Enterobacter sp. (33%). Drug resistance was observed in at least three of the tested antibiotic disks. Conclusion: Findings from this study suggest that the drinking water sources in the Amai Kingdom are bacteriologically poor, with multiple-drug resistant bacteria, and thus of public health importance. Public education on dangers associated with indiscriminate dumping of waste and drug abuse is strongly recommended. © 2017 Ogu et al.

Andrews B.,Islamiah College | Ahmed M.,Thiruvalluvar University
Journal of Chemical and Pharmaceutical Research | Year: 2012

In the present work new and simple synthetic methods of 4-aryl-6-methyl-2-oxo-1,2,3,4 tetrahydropyrimidine-(5)- 1,3,4-thiadiazole-2-amine (3) and 4-aryl-6-methyl-2-oxo-1,2,3,4 tetrahydropyrimidine-(5)-1,3,4-oxadiazole-2- amine (3a) are described. Compound 1 is converted to Carbothiamide 2 by the reaction with ethyl ester followed by thiosemicarbazide. Compound 2 has acted as key intermediate for both the final compounds. In one pathway, 2 is converted to corresponding thiadiazloe 3 by treatment with conc.H 2SO 4 and NH 3, and compound 3a by treatment with I 2 followed by KI and NaOH to furnish the final compound. Structural elucidation is accomplished by IR, 1HNMR and Mass spectral data of the synthesized compounds.

Gokulakrishnan A.,Islamiah College | Ali A.R.L.,Islamiah College
Pharmacological Reports | Year: 2010

The protective effect of epigallocatechin-3-gallate (EGCG) against cigarette smoke (CS) induced alterations in human erythrocyte was studied using an in vitro model. Hemolysis, carboxyhemoglobin, osmotic fragility, hemin, lipid peroxidation (LPO), protein thiol, protein carbonyl, glutathione, antioxidant enzymes, membrane bound ATPases and erythrocyte ghost protein were assessed to investigate the effect of EGCG. Erythrocytes were incubated with CS and/or 10 μM EGCG under physiological conditions of temperature and pH for 2 h. CS significantly increased the percentage of hemolysis, carboxyhemoglobin, hemin, LPO and osmotic fragility in human erythrocytes whereas EGCG pretreatment significantly reduced all the above parameters. The levels of protein carbonyls significantly increased whereas the level of protein thiol decreased significantly in erythrocytes incubated with CS. EGCG pretreatment significantly decreased the levels of carbonyls and increased the level of protein thiol. The level of glutathione, antioxidant enzyme and membrane bound ATPases were decreased significantly in erythrocytes incubated with CS. However, EGCG pretreatment significantly increased the activities of GSH, antioxidant enzymes and membrane bound ATPases. CS incubated erythrocytes showed a progressive loss of the cytoskeleton proteins and formation of low molecular weight bands and protein aggregates. EGCG pretreatment of CS incubated erythrocytes showed a near normal protein profile compared to that of control erythrocytes. The present study divulges that EGCG can reduce the abnormalities of cigarette smoking by ameliorating the oxidative stress. This finding raises the possibility that EGCG may provide protection from CS induced toxicity. Copyright © 2010 by Institute of Pharmacology Polish Academy of Sciences.

Ashar Waheed M.P.,Bharatihiar University | Muthu Mohammed H.S.,Islamiah College
International Journal of PharmTech Research | Year: 2012

This study was designed to investigate the ameliorative effect of Quercetin on Fenvalerate-induced biochemical alterations in human erythrocytes invitro. Erythrocytes are useful model to study the interaction of pesticides with biological membranes. Pesticides are thought to exert damaging effect on biomembranes through free radical generation; therefore antioxidants can play a crucial role in offering protection against pesticide induced oxidative damage. Quercetin is a potential antioxidant, known to be able to protect cells against oxidative damage. The biochemical parameters chosen to evaluate the effect of Quercetin were lipid peroxidation (LPO), selected antioxidant and membrane bound enzymes in erythrocytes. No statistical differences were found in the Quercetin treated groups compared with the control group. Following in vitro exposure, Fenvalerate caused a significant induction of oxidative damage in erythrocytes as evidenced by increased levels of thiobarbituric acid reactive substances (TBARS), and decreased levels of GSH. The activities of superoxide dismutase (SOD), catalase (CAT), Glutathione peroxidase (GPx) were found to be significantly reduced in Fenvalerate treated erythrocytes compared with the control erythrocytes. However, Quercetin pretreatment significantly prevented the decrease in the activities of antioxidant enzymes and membrane bound ATPases. The beneficial effects of Quercetin observed here presumably reflect the ability of this flavonoid to protect cells from the toxic effects of Fenvalerate.

Waheed M.P.A.,Bharathiar University | Mohammed H.S.M.,Islamiah College
International Journal of PharmTech Research | Year: 2012

Fenvalerate is a synthetic pyrethroid pesticide used in agriculture to protect a variety of crops. Fenvalerate exposure is associated with serious health consequences in mammals and other non target species. It has been reported to cause liver damage in rats. Fenvalerate is an oxidative stress inducer in liver and Quercetin is a potential antioxidant and is known for its hepatoprotective properties. Therefore, the aim of the present investigation was to assess the ability of Quercetin to protect liver from Fenvalerate induced toxicity. In rats treated with Fenvalerate enzymatic and non enzymatic hepatic function markers along with MDA were significantly elevated while antioxidant enzyme activities were significantly reduced compared to control group, thereby indicating oxidative stress and liver damage while Quercetin pretreatment followed by Fenvalerate administration showed better recovery as evidenced by the significant reduction of liver specific markers in serum and elevated levels of antioxidants with the depletion of MDA compared to Fenvalerate treated group.

Boobalan G.,Annamalai University | Imran P.M.,Islamiah College | Nagarajan S.,Annamalai University
Chinese Chemical Letters | Year: 2012

Designed and synthesized a new highly water soluble N,N′-bis(2-((5- ((dimethylamino)methyl)furan-2-yl)methylthio)ethyl)perylene-3,4,9, 10-tetracarboxylic diimide from 2-((5-((dimethylamino)methyl)furan-2-yl) methylthio)ethanamine and perylene-3,4,9,10-tetracarboxylic dianhydride. The compound was characterized by 1H, 13C, 2D NMR, mass and IR techniques. The compound is highly fluorescent with good solubility in water and other polar solvents. © 2011 Samuthira Nagarajan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

Mansoor S.S.,C Abdul Hakeem College | Shafi S.S.,Islamiah College
Journal of Molecular Liquids | Year: 2010

The oxidation of benzyl alcohol (BnOH) and a few para-substituted benzyl alcohols by tripropylammonium fluorochromate (TriPAFC) in dimethylsulphoxide (DMSO) leads to the formation of corresponding aldehydes. The reaction is first order each in TriPAFC and the alcohols. The reaction is catalysed by hydrogen ions. The hydrogen ion dependence has the form: kobs = a + b[H +]. The oxidation of α α′-dideuterio benzyl alcohol exhibited a substantial primary kinetic isotope effect (kH/k D = 5.45 at 303 K). Oxidation of benzyl alcohol was studied in 19 different organic solvents. The solvent effect has been analysed using Kamlet's and Swain's multiparametric equation. A mechanism involving a hydride ion transfer via chromate ester is proposed. © 2010 Elsevier B.V. All rights reserved.

Sheik Mansoor S.,C Abdul Hakeem College | Syed Shafi S.,Islamiah College
Arabian Journal of Chemistry | Year: 2014

The oxidation kinetics of some para-substituted anilines by benzimidazolium fluorochromate (BIFC) have been studied in aqueous acetic acid media in the presence of perchloric acid. The reaction is first order with respect to both aniline and BIFC and is catalysed by a hydrogen ion. The rate data obey Hammett relationship. The products of oxidation are the corresponding azo benzenes. Based on the kinetic results and product analysis, a suitable mechanism has been proposed for the reaction of BIFC with anilines. © 2010.

Mansoor S.S.,C Abdul Hakeem College | Shafi S.S.,Islamiah College
Reaction Kinetics, Mechanisms and Catalysis | Year: 2010

The kinetics of oxidation of benzhydrols (BH) by tributylammonium chlorochromate (TriBACC) to the corresponding benzophenones have been studied. The reaction is first order each in the concentration of TriBACC, benzhydrol and H+. The oxidation of (α-C-D) benzhydrol indicates the presence of a primary kinetic isotope effect. The reaction rate have been determined at different temperatures and activation parameters calculated. With an increase in the amount of acetic acid in its aqueous mixture, the rate increases. The reaction does not induce polymerization of acrylonitrile. A mechanism involving hydride ion transfer has been proposed. © Akadémiai Kiadó, Budapest, Hungary 2010.

Andrews B.,Islamiah College | Ahmed M.,Islamiah College
Asian Journal of Chemistry | Year: 2013

In the present investigation, synthetic methods of 4-aryl-6-methyl-2-oxo-1, 2,3,4-tetrahydro pyrimidine-(5)-1,3,4-thiadiazole-2-amine (3) and 4-aryl-6-methyl-2-oxo-1,2,3,4-tetrahydro pyrimidine-(5)-1,3,4-oxadiazole-2-amine (3a) and 4-aryl-6-methyl-2-oxo-1,2,3,4-tetrahydro pyrimidine-(5)-1,3,4- triazole-2-thiol derivative (3b) are described. Compound 1 is converted to carbothiamide 2 by the reaction with ethyl ester followed by thiosemicarbazide. Compound 2 acts as key intermediate for all series of the final compounds. In one pathway, 2 is converted to corresponding thiadiazole 3 by treatment with conc. H2SO4 and NH3 and compound 3a by treatment with I2 followed by KI and NaOH and compound 3b by treatment with 10 % of NaOH to furnish the final compound. Structural elucidation is accomplished by IR, 1H NMR and mass spectral data of the synthesized compounds.

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