Yoldas O.,Izmir University |
Karaca T.,Iskenderun State Hospital |
Bilgin B.C.,Kafkas University |
Yilmaz O.H.,Ankara Occupational Diseases Hospital |
And 7 more authors.
Journal of Surgical Research | Year: 2015
Background: Inhalation of crystalline silica nanoparticles causes pulmonary damage resulting in progressive lung fibrosis. Currently, there is no effective treatment for silicosis. Tamoxifen citrate is a selective estrogen receptor modulator, which is one of the adjuvant treatment choices for breast cancer. It is also known with its inhibitory effect on the production of transforming growth factor-beta (TGF-b) and studied for the anti-fibrotic effect in some fibrotic diseases. The aim of the study was to determine the effect of tamoxifen citrate on the prevention of pulmonary fibrosis and the treatment of silicosis. Methods: A total of 100 adult female Wistar Albino rats (200e250 g) were used in this study. The rats were divided into five groups including 20 rats in each. Rats were exposed to silica for 84 d in all groups. In group 1, rats were sacrificed on the day 84 without receiving treatment. In group 2, rats received 1 mg/kg tamoxifen (tmx1 + 1), from the first day of the study for the whole 114 d of the study. In group 3, (tmx10 + 10) rats were given 10 mg/kg tamoxifen from the first day of the study for the whole 114 d of the study. In group 4 (tmx1), rats were started 1 mg/kg of tamoxifen on day 84 and were given until day 114. In group 5 (tmx10), rats were fed with 10 mg/kg tamoxifen starting from day 84 to day 114. All rats except group 1 were sacrificed on 114 day of the study. Lung inflammation and fibrosis scores, serum TGF β levels, lung smooth muscle antigen and tissue transforming growth factor β (t-TGF-β) antibody staining levels, and number of silicotic rats were compared between groups. Results: Silicosis was caused successfully in all rats in group 1. There were six silicotic rats in group 3 and it was the lowest number of all groups. Plasma TGF-β levels and fibrosis score were significantly lower in all groups when compared with the control group. Tamoxifen could have preventive or treating effects in silicosis and found that lung fibrosis score was significantly lower in rats treated with tamoxifen. Conclusions: Tamoxifen treatment after and/or before induction of silicosis decreased lung fibrosis score with blood TGF-b levels. We hope that this study may introduce a new indication as prophylactic use of tamoxifen in high-risk groups for silicosis and for treatment of silicosis. © 2015 Elsevier Inc. All rights reserved.
Dogan U.B.,Mustafa Kemal University |
Dal M.B.,Iskenderun State Hospital
Surgical Laparoscopy, Endoscopy and Percutaneous Techniques | Year: 2015
Background/Aims: We review our 8-year experience with endoscopic removal of eroded gastric bands. Materials and Methods: From 2006 to 2014, 25 patients were diagnosed with band erosion. Clinical data concerning the endoscopic procedure were recorded prospectively and reviewed retrospectively. To remove the migrated band, we used an endoscopic approach with a Gastric Band Cutter (GBC). Results: The median time interval from the initial gastric band placement to the diagnosis of band erosion was 41 (18 to 67) months. Upper abdominal pain was the most common symptom (40%). In 24 of the 25 patients, we used the GBC to remove the band endoscopically. It was able to cut the band successfully in all cases except 1, where twisting of the cutting wire required conversion from endoscopy to laparotomy. In 2 cases, the band, after being cut, was locked in the gastric wall and required laparotomic removal. In 1 patient, we had to perform a surgery for intragastric penetration of the connecting tube broken close to the band. Our success rate was 88% in the single session, with no complications. Conclusions: Endoscopic removal of a migrated band with the GBC seems to be an effective and safe method for band erosion. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
Kaplan T.,Ufuk University |
Han S.,Ufuk University |
Han U.,Diskapi Yildirim Beyazit Teaching and Research Hospital |
Atac G.K.,Ufuk University |
Yanik S.,Iskenderun State Hospital
Asian Cardiovascular and Thoracic Annals | Year: 2014
Thymolipomas are uncommon tumors of the anterior mediastinum. They may extend into, but rarely stem from, the chest cavity. Furthermore, thymoma arising in a thymolipoma is extremely rare. We report a unique case of thymoma type B1 that originated form a giant thymolipoma located in the chest cavity, which was resected by a lateral thoracotomy in a 23-year-old woman. To our knowledge, this is the first reported case of thymoma type B1 arising within a giant thymolipoma. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
Oz F.,Istanbul University |
Cizgici A.Y.,Istanbul University |
Kaya M.G.,Erciyes University |
Kurt M.,Mustafa Kemal University |
And 3 more authors.
Kardiologia Polska | Year: 2015
Background and aim: Increasing evidence suggests an inverse relationship between bilirubin levels and cardiovascular disease. The present study evaluated the effect of bilirubin level on the slow coronary flow (SCF) phenomenon. Methods: This study was cross-sectional and observational. We enrolled 222 consecutive patients who underwent coronary angiography for suspected ischaemic heart disease and were found to have normal or near-normal coronary arteries. Then, bilirubin levels were measured and coronary flow rate was assessed using the thrombolysis in myocardial infarction (TIMI) frame count. SCF was defined as a TIMI frame count > 27 frames. Results: SCF was observed in at least one coronary vessel in 22 of the 222 subjects, indicating a prevalence of 10%. Serum bilirubin levels were significantly decreased in the SCF group. In multivariate logistic regression analysis, total bilirubin and diabetes mellitus were independent risk factors for SCF. Furthermore, after adjusting for age, sex, and cardiovascular disease risk factors, serum bilirubin level (B = -0.34, p < 0.001) was independently associated with TIMI frame count. Conclusions: These findings suggest that serum total bilirubin levels may be a useful marker for patients with the SCF phenomenon. We believe that further studies are needed to clarify the role of bilirubin in patients with SCF.
Turkmen K.,University of Konya |
Erdur F.M.,University of Konya |
Guney I.,Meram Research and Training Hospital |
Gaipov A.,University of Konya |
And 5 more authors.
International Journal of Nephrology and Renovascular Disease | Year: 2012
Objective: Both the incidence and the prevalence of end-stage renal disease (ESRD) in elderly patients are increasing worldwide. Elderly ESRD patients have been found to be more prone to depression than the general population. There are many studies that have addressed the relationship between sleep quality (SQ), depression, and health related quality of life (HRQoL) in ESRD patients, but previous studies have not confirmed the association in elderly hemodialysis (HD) patients. Therefore, the aim of the present study was to demonstrate this relationship in elderly HD patients. Patients and methods: Sixty-three elderly HD patients (32 females and 31 males aged between 65 and 89 years) were included in this cross-sectional study. A modified Post-Sleep Inventory (PSI), the Medical Outcomes Study 36-item short form health survey, and the Beck Depression Inventory (BDI) were applied. Results: The prevalence of poor sleepers (those with a PSI total sleep score [PSI-4 score] of 4 or higher) was 71% (45/63), and the prevalence of depression was 25% (16/63). Of the 45 poor sleepers, 15 had depression, defined as a BDI score of 17 or higher. Poor sleepers had a significantly higher rate of diabetes mellitus (P = 0.03), significantly higher total BDI scores, and lower Physical Component Scale scores (ie, lower HRQoL) than good sleepers. The PSI-4 score correlated negatively with Physical Component Scale (r = -0.500, P< 0.001) and Mental Component Scale scores (r = -0.527, P< 0.001) and it correlated positively with the BDI score (r = 0.606, P<, 0.001). In multivariate analysis, independent variables of PSI-4 score were BDI score (beta value [β] = 0.350, P< 0.001), Mental Component Scale score (β = -0.291, P< 0.001), and age (β = 0.114, P = 0.035). Conclusion: Poor SQ is a very common issue and is associated with both depression and lower HRQoL in elderly HD patients. © 2012 Morishita et al, publisher and licensee Dove Medical Press Ltd.