Turgut O.,Iskenderun State Hospital |
Ay A.A.,Kirikkale University |
Turgut H.,Iskenderun State Hospital |
Ay A.,Viransehir State Hospital |
And 2 more authors.
Age | Year: 2013
The purpose of the study was to assess whether it is possible to reduce the oxidative damage using antioxidant agents combined with hormone replacement therapy after menopause. In this prospective experimental study, 50 mature femaleWistar albino rats weighing 270-310 g were used. Rats were divided into the following six groups: (1) Ovx group (n=7): The animals underwent bilateral ovariectomy. No drug was administered following bilateral ovariectomy. (2) Ovx+ E2 group (n=7): bilateral ovariectomy+17ß-estradiol (100 μg/kg/day); (3) Ovx+E2+MT5 group (n=7): bilateral ovariectomy+17ß-estradiol (100 μg/kg/day)+melatonin (5 mg/kg/day); (4) Ovx+E2+MT20 group (n=7): bilateral ovariectomy+17ß-estradiol (100 μg/kg/day)+ melatonin (20 mg/kg/day); (5) Ovx+E2+Dxp250 group (n = 7): bilateral ovariectomy + 17ß-estradiol (100 μg/kg/day)+dexpanthenol (250 mg/kg/day); (6) Ovx+E2+Dxp500 group (n=7): bilateral ovariectomy+ 17ß-estradiol (100 μg/kg/day)+dexpanthenol (500 mg/kg/day), and the activity of these antioxidative enzymes and oxidative stress products were measured. Enzymatic activity levels of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase(GSH-Px), and glutathione reductase and levels of free radicals (malondialdehyde (MDA) and nitric oxide) were both analyzed. We observed an increase in the level of GSH activity, but no significant differences in levels of CAT, SOD, and GSH-Px enzymatic activity and in levels of free radical MDA following 17ß-estradiol or additional antioxidant treatment (melatonin or dexpanthenol). Despite the present study indicating that the addition of melatonin and dexpanthenol into the hormone replacement therapy regimen may contribute to the antioxidant effect of estrogen, the existence of limited data in this field indicates that further studies are warranted. © American Aging Association 2013.
PubMed | Derince Training and Research Hospital, Siyami Ersek Thoracic and Cardiovascular Surgery Center Training and Research Hospital, Haseki Training and Research Hospital, Iskenderun State Hospital and Brigham and Women's Hospital
Type: Journal Article | Journal: The American journal of emergency medicine | Year: 2016
Monocyte count to high-density lipoprotein ratio (MHR) has recently emerged as an indicator of inflammation and oxidative stress in the literature. We aimed to investigate the prognostic value of MHR in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention (PCI).A total of 513 patients who were hospitalized with diagnosis of acute ST-segment elevation myocardial infarction and treated with primary PCI were retrospectively enrolled in the study. Demographic and clinical data, admission laboratory parameters, and MHR values were recorded. Inhospital major adverse cardiac events (MACE) and mortality were reported as the clinical outcomes.Twenty-six patients (5%) died, and MACE was observed in 86 patients (17%) during hospital follow-up. Patients were categorized in 3 groups according to tertiles of admission MHR. The rates of inhospital mortality and MACE were significantly higher in tertile 3 group compared to tertile 1 group (10% vs 1%, 27% vs 11%; P < .01 and P < .01). In multivariate regression analysis, age, sex, presence of Killip 3 or 4, left ventricular ejection fraction, troponin I, C-reactive protein, and increased MHR levels (odds ratio, 1.03; 95% confidence interval, 1.01-1.05; P < .01) independently predicted inhospital mortality; age, presence of Killip 3 or 4, troponin I, and increased MHR levels (odds ratio, 1.02; 95% confidence interval, 1.01-1.04; P < .01) independently predicted MACE.Admission MHR values were found to be independently correlated with inhospital MACE and mortality after primary PCI.
Turkmen K.,University of Konya |
Erdur F.M.,University of Konya |
Guney I.,Meram Research and Training Hospital |
Gaipov A.,University of Konya |
And 5 more authors.
International Journal of Nephrology and Renovascular Disease | Year: 2012
Objective: Both the incidence and the prevalence of end-stage renal disease (ESRD) in elderly patients are increasing worldwide. Elderly ESRD patients have been found to be more prone to depression than the general population. There are many studies that have addressed the relationship between sleep quality (SQ), depression, and health related quality of life (HRQoL) in ESRD patients, but previous studies have not confirmed the association in elderly hemodialysis (HD) patients. Therefore, the aim of the present study was to demonstrate this relationship in elderly HD patients. Patients and methods: Sixty-three elderly HD patients (32 females and 31 males aged between 65 and 89 years) were included in this cross-sectional study. A modified Post-Sleep Inventory (PSI), the Medical Outcomes Study 36-item short form health survey, and the Beck Depression Inventory (BDI) were applied. Results: The prevalence of poor sleepers (those with a PSI total sleep score [PSI-4 score] of 4 or higher) was 71% (45/63), and the prevalence of depression was 25% (16/63). Of the 45 poor sleepers, 15 had depression, defined as a BDI score of 17 or higher. Poor sleepers had a significantly higher rate of diabetes mellitus (P = 0.03), significantly higher total BDI scores, and lower Physical Component Scale scores (ie, lower HRQoL) than good sleepers. The PSI-4 score correlated negatively with Physical Component Scale (r = -0.500, P< 0.001) and Mental Component Scale scores (r = -0.527, P< 0.001) and it correlated positively with the BDI score (r = 0.606, P<, 0.001). In multivariate analysis, independent variables of PSI-4 score were BDI score (beta value [β] = 0.350, P< 0.001), Mental Component Scale score (β = -0.291, P< 0.001), and age (β = 0.114, P = 0.035). Conclusion: Poor SQ is a very common issue and is associated with both depression and lower HRQoL in elderly HD patients. © 2012 Morishita et al, publisher and licensee Dove Medical Press Ltd.
Abdel-Rahman E.M.,University of Virginia |
Turgut F.,Iskenderun State Hospital |
Turkmen K.,Selcuk University |
Balogun R.A.,University of Virginia
QJM | Year: 2011
The elderly, (age ≥65 years) hemodialysis (HD) patient population is growing rapidly across the world. The risk of accidental falls is very high in this patient population due to multiple factors which include aging, underlying renal disease and adverse events associated with HD treatments. Falls, the most common cause of fatal injury among elderly, not only increase morbidity and mortality, but also increase costs to the health system. Prediction of falls and interventions to prevent or minimize fall risk and associated complications will be a major step in helping these patients as well as decreasing financial and social burdens. Thus, it is vital to learn how to approach this important problem. In this review, we will summarize the epidemiology, risk factors, pathophysiology and complications of falls in elderly HD patients. We will also focus on available methods to assess and predict the patients at higher risk of falling and will provide recommendations for interventions to reduce the occurrence of falls in this population. © The Author 2011. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved.
PubMed | Adnan Menderes University, Iskenderun State Hospital and Muǧla University
Type: Journal Article | Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians | Year: 2016
This study aimed to investigate maternal serum concentrations of s-Endoglin and compare s-Endoglin with other inflammatory markers in prediction of time to delivery, in pregnancies complicated by preterm premature rupture of membranes (PPROM).Fifty five patients complicated by PPROM whose gestational age were between 2433 weeks and 44 matched healthy pregnant women were included in present study. Maternal concentrations of s-Endoglin concentrations were measured by an enzyme-linked immunosorbent assay (ELISA) and compared with maternal inflammatory markers including interleukin-6 (IL-6), white blood cell (WBC) count and serum C-reactive protein (CRP). The best variable for prediction of preterm birth was computed.Mean s-Endoglin levels in PPROM were lower than control groups (0.240.12pg/ml and 0.690.25pg/ml, respectively, p<0.01). Besides IL-6 (p<0.01), WBC (p=0.016) and CRP (p=0.010) levels were higher in PPROM group. In PPROM group, ROC analysis results of s-Endoglin for prediction of preterm delivery <48 h, <7 days, <32 weeks were not different (p>0.05). For predicting preterm birth before 48 h and 7 days, only IL-6 at cut off value >0.70 (pg/ml) and >0.55 (pg/ml) had area under curve (AUC); 0.871 (0.7750.965), p<0.01, AUC; 0.925 (0.8560.993), p<0.001, respectively.s-Endoglin as an anti-angiogenic marker seemed to have a role in pathogenesis but results of present study showed that, unlike IL-6, it was unsatisfactory for estimating time to delivery in PPROM.
Dogan U.B.,Mustafa Kemal University |
Dal M.B.,Iskenderun State Hospital
Surgical Laparoscopy, Endoscopy and Percutaneous Techniques | Year: 2015
Background/Aims: We review our 8-year experience with endoscopic removal of eroded gastric bands. Materials and Methods: From 2006 to 2014, 25 patients were diagnosed with band erosion. Clinical data concerning the endoscopic procedure were recorded prospectively and reviewed retrospectively. To remove the migrated band, we used an endoscopic approach with a Gastric Band Cutter (GBC). Results: The median time interval from the initial gastric band placement to the diagnosis of band erosion was 41 (18 to 67) months. Upper abdominal pain was the most common symptom (40%). In 24 of the 25 patients, we used the GBC to remove the band endoscopically. It was able to cut the band successfully in all cases except 1, where twisting of the cutting wire required conversion from endoscopy to laparotomy. In 2 cases, the band, after being cut, was locked in the gastric wall and required laparotomic removal. In 1 patient, we had to perform a surgery for intragastric penetration of the connecting tube broken close to the band. Our success rate was 88% in the single session, with no complications. Conclusions: Endoscopic removal of a migrated band with the GBC seems to be an effective and safe method for band erosion. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
Oz F.,Istanbul University |
Cizgici A.Y.,Istanbul University |
Kaya M.G.,Erciyes University |
Kurt M.,Mustafa Kemal University |
And 3 more authors.
Kardiologia Polska | Year: 2015
Background and aim: Increasing evidence suggests an inverse relationship between bilirubin levels and cardiovascular disease. The present study evaluated the effect of bilirubin level on the slow coronary flow (SCF) phenomenon. Methods: This study was cross-sectional and observational. We enrolled 222 consecutive patients who underwent coronary angiography for suspected ischaemic heart disease and were found to have normal or near-normal coronary arteries. Then, bilirubin levels were measured and coronary flow rate was assessed using the thrombolysis in myocardial infarction (TIMI) frame count. SCF was defined as a TIMI frame count > 27 frames. Results: SCF was observed in at least one coronary vessel in 22 of the 222 subjects, indicating a prevalence of 10%. Serum bilirubin levels were significantly decreased in the SCF group. In multivariate logistic regression analysis, total bilirubin and diabetes mellitus were independent risk factors for SCF. Furthermore, after adjusting for age, sex, and cardiovascular disease risk factors, serum bilirubin level (B = -0.34, p < 0.001) was independently associated with TIMI frame count. Conclusions: These findings suggest that serum total bilirubin levels may be a useful marker for patients with the SCF phenomenon. We believe that further studies are needed to clarify the role of bilirubin in patients with SCF.
Ozel H.E.,Iskenderun State Hospital |
Kaynar A.,Iskenderun State Hospital
Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat | Year: 2012
Apocrine hidrocystomas are uncommon cystic proliferations of the apocrine secretory glands. Maxilla is an unexpected involvement site for these tumors. Our study represents the first case of an apocrine hidrocystoma of the maxilla excised by an intraoral (sublabial) approach, being the first to define the radiologic findings of apocrine hidrocystoma on this region. This case is an extremely rare type in terms of the unusual symptomatology, location and size of the tumor. In this article, clinical presentation, surgical findings, histopathological features and treatment of this rare lesion were discussed.
Akkoca A.N.,Iskenderun State Hospital |
Yank S.,Iskenderun State Hospital |
Ozdemir Z.T.,Bozok University |
Cihan F.G.,University of Konya |
And 4 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2014
Aim: Colon adenocarcinoma, is the most common cancer in gastrointesinal system (GIS). The whole world is an important cause of morbidity and mortality. TNM and modified Dukes classification which has great importance in the diagnosis and treatment of Colorectal cancer (CRC). TNM and Modified Dukes classification results of histopathological examination and the demographic characteristics of patients and their relation were investigated. Materials and methods: Lower gastrointestinal operation results of 85 patients were examined accepted to clinical Pathology between January 1997-November 2013. Colon cancer had been diagnosed at 85 patients with pathology materials and staging was done according to the TNM and Modified Duke classification. The demographic characteristics of patients, differentiation grade, lymph node involvement, serous involvement were evaluated retrospectively. Results: In this study 37 patients (43.52%) were men and 48 (56.47%) were women. Ages of patients were between 19 and 87 with a mean age of 57.31 ± 15.31. Lymph node, differentiation, serosa involvement, Modified Dukes and TNM classification was assessed according to sex and age. TNM classification by sex was not statistically significant (p > 0.05). There was no statistically significant relationship between age and differentiation (p = 0.085). Value of differentiation increased towards from 1 to 3 inversely proportional to age. So young patients defined as well-differentiated at the conclusion. Negative relationship was evaluated between age and TNM Class variables. As a result, the relationship between age and TNM was not significant (p > 0.05). However, with increasing age the degree of staging was also found to increase. TNM classification was associated with the differentiation and it was significant (p = 0.043). Conclusion: Colon cancer, when contracted at an early stage, it is suitable for surgery and curative treatment can be done with minimal morbidity and mortality. However, some of the patients have advanced disease at diagnosis and their 5-year survival rate is only 8%. Every year there is prolongation of overall survival of colon cancer. It is so common cancer type so that determination of prognostic factors, disease staging and treatment strategy which affects survival is significant. © 2014, International Journal of Clinical and Experimental Medicine. All rights reserved.
PubMed | Iskenderun State Hospital and Hacettepe University
Type: Journal Article | Journal: Indian journal of ophthalmology | Year: 2016
To evaluate the utility of margin-reflex distance (MRD) as an alternative to levator function (LF) in choosing the appropriate surgical procedure for congenital blepharoptosis.This was a retrospective, observational study.Records of patients with simple (dystrophic) congenital ptosis who were operated and followed for 6 months postoperatively and whose outcomes were deemed as successful were evaluated in the study. Success was defined as a MRD at the last postoperative visit of 3 mm. In all cases, levator resection was performed when LF was >4 mm and frontalis suspension when LF was 4 mm.For statistical evaluations, LF was accepted as the gold standard parameter for deciding on the surgical intervention, and the optimum cutoff point for initial MRD was determined as the point at which sensitivity and specificity was highest at the receiving operating curve for the selection of surgical procedure.Of one hundred and three eyes of ninety patients (44 female/46 male), levator resection was used in 44.7% and frontalis suspension in 55.3%. When the optimum cutoff point for MRD was determined as 0.5 mm, the sensitivity was 71%, specificity was 86%, and the area under the curve that represented the discriminative power of this parameter was found to be 0.826.The MRD at the cutoff point of 0.5 mm may be used as an alternative to LF to determine the type of surgical intervention in patients with congenital blepharoptosis whose LF cannot be reliably obtained in clinical evaluations.