Ishikawa, Japan

Ishikawa Prefectural Nursing University is a public university at Kahoku, Ishikawa, Japan, established in 2000. Wikipedia.

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Kobayashi H.,Ishikawa Prefectural Nursing University | Kakihana W.,Ishikawa Prefectural Nursing University | Kimura T.,University of Tokyo
Journal of NeuroEngineering and Rehabilitation | Year: 2014

Background: The gait of a healthy person is believed to be more regular and symmetrical than those of an individual with a disease. Thus, symmetry and regularity are important indicators of human gait. Methods. The effects of age and gender on gait symmetry and regularity were investigated in 87 Japanese participants by measuring trunk accelerometry during a 7-m walk. The younger group included 26 female and 21 male students, and the elderly group included 24 females and 16 males. Average age for each group was 20 and 70 years, respectively. Gait symmetry and regularity were evaluated on the basis of autocorrelation functions of trunk accelerations of vertical and anteroposterior axes. Results: The relationship between age and gait symmetry and regularity was statistically significant for both vertical and anteroposterior axes. Elderly participants showed lower symmetry and regularity in their gait than young participants. A significant gender effect was observed for the symmetry index of both axes but not for the regularity index. Male participants showed lower gait symmetry than females. An interaction effect between age and gender was significant in the symmetry index of anteroposterior acceleration. Gender effect was appeared more clearly in elderly than young participants. Conclusion: Elderly participants showed a more asymmetrical and irregular gait than young participants. In addition to age, a significant gender effect was observed on gait symmetry. However, the effect size of gender was smaller than that of age, and it was not significant for gait regularity. The gait indices obtained by autocorrelation of trunk acceleration can be considered useful to evaluate aging effect on gait. © 2014 Kobayashi et al.; licensee BioMed Central Ltd.

Ooki S.,Ishikawa Prefectural Nursing University
Twin Research and Human Genetics | Year: 2013

To gain widespread participation, epidemiologic studies of twins from pregnancy through the childhood period are expected to reflect the needs and concerns of families and provide participants with appropriate and useful feedback based on scientific evidence. Our most recent database on families with twins throughout Japan is based on a questionnaire survey conducted from January 2010 to August 2011. Mailed or hand-delivered questionnaires, consisting of over 550 items were used to collect the basic data. The response rate was 40% (956/2,401). This is part of a nation-wide study designed to assess the long-term effect of perinatal conditions on mothers of multiples. Its aim was to study the growth and development of multiples in childhood, and to conduct a genetic epidemiologic study to test the developmental origin of health and disease hypothesis. One of the ultimate aims of this research was to provide evidence-based information on parenting multiples from pregnancy through childhood to families with multiples. Copyright © The Authors 2012.

Background: Most twins after assisted reproductive technology (ART) are dizygotic. Analysis of dizygotic twin pairs is useful in assessing familial aggregation in the development of birth defects. Methods: Using nationwide post-ART data from the Japan Society of Obstetrics and Gynecology, recurrence risk ratios (RRRs)-defined as probandwise concordance rates of birth defects in twins divided by the prevalence of birth defects in the general population-were calculated as indicators of familial aggregation. Birth defects were then reclassified according to the ICD-10 categories corresponding to codes Q00-Q99. From 2004 to 2009, there were 17 258 twin pregnancies. Results: At least 1 birth defect was noted in 236 twin pairs: 11 concordant and 225 discordant pairs. Regarding major organ systems, high probandwise concordance rates were observed for congenital malformations of eye, ear, face, and neck (11.8%), cleft lip and cleft palate (10.5%), congenital malformations of the nervous system (9.8%), and other congenital malformations of the digestive system (9.5%). High RRRs were observed for congenital malformations of eye, ear, face, and neck (RRR = 233), specifically other congenital malformations of the ear (RRR = 449); congenital malformations of the great arteries (RRR = 235), specifically those of the patent ductus arteriosus (RRR = 530); and for cleft lip and cleft palate (RRR = 208), specifically cleft palate with cleft lip (RRR = 609). The probandwise concordance rate of any birth defect (8.9%) was nearly identical to the approximated recurrence risk of sib-pairs (8.8%), which assumed multifactorial inheritance. Conclusions: The present findings suggest that familial aggregation is a factor in some birth defects. © 2012 by the Japan Epidemiological Association.

Ooki S.,Ishikawa Prefectural Nursing University
Journal of pregnancy | Year: 2011

The purpose of the present study was to evaluate the relative risk (RR) of multiple births for birth defects after assisted reproductive technology (ART) using Japanese nationwide data from 2004 to 2008 with singletons as the reference group. In multiples compared to singletons, the percentage of birth defects per pregnancy were significantly higher (RR = 1.88, 95% confidence interval (CI) 1.60-2.13), the percentage of birth defects per live birth was not significantly higher (RR = 0.90, 95% CI 0.78-1.05 or RR = 0.94, 95% CI 0.81-1.10), and the early neonatal mortality rate was significantly higher (RR = 2.68, 95% CI 1.52-4.70 or RR = 2.80, 95% CI 1.60-4.92). The early neonatal mortality per 10,000 live births was slightly higher in ART (5.09) than in the general population (3.86). We concluded that the impact of birth defects after ART would be larger in families with multiples compared to families with singletons, since the mean number of children would be larger in the former.

Ooki S.,Ishikawa Prefectural Nursing University
Journal of Pregnancy | Year: 2012

The purpose of the present study was to examine the effect of single embryo transfer (SET) in assisted reproductive technology (ART) on the reduction of the multiple pregnancy rate. We also estimated the monozygotic (MZ) twinning rates according to the SET diffusion indirectly. A reverse sigmoid curve was assumed and examined using nationwide data of SET from 2007 to 2009 in Japan. The multiple pregnancy rate decreased almost linearly where the SET pregnancy rate was between about 40 and 80 of regression approximation. The linear approximation overestimated multiple pregnancy rates in an early period and underestimated multiple pregnancy rates in the final period. The multiple pregnancy rate seemed to be influenced by the improvement of the total pregnancy rate of ART in the early period and by the MZ twinning after SET in the final period. The estimated MZ twinning rate after SET was around 2. © 2012 Syuichi Ooki.

Ooki S.,Ishikawa Prefectural Nursing University
Environmental Health and Preventive Medicine | Year: 2013

Objectives: The purpose of the present study is to clarify the impact of multiple births in fatal child maltreatment (child death due to maltreatment). Methods: The national annual reports on fatal child maltreatment, which contain all cases from July 2003 to March 2011, published by the Ministry of Health, Labor and Welfare of Japan, were used as the initial sources of information. Parent-child murder-suicide cases were excluded from the analyses. Multiple births, teenage pregnancy and low-birthweight were regarded as the exposed groups. The relative risks (RRs) and their 95 % confidence intervals (CIs) were estimated using the data from the above reports and vital statistics. These analyses were performed both including and excluding missing values. Results: Among 437 fatal child maltreatment cases, 14 multiple births from 13 families were identified. The RRs of multiple births per individual were 1.8 (95 % CI 1.0-3.0) when including missing values and 2.7 (95 % CI 1.5-4.8) when excluding missing values. The RRs of multiple births per family were 3.6 (95 % CI 2.1-6.2) when including missing values and 4.9 (95 % CI 2.7-9.0) when excluding missing values. The RR tended to be much lower than the RR of teenage pregnancy (RR 12.9 or 22.2), but slightly higher than the RR of low-birthweight (RR 1.4 or 2.9). Conclusions: Families with multiple births had elevated risk for fatal child maltreatment both per individual and per family unit. Health providers should be aware that multiple pregnancies/births may place significant stress on families and should provide appropriate support and intervention. © 2013 The Japanese Society for Hygiene.

Ooki S.,Ishikawa Prefectural Nursing University
Journal of Epidemiology | Year: 2010

Background: Despite the rapid increase in the rate of multiple births due to the growth of reproductive medicine, there have been no epidemiologic studies of the secular trends in the impact of multiple births on the rates of low-birth-weight and preterm deliveries in Japan. Methods: Japanese vital statistics for multiple live births were obtained from the Ministry of Health, Labour and Welfare and reanalyzed. With singletons as the reference group, an analysis was performed of secular trends in relative risk and population attributable risk percent of low-birth-weight (<2500 grams), very-low-birth-weight (<1500 grams), and extremely-low-birth-weight (<1000 grams) deliveries, using 1975-2008 vital statistics, and of preterm deliveries (ie, before 37, 32, and 28 weeks), using 1979-2008 vital statistics. Results: The rate of multiple births doubled during the past 2 decades, and about 2% of all neonates are now multiples. The population attributable risk percent tended to increase during the same period for all variables, and was approximately 20% in 2008. Conclusions: The public health impact of the rapid increase in multiple births remains high in Japan. © 2010 by the Japan Epidemiological Association.

Ooki S.,Ishikawa Prefectural Nursing University
International Journal of Women's Health | Year: 2013

Background: Older mothers are becoming more common in Japan. One reason for this is the widespread use of assisted reproductive technology (ART). This study assesses the relationship between maternal age and the risk of birth defects after ART. Methods: Nationwide data on ART between 2004 and 2010 in Japan were analyzed. Diseases that were classified as code Q00-Q99 (ie, congenital malformations, deformations, and chromosomal abnormalities) in the International Classification of Diseases, tenth edition, were selected. There were 219,185 pregnancies and 153,791 live births in total ART. Of these, 1943 abortions, stillbirths, or live births with birth defects were recorded. Percentage of multiple birth defects in total birth defects, the prevalence, crude relative risk and 95% confidence interval per 10,000 pregnancies and per 10,000 live births were analyzed according to the maternal age class (ie, 25-29, 30-34 (reference), 35-39, and 40+ years). Results: Multiple birth defects were observed among 14% of the 25-29 year old class, and 8% among other classes when chromosomal abnormalities were excluded. The prevalence of chromosomal abnormalities per pregnancy and per live birth became significantly and rapidly higher in mothers in the age classes of 30-35 and 40+ years. Nonchromosomal birth defects per pregnancy decreased linearly with advanced maternal age, while the number of nonchromosomal birth defects per live birth formed a gradual U-shaped distribution. The prevalence per pregnancy of congenital malformations of the nervous system was significantly lower with advanced maternal age. The relative risk per live birth was significant regarding congenital malformations of the circulatory system for a maternal age of 40+ years. Some other significant associations between maternal age and birth defects were observed. Conclusion: Maternal age is associated with several birth defects; however, older maternal age in itself does not produce noticeable extra risk for nonchromosomal birth defects overall. © 2013 Ooki, publisher and licensee Dove Medical Press Ltd.

The effect of assisted reproductive technology (ART) and non-ART ovulation stimulation fertility treatment on the number and rate of multiple live births from 1979-2008 in Japan was estimated using two independent data sources, ART statistics and vital statistics. Japanese ART statistics presented by the Japan Society of Obstetrics and Gynecology between 1989 and 2008 were gathered and reanalyzed. The number and rates of ART between 1984 and 1988 were interpolated using an approximation formula, using the values from 1983, when the first ART baby was born in Japan, and the 1989-1992 values. The number of ART multiples between 1979-1982 was set as equal to zero. The minimum (or maximum) number of non-ART iatrogenic multiple births was estimated by subtracting the maximum (or minimum) ART multiples from the total iatrogenic multiples, which was estimated by vital statistics assuming that spontaneous multiple-birth rates according to maternal age class would be constant. There was an overall increase in the non-ART multiple births during the 30-year period, whereas ART multiples tended to increase from 1983 to 2005, and then rapidly decreased thereafter. The number or percentage of ART multiples was almost consistently lower than that of non-ART multiples. The percentage of non-ART multiples (33%) among the total multiples was estimated to be about three times more than the ART multiples (11-12%) in 2008. Given the medical and social impact of multiple births, it is imperative to construct a hospital-based monitoring system for fertility treatments, specially non-ART fertility treatments and multiple births.

Ooki S.,Ishikawa Prefectural Nursing University
Journal of Epidemiology | Year: 2011

Background: The present study used vital-statistics data to estimate the effect of maternal age and fertility treatment on the number and rate of multiple live births in Japan from 1974 through 2009. Methods: Japanese vital statistics published by the Ministry of Health, Labour and Welfare from 1974 to 2009 were gathered and reanalyzed with regard to maternal age class and plurality of live births. The numbers of spontaneous and iatrogenic multiple births during 1977-2009 were estimated, with the assumption that spontaneous multiple-birth rates according to maternal age class would be constant and equal to those of baseline values, ie, the means between 1974 and 1976. Results: During the 25-year period, multiple-birth rates according to maternal age class increased after the late 1980s. This tendency was obvious in women aged 35 to 39 years. The estimated numbers of iatrogenic multiple births remained nearly constant in women aged 20 to 24 years and greatly increased in women aged 30 to 34 and 35 to 39 years. The rate (per 1000 live births) of iatrogenic multiple births gradually increased from 0.7 (1977) to 1.3 (1986), then rapidly and markedly increased from 1.3 (1986) to 11.4 (2005), and finally decreased to 8.1 (2009). The estimated maximum percentage of iatrogenic multiple births was 50.0%, in 2004 and 2005. Conclusions: The rapid increases in Japan in the number and rate of multiples born to women older than 30 years are likely due to iatrogenic rather than spontaneous multiple births. © 2011 by the Japan Epidemiological Association.

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