Esfahan, Iran

Isfahan University of Medical science is a university of higher education in basic medical science, clinical medical science and health services in Iran.Isfahan University of Medical science is one of the most prestigious Iranian medical schools and admission to the University is limited to the top students who pass the national entrance examination administered yearly by the Ministry of Culture and Higher Education.The university is located in southern Isfahan, Hezarjarib street.Isfahan University of Medical science provides both undergraduate and graduate programs in 32 main departments. The student body consists of about 12000 students from all the 31 Provinces of Iran and some foreign countries. Funding for Isfahan University of Medical science is provided by the government and some through private investments. Wikipedia.


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Tabesh M.,Isfahan University of Medical Sciences | Salehi-Abargouei A.,Isfahan University of Medical Sciences | Esmaillzadeh A.,Isfahan University of Medical Sciences
Journal of Clinical Endocrinology and Metabolism | Year: 2013

Background: Although several studies have investigated the association between maternal serum vitamin D levels and risk of pre-eclampsia, findings are inconsistent. This systematic review and meta-analysis of published observational studies was conducted to summarize the evidence on the association between maternal serum vitamin D levels and risk of pre-eclampsia. Methods: PubMed, ISI (Web of science), SCOPUS, SCIRUS, Google Scholar, and EMBASE databases weresearched to identify related articles published throughDecember2012. For systematic review, we found 15 articles that assessed the association between maternal serum vitamin D levels and risk of pre-eclampsia. The meta-analysis was done on 8 studies that reported odds ratios or relative risks for pre-eclampsia. Between-study heterogeneity was examined using Cochran's Q test and I2. Subgroup analysis and meta-regression were used to find possible sources of heterogeneity. Results: The meta-analysis on 8 relevant papers revealed an overall significant association between vitamin D deficiency and risk of pre-eclampsia; however, there was significant between-study heterogeneity (I2=52.7%; P=.039). In the subgroup analysis,wefound that the overall effect was significant for studies that defined vitamin D deficiency as 25(OH)D ≤ 50 nmol/L (20 ng/mL), but not for those that considered it as <38 nmol/L (15.2 ng/mL). The association was seen for "cohort or nested case-control studies" as well as for "cross-sectional or case-control studies" (2.78; 1.45- 5.33; P=.002).Whenthe analysis was done by study location, the associations remained significant only for studies that came from the United States. Conclusion: There was a significant relationship between vitamin D deficiency and increased risk of pre-eclampsia. Further studies are required, particularly in developing countries. Copyright © 2013 by The Endocrine Society.


Esmaillzadeh A.,Isfahan University of Medical Sciences | Azadbakht L.,Isfahan University of Medical Sciences
Journal of Nutrition | Year: 2012

Independent association between legume intake and systemic inflammation is not well documented. The traditional Iranian diet provides an opportunity to assess the association between legume intake and health outcomes. This study was carried out to examine legume consumption in relation to serum concentrations of adhesion molecules and inflammatory biomarkers among Iranian women. In this cross-sectional study, 486 Tehrani female teachers were investigated. A trained dietitian administered a validated semiquantitative FFQ for assessment of usual dietary intakes. Legume intake was calculated by summing up the consumption of lentils, peas, chickpeas, different kinds of beans including broad beans, and chickling vetch. To measure serum concentrations of adhesion molecules and inflammatory biomarkers, a fasting blood sample was taken. After statistically controlling for potential confounders, individuals in the highest tertile of legume intake had lower serum concentrations of E-selectin (percent difference between the lowest and highest tertile: -14.1%; P = 0.04), soluble intercellular adhesion molecule-1 (-20.3%; P<0.01), and soluble vascular cell adhesion molecule-1 (-15.6%; P = 0.01) compared with those in the lowest tertile. Legume intake was inversely associated with serum concentrations of high sensitive CRP (hs-CRP), TNFα, and IL-6, even after controlling for potential confounders and dietary variables (percent difference between the lowest and highest tertile for hs-CRP: -39.2%, P<0.001; for TNFα: -15.9%, P = 0.04; and for IL-6: -39.5%, P<0.01). Legume intake and concentrations of serum amyloid A were not correlated. Legume consumption is inversely associated with serum concentrations of adhesion molecules and inflammatory biomarkers among Iranian women. © 2012 American Society for Nutrition.


Tolou-Ghamari Z.,Isfahan University of Medical Sciences
Journal of Nephropathology | Year: 2012

Context: In the meadow of medical sciences substituting a diseased organ with a healthy one from another individual, dead or alive, to allow a human to stay alive could be consider as the most string event. In this article we review the history of transplantation, mechanisms of rejection, nephro-neurotoxicity of tacrolimus and cyclosporin in organ transplantations. Evidence Acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. Results: The first reference to the concept of organ transplantation and replacement for therapeutic purposes appears to be to Hua-To (136 to 208 A.D), who replaced diseased organs with healthy ones in patients under analgesia induced with a mixture of Indian hemp. In 1936, the first human renal transplant performed by Voronoy in Russia. The first liver transplant in humans was performed on March 1, 1963 by Starzl in Denver, USA. Medawar was the first to assert that rejection was an immunological response, with the inflammatory reaction due to lymphocyte infiltration. Consequently, rational immunosuppressive therapies could inhibit deleterious T-cell responses in an antigen specific manner. Conclusions: Searching related to the history of organ transplantation from mythic to modern times suggests that, to prevent graft rejection, minimize nephro and neuro toxicity monitoring of immunosupressive concentrations could provide an invaluable and essential aid in adjusting dosage to ensure adequate immunosuppression. © 2012, Society of Diabetic Nephropathy Prevention. All rights reserved.


Iravani S.,Isfahan University of Medical Sciences
Green Chemistry | Year: 2011

In recent years, the development of efficient green chemistry methods for synthesis of metal nanoparticles has become a major focus of researchers. They have investigated in order to find an eco-friendly technique for production of well-characterized nanoparticles. One of the most considered methods is production of metal nanoparticles using organisms. Among these organisms plants seem to be the best candidates and they are suitable for large-scale biosynthesis of nanoparticles. Nanoparticles produced by plants are more stable and the rate of synthesis is faster than in the case of microorganisms. Moreover, the nanoparticles are more various in shape and size in comparison with those produced by other organisms. The advantages of using plant and plant-derived materials for biosynthesis of metal nanoparticles have interested researchers to investigate mechanisms of metal ions uptake and bioreduction by plants, and to understand the possible mechanism of metal nanoparticle formation in plants. In this review, most of the plants used in metal nanoparticle synthesis are shown. © 2011 The Royal Society of Chemistry.


Shemirani H.,Isfahan University of Medical Sciences
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia | Year: 2012

Contrast-induced nephropathy (CIN) is characterized by acute deterioration of renal function that occurs after parenteral administration of contrast media in the absence of other causes. Although no definite proof has been obtained yet, the risk of diuretics or angiotensin-converting enzyme inhibitors (ACEI) to exacerbate CIN has been reported because of their effects on renal perfusion. This study was conducted to assess the protective effect of hydration alone in the prevention of CIN after percutaneous coronary intervention (PCI) in patients on diuretics or ACEI. This randomized clinical trial was conducted at the Chamran Hospital, Isfahan University of Medical Sciences, Iran, during the years 2006-2007. The study patients were divided into four groups, each group containing 60 patients. Patients in groups A and B were on regular treatment with ACEI (captopril) and patients in groups C and D were on regular diuretic (furosemide) therapy. About 36 h before PCI, captopril in group A and furosemide in group C were discontinued. The serum creatinine (Cr) levels were measured at the time of performing PCI and 24 h and 48 h after PCI in all patients. All patients received 1 mL/kg/h normal saline (0.9%) 12 h before and 24 h after PCI. The occurrence of CIN after PCI was diagnosed based on the following formula: Cr level after PCI - Cr level before PCI. If this value was greater than 0.5 mg/dL, it was coded as one and if the value was less than 0.5 mg/dL, it was coded as zero. The mean difference was analyzed and compared among the four groups by the ANOVA test. Three patients (5%) in group A, two patients (3.3%) in group B, two patients (3.3%) in group C and one patient (1.6%) in group D had a >0.5 mg/dL difference in serum Cr. The difference seen between these groups was not statistically significant (P > 0.05). This study shows that although furosemide and captopril can exacerbate CIN by impairment of renal perfusion, this can be prevented by hydration and discontinuation of furosemide and captopril may not be required.


Nasri H.,Isfahan University of Medical Sciences
Journal of Nephropathology | Year: 2012

Antiphospholipid syndrome (APS) is being increasingly recognized as an important cause of kidney injury due to thrombosis at any location within the renal vasculature. The term antiphospholipid syndrome nephropathy (APSN) refers to the kidney damage caused by vascular lesions in the glomeruli, arterioles and/ or interlobular arteries in patients with antiphospholipid antibodies. APSN manifests with hypertension, acute and/or chronic kidney failure, and often a lowgrade proteinuria. © 2014 by Journal of Nephropathology (JNP).


Baradaran A.,Isfahan University of Medical Sciences
Journal of Nephropathology | Year: 2012

Studies suggested that serum lipoprotein (a) [Lp (a)] concentration may take part in aggravation of diabetic nephropathy. In contrast, some investigators believe that, the association of Lp (a) with diabetic nephropathy is likely to be weak or nonexistent. It seems that serum Lp (a) can be considered as a promising predictive factor for the diagnosis of earlier diabetic nephropathy, However, prospective studies are needed to determine its role. © 2014 by Journal of Nephropathology (JNP).


Saneei P.,Isfahan University of Medical Sciences | Salehi-Abargouei A.,Isfahan University of Medical Sciences | Esmaillzadeh A.,Isfahan University of Medical Sciences
Obesity Reviews | Year: 2013

Background: Although several cross-sectional studies have investigated serum vitamin D levels in relation to body mass index (BMI), findings are inconsistent. Objective: This systematic review and meta-analysis of published cross-sectional data was conducted to summarize the evidence on the link between serum vitamin D levels and BMI in adults. Methods: PubMed, ISI Web of Science, Scopus and Google scholar database were searched to May 2012 for all relevant published papers. We found 34 articles that reported the correlation coefficients between serum 25-hydroxy vitamin D (25(OH)D) levels and BMI in apparently healthy adults (>18 years). The primary analysis was done on these 34 papers that reported 37 correlation coefficients. To find the source of between-study heterogeneity, our secondary analysis was confined to eight studies that had used random sampling method and reported the correlations for the whole population. Results: Our meta-analysis on 34 relevant papers revealed an overall significant inverse, but weak, association between serum 25(OH)D levels and BMI (Fisher's Z=-0.15, 95% CI: -0.19, -0.11) with a significant heterogeneity between studies. In the subgroup analysis based on gender and study location (East vs. West), the inverse associations were significant in both genders (male: Fisher's Z=-0.11, 95% CI: -0.14, -0.08 and female: -0.14, 95% CI: -0.21, -0.08) and both study locations (East: -0.09, 95% CI: -0.14, -0.04 and West: -0.23, 95% CI: -0.31, -0.17). In the subgroup analysis based on developmental status of countries, the weak inverse association remained significant in developed countries (-0.17, 95% CI: -0.21, -0.14), but not in developing nations (-0.10, 95% CI: -0.20, 0.01). Using meta-regression, we found that latitude (P=0.91) or longitude (P=0.2) of cities did not significantly contribute to the computed effect sizes. When we restricted our analysis to eight selected studies that used random sampling method, we reached the same findings. In this analysis, gender and developmental status of countries explained the between-study heterogeneity. Conclusion: There is a significant inverse weak correlation between serum 25(OH)D levels and BMI in adult population, except for women living in developing countries. Further research particularly in developing countries and populations living near the equator is needed. © 2013 The Authors. obesity reviews © 2013 International Association for the Study of Obesity.


Eskandari S.,Isfahan University of Medical Sciences
International journal of nanomedicine | Year: 2011

The treatment of brain disorders is one of the greatest challenges in drug delivery because of a variety of main barriers in effective drug transport and maintaining therapeutic concentrations in the brain for a prolonged period. The objective of this study was delivery of valproic acid (VPA) to the brain by intranasal route. For this purpose, nanostructured lipid carriers (NLCs) were prepared by solvent diffusion method followed by ultrasonication and characterized for size, zeta potential, drug-loading percentage, and release. Six groups of rats each containing six animals received drug-loaded NLCs intraperitoneally (IP) or intranasally. Brain responses were then examined by using maximal electroshock (MES). The hind limb tonic extension:flexion inhibition ratio was measured at 15-, 30-, 60-, 90-, and 120-minute intervals. The drug concentration was also measured in plasma and brain at the most protective point using gas chromatography method. The particle size of NLCs was 154 ± 16 nm with drug-loading percentage of 47% ± 0.8% and drug release of 75% ± 1.9% after 21 days. In vivo results showed that there was a significant difference between protective effects of NLCs of VPA and control group 15, 30, 60, and 90 minutes after treatment via intranasal route (P < 0.05). Similar protective effect was observed in rats treated with NLCs of VPA in intranasal route and positive control in IP route (P > 0.05). Results of drug determination in brain and plasma showed that brain:plasma concentration ratio was much higher after intranasal administration of NLCs of VPA than the positive control group (IP route). In conclusion, intranasal administration of NLCs of VPA provided a better protection against MES seizure.


Sabzghabaee A.M.,Isfahan University of Medical Sciences
Medicinski arhiv | Year: 2012

Natural products are proved to play a good role as an alternative to synthetic chemicals in many clinical conditions. Hypercholesterolemia is the most important risk factor for atherosclerosis. Previous studies showed that Nigella sativa L. has both antioxidant and lipid lowering potentials. To evaluate the efficacy of the seeds of Nigella sativa on the treatment of hyperlipidemia. In this randomized, placebo controlled clinical trial which was conducted in Isfahan city (Iran), 88 subjects aged > or =18 years with a total cholesterol concentration >200 mg/dl were included. According to the patients" profiles number, they were randomized to receive either N. sativa capsules or the matching placebo. Each N sativa capsule contained 500 +/- 10 mg N. sativa crushed seeds, and patients had to take 2 g N. sativa per day for 4 weeks. Fasting baseline laboratory values (fasting blood sugar, total cholesterol, low density lipoprotein, high density lipoprotein and triglyceride) were obtained for all parameters on each subject prior to the start of the study and at the end of 4 weeks. In our study a significant decrease was observed in the concentration of total cholesterol (4.78%), Low density lipoprotein (7.6%) and Triglyceride (16.65%), and this decrease was more significant for TG concentration. N. sativa had not any beneficial effects on Fasting blood sugar and High density lipoprotein. According to the results of our present study it seems that N. sativa may have some beneficial therapeutic effects in the treatment of hyperlipidemia. However, further investigations with a larger sample size are necessary.

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