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WEST PALM BEACH, FL, United States

Feng L.,University of Illinois at Urbana - Champaign | Musto C.J.,University of Illinois at Urbana - Champaign | Kemling J.W.,University of Illinois at Urbana - Champaign | Lim S.H.,Isense, Llc | Suslick K.S.,University of Illinois at Urbana - Champaign
Chemical Communications | Year: 2010

A colorimetric sensor array has been developed for the rapid and sensitive detection of 20 toxic industrial chemicals (TICs) at their PELs (permissible exposure limits). The color changes in an array of chemically responsive nanoporous pigments provide facile identification of the TICs with an error rate below 0.7%. © The Royal Society of Chemistry. Source

Embodiments of the present invention provide a device and method for treating animal skin to produce tautness in the skin during the insertion of an analyte sensor. A device in accordance with embodiments of the present invention includes a housing that partially encloses a cavity and is adapted for mounting onto animal skin and a sensor insertion module adapted to insert an analyte sensor through animal skin.

Embodiments of the present invention provide for raising a background current setting for a biosensor above the actual (measured) background current present (i.e., overestimating the background current), particularly in the hypoglycemic range, to improve sensor accuracy and decrease the chance of glucose value overestimation by the sensor.

Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase II | Award Amount: 1000.00K | Year: 2016

DESCRIPTION provided by applicant Sepsis is the leading cause of deaths in US hospitals contributing to or causing of all US hospital deaths and is the most expensive condition treated in US hospitals costing more than $ billion annually More than million blood culture bottles are produced annually with a market size greater than $ B in the US and EU alone The two year phase II period spanned February to February R AI The developments funded in part by this grant have created a new paradigm to diagnose blood stream infection causing sepsis The work of this grant has assisted in creating the SpecID blood culture system which the company is now commercializing The SpecID solution replaces the present step process for characterization of blood samples currently divided into detection of infection an obligatory Gram stain for all positive cultures performed on the bench by trained technician and then species ID by MALDI TOF again requiring skilled sample preparation The SpecID solution combines faster detection more accurate Gram status determination than the benchtop stain and ID more accurate than MALDI in a single fully automated step which reduces the time to ID streamlines lab workflow and saves significant cost The result is improved patient outcomes and improved lab operating performance Phase IIB aims address application to clinical human specimens along with development of instruments and media appropriate for commercial use The objectives of this proposal reflect the major goals required to achieve commercial entry of the SpecID smart culture system into commercial high volume laboratories including development of the SpecID blood culture instrument blood culture bottle sensor attachment and the clinical and analytical studies to prove performance gain regulatory approval and make first sales PUBLIC HEALTH RELEVANCE Sepsis is the leading cause of deaths in US hospitals contributing to or causing of all US hospital deaths and is the most expensive condition treated in US hospitals costing for than $ billion annually Rapid identification of the infectio is critical for effective treatment The ultimate goal of this project is to bring hospitals a new technology solution that reduces the time to identification in a single automated instrument The result is improved patient outcomes and importantly in todayandapos s cost critical healthcare system the solution is less expensive than current practice

Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 149.74K | Year: 2013

DESCRIPTION (provided by applicant): Acute pesticide poisoning remains a vast health problem in the developed and developing world. Domestically, a 2004 study estimates that 18 of every 100,000 US agricultural workers suffer from acute pesticide poisoningand a 2002 study of California air found dangerous levels of three pesticides in urban areas. Since pesticides are primarily applied by sprayers or aerially from planes, where spray drift can translate pesticides far from their targeted areas, widespread monitoring of pesticide concentration at the site of their use and in surrounding areas is required to protect the public from dangerous levels of exposure. However, current monitoring strategies are too slow and costly to do this on a widespread scale. iSense, LLC has developed a novel sensor technology that can detect various toxic industrial chemicals (TICs) across multiple chemical moieties below their permissible exposure (PEL) limit. The technology is rapid, inexpensive and capable of distinguishing between TICS as well as complex mixtures of compounds. We propose to test, improve and optimize this technology toward the detection and identification of organophosphate pesticides, the leading type of pesticide identified in US pesticide poisoning. If successful, iSense technology could drastically reduce unhealthy pesticide exposure and improve medical treatment by simultaneously identifying the pesticides responsible for pesticide poisoning. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Theproposed research will develop and test a novel array based sensor technology for the detection and identification of organophosphate pesticides. If successful, the proposed effort will yield technology to rapidly detect and identify pesticides, drastically reducing unhealthy pesticide exposure and allowing for the prompt administration of appropriate medical treatment when unhealthy exposure persists.

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