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Buenos Aires, Argentina

Bendtsen L.,Copenhagen University | Munksgaard S.B.,Copenhagen University | Tassorelli C.,University of Pavia | Nappi G.,University of Pavia | And 7 more authors.
Cephalalgia | Year: 2014

Objective: The objective of this article is to investigate whether headache-related disability, depression and anxiety can be reduced by detoxification and prophylactic treatment in patients with medication-overuse headache (MOH). Methods: Patients with MOH were included from six centres in Europe and Latin America in a seven-month cohort study. Before and six months after treatment, the degree of disability was measured by the Migraine Disability Assessment (MIDAS) questionnaire, while anxiety and depression were measured by the Hospital Anxiety and Depression Scale (HADS). Results: A total of 694 patients with MOH were included, of whom 492 completed the study. Headache days were reduced by 58.4% from 23.6 to 9.8 days per month at six months (p<0.001). The MIDAS score was reduced by 57.1% from baseline 59.9 to 25.7 (p<0.001). Number of patients with depression was reduced by 50.7% from 195 to 96 and number of those with anxiety was reduced by 27.1% from 284 to 207 (both p<0.001). Conclusions: Disability, depression and anxiety were considerably reduced in patients with MOH by detoxification and prophylactic treatment. This emphasises the urgent need for increased awareness about avoiding overuse of headache medications and demonstrates that not only headache frequency but also disability are remarkably improved by adequate intervention. © 2013 International Headache Society. Source


Tassorelli C.,University of Pavia | Jensen R.,Copenhagen University | Allena M.,University of Pavia | De Icco R.,University of Pavia | And 8 more authors.
Cephalalgia | Year: 2014

Introduction: The management of medication-overuse headache (MOH) is often difficult and no specific guidelines are available as regards the most practical and effective approaches. In this study we defined and tested a consensus protocol for the management of MOH on a large population of patients distributed in different countries. Subjects and methods: The protocol was based on evidence from the literature and on consolidated expertise of the members of the consensus group. The study was conducted according to a multicentric interventional design with the enrolment of 376 MOH subjects in four centres from Europe and two centres in Latin America. The majority of patients were treated according to an outpatient detoxification programme. The post-detoxification follow-up lasted six months. Results: At the final evaluation, two-thirds of the subjects were no longer overusers and in 46.5% of subjects headache had reverted back to an episodic pattern of headache. When comparing the subjects who underwent out-patient detoxification vs those treated with in-patient detoxification, both regimens proved effective, although the drop-out rate was higher in the out-patient approach. Conclusions: The present findings support the effectiveness and usability of the proposed consensus protocol in different countries with different health care modalities. © International Headache Society 2014. Source


ISALUD University | Entity website

Licenciatura en Gestin Ambiental La Licenciatura en Gestin Ambiental de la Universidad Isalud se caracteriza por tener un enfoque interdisciplinario e integrador de las variables que intervienen en el fenmeno ambiental. Esta perspectiva permitir a los profesionales egresados intervenir en la regulacin de los distintos aspectos de la evaluacin y la explotacin de recursos, la produccin industrial, la competitividad y el posicionamiento de las industrias en el mercado, el desarrollo de nuevos productos, los emprendimientos energticos y el anlisis de proyectos de inversin ...


ISALUD University | Entity website

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ISALUD University | Entity website

Centro de Estudios en Salud Mental (CESAM) Direccin Dr. Hugo Barrionuevo Mdico Psiquiatra (UBA), Mdico Sanitarista (Academia Nacional de Medicina), Especialista en Garanta de Calidad de la Atencin Mdica (Univ ...

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