Isabella Thoburn College

Lucknow, India

Isabella Thoburn College

Lucknow, India

Time filter

Source Type

Sanghi D.,University of Lucknow | Mishra A.,University of Lucknow | Sharma A.C.,University of Lucknow | Raj S.,Ramaiah Medical College | And 5 more authors.
Journal of the American College of Nutrition | Year: 2015

Background and Objective: Nutritional imbalance, combined with endocrine abnormalities, may be involved in the pathogenesis of osteoarthritis (OA). This study was conducted to determine the association of OA with dietary factors, such as quantity and quality of nutrient intake.Methods: This case-control study enrolled 180 knee osteoarthritis (KOA) subjects who met the American College of Rheumatology definition of KOA, with an equal number of matched controls. Outcome measures, such as dietary nutrient intake and its frequency, were recorded using a food frequency questionnaire.Results: Compared to controls, cases were older individuals with a higher body mass index (BMI). Physical activity scores were lower in female cases compared to male cases and controls. A significantly higher intake of phosphorus and fat was observed in overall cases (fat in females only). A significantly lower intake of vitamin C and vitamin D was observed in overall cases and the significance of vitamin D persisted on gender-wise bifurcation. On multiple logistic regression analysis, the intake of vitamin D (odds ratio [OR] = 0.79) and vitamin C (OR = 0.97) was inversely associated with the presence of KOA in the observation group, especially in females. Generally, the intake of food servings/day, green leafy vegetables (GLVs), and fats/oils was higher, whereas the intake of fruits, milk/milk products, and meat/poultry was lower in cases compared to controls.Conclusion: Low intake of vitamin D and vitamin C is a possible risk factor for KOA. Certain food groups, such as fruits, milk/milk products, and meat/poultry are beneficial for KOA. Further studies are needed to elucidate the associations between diet and KOA. © 2015, Copyright © American College of Nutrition.


Varma-Basil M.,University of Delhi | Garima K.,University of Delhi | Pathak R.,University of Delhi | Pathak R.,Oakland University | And 5 more authors.
Journal of Clinical Microbiology | Year: 2013

The limitations of conventional methods of identification of Mycobacterium tuberculosis have led to the development of several nucleic acid amplification techniques which have the advantage of being rapid, sensitive, and specific. However, their expense or the need for technical expertise makes it difficult to use them in regions in which tuberculosis is endemic. A novel PCR restriction analysis (PRA) of the hsp65 gene was therefore developed for rapid screening of clinical isolates to identify Mycobacterium spp. The restriction enzymes NruI and BamHI were selected to obtain a limited number of restriction patterns to further differentiate between Mycobacterium tuberculosis complex (MTBC) and nontuberculous mycobacteria (NTM). Three hundred ten isolates from clinical specimens and 24 reference strains were tested. The assay correctly identified 295 of the 310 culture isolates as MTBC, while the remaining 15 isolates were identified as NTM. Of the isolates tested, 135 MTBC strains and all 15 NTM were also confirmed by PRA using Sau96I and CfoI. Thirty-eight randomly selected MTBC strains and all 15 NTM were further confirmed by sequencing. The NruI/BamHI PRA was simple, as it did not require any elaborate analyses. It was cost-effective, rapid, highly sensitive, and specific and did not require technical expertise. The assay can, therefore, be used as a simple screening test not only to detect Mycobacterium spp. but also to differentiate MTBC from NTM in peripheral laboratories with minimal availability of funds. © 2013, American Society for Microbiology.


Dixit S.,University of Lucknow | Agarwal G.G.,University of Lucknow | Singh J.V.,University of Lucknow | Kant S.,University of Lucknow | Singh N.,Isabella Thoburn College
Indian Journal of Community Medicine | Year: 2011

Background: Perceived body image is an important potential predictor of nutritional status. Body image misconception during adolescence is unexplored field in Indian girls. Objectives: To study the consciousness of adolescent girls about their body image. Materials and Methods: This multistage observational study was conducted on 586 adolescent girls of age 10-19 years in Lucknow district (151 from rural, 150 from slum, and 286 from urban area) of Uttar Pradesh, India. Information on desired and actual body size was collected with the help of predesigned questionnaire. Results: 20.5% of studied girls show aspiration to become thin, who already perceived their body image as too thin. 73.4% adolescent girls were satisfied with their body image, while 26.6% were dissatisfied. The dissatisfaction was higher among girls of urban (30.2%) and slum (40.0%) areas in comparison to rural (22.5%) area. Percentage of satisfied girls was less in the 13-15 years (69.9%) age groups in comparison to 10-12 years (76.5%) and 16-19 years (76.4%). Among girls satisfied with their body image, 32.8% girls were found underweight, and 38.4% were stunted. Underweight girls (42.1%) and stunted girls (64.9%) were higher in number within satisfied girls of slum area. Among all of these adolescent girls, 32.8% of girls had overestimated their weight, while only 4.9% of girls had underestimated their weight. Conclusions: This study concludes that desire to become thin is higher in adolescent girls, even in those who already perceived their body image as too thin.


Ahmad R.,Eras Lucknow Medical College & Hospital | Khan T.,Isabella Thoburn College | Ahmad B.,Eras Lucknow Medical College & Hospital | Misra A.,Eras Lucknow Medical College & Hospital | Balapure A.K.,CSIR - Central Electrochemical Research Institute
Parasitology Research | Year: 2016

Tapeworms (cestodes) are segmented flatworms responsible for causing diseases that may prove fatal and difficult to treat in the absence of proper treatment and efficient drugs. Neurocysticercosis (NCC) is a common parasitic infection of the central nervous system and a major contributor to epilepsy caused by the metacestode (larva) of the human tapeworm Taenia solium, characterized by a range of pathological symptoms including epileptic seizures, headaches, and hydrocephalus. Cysticercosis is considered as a “biological imprint” of the socioeconomic development of a community in general and a country in particular. It is the single most common cause of epilepsy in the resource-poor endemic regions of the world, including most of South and Central America, India, Southeast Asia, China, and sub-Saharan Africa. A vast degree of variation in the neuropathology and clinical symptoms of NCC often makes it difficult to diagnose and manage. To add to it, emerging drug resistance to known anti-parasitic agents, together with the inability of these agents to prevent re-infection and relapse, further complicates the disease scenario. The aim of the current review was to provide the latest update on NCC with special emphasis on the Indian scenario, along with current and novel methods of diagnosis as well as scope of development for novel detection techniques, novel targets for drug development, and therapeutic interventions, as well as future challenges. © 2016 Springer-Verlag Berlin Heidelberg


Gupta B.,Chhatrapati Shahuji Maharaj Medical University | Kant S.,Chhatrapati Shahuji Maharaj Medical University | Mishra R.,Isabella Thoburn College
International Journal of Tuberculosis and Lung Disease | Year: 2010

BACKGROUND: Identifying chronic obstructive pulmonary disease (COPD) patients with malnutrition is important to prevent associated mortality due to poor pulmonary function. There is currently no consensus regarding the application of the subjective global assessment (SGA) tool in Indian patients. OBJECTIVE: To assess nutritional status using the SGA method in Indian COPD patients. METHODS: A total of 106 hospitalised patients with COPD were included (mean age 55.58 ± 7.82, male/female = 92/14). Pulmonary function tests, anthropometric measurements and biochemical tests were conducted in all subjects. The association of SGA scores (A, B or C) and body mass index (BMI) groups with other biochemical parameters were tested for statistical signifi cance. RESULTS: Of the 106 patients, 83% were malnourished (BMI < 20 kg/m 2). According to SGA scores, 17.0% were well nourished, 59.5% were moderately malnourished and 23.5% were severely malnourished. SGA scores correlated positively with pulmonary function parameters and negatively with anthropometric parameters. However, there was no correlation for biochemical parameters. CONCLUSION: The SGA is a simple screening tool for the assessment of the nutritional status of COPD patients in India. © 2010 The Union.


Lawrence A.,Isabella Thoburn College | Fatima N.,Isabella Thoburn College
Proceedings of the Air and Waste Management Association's Annual Conference and Exhibition, AWMA | Year: 2014

Particulate matter (PM10, PM2.5, and PM1.0) on indoors in 10 residential homes consisting of five roadside and five urban homes in different microenvironments of Lucknow were studied. The main indoor sources contributing to the elevated particulate concentrations were identified. Survey of houses suggested that outdoor sources as well as indoor activities influenced the coarse and specially the fine particulate concentrations of indoors in houses located in different microenvironments in all the seasons. PM10, PM2.5, and PM1.0 concentrations were maximum during winters, in which large amount of anthropogenic pollutants emissions exist due to increase human activities and more space heating. Household activities, e.g., cooking on stoves, indoor smoking, and outdoor vehicular traffic, and garbage burning were the major sources of particulate emissions indoor. This is an abstract of a paper presented at the AWMA's 107th Annual Conference & Exhibition (Long Beach, CA 6/24-27/2014).


Lawrence A.,Isabella Thoburn College | Fatima N.,Isabella Thoburn College
Science of the Total Environment | Year: 2014

Investigations were carried out during the summer season (March-June 2012) to observe the quality of indoor air by monitoring the levels of some selected air pollutants at 15 different houses covering the urban areas of Lucknow City. Concentrations of CO2, CO, PM10, PM2.5, SO2 and NO2 were monitored indoors and outdoors simultaneously and I/O ratios were calculated. Regression analysis for I/O relationship was performed to assess the contribution of outdoor sources to indoor air quality. Air Quality Index (AQI) for indoor air was also calculated to have an idea about the quality of indoor air and their health effects. In collaboration with the medical college doctors of the city, we surveyed 197 persons to find out different diseases/symptoms being faced due to indoor air pollution. Results of the study revealed that the average levels of PM10 and PM2.5 were above the permissible limits laid by WHO at densely populated and roadside sites with 189μg/m3 (PM2.5 76μg/m3) and 226μg/m3 (PM2.5 91μg/m3) respectively. Correlation analysis showed positive results. At sites like Alambagh and Chowk, the indoor AQI range was alarming with the values of 302 and 209. Survey results also showed that 46% of urban people suffered from acute respiratory infections like bronchial asthma, headache, depression and dizziness and these people were mostly from Roadside colonies. © 2013 Elsevier B.V.


Kushwaha S.,Punjab Agricultural University | Betsy A.,Isabella Thoburn College | Chawla P.,Punjab Agricultural University
Studies on Ethno-Medicine | Year: 2012

Ashwagandha (Withania somnifera) is widely used in Ayurvedic medicine, and it is one of the ingredients in many formulations to increase energy, improve overall health and longevity, and prevent disease. The main objective of the study was to analyze the efficacy of Ashwagandha root powder with water and with milk in treatment of hypertension. The experiment was conducted on 51 stress-oriented hypertensive subjects in the age group of 40 to 70 years, selected by purposive sampling. Subjects were divided into group I and group II. Supplementation of 2gm of Ashwagandha root powder was given to group I and group II with milk and water respectively in morning. Blood pressure was also recorded over a period of three months. Overall decrease in systolic blood pressure was found though it was non- significant. Further, decrease in systolic blood pressure was significant in group I, whereas decrease in diastolic blood pressure was significant in both the groups. Hence, supplementation of Ashwagandha with milk is recommended in treatment of stress- oriented hypertension. © Kamla-Raj 2012.


PubMed | Isabella Thoburn College
Type: | Journal: The Science of the total environment | Year: 2014

Investigations were carried out during the summer season (March-June 2012) to observe the quality of indoor air by monitoring the levels of some selected air pollutants at 15 different houses covering the urban areas of Lucknow City. Concentrations of CO2, CO, PM10, PM2.5, SO2 and NO2 were monitored indoors and outdoors simultaneously and I/O ratios were calculated. Regression analysis for I/O relationship was performed to assess the contribution of outdoor sources to indoor air quality. Air Quality Index (AQI) for indoor air was also calculated to have an idea about the quality of indoor air and their health effects. In collaboration with the medical college doctors of the city, we surveyed 197 persons to find out different diseases/symptoms being faced due to indoor air pollution. Results of the study revealed that the average levels of PM10 and PM2.5 were above the permissible limits laid by WHO at densely populated and roadside sites with 189 g/m(3) (PM2.5 76 g/m(3)) and 226 g/m(3) (PM2.5 91 g/m(3)) respectively. Correlation analysis showed positive results. At sites like Alambagh and Chowk, the indoor AQI range was alarming with the values of 302 and 209. Survey results also showed that 46% of urban people suffered from acute respiratory infections like bronchial asthma, headache, depression and dizziness and these people were mostly from Roadside colonies.


PubMed | Eras Lucknow Medical College & Hospital, CSIR - Central Electrochemical Research Institute and Isabella Thoburn College
Type: Review | Journal: Parasitology research | Year: 2016

Tapeworms (cestodes) are segmented flatworms responsible for causing diseases that may prove fatal and difficult to treat in the absence of proper treatment and efficient drugs. Neurocysticercosis (NCC) is a common parasitic infection of the central nervous system and a major contributor to epilepsy caused by the metacestode (larva) of the human tapeworm Taenia solium, characterized by a range of pathological symptoms including epileptic seizures, headaches, and hydrocephalus. Cysticercosis is considered as a biological imprint of the socioeconomic development of a community in general and a country in particular. It is the single most common cause of epilepsy in the resource-poor endemic regions of the world, including most of South and Central America, India, Southeast Asia, China, and sub-Saharan Africa. A vast degree of variation in the neuropathology and clinical symptoms of NCC often makes it difficult to diagnose and manage. To add to it, emerging drug resistance to known anti-parasitic agents, together with the inability of these agents to prevent re-infection and relapse, further complicates the disease scenario. The aim of the current review was to provide the latest update on NCC with special emphasis on the Indian scenario, along with current and novel methods of diagnosis as well as scope of development for novel detection techniques, novel targets for drug development, and therapeutic interventions, as well as future challenges.

Loading Isabella Thoburn College collaborators
Loading Isabella Thoburn College collaborators