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Lucknow, India

Prasad U.,Isabella Thoburn College | Singh G.,Sam Higginbottom Institute of Agriculture, Technology and Sciences | Pant A.B.,Indian Institute of Toxicology Research
Toxicology International | Year: 2012

An online human health risk assessment system (OHHRAS) has been designed and developed in the form of a prototype database-driven system and made available for the population of India through a website - www.healthriskindia. in. OHHRAS provide the three utilities, that is, health survey, health status, and bio-calculators. The first utility health survey is functional on the basis of database being developed dynamically and gives the desired output to the user on the basis of input criteria entered into the system; the second utility health status is providing the output on the basis of dynamic questionnaire and ticked (selected) answers and generates the health status reports based on multiple matches set as per advise of medical experts and the third utility bio-calculators are very useful for the scientists/researchers as online statistical analysis tool that gives more accuracy and save the time of user. The whole system and database-driven website has been designed and developed by using the software (mainly are PHP, My-SQL, Deamweaver, C++ etc.) and made available publically through a database-driven website (www.healthriskindia.in), which are very useful for researchers, academia, students, and general masses of all sectors. Source

Jain P.,University of Lucknow | Kant S.,University of Lucknow | Mishra R.,Isabella Thoburn College
Journal of the American College of Nutrition | Year: 2011

Background and Objective: The role of food allergy in asthma is well recognized but is poorly quantified. The aim of the present study was to document perceived food items as allergens and to determine their association with age, sex, socioeconomic status (SES), family history of asthma, smoking history, duration of illness, and total serum immunoglobulin (Ig)E. Methods: A total of 261 clinically and spirometrically diagnosed patients with asthma were included in this study on an accrual basis. Of these, 237 patients thought that their asthma became aggravated after consumption of at least 1 food item. The perceived food item allergy and its association with age, sex, SES, family history of asthma, smoking history, duration of illness, and total serum IgE were assessed using a detailed, open-ended questionnaire. Results: Food items were perceived as main allergens by 90% (237/261) of responders. Sixty-five percent (154/237) of patients who perceived at least 1 food item as an allergen had high total serum IgE levels. Of 22 suspected food items, 16 were significantly (p<0.05) associated with at least 1 of the 6 study parameters. Conclusion: Food items play a major role as food allergens on the basis of perception in asthmatic individuals. Some suspected food items are significantly associated with the demographic profile of asthmatic individuals. Source

Dixit S.,University of Lucknow | Agarwal G.G.,University of Lucknow | Singh J.V.,University of Lucknow | Kant S.,University of Lucknow | Singh N.,Isabella Thoburn College
Indian Journal of Community Medicine | Year: 2011

Background: Perceived body image is an important potential predictor of nutritional status. Body image misconception during adolescence is unexplored field in Indian girls. Objectives: To study the consciousness of adolescent girls about their body image. Materials and Methods: This multistage observational study was conducted on 586 adolescent girls of age 10-19 years in Lucknow district (151 from rural, 150 from slum, and 286 from urban area) of Uttar Pradesh, India. Information on desired and actual body size was collected with the help of predesigned questionnaire. Results: 20.5% of studied girls show aspiration to become thin, who already perceived their body image as too thin. 73.4% adolescent girls were satisfied with their body image, while 26.6% were dissatisfied. The dissatisfaction was higher among girls of urban (30.2%) and slum (40.0%) areas in comparison to rural (22.5%) area. Percentage of satisfied girls was less in the 13-15 years (69.9%) age groups in comparison to 10-12 years (76.5%) and 16-19 years (76.4%). Among girls satisfied with their body image, 32.8% girls were found underweight, and 38.4% were stunted. Underweight girls (42.1%) and stunted girls (64.9%) were higher in number within satisfied girls of slum area. Among all of these adolescent girls, 32.8% of girls had overestimated their weight, while only 4.9% of girls had underestimated their weight. Conclusions: This study concludes that desire to become thin is higher in adolescent girls, even in those who already perceived their body image as too thin. Source

Masih J.,Wilson College | Lawrence A.J.,Isabella Thoburn College | Singhvi R.,U.S. Environmental Protection Agency | Taneja A.,Dr. B.R. Ambedkar University
10th International Conference on Healthy Buildings 2012 | Year: 2012

Twenty-three polycyclic aromatic hydrocarbons (PAHs) were measured simultaneously in indoor and outdoor environments of rural houses in a semiarid region of rural India during winter, summer and rainy season (November 2008 - September 2009). The concentration of TPAHs in the homes was 1324.12 ng/m 3 in indoor with an average concentration of 77.88 ng/m3 and in outdoor air it was 1627.04 ng/m3 with an average of 73.95 ng/m3. The concentration of PAH in indoor air ranged from 12.80±2.21 to 645.83±206.99 ng/m3, whereas in outdoor air it ranged from 16.64±2.63 to 720.33±361.22 ng/m3. The total concentration of PAHs in winter season was 53.19%, 48.28% higher in indoor and outdoor from summer season and from rainy season it was 162.58% (indoor), 167.56% (outdoors) higher. The two, three and four rings PAHs were predominantly in vapor phase while the five and six rings PAHs were primarily associated with the particulate phase. Among the 23 studied PAHs, naphthalene was the most abundant PAH contributed 29-55% of the sum of the total PAHs concentartion. The trend of the concentrations of the major PAHs found in present study were Nap>2 Methyl Nap>1 Methyl Nap>Biphenyl> Acenapthylene at indoor and outdoor atmosphere in the rural homes. The average B(a)P-equivalent exposure, calculated by using toxic equivalent factors (TEFs) was 16.24 ng/m3 in indoor and 41.46 ng/m3 in outdoor air. Factor analysis revealed that in indoor sources of PAHs were oil fumes, smoking and incense burning whereas in outdoor PAHs mainly generated from biomass burning, cooking activities and diesel exhaust. Source

Varma-Basil M.,University of Delhi | Garima K.,University of Delhi | Pathak R.,University of Delhi | Pathak R.,Oakland University | And 5 more authors.
Journal of Clinical Microbiology | Year: 2013

The limitations of conventional methods of identification of Mycobacterium tuberculosis have led to the development of several nucleic acid amplification techniques which have the advantage of being rapid, sensitive, and specific. However, their expense or the need for technical expertise makes it difficult to use them in regions in which tuberculosis is endemic. A novel PCR restriction analysis (PRA) of the hsp65 gene was therefore developed for rapid screening of clinical isolates to identify Mycobacterium spp. The restriction enzymes NruI and BamHI were selected to obtain a limited number of restriction patterns to further differentiate between Mycobacterium tuberculosis complex (MTBC) and nontuberculous mycobacteria (NTM). Three hundred ten isolates from clinical specimens and 24 reference strains were tested. The assay correctly identified 295 of the 310 culture isolates as MTBC, while the remaining 15 isolates were identified as NTM. Of the isolates tested, 135 MTBC strains and all 15 NTM were also confirmed by PRA using Sau96I and CfoI. Thirty-eight randomly selected MTBC strains and all 15 NTM were further confirmed by sequencing. The NruI/BamHI PRA was simple, as it did not require any elaborate analyses. It was cost-effective, rapid, highly sensitive, and specific and did not require technical expertise. The assay can, therefore, be used as a simple screening test not only to detect Mycobacterium spp. but also to differentiate MTBC from NTM in peripheral laboratories with minimal availability of funds. © 2013, American Society for Microbiology. Source

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