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Cuevas P.,IRYCIS | Sueiro A.,Hospital Universitario Ramon y Cajal | Navio P.,Hospital Universitario Ramon y Cajal | Gimenez-Gallego G.,CSIC - Biological Research Center
BMJ Case Reports | Year: 2012

The effectiveness of local application, by inhalation, of dobesilate, an inhibitor of fibroblast growth factor signalling, in a patient with squamous cell lung carcinoma is reported. To our knowledge, these are the first published data on the efficacy of dobesilate in the treatment of this disease. The antimitotic, antiangiogenic, proapoptotic and anti-inflammatory activities of dobesilate can be important factors to consider, in explaining the efficacy of the treatment. Dobesilate administration can be a therapeutic option in patients with lung cancer having poor performance status or severe complications. Copyright 2012 BMJ Publishing Group. All rights reserved.


Cuevas P.,Alfonso X El Sabio University | Cuevas P.,Hospital Of Dia Pio Xii | Outeirino L.A.,Hospital Of Dia Pio Xii | Azanza C.,Hospital Of Dia Pio Xii | And 2 more authors.
Military Medical Research | Year: 2015

Background: Dry eye is a multifactor disease of the tear film and ocular surface that substantially affects quality of life. Case presentation: Dobesilate administered as eye drops was well tolerated and effective in treating both the objective signs and subjective symptoms of dry eye disease in this 2-week study. Conclusion: To the best of our knowledge, this is the first clinical report of using dobesilate in eye drops. Dobesilate may provide a novel approach to treating drying diseases of the eye. © 2015 Cuevas et al.


The effectiveness of local application, by inhalation, of dobesilate, an inhibitor of fibroblast growth factor signalling, in a patient with squamous cell lung carcinoma is reported. To our knowledge, these are the first published data on the efficacy of dobesilate in the treatment of this disease. The antimitotic, antiangiogenic, proapoptotic and anti-inflammatory activities of dobesilate can be important factors to consider, in explaining the efficacy of the treatment. Dobesilate administration can be a therapeutic option in patients with lung cancer having poor performance status or severe complications.


PubMed | IRYCIS
Type: | Journal: BMJ case reports | Year: 2012

The effectiveness of local application, by inhalation, of dobesilate, an inhibitor of fibroblast growth factor signalling, in a patient with squamous cell lung carcinoma is reported. To our knowledge, these are the first published data on the efficacy of dobesilate in the treatment of this disease. The antimitotic, antiangiogenic, proapoptotic and anti-inflammatory activities of dobesilate can be important factors to consider, in explaining the efficacy of the treatment. Dobesilate administration can be a therapeutic option in patients with lung cancer having poor performance status or severe complications.

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