La Riche, France
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Valensi P.,Paris Nord University | Extramiana F.,University Paris Diderot | Lange C.,French Institute of Health and Medical Research | Lange C.,University Paris - Sud | And 6 more authors.
Diabetic Medicine | Year: 2011

Objectives To evaluate in a general population, the relationships between dysglycaemia, insulin resistance and metabolic variables, and heart rate, heart rate recovery and heart rate variability. Methods Four hundred and forty-seven participants in the Data from an Epidemiological Study on the Insulin Resistance syndrome (DESIR) study were classified according to glycaemic status over the preceding 9years. All were free of self-reported cardiac antecedents and were not taking drugs which alter heart rate. During five consecutive periods: rest, deep breathing, recovery, rest and lying to standing, heart rate and heart rate varability were evaluated and compared by ANCOVA and trend tests across glycaemic classes. Spearman correlation coefficients quantified the relations between cardio-metabolic risk factors, heart rate and heart rate varability. Results Heart rate differed between glycaemic groups, except during deep breathing. Between rest and deep-breathing periods, patients with diabetes had a lower increase in heart rate than others (Ptrend<0.01); between deep breathing and recovery, the heart rate of patients with diabetes continued to increase, for others, heart rate decreased (Ptrend<0.009). Heart rate was correlated with capillary glucose and triglycerides during the five test periods. Heart rate variability differed according to glycaemic status, especially during the recovery period. After age, sex and BMI adjustment, heart rate variability was correlated with triglycerides at two test periods. Change in heart rate between recovery and deep breathing was negatively correlated with heart rate variability at rest, (r=-0.113, P<0.05): lower resting heart rate variability was associated with heart rate acceleration. Conclusions Heart rate, but not heart rate variability, was associated with glycaemic status and capillary glucose. After deep breathing, heart rate recovery was altered in patients with known diabetes and was associated with reduced heart rate variability. Being overweight was a major correlate of heart rate variability. © 2011 The Authors. Diabetic Medicine © 2011 Diabetes UK.

Skilton M.R.,Baker IDI Heart and Diabetes Institute | Chin-Dusting J.P.F.,Baker IDI Heart and Diabetes Institute | Dart A.M.,Baker IDI Heart and Diabetes Institute | Brazionis L.,University of Melbourne | And 6 more authors.
Atherosclerosis | Year: 2011

Objective: To determine which metabolic and cardiovascular risk factors are associated with the change in ankle brachial pressure index and incident peripheral arterial disease over 9 years, and whether these associations differ between healthy weight and overweight & obese individuals. Methods: Metabolic factors, change in ankle brachial pressure index and incidence of peripheral arterial disease (ankle brachial pressure index <0.90) over 9-years were determined in 2139 healthy weight and 1453 overweight & obese participants from the D.E.S.I.R. study. Results: Fasting glucose, insulin, HDL-cholesterol, systolic blood pressure and pulse pressure were all directly associated with the incidence of peripheral arterial disease, however BMI and the metabolic syndrome were not. There was some evidence that the associations of fasting insulin (Pheterogeneity=0.06), insulin resistance (Pheterogeneity=0.08) and β-cell function (Pheterogeneity=0.004) with change in ankle brachial pressure index, differed between healthy weight and overweight & obese subjects. Principal components analysis identified a classical metabolic syndrome cluster, and an alternative clustering of metabolic factors that was characterised by high pulse pressure, high HDL-cholesterol and low triglycerides. This alternative cluster of cardiovascular and metabolic risk factors was associated with reductions in ankle brachial pressure index and an increased incidence of peripheral arterial disease (both P<0.0001). Conclusions: Overweight & obesity do not increase the risk of developing peripheral arterial disease. We identified an alternative cluster of metabolic factors that is strongly associated with reductions in ankle brachial pressure index and an increased incidence of peripheral arterial disease. © 2011 Elsevier Ireland Ltd.

Gautier A.,Rennes University Hospital Center | Balkau B.,French Institute of Health and Medical Research | Balkau B.,University Paris - Sud | Lange C.,French Institute of Health and Medical Research | And 4 more authors.
Diabetologia | Year: 2010

Aims/hypothesis: Risk factors for incident type 2 diabetes, in particular, hepatic markers, have rarely been studied in leaner individuals. We aimed to identify the metabolic and hepatic markers associated with incident diabetes in men and women with a BMI of <27 kg/m2 and to compare them with those in individuals with a BMI of ≥27 kg/m2. Methods: Risk factors for 9 year incident diabetes were compared in the French Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort. Comparisons were made between the 2,947 participants with a BMI of <27 kg/m2 and the 879 with a BMI of ≥27 kg/m2. Results: There were 92 incident cases of diabetes in individuals with a BMI of <27 kg/m2 and 111 in those with a BMI of ≥27 kg/m2. Among those who were not markedly overweight, classical biological markers were associated with 9 year incident diabetes, glycaemia being the strongest predictor. γ-Glutamyltransferase (GGT), either considered as a continuous variable or at levels ≥20 U/l, was associated with incident diabetes, with a stronger effect in the BMI <27 kg/m2 group: OR 1.59 (95% CI 1.29-1.97, p<0.001) in comparison with OR 1.07 (95% CI 0.82-1.38, p=0.63) for those with a BMI of ≥27 kg/m2 (results after adjustment for alcohol intake, alanine aminotransferase, waist circumference and the HOMA insulin resistance index). Conclusions/interpretation: In individuals with a BMI of <27 kg/m2, GGT was the strongest predictor of diabetes after fasting hyperglycaemia. This association with incident diabetes remained after adjustment for conventional markers of insulin resistance, suggesting potential interactions between GGT, enhanced hepatic neoglucogenesis and/or early alterations of insulin secretion.

PubMed | University Paris Diderot, French Institute of Health and Medical Research, Paris-Sorbonne University, University Paris - Sud and IRSA
Type: | Journal: Diabetes & metabolism | Year: 2016

Adiponectin is an adipocyte-secreted protein associated with insulin sensitivity. T-cadherin is a receptor for high and medium molecular weight adiponectin. In GWAS, T-cadherin gene (CDH13) polymorphisms are associated with circulating adiponectin levels. This study investigated the associations between genetic variants of CDH13 and type 2 diabetes (T2D), and its related parameters, in a Caucasian population.Two polymorphisms of CDH13 (rs11646213 and rs3865188) were genotyped in two French cohorts, a general population from the D.E.S.I.R. study (n=5212) and people with T2D in the DIABHYCAR study (n=3123). Baseline adiponectin levels were measured in D.E.S.I.R. participants who were normoglycaemic at baseline, but hyperglycaemic after 3 years (n=230), and in controls who remained normoglycaemic (n=226) throughout.In a cross-sectional analysis, CDH13 genotype distributions differed between those with and without T2D, with T2D odds ratios (OR) of 1.11 (95% CI: 1.04-1.18; P=0.001) and 0.92 (95% CI: 0.87-0.98; P=0.01) for rs11646213 and rs3865188, respectively. The rs11646213 variant, associated with a higher OR for T2D, was also associated with higher BMI (P=0.03) and HbA Conversely, the rs3865188 variant, associated with a lower OR for T2D, was also associated with lower BMI (P=0.03), HbACDH13 polymorphisms are associated with prevalent T2D in this French population study. The association may be mediated through effects on BMI and/or plasma adiponectin.

PubMed | French Institute of Health and Medical Research and IRSA
Type: Journal Article | Journal: BMC public health | Year: 2017

In aggregate studies, ecological indices are used to study the influence of socioeconomic status on health. Their main limitation is ecological bias. This study assesses the misclassification of individual socioeconomic status in seven ecological indices.Individual socioeconomic data for a random sample of 10,000 persons came from periodic health examinations conducted in 2006 in 11 French departments. Geographical data came from the 2007 census at the lowest geographical level available in France. The Receiver Operating Characteristics (ROC) curves, the areas under the curves (AUC) for each individual variable, and the distribution of deprived and non-deprived persons in quintiles of each aggregate score were analyzed.The aggregate indices studied are quite good proxies for individual deprivation (AUC close to 0.7), and they have similar performance. The indices are more efficient at measuring individual income than education or occupational category and are suitable for measuring of deprivation but not affluence.The study inventoried the aggregate indices available in France and evaluated their assessment of individual SES.

PubMed | Qatar Biomedical Research Institute, French Institute of Health and Medical Research, University of Paris Pantheon Sorbonne, Imperial College London and 3 more.
Type: Journal Article | Journal: Molecular metabolism | Year: 2016

Characterizing specific metabolites in sub-clinical phases preceding the onset of type 2 diabetes to enable efficient preventive and personalized interventions.We developed predictive models of type 2 diabetes using two strategies. One strategy focused on the probability of incidence only and was based on logistic regression (MRS1); the other strategy accounted for the age at diagnosis of diabetes and was based on Cox regression (MRS2). We assessed 293 metabolites using non-targeted metabolomics in fasting plasma samples of 1,044 participants (including 231 incident cases over 9 years) used as training population; and fasting serum samples of 128 participants (64 incident cases versus 64 controls) used as validation population. We applied a LASSO-based variable selection aiming at maximizing the out-of-sample area under the receiver operating characteristic curve (AROC) and integrated AROC.Sixteen and 17 metabolites were selected for MRS1 and MRS2, respectively, with AROC=90% and 73% in the training and validation populations, respectively for MRS1. MRS2 had a similar performance and was significantly associated with a younger age of onset of type 2 diabetes (=-3.44 years per MRS2 SD in the training population, p=1.5610(-7); =-4.73 years per MRS2 SD in the validation population, p=4.0410(-3)).Overall, this study illustrates that metabolomics improves prediction of type 2 diabetes incidence of 4.5% on top of known clinical and biological markers, reaching 90% in total AROC, which is considered the threshold for clinical validity, suggesting it may be used in targeting interventions to prevent type 2 diabetes.

BUENOS AIRES, Argentina, Nov. 11, 2016 /PRNewswire/ -- IRSA Inversiones y Representaciones S.A. (NYSE: IRS; BASE: IRSA), the leading real estate company in Argentina, today announces its results for the first three months of Fiscal Year 2017 Ended September 30, 2016. HIGHLIGHTS...

News Article | October 26, 2015

Microsoft is making some big moves to corner the lucrative police camera cloud storage industry. Today, the company announced a partnership with their chief rival in the space, Taser, to create new cloud services for law enforcement The new cloud services are mainly designed for creating an integrated system for retrieving and viewing police body camera footage and other evidence online. In a blog post, Microsoft vice president of U.S. state and local government Michael Donlan said that "Officers will be able to securely capture, store, and manage digital evidence through a trusted cloud platform that connects each part of the investigation process and streamlines operations from beginning to end. Microsoft Azure will also power next-generation analytics and collaboration with stakeholders throughout the criminal justice system." Up until now, Microsoft and Taser were rivals trying to attract police departments and other law enforcement agencies to each other's respective platforms. Microsoft already has partnerships with video camera manufacturers Vievu and Getac/IRSA. Taser, despite being best known for their electroshock weapons, is also a major player in the police body camera industry thanks to their purchase of a company called in 2010. Earlier in 2015, the Justice Department announced they were investing $20 million in helping police departments acquire body cameras. Because each police department, no matter the size, requires storage and contracts with their vendors, the area promises to be a financial growth area for companies providing cameras and cloud storage. The move is also a poke in the eye to Amazon Web Services, Taser’s previous preferred vendor of choice.

Avenida is set on cementing its leadership position Argentina’s e-commerce market after a $30 million Series C led by Naspers with participation from Tiger Global (both firms are returning investors). Combined with its previous rounds, this brings Avenida’s total capital raised so far to $52 million. The company launched in 2013 after co-founders Federico Malek and Alan Kraus saw that there wasn’t a pure-play e-commerce business, with its own warehouses and in-house logistics system, in Argentina. The two worked for nearly four years at Groupon after the group-deals giant acquired their previous business, Wallooz, and they were eager for a new challenge. “We said, let’s start the Amazon of Argentina, which is the second largest e-commerce market [in Latin America],” says Malek. The company quickly got its first round of funding from IRSA, the largest shopping mall operator in Buenos Aires. Avenida now processes 20,000 orders every month and expects gross merchandise volume, or total sales, of $30 million in 2015, compared to $8 million last year. A pure-play business model allows Avenida to control the entire customer experience from browsing to last-mile delivery. This is especially important because e-commerce still constitutes just four percent of the total retail market in Argentina. The country’s smartphone penetration rate is over 70 percent, however, so Malek expects that number to grow quickly. One of Avenida’s main challenges was the lack of logistics providers who could provide the kind of immediate and trackable service it needed to reassure people making major purchases online for the first time. “The logistics companies here are not prepared for e-commerce. Customers want fast fulfillment of their orders and they want to know where their packages are at every moment, and the companies we have in this country just can’t provide that, so we had to build our own,” says Malek. “We talk a lot to the guys from Flipkart because they have the same investors as we do. They have the same challenge in India.” Eighty percent of Avenida’s orders are currently delivered overnight to its 11 pickup locations in Buenos Aires. These small storefronts are cheaper to run than retail stores, but still allow customers to interact with Avenida’s staff, which helps build trust and brand loyalty. The company competes against traditional retailers that also operate online businesses, but, like Amazon and other e-commerce businesses, is able to offer lower prices and larger inventory because it doesn’t have to pay for a lot of infrastructure. “Providing good customer service is how we build confidence in the public in Argentina and break the barrier, so more people move from brick and mortar to online shopping,” says Malek. Avenida will use its Series C to improve its technology platform and open more pickup locations in Buenos Aires and smaller cities like La Plata, Rosaria, and Mendoza before expanding in the rest of Argentina.

BUENOS AIRES, Argentina, Nov. 9, 2016 /PRNewswire/ -- IRSA Propiedades Comerciales S.A. (NASDAQ: IRCP; MERVAL: IRCP), the leading commercial real estate company in Argentina, today announces its results for the three month period of FY 2017 ended September 30, 2016. HIGHLIGHTS...

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