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Taromaru G.C.M.,Irmandade da Santa Casa de Misericordia de Sao Paulo and Santa Casa de Sao Paulo | de Oliveira V.M.,Irmandade da Santa Casa de Misericordia de Sao Paulo and Santa Casa de Sao Paulo | Silva M.A.L.G.,Irmandade da Santa Casa de Misericordia de Sao Paulo and Santa Casa de Sao Paulo | Montor W.R.,Irmandade da Santa Casa de Misericordia de Sao Paulo and Santa Casa de Sao Paulo | And 3 more authors.
Oncology Letters | Year: 2012

The objective of this study was to evaluate the correlation between cyclooxygenase-2 (COX-2) and markers of cell proliferation and apoptosis, including, Bcl-2, Bax, Ki-67 and the type I insulin-like growth factor (IGF) receptor (IGF1-R) in ductal carcinoma in situ (DCIS) and infiltrating ductal carcinoma (IDC), present in the same surgical specimen. A total of 110 cases were evaluated using tissue microarrays. Cases were classified in scores from 0 to 3 according to predefined methods. The results showed that the positivity rates were COX-2 in 87% of cases in DCIS and IDC; Bcl-2 in 55% of cases in DCIS and IDC; Bax in 23% of cases in IDC and 19% in DCIS, IGF-1 in 24% of cases in DCIS and IDC; and Ki-67 in 81% of cases in DCIS and IDC. We also observed a positive correlation between the expression of COX-2 and IGF1-R (p=0.045). Our results demonstrate a positive correlation between the expression of COX-2 and IGF1-R in DCIS and IDC, demonstrating that they are involved in breast cancer carcinogenesis. Further studies are required to prove the effectiveness of COX-2 and IGF1-R inhibitors for the prevention and treatment of breast cancer, as well as to explain their mechanism of action.

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