Irmandade da Santa Casa de Misericordia de Sao Paulo and Santa Casa de Sao Paulo

São Paulo, Brazil

Irmandade da Santa Casa de Misericordia de Sao Paulo and Santa Casa de Sao Paulo

São Paulo, Brazil
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Taromaru G.C.M.,Irmandade da Santa Casa de Misericordia de Sao Paulo and Santa Casa de Sao Paulo | de Oliveira V.M.,Irmandade da Santa Casa de Misericordia de Sao Paulo and Santa Casa de Sao Paulo | Silva M.A.L.G.,Irmandade da Santa Casa de Misericordia de Sao Paulo and Santa Casa de Sao Paulo | Montor W.R.,Irmandade da Santa Casa de Misericordia de Sao Paulo and Santa Casa de Sao Paulo | And 3 more authors.
Oncology Letters | Year: 2012

The objective of this study was to evaluate the correlation between cyclooxygenase-2 (COX-2) and markers of cell proliferation and apoptosis, including, Bcl-2, Bax, Ki-67 and the type I insulin-like growth factor (IGF) receptor (IGF1-R) in ductal carcinoma in situ (DCIS) and infiltrating ductal carcinoma (IDC), present in the same surgical specimen. A total of 110 cases were evaluated using tissue microarrays. Cases were classified in scores from 0 to 3 according to predefined methods. The results showed that the positivity rates were COX-2 in 87% of cases in DCIS and IDC; Bcl-2 in 55% of cases in DCIS and IDC; Bax in 23% of cases in IDC and 19% in DCIS, IGF-1 in 24% of cases in DCIS and IDC; and Ki-67 in 81% of cases in DCIS and IDC. We also observed a positive correlation between the expression of COX-2 and IGF1-R (p=0.045). Our results demonstrate a positive correlation between the expression of COX-2 and IGF1-R in DCIS and IDC, demonstrating that they are involved in breast cancer carcinogenesis. Further studies are required to prove the effectiveness of COX-2 and IGF1-R inhibitors for the prevention and treatment of breast cancer, as well as to explain their mechanism of action.


PubMed | Irmandade da Santa Casa de Misericordia de Sao Paulo and Santa Casa de Sao Paulo
Type: Journal Article | Journal: Oncology letters | Year: 2012

The objective of this study was to evaluate the correlation between cyclooxygenase-2 (COX-2) and markers of cell proliferation and apoptosis, including, Bcl-2, Bax, Ki-67 and the type I insulin-like growth factor (IGF) receptor (IGF1-R) in ductal carcinoma in situ (DCIS) and infiltrating ductal carcinoma (IDC), present in the same surgical specimen. A total of 110 cases were evaluated using tissue microarrays. Cases were classified in scores from 0 to 3 according to pre-defined methods. The results showed that the positivity rates were COX-2 in 87% of cases in DCIS and IDC; Bcl-2 in 55% of cases in DCIS and IDC; Bax in 23% of cases in IDC and 19% in DCIS, IGF-1 in 24% of cases in DCIS and IDC; and Ki-67 in 81% of cases in DCIS and IDC. We also observed a positive correlation between the expression of COX-2 and IGF1-R (p=0.045). Our results demonstrate a positive correlation between the expression of COX-2 and IGF1-R in DCIS and IDC, demonstrating that they are involved in breast cancer carcinogenesis. Further studies are required to prove the effectiveness of COX-2 and IGF1-R inhibitors for the prevention and treatment of breast cancer, as well as to explain their mechanism of action.

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