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Corteno Golgi, Italy

Beneventi F.,IRCSS S. Matteo Hospital | Locatelli E.,IRCSS S. Matteo Hospital | Giorgiani G.,Paediatric Oncohematology Unit | Zecca M.,Paediatric Oncohematology Unit | And 6 more authors.
BJOG: An International Journal of Obstetrics and Gynaecology | Year: 2014

Objective To evaluate gonadal function and uterine volume in a cohort of female survivors treated by chemotherapy, radiotherapy, and/or stem cell transplantation (SCT) for childhood malignant and non-malignant diseases. Design An observational study. Setting S. Matteo Hospital, Pavia, Italy. Population A cohort of 135 female survivors. Methods A clinical, hormonal, and ultrasonographic evaluation. Thirty-three patients (24%) had non-malignant haematologic diseases (thalassaemia or sickle cell anaemia), 68 (50%) had leukaemia, 23 (17%) had lymphomas, and 11 (8%) had solid tumours. In total, 106 patients had received SCT, preceded by a conditioning regimen. Main outcome measures Anti-Müllerian hormone (AMH) and Inhibin-B, and uterine volume. Results The median concentrations of AMH and Inhibin-B in the entire cohort were 0.12 ng/ml (interquartile range, IQR, 0.1-0.5 ng/ml) and 3.5 pg/ml (IQR 0.1-13.2 pg/ml), respectively. In a stepwise ordered logistic regression analysis, conventional chemotherapy for the treatment of malignancies, as opposed to total body irradiation (TBI), was the only oncologically significant predictor of increased AMH levels (OR 4.8, 95% CI 1.9-12, P < 0.001). Conditioning treatment before or after menarche did not influence AMH concentrations (P = 0.24). The best predictor of reduced uterine volume was TBI during the preparation for the allograft (OR 3.5, 95% CI 1.4-8.4, P = 0.006). Increasing age at treatment (OR 0.86, 95% CI 0.77-0.95, P = 0.04), chemotherapy, as opposed to other treatments (OR 0.09, 95% CI 0.03-0.28, P < 0.001), and solid tumours as opposed to either leukaemia/lymphomas or non-malignant diseases (OR 0.2, 95% CI 0.07-0.56, P = 0.002) were associated with larger uterine volumes. Conclusions Conditioning therapies for SCT, including TBI, had the worst effects on uterine volume and gonadal reserve. Increasing age at treatment and conventional chemotherapy were associated with less detrimental effects on uterine volume. © 2014 Royal College of Obstetricians and Gynaecologists.

Beneventi F.,IRCSS S. Matteo Hospital | Locatelli E.,IRCSS S. Matteo Hospital | Cavagnoli C.,IRCSS S. Matteo Hospital | Simonetta M.,IRCSS S. Matteo Hospital | And 7 more authors.
Diabetes Research and Clinical Practice | Year: 2014

Aim: To investigate the effects of uncomplicated vaginal delivery and epidural analgesia on fetal acid-base parameters in women with gestational diabetes (GDM) compared with controls. Methods: A retrospective case-control study of 142 women with gestational diabetes and 284 controls. To evaluate the effect of diabetes and analgesia on acid-base status correcting for potential confounders we used ordered logistic equations including quartiles of fetal arterial acid-base parameters collected at birth as outcomes and categories of diabetes and epidural analgesia as explanatory variables. Results: In the GDM group cord base deficit (-2.63. mmol/l, interquartile range [IQR]. = 4.2 to -0.65. mmol/l vs. -1.9. mmol/l, IQR. = -3.3 to -0.2. mmol/l, p= 0.009, odds ratio (OR). = 1.51, 95% confidence interval (CI). = 1.04-2.18) was lower and concentration of calcium higher (1.49. mmol/l, IQR. = 1.42-1.56. mmol/l vs. 1.47. mmol/l, IQR. = 1.41-1.51. mmol/l, p= 0.009, OR. = 1.69, 95% CI. = 1.12-2.56) compared with controls. Epidural analgesia in the GDM group was associated with reduced cord concentration of glucose (84.0. mg/dl [4.7. mmol/l], IQR. = 70-103.3. mg/dl vs. 92.5. mg/dl [5.1. mmol/l], IQR. = 76.5-121.8. mg/dl, p= 0.004), lactate (2.65. mmol/l (IQR. = 1.80-4.20) vs. 3.70. mmol/l (IQR. = 2.90-5.55. mmol/l), p= 0.002) and less pronounced base deficit (-2.05. mmol/l, IQR. = -3.90 to -0.17. mmol/l vs. -2.8, IQR. = -5.57 to -1.05. mmol/l, p= 0.01, OR. = 0.7, 95% CI. = 0.49-0.99). Conclusions: In uncomplicated pregnancies and deliveries, well-controlled gestational diabetes mellitus has potentially significant detrimental effects on fetal acid-base status at birth. Epidural analgesia reduces cord arterial glucose and lactates. © 2014 Elsevier Ireland Ltd.

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