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Rosny-sous-Bois, France
Rosny-sous-Bois, France
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Maillot P.,University of Rennes 1 | Ferre S.,University of Rennes 1 | Cellier P.,INSA Rennes | Ducasse M.,INSA Rennes | Partouche F.,IRCGN
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2017

Knowledge acquisition is a central issue of the Semantic Web. Knowledge cannot always be automatically extracted from existing data, thus contributors have to make efforts to create new data. In this paper, we propose FORMULIS, a dynamic form-based interface designed to make RDF data authoring easier. FORMULIS guides contributors through the creation of RDF data by suggesting fields and values according to the previously filled fields and the previously created resources. © Springer International Publishing AG 2017.


Maillot P.,University of Rennes 1 | Ferre S.,University of Rennes 1 | Cellier P.,INSA Rennes | Ducasse M.,INSA Rennes | Partouche F.,IRCGN
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2017

Knowledge acquisition is a central issue of the Semantic Web. Knowledge cannot always be automatically extracted from existing data, thus domain experts are required to manually produce it. On the one hand, learning formal languages such as RDF represents an important obstacle to non-IT experts. On the other hand, well-known data input interfaces do not address well the relational nature and flexibility of RDF. Furthermore, it is difficult to maintain data quality through time, and across contributors. We propose FORMULIS, a form-based interface for guided RDF authoring. It hides RDF notations, addresses the relational aspects with nested forms, and guides users by computing intelligent filling suggestions. Two user experiments show that FORMULIS helps users maintain good data quality, and can be used by users without Semantic Web knowledge. © 2017, Springer International Publishing AG.


Cohier C.,French Institute of Health and Medical Research | Cohier C.,University of Paris Descartes | Cohier C.,University Paris Diderot | Chevillard L.,French Institute of Health and Medical Research | And 12 more authors.
Toxicological Sciences | Year: 2017

Respiratory depression and fatalities have been attributed to ethanol/buprenorphine (BUP) combination in drug addicts maintained with BUP/naloxone or BUP alone. The exact mechanisms of the ethanol/BUP interaction and the contribution to the toxicity of norbuprenorphine (NBUP), the main BUP metabolite with respiratory depressant properties are unknown. We investigated the sedative and plethsymographic effects resulting from the co-administration of intragastric ethanol (3 g/kg) and intravenous BUP (30 mg/kg) in Sprague-Dawley rats. We determined the whole blood pharmacokinetics of ethanol (using gas chromatography coupled to mass spectrometry), BUP and its metabolites (using liquid chromatography coupled to tandem mass spectrometry) and investigated the mechanisms of drug-drug interactions in the presence or absence of naloxone (7.5 mg/kg). Ethanol/BUP and ethanol/BUP/naloxone combinations significantly deepened sedation in comparison to BUP alone (P < .01) and BUP/naloxone (P < .05), respectively. Ethanol/BUP combination significantly increased the inspiratory time and decreased the minute volume in comparison to BUP alone (P < .01 and P < .01, respectively) and ethanol/BUP/naloxone (P < .05 and P < .01, respectively). Neither naloxone nor flumazenil reversed ethanol/BUP-induced sedation and respiratory depression. In the presence of ethanol, the area under the BUP concentration-time curve was significantly decreased (P < .05), BUP volume of distribution increased (P < .05) and the metabolic ratios of NBUP and norbuprenorphine-3-glucuronide increased (P < .01). In conclusion, the ethanol/BUP combination results in marked sedation and respiratory depression in the rat, prevented but not reversed by naloxone. Ethanol/BUP interactions are mainly pharmacokinetic resulting in increased NBUP production. Despite the non-reversal by naloxone and flumazenil of the effects attributed to the ethanol/BUP combination, protection provided by naloxone suggests an additional pharmacodynamic interaction. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology.


Muehlethaler C.,University of Lausanne | Massonnet G.,University of Lausanne | Deviterne M.,University of Lausanne | Bradley M.,Chemistry Unit | And 12 more authors.
Forensic Science International | Year: 2013

This study represents the most extensive analysis of batch-to-batch variations in spray paint samples to date. The survey was performed as a collaborative project of the ENFSI (European Network of Forensic Science Institutes) Paint and Glass Working Group (EPG) and involved 11 laboratories. Several studies have already shown that paint samples of similar color but from different manufacturers can usually be differentiated using an appropriate analytical sequence. The discrimination of paints from the same manufacturer and color (batch-to-batch variations) is of great interest and these data are seldom found in the literature. This survey concerns the analysis of batches from different color groups (white, papaya (special shade of orange), red and black) with a wide range of analytical techniques and leads to the following conclusions. Colored batch samples are more likely to be differentiated since their pigment composition is more complex (pigment mixtures, added pigments) and therefore subject to variations. These variations may occur during the paint production but may also occur when checking the paint shade in quality control processes. For these samples, techniques aimed at color/pigment(s) characterization (optical microscopy, microspectrophotometry (MSP), Raman spectroscopy) provide better discrimination than techniques aimed at the organic (binder) or inorganic composition (fourier transform infrared spectroscopy (FTIR) or elemental analysis (SEM - scanning electron microscopy and XRF - X-ray fluorescence)). White samples contain mainly titanium dioxide as a pigment and the main differentiation is based on the binder composition (C-H stretches) detected either by FTIR or Raman. The inorganic composition (elemental analysis) also provides some discrimination. Black samples contain mainly carbon black as a pigment and are problematic with most of the spectroscopic techniques. In this case, pyrolysis-GC/MS represents the best technique to detect differences. Globally, Py-GC/MS may show a high potential of discrimination on all samples but the results are highly dependent on the specific instrumental conditions used. © 2013 Elsevier Ireland Ltd.


The relative abundance of certain stable isotope constituents of the material is a considerable information source and behaves as a memory of the origins (synthesis or biosynthesis) and transformation of the material. This "signature" then can be run in the process of inference of the origin of a common source in scientific police. In certain cases, it constitutes a legal method of identification.


Frere B.,Incendies et Explosifs ECX | Bernier G.,IRCGN | Ducellier T.,IRCGN | Rigal O.,IRCGN
Actualite Chimique | Year: 2010

When firearms are found on a crime scene, investigators frequently sniff the canon aperture in order to identify which of them could have been used recently. This technique gives useful information but is not based on a scientific and validated methodology. In order to solve this problem the French Gendarmerie Forensic Research Institute has developed and validated an analytical method based on extraction of aromatic hydrocarbon residues by solid phase micro-extraction (SPME), followed by gas chromatography coupled with mass spectrometry (GC/MS).


Boulassel B.,Service Medecine Legale | Sadeg N.,Center Hospitalier Rene Dubos | Roussel O.,IRCGN | Perrin M.,IRCGN | Belhadj-Tahar H.,Groupe Recherche et Expertise Toxicologiques
Forensic Science International | Year: 2011

We report here a fatal intoxication case involving ammonium vanadate. A 24-year-old woman was admitted to the Emergency Department for abdominal pain, nausea, vomiting, multiple daily diarrheas, hypoglycaemia (0.2g/L) and severe acute renal failure with glomerular filtration rate estimated at 21ml/min. This patient had taken an undetermined amount of ammonium vanadate 12h after ingesting. She died next morning in the context of respiratory distress despite intensive care and oxygen therapy. The autopsy revealed widespread asphyxia syndrome and erosive gastritis. Determination of vanadium concentration in blood was carried out by means of mass spectrometer (ICP-MS) using rhodium (103Rh) as the internal standard. The vanadium concentration was 6.22mg/L, corresponding to 6000 times higher than normal concentration in the general population. The latency and the brutality of clinical picture degradation seem to be in consideration of systemic poisoning by vanadium leading to inhibition of the cellular respiratory process. © 2010 Elsevier Ireland Ltd.


PubMed | French Institute of Health and Medical Research and IRCGN
Type: | Journal: Toxicological sciences : an official journal of the Society of Toxicology | Year: 2016

Respiratory depression and fatalities have been attributed to ethanol/buprenorphine combination in drug addicts maintained with buprenorphine/naloxone or buprenorphine alone. The exact mechanisms of the ethanol/buprenorphine interaction and the contribution to the toxicity of norbuprenorphine, the main buprenorphine metabolite with respiratory depressant properties are unknown. We investigated the sedative and plethsymographic effects resulting from the co-administration of intragastric ethanol (3g/kg) and intravenous buprenorphine (30mg/kg) in Sprague-Dawley rats. We determined the whole blood pharmacokinetics of ethanol (using gas chromatography coupled to mass spectrometry), buprenorphine and its metabolites (using liquid chromatography coupled to tandem mass spectrometry) and investigated the mechanisms of drug-drug interactions in the presence or absence of naloxone (7.5mg/kg). Ethanol/buprenorphine and ethanol/buprenorphine/naloxone combinations significantly deepened sedation in comparison to buprenorphine alone (P<.01) and buprenorphine/naloxone (P<.05), respectively. Ethanol/buprenorphine combination significantly increased the inspiratory time and decreased the minute volume in comparison to buprenorphine alone (P<.01 and P<.01, respectively) and ethanol/buprenorphine/naloxone (P<.05 and P<.01, respectively). Neither naloxone nor flumazenil reversed ethanol/buprenorphine-induced sedation and respiratory depression. In the presence of ethanol, the area under the buprenorphine concentration-time curve was significantly decreased (P<.05), buprenorphine volume of distribution increased (P<.05) and the metabolic ratios of norbuprenorphine and norbuprenorphine-3-glucuronide increased (P<.01). In conclusion, the ethanol/buprenorphine combination results in marked sedation and respiratory depression in the rat, prevented but not reversed by naloxone. Ethanol/buprenorphine interactions are mainly pharmacokinetic resulting in increased norbuprenorphine production. Despite the non-reversal by naloxone and flumazenil of the effects attributed to the ethanol/buprenorphine combination, protection provided by naloxone suggests an additional pharmacodynamic interaction.

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