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Cerqua S.,Clinic Villa Margherita | Angelucci F.,IRCCS Santa Lucia Foundation
Journal of Cosmetic and Laser Therapy | Year: 2013

In a minority of patients undergoing liposuction, superficial irregularities (or skin depression) in the operated area may occur. Macrolane is a gel composed of hyaluronic acid (HA), used for volume restoration of soft tissues. In this study, the authors investigated the effectiveness, maintenance, and safety of Macrolane as a "non-surgical" treatment to correct skin depression after liposuction. Twelve female patients were included. Macrolane was injected at a subdermal superficial plane using an intramuscular or spinal needle. In all patients, Macrolane was successful in correcting skin depression. No relevant side effects were observed. At 8 months post-injection, a persistence of correction of 60-70% was still present in 90% of the patients. In conclusion, Macrolane filler injections are a predictable, safe, and long-lasting non-surgical procedure to fill contour defects that arise after liposuction, and represent a good option for patients who refuse to undergo an additional surgery to fill the arisen skin depressions. © 2013 Informa UK, Ltd. Source


Leggio M.,Ataxia Laboratory | Leggio M.,University of Rome La Sapienza | Molinari M.,IRCCS Santa Lucia Foundation
Cerebellum | Year: 2015

“Looking into the future” well depicts one of the most significant concepts in cognitive neuroscience: the brain is constantly predicting future events. Such directedness toward the future has been recognized to be relevant to and beneficial for many aspects of information processing in humans, such as perception, motor and cognitive control, decision-making, theory of mind, and other cognitive processes. Because one of the most adaptive characteristics of the brain is to correct errors, the ability to look into the future represents the best chance to avoid repeating errors. Within the structures that constitute the “predictive brain,” the cerebellum has been proposed to have a central function, based on its ability to generate internal models. We suggested that “sequence detection” is the operational mode of the cerebellum in predictive processing. According to this hypothesis, the cerebellum detects and simulates repetitive patterns of temporally or spatially structured events and generates internal models that can be used to make predictions. Consequently, we demonstrate that the cerebellum recognizes serial events as a sequence, detects a sequence violation, and successfully reconstructs the correct sequence of events. Thus, we hypothesize that pattern detection and prediction and processing of anticipation are cerebellum-specific functions within the brain and that the sequence detection hypothesis links the multifarious impairments that are reported in patients with cerebellar damage. We propose that this cerebellar operational mode can advance our understanding of the pathophysiological mechanisms in various clinical conditions, such as schizophrenia and autism. © 2014, Springer Science+Business Media New York. Source


Paolucci S.,IRCCS Santa Lucia Foundation
European Journal of Physical and Rehabilitation Medicine | Year: 2013

Antidepressants are a heterogeneous class of drugs that have been developed for the treatment of mood disorders. In the past several years, they have been used in poststroke survivors to treat poststroke depression, central poststroke pain, and poststroke fatigue and as an adjuvant for functional recovery and cognitive function. However, there are still some relevant points to clarify regarding the real role of antdidepressants in stroke patients and further researches are needed to deeply explore their effects on rehabilitation results. Source


Consalvi S.,IRCCS Santa Lucia Foundation | Saccone V.,IRCCS Santa Lucia Foundation | Mozzetta C.,CNR Institute of Neuroscience
Epigenomics | Year: 2014

Duchenne muscular dystrophy (DMD) is a life-threatening genetic disease that currently has no available cure. A number of pharmacological strategies that aim to target events downstream of the genetic defect are currently under clinical investigation, and some of these are outlined in this report. In particular, we focus on the ability of histone deacetylase inhibitors to promote muscle regeneration and prevent the fibro-adipogenic degeneration of dystrophic mice. We describe the rationale behind the translation of histone deacetylase inhibitors into a clinical approach, which inspired the first clinical trial with an epigenetic drug as a potential therapeutic option for DMD patients. © 2014 Future Medicine Ltd. Source


Merlo P.,IRCCS Santa Lucia Foundation | Cecconi F.,University of Rome Tor Vergata | Cecconi F.,Danish Cancer Society
EMBO Journal | Year: 2013

Autophagy is a catabolic mechanism that selectively eliminates long-lived proteins, aggregates and damaged organelles and is thereby fundamental in maintaining cellular homeostasis. As a prosurvival mechanism, autophagy is carefully regulated and its dysfunction is associated with cancer development. Work of Huang et al (2013) in this issue of The EMBO Journal identifies the apoptosis inhibitor XIAP as a novel repressor of autophagy-a function that significantly contributes to its tumorigenecity. © 2013 European Molecular Biology Organization. Source

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