Entity

Time filter

Source Type


Fekrazad R.,Tehran University of Medical Sciences | Sadeghi Ghuchani M.,Golestan University of Medical Sciences | Eslaminejad M.B.,Royan Institute for Stem Cell Biology and Technology | Taghiyar L.,Royan Institute for Stem Cell Biology and Technology | And 5 more authors.
Journal of Photochemistry and Photobiology B: Biology | Year: 2015

Objective This study evaluated the effect of Low Level Laser Therapy (LLLT) and Mesenchymal Stem Cells (MSCs) on bone regeneration. Background data Although several studies evaluated the effects of MSCs and LLLT, there is little information available regarding in vivo application of LLLT in conjunction with MSCs. Methods Forty-eight circular bone defects (6 mm in diameter) were prepared in the calvaria of 12 New-Zealand white rabbits. The defects of each animal were randomly assigned to 4 groups: (C) no treatment; (L) applying LLLT; (SC) filled with MSCs; (SCL) application of both MSCs and LLLT. LLL was applied on alternate days at wavelength of 810 nm, power density of 0.2 W/cm2 and a fluency of 4 J/cm2 using a Gallium-Aluminum-Arsenide (GaAlAs) diode laser. The animals were sacrificed after 3 weeks and then histological samples were evaluated to determine the amount of new bone formation and the remaining scaffold and inflammation. Results The histological evaluation showed a statistically significant increase in new bone formation of LLLT group relative to the control and the other two experimental groups (p < 0.05). There was no significant difference in bone formation of the control group compared to experimental groups filled with MSCs. Laser irradiation had no significant effect on resorption of the scaffold material. In addition, inflammation was significantly reduced in LLLT group compared to the control defects and the other two experimental groups. Conclusion Low level laser therapy could be effective in bone regeneration but there is no evidence of a synergistic effect when applied in conjunction with MSCs. © 2015 Elsevier B.V. All rights reserved.


Fekrazad R.,Tehran University of Medical Sciences | Mirmoezzi A.,Private Practice | Kalhori K.A.,Iranian Medical Laser Association | Arany P.,U.S. National Institutes of Health
Journal of Photochemistry and Photobiology B: Biology | Year: 2015

Background and objective: Many studies have demonstrated that low-level laser therapy (LLLT) can improve wound healing in non-diabetic and diabetic animals. We compared the effects of red, green, and blue lasers in terms of accelerating oral wound healing in diabetic rats. Material and methods: Diabetes was successfully induced in 32 male Wistar rats using intraperitoneal injection of Streptozotocin (150 mg/kg). After intraperitoneal injection of the anesthetic agent, a full-thickness oral wound (10 mm × 2 mm) was created aseptically with a scalpel on hard palate of the diabetic rats. The study was performed using red (630 nm), green (532 nm), and blue (425 nm) lasers and a control group. We used an energy density of 2 J/cm2 and a treatment schedule of 3 times/week for 10 days. The area of wounds was measured and recorded on a chart for all rats. On the 10th day, the samples were then sacrificed and a full-thickness sample of wound area was prepared for pathological study. Results: We observed a significant difference (p < 0.001) in the mean slope values of wound healing between treatment and control groups. Moreover, the mean slope of wound healing differed significantly between red laser and two other lasers - blue and green (p < 0.001). The mean slopes of wound healing were not significantly different between blue laser and green laser (p = 0.777). Conclusion: The results of the present study provide evidence that wound healing is slower in control rats compared to the treatment groups. Moreover, the findings suggest that wound healing occurs faster with red laser compared to blue and green lasers. © 2015 Elsevier B.V. All rights reserved.


Soleimanpour H.,Tabriz University of Medical Sciences | Gahramani K.,Iranian Medical Laser Association | Taheri R.,Iranian Medical Laser Association | Golzari S.E.J.,Tabriz University of Medical Sciences | And 3 more authors.
Lasers in Medical Science | Year: 2014

Background Osteoarthritis (OA) is one of the most common joint disorders in the elderly which could be associated with considerable physical disability. Patients and methods In a descriptive, prospective study, 33 patients enrolled in the study from which 15 people were excluded due to incomplete course of treatment, leaving the total number of 18 patients with knee osteoarthritis. Gal-Al-As diode laser device was used as a source of low-power laser. Patients were performed laser therapy with a probe of LO7 with a wavelength of 810 nm and 50 mW output power in pulse radiation mode (F = 3,000, peak power = 80 W, Δt = 200 ns, density = 0.05 W/cm2, dose = 6 J/cm2, area = 1 cm2) and also a probe of MLO1K with a power output of 30 mW and a wavelength of 890 nm in pulse radiation mode (F = 3,000 Hz, peak power = 50 W, Δt = 200 ns, density = 0.017 W/cm2, total dose = 10 J/cm2), and were given low-level laser therapy (LLLT) three times a week with a total number of 12 sessions. Data were analyzed using SPSS ver. 15, and the obtained data were reported as mean ± SD and frequency (%). To analyze the data, repeated measurement and marginal homogeneity approaches were used. Results In the current study, a significant reduction was observed regarding the nocturnal pain, pain on walking and ascending the steps, knee circumference, distance between the hip and heel, and knee to horizontal hip to heel distance at the end of the treatment course. Conclusions In brief, the current study focuses on the fact that LLLT is effective in reducing pain in knee osteoarthritis. © 2014 Springer-Verlag London.


Alijanpoor R.,Iranian Medical Laser Association | Bejehmir A.P.,Babol University of Medical Sciences | Mokmeli S.,Iranian Medical Laser Association
Photomedicine and Laser Surgery | Year: 2011

Objective: The purpose of this study was to introduce adjunct therapy to intense pulsed light (IPL) and to assess it in terms of safety, expense, feasibility, and efficacy. Background data: Currently there is no satisfactory, efficient method for long-term white hair removal. Methods: We conducted a randomized clinical trial of hirsute patients with excessive white hair on the chin and cheeks. In addition to IPL, the patients were randomly assigned to have their white hair colored with either black eyeliner or black hair dye as an adjunct to IPL aided for of six sessions (with a 4-week interval between sessions). The primary efficacy outcome, which was defined as the outcome after six sessions of therapy, was scored as poor (<30%), fair (30-60%) or good (>60%) response to white hair removal in predefined areas. The secondary outcome was recurrence 6 months after the final therapy session. Results: In the eyeliner group (n=31), 15 (48.4%) individuals showed a fair response, and 16 (51.6%) individuals showed a good response. In the color-dye group (n=31), 1 (3.2%), 17 (54.8%) and 13 (41.9%) participants scored poor, fair, and good, respectively. There were no differences in clinician judgment of the treatment success between the eyeliner and color-dye groups after the six therapy sessions (p=0.895). Thirty-one patients had 6 months of visits (11 in the hair dye and 20 in the eyeliner group). Three participants in the color-dye group and five participants in the eyeliner group failed to show improvement 6 months after the laser surgery. There was no distinguishable pattern of failure between the two study groups (p=1). Conclusion: This study supports that hair coloring is an efficient and feasible technique that can be combined with IPL to eliminate white facial hair. © 2011 Mary Ann Liebert, Inc.

Discover hidden collaborations