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Teimourian S.,Iran University of Medical SciencesTehran | Teimourian S.,University of Tehran | Teimourian S.,Islamic Azad UniversityTehran | Masoudzadeh N.,University of Tehran | Masoudzadeh N.,Islamic Azad UniversityTehran
European Journal of Pharmacology | Year: 2015

Abstract Crohn's disease (CD), a subcategory of inflammatory bowel disease, is an immune-related disorder characterized by inflammation of the gastrointestinal mucosa, which can take place in any region along the alimentary tract. The most important gene involved in the etiology of CD is NOD2/CARD15 located on chromosome 16. It has been shown that CARD15 is overexpressed in monocytes of CD patients. The common treatment for the disease is anti-TNF-alpha drugs, the most hopeful of which are probably infliximab and etanercept. Infliximab rapidly reduces signs and symptoms of active Crohn's disease. In contrast, etanercept shows no such effect. In the present study, we evaluated the effects of the CARD15 gene overexpression in monocytic cell line U937 in the production of anti-inflammatory cytokine, IL-10, and proinflammatory cytokine, Il-1 beta, produced after incubation with infliximab, adalimumab, and etanercept separately. Our results show that infliximab and adalimumab significantly decreased IL-10 and IL-1beta secretion levels. However, etanercept inhibition of secretion was less compared with infliximab or adalimumab. In all three cases, suppression of cytokine production is reduced by CARD15 overexpression. © 2015 Elsevier B.V. Source


Abdi A.,University of Tabriz | Karimi A.,University of Tabriz | Karimi A.,Iran University of Medical SciencesTehran | Razzaghi M.,University of Tabriz
Journal of Environmental Chemical Engineering | Year: 2016

In this research, removing dissolved oxygen (DO) from water by means of granular biocatalyst (GB) was investigated. GB was prepared by granulation of glucose oxidase (GOx) adsorbed on MnO2 micro-sized particles by calcium alginate. Prepared biocatalyst was able to remove DO and decompose produced hydrogen peroxide simultaneously. Factors affecting DO removal including temperature, pH and glucose concentration were studied; at the optimum condition which was achieved to be 30 °C, 6.85 and 80 mM respectively, DO was removed completely. Stability of enzymatic activity of GB was investigated. Besides, Water deoxygenation was studied in a packed bed reactor by GB utilization at optimum operating condition. The highest deoxygenation rate was observed at feed flow rate of 375 mL/min. Residence time distribution of packed bed reactor was calculated at two flow rates with pulse injection of tracer into reactor inlet. © 2016 Published by Elsevier Ltd. Source


Sharifi G.,Shahid Beheshti University | Bakhtevari M.H.,Shahid Beheshti University | Alghasi M.,Iran University of Medical SciencesTehran | Saberi M.,Erfan General HospitalTehran | And 3 more authors.
Clinical Neurology and Neurosurgery | Year: 2015

Abstract Background Intrasellar location of schwannoma is extremely rare, although intracranial schwannomas are common in the central nervous system. The aim of the present study is to describe a calcified intrasellar schwannoma case. Materials and methods We represent a 45-year-old woman who had suffered from headaches; right side facial pain and visual disturbance which had worsen during the last week prior to admission. Physical examinations were normal except for the bitemporal visual field hemianopia which match with perimetry examination. MRI demonstrated an unusual seemingly calcified mass lesion in the sellar region which was mimicking pituitary macro adenoma. Result Total resection of the tumor achieved through endoscopic transnasal transsphenoidal approach by extracapsular dissection and pathologic examination of the tumor revealed calcified schwannoma. Conclusion The differential diagnoses of sellar and suprasellar lesions include pituitary adenomas, craniopharyngiomas, meningiomas, and many others. However, schwannoma is not usually included, because the occurrence of schwannoma in the sellar or suprasellar region is extremely rare. Only few cases of intrasellar schwannomas have been reported in the literature, all of which presented a suprasellar extension similar to that of our case. Fascinating surgical point is managing very firm tumor through transsphenoidal corridor which we handle it by very sharp, debulking and extracapsular removal. © 2015 Elsevier B.V. Source


Mohseni-Bandpi A.,Shahid Beheshti University | Kakavandi B.,Ahvaz Jundishapur University of Medical Sciences | Kalantary R.R.,Iran University of Medical SciencesTehran | Azari A.,University of Tehran | Keramati A.,University of Tehran
RSC Advances | Year: 2015

Magnetic nanoparticles (MNPs) have recently been adopted by researchers in the field of adsorption/biosorption for separation of pollutants from aqueous solutions. In this paper, chitosan was impregnated with magnetite nanoparticles through a chemical co-precipitation method to fabricate hybrid adsorbents of Fe3O4-chitosan. The physicochemical and structural properties of the adsorbent were characterized, and then the performance of the adsorbent was evaluated for fluoride removal from water. The operational factors affecting the adsorption process, including pH, contact time, adsorbent dosage, initial fluoride concentration, and temperature, were studied. Various isotherm and kinetic models were also used to evaluate the fit of the experimental data with the modeled results. The equilibrium data were well described by the Freundlich model. The kinetics of the adsorption process followed the pseudo-second-order model. Recycling results suggested that the Fe3O4-chitosan particles maintain a great reusability potential for five consecutive cycles. Findings also showed that the Fe3O4-chitosan can be easily regenerated via acid treatment. The results of the present work highlighted the potential of using the Fe3O4-chitosan magnetic composite for the removal of fluoride from water. In conclusion, Fe3O4-chitosan can be considered as an appropriate adsorbent for fluoride removal from water, because it can be separated both quickly and easily, it has high efficiency, and it does not lead to secondary pollution. This journal is © The Royal Society of Chemistry. Source


Sabour H.,University of Tehran | Javidan A.N.,University of Tehran | Latifi S.,University of Tehran | Shidfar F.,Iran University of Medical SciencesTehran | And 4 more authors.
Journal of Spinal Cord Medicine | Year: 2015

Context: Omega-3 fatty acids have been recently proposed to induce neural improvement in patients with spinal cord injury (SCI) while affecting some hormones including leptin and adiponectin. Objectives: We tried to evaluate the effect of omega-3 fatty acids on circulatory concentrations of leptin and adiponectin among these patients. Design: This study is a double-blinded randomized clinical trial with intervention duration of 14 months. Setting: A tertiary rehabilitation center. Participants: Total of 104 patients with SCI who did not meet our exclusion criteria entered the study. Those with history of diabetes, cancer, endocrinology disease, acute infection, and use of special medications were excluded. Patients were divided randomly into the treatment and control group by using permuted balanced block randomization. Intervention: The treatment group received two MorDHA® capsules per day (each capsule contain 465 mg of docosahexaenoic acid (DHA) and 63 mg of eicosapentaenoic acid (EPA)) for 14 months while the control group received placebo capsules with similar color, shape, and taste. Main outcomes measures: Leptin and adiponectin concentrations in plasma were measured at the beginning of trial and then after 6 and 14 months. Results: Fourteen months of treatment with DHA and EPA did not influence concentrations of leptin but adiponectin level was significantly decreased (P: 0.03). Weight was positively correlated with leptin level at stage 0 of trial (P: 0.008, r = 0.41) while this association was attenuated through stages of trial after intervention. Conclusion: Our data show that omega-3 fatty acids may not affect plasma concentrations of leptin but adiponectin level is decreased in patients with SCI. Moreover, this intervention influences the linear relationship between weight and leptin after 14 months administration of DHA and EPA. © The Academy of Spinal Cord Injury Professionals, Inc. 2015. Source

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