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Mundhada Y.,Rashtrasant Tukadoji Maharaj Nagpur University | Dixit P.,IPS Academy | Umathe S.,Rashtrasant Tukadoji Maharaj Nagpur University
Journal of Psychopharmacology | Year: 2012

Nicotinic acetylcholine receptors mediate some of the rewarding and motivational effects of ethanol, including relapses. Relapses are common in drug addicts during abstinence when exposure to any stressor ensues. However, the role of nicotinic acetylcholine receptors in the ethanol- and stress-induced reinstatement of ethanol-induced conditioned place preference has not yet been explored. Therefore, the present study investigated the influence of mecamylamine, a nicotinic acetylcholine receptors antagonist on acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in adult male Swiss mice. The results revealed that mecamylamine (0.1-10 μg/mouse, intracerebroventricularly) dose dependently prevented the development, expression, and reinstatement of ethanol-induced conditioned place preference. Further, acute treatment with mecamylamine blocked the restraint stress and forced swim stress-induced reinstatement of ethanol-induced conditioned place preference. All of these treatments had no influence on the locomotor activity. Therefore, it is concluded that mecamylamine blocks the acquisition, expression and reinstatement of conditioned reinforcing effects of ethanol without per se reinforcing or aversive influence. This ability of mecamylamine might be a potential advantage in the treatment of alcoholism. © British Association for Psychopharmacology 2012.

Dixit P.,IPS Academy | Umathe S.,Rashtrasant Tukadoji Maharaj Nagpur University
Epilepsy and Behavior | Year: 2010

Berberine, an isoquinoline alkaloid is reported to modulate several neurotransmitter systems like N-methyl-D-aspartate, nitric oxide and serotonin, which modulate convulsions. In addition, it is suggested that Berberis vulgaris may be useful in treatment of convulsion and epilepsy. Therefore, the present study investigated the effects of berberine in pentylenetetrazole, maximal electroshock (MES) and kainic acid (KA)-induced convulsions. The latency for development of convulsions and mortality rate was recorded in these models using mice. The results revealed that in MES-induced seizures model, berberine (10 and 20. mg/kg, i.p.) decreased duration of tonic hind limb extension and percent mortality. Moreover, these doses of berberine also protected mice against KA-induced clonic convulsions and decreased mortality. Berberine also protected mice against NMDA-induced turning behavior. Further, the anticonvulsant doses of berberine did not show any signs of motor in-coordination when tested in rotarod test. In conclusion, berberine exhibits anticonvulsant activity by modulating neurotransmitter systems and may find clinical application. © 2010 Elsevier Inc.

A series of 3H-1, -2, -4 triazolinone aryl and nonaryl substituents were subjected to QSAR analysis. Different statistically significant models were obtained, from which the most robust models for QSAR were obtained with r 2 = 0.7968 and q2 = 0.7164 in model 1 for aryl triazolinones, and r2 = 0.7499 and q2 = 0.6290 for nonaryl triazolinones. The physicochemical descriptor HDonorCount and alignment-independent descriptors T-2-N-6, T-2-Cl-6, and T-2-N-4 were found to show significant correlation with biologic activity in aryl triazolinones. PolarSurfaceAreaExcludingPandS, HydrogenCount, and 6ChainCount were significant receptors in the case of nonaryl triazolinones. © 2009 Birkhäuser Boston.

Dubey N.,IPS Academy | Dubey N.,Devi Ahilya University | Mandhanya M.,IPS Academy | Kumar Jain D.,IPS Academy
Journal of Pharmaceutical Analysis | Year: 2012

Prevention of cross contamination with active pharmaceutical ingredients is crucial and requires special attention in pharmaceutical industries. Current method validation describes the determination of Nabumetone (NAB) residue on a stainless steel surface using swab sampling with a sensitive HPLC-DAD analysis. The acceptance limit was decided as 2 μg swab per 100 cm2. Cotton swabs impregnated with extraction solution were used to determine residual drug content. Recoveries were 90.88%, 91.42%, and 92. 21% with RSD ranging from 2.2% to 3.88% at three concentration levels. Residual concentration was found to be linear in the range of 0.1-4.56 μg/mL, when estimated using a Phenomenex Luna C18 (25 cm×5 μm×4.6 mm i.d.) column at 1.0 mL/min flow rate and 230 nm. The mobile phase consisted of a mixture of methanol:acetonitrile:water (55:30:15, v/v/v). The LOD and LOQ for NAB were found to be 0.05 and 0.16 μg/mL, respectively. The validated method was found to be simple, selective and sensitive for demonstration of cleaning validation of NAB residues on a stainless steel surface. © 2012 Xi'an Jiaotong University.

Jain D.,IPS Academy | Mishra G.,Devi Ahilya University
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | Year: 2014

In this paper, we analyze the effect of the betatron oscillation on spontaneous emission and gain spectrum of an optical klystron wave guide free electron laser. The analysis also includes the effects of length mismatch of the two undulator sections of the klystron configuration. We observe that intensity and gain can be change with length mismatch parameter without changing the central emission frequency. © 2014 Elsevier B.V.

Rajput M.S.,IPS Academy | Agrawal P.,MGM Medical College
Indian Journal of Cancer | Year: 2010

Cancer microsphere technology is the latest trend in cancer therapy. It helps the pharmacist to formulate the product with maximum therapeutic value and minimum or negligible range side effects. Cancer is a disease in which the abnormal cells are quite similar to the normal cells, with just minute genetic or functional change. A major disadvantage of anticancer drugs is their lack of selectivity for tumor tissue alone, which causes severe side effects and results in low cure rates. Thus, it is very difficult to target abnormal cells by the conventional method of the drug delivery system. Microsphere technology is probably the only method that can be used for site-specific action, without causing significant side effects on normal cells. This review article describes various microspheres that have been prepared or formulated to exploit microsphere technology for targeted drug therapy in various cancers. We looked at the usefulness of microspheres as a tool for cancer therapy. The current review has been done using PubMed and Medline search with keywords.

Jawanjal H.,IPS Academy
Journal of complementary & integrative medicine | Year: 2012

The antiulcer activity of 70% methanolic extract of fruits of Terminalia belerica Roxb. (Combretaceae) was evaluated using ethanol induced, aspirin induced, cold stress restraint and pylorus ligated ulcer in rats. The methanolic extract (100, 250, 500, 1000 mg/kg, p.o.) significantly suppressed the peptic ulcer induced by ethanol. Methanolic extract at a dose of 500 mg/kg showed, promising antiulcer activity hence, this dose was selected for further evaluation of antiulcer studies. The methanolic extract (500 mg/kg) showed significant (p<0.05) reduction in gastric volume, free acidity, total acidity, ulcer index, protein and pepsin content and increase in mucus content in pylorus ligated rats as compared to control. Treatment with Terminalia belerica methanolic extract further provided significant antiulcer protection against aspirin induced ulcers but not in cold stress restraint model. These results suggested that the 70% methanolic extract of Terminalia belerica increased resistance to necrotizing agents, providing a direct protective effect on the gastric mucosa and exhibited antiulcer effect.

Arya L.D.,Shri Gs Institute Of Technology And Science | Koshti A.,IPS Academy | Choube S.C.,Rajiv Gandhi University
International Journal of Electrical Power and Energy Systems | Year: 2013

This paper presents a methodology for composite distribution system well being analysis based on non-sequential Monte Carlo simulation technique accounting uncertainties in capacity of distribution substation and distributed generation (DG). The method is based on a system state transition sampling approach which is used to calculate frequency and duration indices along with probabilities in healthy state, marginal state and risky state for a composite distribution system. Capacity of distribution substation and distributed generations are considered as normally distributed i.e. continuous capacity. The effectiveness of the method for evaluation of annual well being indices is demonstrated for a sample test system with DG capacity variation considering a seven step load model based on annual load duration curve. A comparative study is carried out which illustrates the effect of distributed generation capacity on well being indices of a distribution system. © 2012 Elsevier Ltd. All rights reserved.

Dubey N.,IPS Academy | Jain D.,IPS Academy | Jadhawani S.,IPS Academy
Journal of Planar Chromatography - Modern TLC | Year: 2012

A stability-indicating high-performance thin-layer chromatographic (HPTLC) method has been developed for the determination of simultaneous determination of famotidine (FAMO), paracetamol (PCM), and ibuprofen (IBU) in tablet dosage forms. The separation was achieved on TLC aluminum plates precoated with silica gel 60F-254 using chloroform-methanol-ethyl acetate-acetic acid (21.5:16.1:59.1:3.2%, v/v/v/v) as the mobile phase. The densitometric analysis was carried out at 256 nm. Compact spots appeared at R F 0.21 ± 0.01, 0.80 ± 0.02, and 0.89 ± 0.01 for FAMO, PCM, and IBU, respectively. Linear regression analysis revealed linearity in the range of 160-960 ng per spot for FAMO, 400-2400 ng per spot for PCM, and 600-3600 ng per spot for IBU. Drugs were subjected to acid and alkali hydrolyses, forced oxidation, thermal and photodegradation treatments. The degraded products were well separated from the pure drugs. Statistical analysis proved that the method is precise, accurate, selective, and economical and may be used for routine analysis of FAMO, PCM, and IBU in tablet dosage forms. © Akadémiai Kiadó, Budapest.

Deotale A.J.,IPS Academy | Nandedkar R.V.,IPS Academy
Materials Today: Proceedings | Year: 2016

Effect of heat treatment was observed on size, strain and band gap of iron oxide nanoparticles. Mixed phase (γ-Fe2O3 and α -Fe2O3) of iron oxide nanoparticles were obtained with increasing annealing temperature from 100°C - to 700°C. Minimum particle size of 40 nm was calculated around 400 °C using X-ray diffraction. The relation between size, strain and band gap of iron oxide nanoparticles has been established with the help of UV- VIS spectroscopy. Sample annealed at 400°C shows direct and indirect band gap at 1.75 eV and 1.67 eV respectively. The band gap & particle size of the nanoparticles are decreasing with increasing annealing temperature up to 400°C. Thereafter, it increases with increase in annealing temperature. But for 40 nm particles the lattice strain is 5 times larger in comparison to strain in larger particle. Strain is larger in mixed phase (before 400 °C) than pure phase (after 400 °C). The present results indicate that the direct variation of band gap with particle size is due to annealing effect which changes the phase, strain and size of nanoparticles. © 2016 Elsevier Ltd.

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