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Mundhada Y.,Rashtrasant Tukadoji Maharaj Nagpur University | Dixit P.,IPS ACADEMY | Umathe S.,Rashtrasant Tukadoji Maharaj Nagpur University
Journal of Psychopharmacology | Year: 2012

Nicotinic acetylcholine receptors mediate some of the rewarding and motivational effects of ethanol, including relapses. Relapses are common in drug addicts during abstinence when exposure to any stressor ensues. However, the role of nicotinic acetylcholine receptors in the ethanol- and stress-induced reinstatement of ethanol-induced conditioned place preference has not yet been explored. Therefore, the present study investigated the influence of mecamylamine, a nicotinic acetylcholine receptors antagonist on acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in adult male Swiss mice. The results revealed that mecamylamine (0.1-10 μg/mouse, intracerebroventricularly) dose dependently prevented the development, expression, and reinstatement of ethanol-induced conditioned place preference. Further, acute treatment with mecamylamine blocked the restraint stress and forced swim stress-induced reinstatement of ethanol-induced conditioned place preference. All of these treatments had no influence on the locomotor activity. Therefore, it is concluded that mecamylamine blocks the acquisition, expression and reinstatement of conditioned reinforcing effects of ethanol without per se reinforcing or aversive influence. This ability of mecamylamine might be a potential advantage in the treatment of alcoholism. © British Association for Psychopharmacology 2012.

Rajput M.S.,IPS ACADEMY | Agrawal P.,MGM Medical College
Indian Journal of Cancer | Year: 2010

Cancer microsphere technology is the latest trend in cancer therapy. It helps the pharmacist to formulate the product with maximum therapeutic value and minimum or negligible range side effects. Cancer is a disease in which the abnormal cells are quite similar to the normal cells, with just minute genetic or functional change. A major disadvantage of anticancer drugs is their lack of selectivity for tumor tissue alone, which causes severe side effects and results in low cure rates. Thus, it is very difficult to target abnormal cells by the conventional method of the drug delivery system. Microsphere technology is probably the only method that can be used for site-specific action, without causing significant side effects on normal cells. This review article describes various microspheres that have been prepared or formulated to exploit microsphere technology for targeted drug therapy in various cancers. We looked at the usefulness of microspheres as a tool for cancer therapy. The current review has been done using PubMed and Medline search with keywords.

Dixit P.,IPS ACADEMY | Umathe S.,Rashtrasant Tukadoji Maharaj Nagpur University
Epilepsy and Behavior | Year: 2010

Berberine, an isoquinoline alkaloid is reported to modulate several neurotransmitter systems like N-methyl-D-aspartate, nitric oxide and serotonin, which modulate convulsions. In addition, it is suggested that Berberis vulgaris may be useful in treatment of convulsion and epilepsy. Therefore, the present study investigated the effects of berberine in pentylenetetrazole, maximal electroshock (MES) and kainic acid (KA)-induced convulsions. The latency for development of convulsions and mortality rate was recorded in these models using mice. The results revealed that in MES-induced seizures model, berberine (10 and 20. mg/kg, i.p.) decreased duration of tonic hind limb extension and percent mortality. Moreover, these doses of berberine also protected mice against KA-induced clonic convulsions and decreased mortality. Berberine also protected mice against NMDA-induced turning behavior. Further, the anticonvulsant doses of berberine did not show any signs of motor in-coordination when tested in rotarod test. In conclusion, berberine exhibits anticonvulsant activity by modulating neurotransmitter systems and may find clinical application. © 2010 Elsevier Inc.

A series of 3H-1, -2, -4 triazolinone aryl and nonaryl substituents were subjected to QSAR analysis. Different statistically significant models were obtained, from which the most robust models for QSAR were obtained with r 2 = 0.7968 and q2 = 0.7164 in model 1 for aryl triazolinones, and r2 = 0.7499 and q2 = 0.6290 for nonaryl triazolinones. The physicochemical descriptor HDonorCount and alignment-independent descriptors T-2-N-6, T-2-Cl-6, and T-2-N-4 were found to show significant correlation with biologic activity in aryl triazolinones. PolarSurfaceAreaExcludingPandS, HydrogenCount, and 6ChainCount were significant receptors in the case of nonaryl triazolinones. © 2009 Birkhäuser Boston.

Jain D.,IPS ACADEMY | Mishra G.,Devi Ahilya University
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | Year: 2014

In this paper, we analyze the effect of the betatron oscillation on spontaneous emission and gain spectrum of an optical klystron wave guide free electron laser. The analysis also includes the effects of length mismatch of the two undulator sections of the klystron configuration. We observe that intensity and gain can be change with length mismatch parameter without changing the central emission frequency. © 2014 Elsevier B.V.

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