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Kolkata, India

Tiwari P.,IPGMER and SSKM Hospital
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia | Year: 2012

Synchronous occurrence of two or more than two primary cancers of the urinary tract is quite rare, and poses a difficult treatment challenge. Here, we present a case of synchronous renal cell carcinoma, transitional cell carcinoma of urinary bladder and adenocarcinoma of prostate diagnosed within a short period. To the best of our knowledge, this is the first case reported from India and the youngest patient reported in the literature having this combination of urinary cancers.

Mukherjee M.,Burdwan Medical College | Paul R.,IPGMER and SSKM Hospital
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2011

This study was done to find out modern demographic trends of aspiration and different foreign bodies posing a risk. For this study, 94 patients with suspected foreign body aspiration (FBA) were selected. Detailed history, especially age, suspected Foreign body (FB) and mode of onset were noted and a thorough clinical examination was done. X-ray chest and neck, antero-posterior and lateral view was the only investigation done in all. Rigid bronchoscopy under general anaesthesia was done in all the cases of suspected FBA for diagnostic cum therapeutic purpose. Among 94 patients 70. 2% i. e. 66 were within 5 years of age and most were within 2-3 years of age. Rigid bronchoscopy was done in all the cases and foreign body was successfully retrieved in 78. 7% of cases. Bronchoscopy was negative in the rest of the cases. The Most common site of lodgment was the right bronchus followed by the left bronchus, the trachea and other sites. Vegetables were the most common FBs as they were found in 26 cases. Whistles from small plastic toys were the single most common FB(15). Other foreign bodies were small plastic and metallic parts, safety pins, jewellery etc. Children under 5 years of age are at greatest risk of FBA. Different vegetables and whistles of low grade toys are the most commonly aspirated FB. Detailed history is most important for diagnosis. X-ray is not a reliable tool for diagnosis. Bronchoscopy should be done whenever a foreign body is suspected in the airway. © 2011 Association of Otolaryngologists of India.

Saha K.,NRS Medical College and Hospital | Chaterjee S.,IPGMER and SSKM Hospital
Journal of Association of Physicians of India | Year: 2012

Background and objective: There is scarcity of clinical data regarding hydatid lung disease from Indian subcontinent. In this retrospective study we analyzed the cumulative data over five year's period from two tertiary care hospitals of Kolkata to determine the presentation, treatment and outcome of hydatid disease of lung. Method: We analyzed 106 patients on the basis of clinical findings, radiological findings [chest X-ray - PA and lateral view, CT scan of thorax and upper abdomen, ultrasonography (uSG) of thorax and upper abdomen] and serological test IgG ElISA (enzyme linked immunosorbent assay) against echinococcus granulosus antigen along with the mode of diagnosis, indications and types of surgery, and outcome of treatment with chemotherapy (albendazole), surgery and combined surgery with chemotherapy. Result: There was female preponderance with median age of presentation 33 years with interquartile range of 7. At the time of diagnosis 14.15% patients were asymptomatic. Cough was the commonest symptom (73.58%) followed by chest pain (54.72%). Single sharply demarcated round or oval homogenous opacity was the commonest radiological sign (81.13%). Complicated cysts such as lung abscess, pleural involvement, pneumonitis and fibrosis were noted in 10.38%, 13.21%, 7.55% and 11.32% cases respectively. We found that serological test was only 77.01% sensitive. Eighty-two (86.32%) patients underwent surgery, and 56.10% of them received additional chemotherapy with albendazole. The types of operation performed were pericystectomy (in 91.46% cases), lobectomy (in 6.10% cases) and pneumonectomy (in 2.44% cases). Perioperative mortality was nil but morbidity was found in 10.98% cases with empyema (8.54%), the commonest complication. Thirteen inoperable patients were treated with albendazole, among them 8 showed reduction of cyst-size, 3 showed no change and 2 patients showed obliteration of cyst. Conclusion: Surgery is a safe and effective way of treatment for thoracic hydatid cyst along with perioperative albendazole therapy. There is a scope for chemotherapy with albendazole in inoperable cases. © JAPI.

Alcoholic liver disease is a major source of morbidity and mortality worldwide. Twin studies had demonstrated heritability of alcoholic liver disease. Although to date only Adiponutrin (PNPLA3) rs738409 polymorphism (I148M) had been unequivocally proved to be associated with increased risk of alcoholic liver disease across different ethnicities. This protein was previously thought to have a predominant lipolytic role. However, recent investigations have provided evidence of lipogenic activity of this protein. The current hypothesis paper is summarizing the recent evidences gleaned in biological role of Adiponutrin and bioinformatic pointers towards a role in lipid trafficking. A critical appraisal of the utility of murine models and cell based systems in investigating Adiponutrin is also presented. As the HepG2 cell line harbors the I148M mutation in homozygous state it is hypothesized that this should represent an ideal model system for PNPLA3 biology. Thus, as Adiponutrin is proposed as having both lipolytic and lipogenic/lipid trafficking roles it is termed as a Yin-Yang protein in analogy to ancient Chinese wisdom. © 2015 Elsevier Ltd.

Das S.,IPGMER and SSKM Hospital | Sen S.,Medical College | Mukherjee A.,Medical College | Chakraborty D.,Medical College | Mondal P.K.,Medical College
Asian Pacific Journal of Cancer Prevention | Year: 2012

Aim: Breast cancer is one of the most common cancers of women in India with high fatality rate. Over a 1 year study period 105 consecutive biopsy or fine needle aspiration cytology confirmed breast cancer patients were interviewed by direct questionnaire method regarding risk factors attending Surgery and Radiotherapy OPD of Medical College Kolkata, West Bengal while taking other 105 patients attending Surgery Department for some other disease as controls. The data were compiled in MS Excel 2007 and analyzed by Epi info 3.5.1 software. Among the cases, rural residence, illiteracy and low socio-economic status was significantly higher than controls. Late onset of menarche, late onset of menopause, ever OCP usage, breast feeding for 1-2 years and age of 1st childbirth between 20-30 years were found to be significant protective factors. People should be made aware regarding the modifiable risk factors to prevent breast cancer.

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