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Bera G.,IPGME and R | Das A.,Park Clinic | Chatterjee S.,Park Clinic | Chatterjee U.,IPGME and R
Journal of Pediatric Neurosciences | Year: 2017

Rosette-forming glioneuronal tumor (RGNT) is a rare variety of slow growing mixed glioneuronal tumor involving primarily fourth ventricular region and occurring predominantly in young adults. We present a case of a 16-year-old boy who presented with dizziness and occipital headache. On radiological evaluation, a fairly large hypodense posterior fossa mass lesion in relation to the left side of the vermis, with a large cystic component was found. Surgical resection of the tumor was performed. Histopathological examination showed a biphasic tumor composed of bland neurocytic cells, arranged in the form of neurocytic rosettes along with glial areas resembling low-grade glioma. The neurocytic rich region shows strong synaptophysin positivity in the neuropil-rich core of the rosettes. Methylation-inhibited binding proliferative index was low (<1%). Based on these features, a diagnosis of RGNT was made. RGNT of the fourth ventricle should be considered in differential diagnosis of posterior fossa lesions, especially in relation to fourth ventricle and vermis in young adults. © 2017 Journal of Pediatric Neurosciences Published by Wolters Kluwer- Medknow.

Chakrabarti S.,ESI PGIMSR | Datta A.S.,IPGME and R | Hira M.,Calcutta Medical College and Hospital
Asian Pacific Journal of Cancer Prevention | Year: 2012

Background: Though open surgical biopsy is the procedure of choice for the diagnosis of bone tumors, many disadvantages are associated with this approach. The present study was undertaken to evaluate the role of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of bony tumors and tumor-like lesions which may be conducted in centers where facilities for surgical biopsies are inadequate. Methods: The study population consisted of 51 cases presenting with a skeletal mass. After clinical evaluation, radiological correlation was done to assess the nature and extent of each lesion. Fine needle aspiration was performed aseptically and smears were prepared. Patients subsequently underwent open surgical biopsy and tissue samples were obtained for histopathological examination. Standard statistical methods were applied for analysis of data. Results: Adequate material was not obtained even after repeated aspiration in seven cases, six of which were benign. Among the remaining 44 cases, diagnosis of malignancy was correctly provided in 28 (93.3%) out of 30 cases and categorical diagnosis in 20 (66.67%). Interpretation of cytology was more difficult in cases of benign and tumor-like lesions, with a categorical opinion only possible in seven (50%) cases. Statistical analysis showed FNAC with malignant tumors to have high sensitivity (93.3%), specificity (92.9%) and positive predictive value of 96.6%, whereas the negative predictive value was 86.7%. Conclusion: FNAC should be included in the diagnostic workup of a skeletal tumor because of its simplicity and reliability. However, a definitive pathologic diagnosis heavily depends on compatible clinical and radiologic features which can only be accomplished by teamwork. The cytological technique applied in this study could detect many bone tumors and tumor-like conditions and appears particularly suitable as a diagnostic technique for rural regions of India as other developing countries.

Das P.,Midnapore Medical College | Basu M.,IPGME and R | Dutta S.,IPGME and R
Lung India | Year: 2012

Introduction: Tuberculosis is a public health problem in India. The patients of Tuberculosis hide their disease from family, relatives, and community due to the presence of stigma. This study was conducted to assess the knowledge, awareness, and perception regarding social variables of tuberculosis among patients and to associate the awareness with their literacy status. Materials and Methods: Type of study was observational, descriptive, and epidemiological. Study design was cross-sectional. Study setting was general out-patient department of tertiary care hospitals of West Bengal. Sample size was 464 (Four hundred sixty four) patients. The collected data were tabulated, analyzed, and interpreted by proper statistical methods (by percentage and Z test). Results: 60.34% of study population was male. More than one third was illiterate (37.93%). Majority (91.38%) had heard about tuberculosis (TB). Correct answer on cause (infection) was responded by 16.81% patients. About 72.41% had heard about TB from an informal contact. The correct response on mode of spread of TB was told by 31.47% patients. About 62.07% correctly answered that cough was the commonest symptom. 82.76% knew about curability of the disease. Isolation of patient (08.62%) and avoidance of sharing of food (06.03%) were reported as preventive measures. The literacy status had a significant influence on awareness about TB. Conclusion: An attempt could be made in future to improve awareness among illiterates to remove myths and misconceptions, to allay the social stigma attached with it, to decrease TB transmission.

Mukherjee S.,IPGME and R | Ghosh S.N.,BIN and P | Chatterjee U.,IPGME and R | Chatterjee S.,Park Clinic
Neurology India | Year: 2011

Context: Although most of the meningiomas are benign, some of them are associated with a less favorable clinical outcome. The major prognostic question regarding meningiomas is the prediction of recurrence which is largely dependent on the histopathological type, grading, proliferation indices and progesterone receptor status. Aims: Our study was done to assess the expression of Ki-67 and progesterone receptor (PR) in different histological types, grades, recurrent and non-recurrent meningiomas. Materials and Methods: A total of 60 cases were collected over a period of 2.5 years. Hematoxylin and eosin staining was done for histological typing and grading of the tumors. Immunohistochemical staining was done for Ki-67 and PR using standard immunoperoxidase technique and Ki-67 Labeling Index (LI) and PR score was calculated. Results: Mean Ki-67 LI was significantly higher in males versus females, in Grade II versus Grade I, in recurrent versus non-recurrent and in PR-negative versus PR-positive meningiomas. Moreover, considering Grade I and Grade II-meningiomas separately, mean Ki-67 LI was significantly higher in recurrent cases. PR positivity was significantly higher in females versus males, in Grade I versus Grade II and in non-recurrent versus recurrent meningiomas. Correlation between Ki-67 LI and PR expression was also evaluated and a strong inverse correlation was found between Ki-67 LI and PR expression. A strong negative correlation was also established between the values of Ki-67 LI and recurrence-free survival. Conclusion: Our results establish that the immunodetection of Ki-67 LI and PR expression in meningiomas provides a practical tool for assessing the biological behavior of meningiomas.

Saha A.K.,KPC Medical College | Sahadalal B.,IPGME and R
International Journal of Pharma and Bio Sciences | Year: 2016

Nearly 400 red blood cell antigens have been grouped into 30 major blood groups, of which, ABO and Rhesus blood group systems are most important for prevention of serious life threatening transfusion reaction, parental testing, legal medicine and extensive population based genetic studies. Our aim of this study was to determine as well as comparing the frequency of ABO and Rhesus blood group systems in the blood donors of Cancer Hospital, Barasat, West Bengal. A retrospective study was conducted in a blood bank of this cancer hospital over a period of three years. The blood was tested and grouped by test tube agglutination technique by commercially available standard monoclonal antisera. Out of total 5128 blood donors, male and females were 4227 (82.42%) and 901 (17.57%) respectively. Regarding ABO blood group systems, B was found to be the commonest (1873, 36.52%), followed by O (1604, 31.27%), A (1130, 22.03%) and AB (521, 10.15%). Regarding Rhesus blood grouping systems, 4987 (97.25%) was Rh positive and 141 (2.74%) Rh negative. This study may be a corner-stone of Improvement of the blood bank data base system as well as blood transfusion services required in case of emergencies. It can prevent missmatched severe life threatening blood transfusion reaction. It can be future predictor of several morbid and mortal diseases.

Adhikary B.,IPGME and R | Yadav S.K.,IPGME and R | Bandyopadhyay S.K.,IPGME and R | Chattopadhyay S.,Bhabha Atomic Research Center
Food and Function | Year: 2011

The modulation of the cyclooxygenase-independent pathway by the green tea-derived polyphenol, epigallocatechin gallate (EGCG) during its healing action against indomethacin (IND)-induced stomach ulceration in mice was investigated. On the 3rd day of its administration, IND (18 mg kg-1) induced maximum stomach ulceration which was associated with increased myeloperoxidase (MPO) activity (2.1-fold, p < 0.001), and inducible nitric oxide synthase (iNOS) expression (2.5-fold, p < 0.001), along with augmented levels of serum nitrite (1.3-fold, p < 0.001), selectins and cell adhesion molecules (CAMs), as well as reduced endothelial nitric oxide synthase (eNOS) expression (53%, p < 0.001). Treatment with EGCG (2 mg kg-1) and omeprazole (3 mg kg-1) for 3 days reversed these parameters, and provided excellent (76-77%) ulcer healing. © 2011 The Royal Society of Chemistry.

Ghosh A.,ESI PGIMSR and ESIC Medical College | Biswas A.K.,Medical College and Hospital | Banerjee A.,IPGME and R
Neurology India | Year: 2015

Background: This study was undertaken to find out if metabolic syndrome (MetS) in the elderly was associated with cognitive decline and also if this association was modified by the presence of inflammation. Materials and Methods: 100 patients more than 60 years of age were divided into 2 groups of 50 each and were age and sex matched. Group 1 and 2 had patients with and without MetS, respectively. The individual components of MetS were measured in each patient. Cognitive decline was measured by Modified Mini-Mental Score (3MS) of Teng. Inflammation was measured by high-sensitivity C-reactive protein (hs-CRP). Results: Fasting hyperglycemia was the most common component of MetS (60% of group 1). The mean serum hs-CRP in patients of group 1 was 6.56 ± 9.72 while that in the patients of group 2 was 1.95 ± 1.93. In the group-1, 36% (n = 18) patients were having a decreased 3MS, whereas in group-2, 22% (n = 11) were having a decreased 3MS. MetS was associated with an odd's ratio of 1.99 for developing cognitive decline. 3MS had a negative correlation with hs-CRP values. Regression analysis showed a significant association of hs-CRP and MetS with cognitive decline in the elderly population. Conclusion: Cognitive decline in the elderly is associated with the presence of inflammation and MetS. Hence, early identification of the high-risk groups may offer benefit by disease course modification and better caregiving.

Mandal D.,IPGME and R
The Journal of the Association of Physicians of India | Year: 2011

To analyze whether the obese women have an increased risk of pregnancy complications and adverse fetal outcome. The longitudinal prospective study was carried out in the Obst and Gynae department, IPGME and R, Kolkata. The study enrolled 422 pre-pregnant obese women with pregnancy as study population and equal number of non obese pregnant mothers as controls. Body mass index (BMI) was > or = 30.0 kg/m2 and 20-22 kg/m2 in obese and control group respectively. In comparison to average weight pregnant women, obese pregnant women were at increased risk of gestational diabetes mellitus (19.43 vs 3.79%; p < 0.001), pregnancy induced hypertension (12.32 vs 2.36%; p < 0.001), pre-eclampsia (8.76 vs 3.31%; p < 0.001), preterm labor in less than 34 week gestation (7.58 vs 3.55%; p < 0.001), cesarean section (36.72 vs 17.53%; p < 0.001), instrumental deliveries (12.32 vs 5.21%; p < 0.001) and postpartum infection morbidities (9.95 vs 3.79%; p < 0.001). These women were more prone to develop overt diabetes (2.36% vs 0) and chronic hypertension (5.21 vs .47% ) in future as well. Neonates of obese women were mostly large for gestational age, macrosomic and they had high incidences of birth injuries, shoulder dystocia, premature deliveries, late fetal deaths and congenital malformations particularly spina bifida, cleft lip, cleft palate and heart defect. As obesity is considered to be a modifiable risk factor, preconception counseling and creating awareness regarding health risks associated with over weight and obesity should be encouraged.

Mukhopadhyay M.,Calcutta National Medical College and Hospital | Saha A.K.,Calcutta National Medical College and Hospital | Sarkar A.,IPGME and R
Indian Journal of Surgery | Year: 2010

Polymastia is a term that is used to describe the presence of more than two breasts in human beings. It is synonymous with supernumerary or accessory breast tissue. Ectopic breast tissue (EBT) may occur any where along the primitive embryonic milk lines, which extend from the axilla to the groin, and may occur unilaterally or bilaterally. In the EBT any disease can develop that affects the normal breast, including fibroadenoma. Since publications describing this anomaly are rare, we decided to report a case of fibroadenoma in axillary breast tissue. © 2010 Association of Surgeons of India.

Bisoi S.,IPGME and R
Indian journal of public health | Year: 2012

About 400 million individuals worldwide have been affected by the inherited disorder of glucose-6-phosphate dehydrogenase (G6PD) deficiency that predisposes individuals to neonatal jaundice or hemolytic crisis due to drugs or infections. A descriptive observational study with longitudinal design was undertaken among 109 live newborns, delivered in labor room of IPGME and R, Kolkata during the period from June to August 2009. An objective of the study was to estimate the occurrence of G6PD deficiency among newborns and its association with different socio-demographic, clinical and gestational characteristics. 14.68% newborns were found G6PD deficient. This occurrence was not significantly related to gender, religion and ethnicity, consanguineous marriage of the parents, gestational age and birth weight of the baby. Development of severe jaundice (total serum bilirubin >15 mg/dl) was found 23.8% among G6PD deficient babies and 12.5% among non-G6PD deficient. This difference was statistically not significant.

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